A*STAR Genome Institute of Singapore (A*STAR GIS)

With Technology to Biology: The Single-Cell Functional Genomics Revolution

A cfDNA-based assay for early detection for cancer

A cfDNA-based assay for early detection for cancer

With Technology to Biology: The Single-Cell Functional Genomics Revolution

Dr. Angli Xue- Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk

Dr. Zhen Qiao- Population-scale single-cell multiomics reveals cell type-specific genetic regulation and selection in clonal haematopoiesis

Engineered Nanobodies to Direct and Visualize Immune Tolerance

Multi-Dimensional Phenotyping: Integrating In Situ Sequencing and Spatial Multiomics

Cancer genes beyond chromosomes

Analysis of cell coordination at different scales: computational attempts.

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical niches.

Dissecting the clonal dynamics of chemotherapy resistance:  Resistance, sensitivity, and drug persisters

3D genome folding and transcription regulation

The ecDNA Epigenome: from Permissive Chromatin to Actionable Vulnerability

Elucidating Cancer Gene Expression From Transcriptome to Epitranscriptome to Proteome: Algorithms & Biomarkers

Genomic and Functional Landscapes of ecDNA-Driven Cancers

Nuclear RNA sorting

Good Enough Practices for reproducible bioinformatics

A novel approach for single-cell 3D spatial omics

Towards a comprehensive single-cell picture of RNA isoforms in mouse and human brain and their diseases – or – Single-cell isoforms in time and space

The ecDNA Epigenome: from Permissive Chromatin to Actionable Vulnerability

A viral noncoding RNA is a master regulator of gene expression that defines host cell identity and function.

Beyond snapshots: Mapping RNA life cycle in developing cells by novel spatial omics technologies