Latest Scientific Journal Publications

Separation of human erythrocyte membrane associated proteins with one-dimensional and two-dimensional gel electrophoresis followed by identification with matrix-assisted laser desorption/ionization-time of flight mass spectrometry.

Proteomics

Low, T.Y., Seow, T.K., & Chung, M. C. M.

Interrogating the transcriptome.

Trends Biotechnol

Ruan Y, Le Ber P, Hui Ng H, Liu ET

Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1

Nature Structural and Molecular Biology

Mousheng Wu, Lei Lu, Wanjin Hong, Haiwei Song

*The topoisomerase inhibitor camptothecin sensitizes mouse hepatocytes in vitro and in vivo to tumour necrosis factor-induced apoptosis

Hepatology

Hentze H, Latta M, Kunstle G, Dhakshinamoorthy S, Ng D, Porter AG, Wendel A

15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis.

Genome Res

Lo J, Lee S, Xu M, Liu F, Ruan H, Eun A, He Y, Ma W, Wang W, Wen Z and Peng J

A HEX-1 crystal lattice required for Woronin body function in Neurospora crassa

Nat. Struct. Biol

Yuan P, Jedd G, Kumaran D, Swaminathan S, Shio H, Hewitt D, Chua NH and Swaminathan K

A motif rich in charged residues determines product specificity in isomaltulose synthase.

FEBS Lett

Zhang D, Li N, Swaminathan K and Zhang LH

A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts.

J. Cell Sci

Yu F, Morin X, Kaushik R, Bahri S, Yang X, Chia W.

A Notch feeling of somite segmentation and beyond

Developmental Biology

Rida PC, Le Minh N, Jiang YJ.

A Novel dimer of a C-type lectin-like heterodimer from the venom of Calloselasma rhodostoma (Malayan pit viper).

FEBS Letters

Wang, R., Kong, C., Kolatkar, P., Chung, M. C. M.

A novel severe acute respiratory syndrome coronavirus protein, u274, is transported to the cell surface and undergoes endocytosis

J. Virol.

Tan YJ, Teng E, Shen S, Tan TH, Goh PY, Fielding BC, Ooi EE, Tan HC, Lim SG, Hong W

A transcriptional initiator overlaps with a conserved YY1 binding site in the long control region of human papillomavirus type 16.

Virology

Tan SH, Baker CC, Stunkel W and Bernard HU

Acyl-homoserine lactone acylase from Ralstonia str. XJ12B represents a novel and potent class of quorum quenching enzymes.

Mol. Microbiol.

Lin YH, Xu JL, Hu J, Wang LH, Ong SL, Leadbetter JR and Zhang LH

An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors

FEBS Letters

Choong, M. L., Tan, L. K., & Lo, S. L., Ee-Chee Ren, Ou, K., Ong, S.E, Liang, R.C.M.Y, Seow, T.K., & Chung, M. C. M.

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

NATURE

R. Pillai and V. Brusic (with Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, et al.)

Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions.

Cell

Cai Y, Yu F, Lin S, Chia W and Yang X

Application of comparative genomics to the analysis of vertebrate regulatory elements

Brief. Funct. Genomic Proteomic

Gilligan P, Venkatesh B

ArhGAP15, a novel human RacGAP protein with GTPase binding property.

FEBS Lett

Seoh ML, Ng CH, Yong J, Lim L and Leung T

Cellular RNA helicase p68 relocalization and interaction with the Hepatitis C Virus NS5B protein and its potential role in HCV RNA replication

J. Virol.

Goh PY, Tan YJ, Lim SP, Tan YH, Lim SG, Fuller-Pace F, Hong W

Characterization of a unique group-specific protein (U122) from the Severe Acute Respiratory Syndrome (SARS) coronavirus

J. Virol.

Fielding BC, Tan YJ, Shuo S, Tan THP, Ooi EE, Lim SG, Hong W, Goh PY

Choong, M. L., Tan, L. K., & Lo, S. L., Ee-Chee Ren, Ou, K., Ong, S.E, Liang, R.C.M.Y, Seow, T.K., & Chung, M. C. M.

FEBS Letters

Choong, M. L., Tan, L. K., & Lo, S. L., Ee-Chee Ren, Ou, K., Ong, S.E, Liang, R.C.M.Y, Seow, T.K., & Chung, M. C. M.

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

CANCER CELL

J. Li, H. Liu, L. Wong

Cloning and characterization of a metalloprotease from Vibrio harveyi strain AP6.

Gene

Teo JWP, Zhang LH and Poh CL

Cloning and Expression of Immunoreactive Antigens from Mycobacterium tuberculosis.

Clinical and Diagnostic Laboratory Immunology

Lim R.L.H., Tan L.K., Lau W.F., Chung M.C.M., Dunn R., Too H.P. and Chan L

ClustalW-MPI: ClustalW Analysis Using Distributed and Parallel

in press, Bioinformatics

Kuo-Bin Li

Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection

The Lancet

Ruan Yijun , Wei Chia Lin , Ling Ai Ee , Vinsensius Vega S B , Thoreau Herve , Su Yun Se Thoe , Chia Jer-Ming , Ng Wei Pern Patrick , Chiu Kuo Ping , Lim Landri , Zhang Tao , Chan Kwai Peng , Lynette Oon Lin Ean , Ng Mah Lee , Leo Yee Sin , Ng Fong-Poh Lisa , Ren Chee Ee , Stanton W Lawrence , Long M. Philip , Liu Tak-Bun Edison. (Ruan and Wei contributed equally to this publication)

Compartmentalization of Fas and Fas ligand may prevent auto- and paracrine apoptosis in epithelial cells.

Exp. Cell Res

Tan KH and Hunziker W

CpG methylation of human papillomavirus-16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression.

J. Virol.

Badal V, Chuang LSH, Badal S, Tang E, Villa LL, Wheeler CM, Li BFL and Bernard HU

Crystal Structure and Functional Analysis of the Eukaryotic Class II Release Factor eRF3 from S. pombe

Mol. Cell

Kong CG, Ito K, Walsh AM, Wada M, Liu YY, Kumar S, Barford D, Nakamura Y, Song HW

Crystallization and preliminary X-ray analysis of candoxin, a novel reversible neurotoxin from the Malayan krait Bungarus candidus

Acta Crystallographica

Paaventhan P , Joseph S. Jeremiah , Nirthanan S , Rajaseger G , Gopalakrishnakone P , Kini RM , Kolatkar PR

Dependence of Pre-mRNA introns on PRP17, a non-essential splicing factor: Implications for efficient progression through cell cycle transitions.

Nucleic Acids Res

Chawla G, Sapra A, Surana U and Vijayraghavan U

Duplication, degeneration and subfunctionalization of the nested synapsin-Timp genes in Fugu rubripes.

Trends Genet

Yu WP, Brenner S and Venkatesh B

Expression, crystallization and preliminary X-ray analysis of isomaltulose synthase (PalI) from Klebsiella sp. LX3.

Acta Cryst

Li N, Zhang DH, Zhang LH and Swaminathan K

Extensive expansion of the claudin gene family in the teleost fish, Fugu rubripes

Genome Res.

Loh YH, Christoffels A, Brenner S, Hunziker W, Venkatesh B

Floral homeotic genes are targets of gibberellin signaling in flower development

Proc Natl Acad Sci (USA) 

Yu H, Ito T, Zhao Y, Peng JR, Kumar P, Meyerowitz EM

Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes

Mol. Biol. Evol.

Christoffels A, Koh EGL, Chia J, Brenner S, Aparicio S, Venkatesh B

Genomic and proteomic perspectives in cell culture engineering

J. Biotechnol

Korke, R., Rink, A., Seow, T.K., Chung, M.C.M., Beattie, C. W., Hu, W.S.

Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity.

Gene

Tan I, Cheong A, Lim L and Leung T

GIT1 activates PAK through a mechanism independent of p21 binding

Mol. Cell. Biol.

Loo TH, Ng Y-W, Lim L, Manser E

GLUT4 recycles via a TGN subdomain enriched in syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.

Mol. Biol.Cell

Shewan AM, van Dam EM, Martin S, Tang BL, Hong W, Bryant NJ and James DE

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.

EMBO J

Lufei C, Ma J, Huang G, Zhang T, Novotny-Diermayr V, Ong T, and Cao X

Group D prothrombin activators from snake venom are structural homologues of mammalian blood coagulation factor Xa

Biochemical Journal

Rao VS , Joseph S. Jeremiah , Kini RM

Hepatocellular carcinoma: From bedside to proteomics (Review Paper)

Proteomics

Seow, T. K., Liang R. C. M. Y., Leow, C. K. and Chung, M. C. M.

Hgc1, a novel hypha-specific G1 cyclin-related protein regulates C. albicans hyphal morphogenesis

EMBO J.

Zheng X, Wang YM, Wang Y

Hox gene clusters in the Indonesian coelacanth, Latimeria menadoensis.

Proc. Natl. Acad. Sci. (USA)

Koh EGL, Lam K, Christoffels A, Erdmann MV, Brenner S and Venkatesh B

Human growth hormone regulated HOXA1 is a human mammary epithelial oncogene.

J. Biol. Chem

Zhang X, Zhu T, Chen Y, Mertani HC, Lee KO and Lobie PE

Identification of a serine protease inhibitor homologue in Bird's Nest by an integrated proteomics approach.

Electrophoresis

Ou, K., Seow, T. K., Liang R. C. M. Y., Lee, B. W., Goh, D. L. M., Chua, K. Y., and Chung, M. C. M.

Identification of chelerythrine as an inhibitor of BclXL function.

J. Biol. Chem

Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD and Yu VC

Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis

Yeast

Chen XQ, Du X, Liu J, Balasubramanian MK, Balasundaram D

Identification of the essential histidine residue for high-affinity binding of AlbA protein to albicidin antibiotics

Microbiol. UK

Weng LX, Xu JL, Li Q, Birch RG and Zhang LH

Identification of the essential histidine residue for high-affinity binding of AlbA protein to albicidin antibiotics.

Microbiol. UK

Weng LX, Xu JL, Li Q, Birch RG and Zhang LH

Iguana encodes a novel zinc finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo

Genes Dev.

Wolff C, Roy S, Lewis K, Schauerte H, Joerg-Rauch G, Kirn A, Weiler C, Geisler R, Haffter P, Ingham PW

Immunochemical characterization of edible bird's nest allergens

J. Allergy Clin. Immun

Goh, D. L. M., Chua, K. Y., Chew, F. T., Liang, R. C. M. Y., Seow, T. K., Ou, K., Yi, F. C., and Lee, B. W.

Inactivation of dispatched1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo

Dev. Biol.

Nakano Y, Kim R, Kawakami A, Roy S, Schier A, Ingham PW

Low glutamine fed-batch cultures of 293HEK serum-free suspension cells for adenovirus production.

Biotechnol. Progess

Lee, Y.Y., Yap M.G.S., Hu, W-S and Wong, T.K.K.

Mapping of three translocation breakpoints associated with orofacial clefting within 6p24 and identification of new transcripts within the region

Cytogenet. Genome Res.

Davies SJ, Wise C, Venkatesh B, Mirza G, Jefferson A., Volpi EV, Ragoussis J

Microenvironment-driven changes in the expression profile of hematopoietic cobblestone area-forming cells

Ann Hematol.

Choong ML, Luo B, Lodish HF

Mind Bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

Dev. Cell

Itoh M, Kim CH, Palardy G, Oda T, Jiang YJ, Maust D, Yeo SY, Lorick K, Wright GJ, Ariza-McNaughton L, Weissman AM, Lewis J, Chandrasekharappa SC and Chitnis AB

Molecular cloning of growth hormone-encoding DNA of an Indian major carp, Labeo rohita, and its expression in Escherichia coli and zebrafish

Gen. Com. Endocrinol

Venugoal, T , Anathy, V , Pandian, T.J. , Mathavan, Sinnakarupan

Molecular cloning of the pufferfish (Takifugu rubripes) Mx gene and functional characterization of its promoter.

Immunogenetics

Yap WH, Tay A, Brenner S and Venkatesh B

Molecular cloning of the pufferfish (Takifugu rubripes) Mx gene and functional characterization of its promoter.

J. Biol. Chem

Graichen R, Sandstedt J, Goh EL, Isaksson OG, Tornell J and Lobie PE

Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the anti-oxidant response element counteracts apoptosis of neuroblastoma cells

J. Biol. Chem.,

Dhakshinamoorthy S, Porter AG

Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain

Dev. Cell

Cheng YC, Amoyel M, Qiu X, Jiang YJ, Xu Q, Wilkinson DW

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia

Oncogene

Osato M

Prevalence of Candida Species Including Candida dubliniensis in Singapore.

J. Clin. Microbiol

Yang CW, Barkham TMS, Chan FY and Wang Y

Prevalence of Candida Species Including Candida dubliniensis in Singapore. .

J. Clin. Microbiol

Yang CW, Barkham TMS, Chan FY and Wang Y

Proteome analysis of a human hepatocellular carcinoma cell line, HCC-M: An update

Electrophoresis

Ou, K., Seow, T. K., Liang, R. C. M. Y., Ong, S. E., and Chung, M. C. M.

Proteome analysis of butyrate-treated human colon cancer cells (HT-29).

Int.J. Cancer

Tan, S., Seow, T.K., Liang, R.C.M.Y., Koh, S., Lee, C.P.C., Chung, M.C., M., & Hooi S.C.

Proteome analysis of conditional medium from mouse embryonic fibroblast feeder layers which support the growth of human embryonic stem cells.

Proteomics

Lim, W.E., & Bodnar, A.

Proteome database of hepatocellular carcinoma

Journal of Chromatography

Liang, R.C.M.Y., Neo, C.H. , Lo, S. L., Tan, G. S., & Chung, M. C. M.

Proteomic investigation of metabolic shift in mammalian cell culture

Biotechnol

Seow, T.K., Korke, R., Liang, R.C.M.Y., Ong, S.E., Ou, K., Wong, K., Hu, W.S., and Chung, M.C.M.

PTPa regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration.

J. Cell Biol

Zeng L, Si X, Yu WP, Le HT, Ng KP, Teng RM, Ryan K, Wang DZ, Ponniah S and Pallen CJ

Quormone turnover in Agrobacterium tumefaciens is regulated by starvation signal and stress alarmone (p)ppGpp

Mol. Microbiol.

Zhang HB, Wang C, Zhang LH

Quorum quenching and proactive host defense.

Trends Plant Sci

Zhang LH

Restricted genomic fraction-polymerase chain reaction (RGF-PCR): A novel technique to isolate different copies of a multi-copy gene

Curr.Sci.

Kumaresan G , Mathavan Sinnakarupan

Risk factors for proteinuria in a large, multiracial, Southeast Asian population

J Am Soc Nephrol

Ramirez SP, McClellan W, Port FK, , Hsu I-Hong Stephen

Role of solvent in interactions between fatty acids-based formulations and lipids in porcine stratum corneum.

J Control Release

Wang MY, Yang YY, Heng PW

RUNX transcription factors as key targets of TGF-beta superfamily signalling

Curr.Opin. Genet. Dev

Ito Y and Miyazono K

Runx2 and Runx3 are essential for chondrocyte maturation and Runx2 regulates limb growth through induction of Indian hedgehog

Genes Dev.

Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zannma A, Tanaka K, Ito Y, Komori

Structure-activity relationships of antileishmanial and antimalarial chalcones.

Bioorg Med Chem

Liu M, Wilairat P, Croft SL, Tan AL and Go ML

Synthesis of guanidinoglycosides with the inventive use of mitsunobu conditions and 1,8-diazabicyclo[5.4.0]undec-7-ene.

Synthesis

Lin P, Heng SCH and Sim MM

The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling

Nature Genetics

Sarah Baxendale, Claire Davison, Claire Muxworthy, Christian Wolff, Philip W Ingham, Sudipto Roy

The binary interacting network of the conserved oligomeric Golgi (COG) tethering complex

J. Biol. Chem.

Loh E, Hong W

The Drosophila EAST protein associates with a nuclear remnant during mitosis and constrains chromosome mobility

J. Cell Sci

Wasser M and Chia W

The next step in systems biology: simulating the temporospatial dynamics of molecular network

Bioessays

Zhu H, Huang S, Dhar P

Tome-1, wee1 and onset of mitosis: coupled destruction for timely entry.

Mol. Cell

Lim HH and Surana U

Two-dimensional electrophoresis map of the human hepatocellular carcinoma cell line, HCC-M, and identification of the separated proteins by mass spectrometry.

Electrophoresis

Teck Keong Seow, Shao-En Ong, Rosa C M Y, Liang, Ee-Chee Ren, Lily Chan, Keli Ou, Maxey C M Chung

Viral virulence protein suppresses RNAi mediated defence but upregulates the role of miRNA in host gene expression

Plant Cell

Chen J, Li WX, Xie D, Peng JR, Ding SW