It’s the contact lens solution that made headlines everywhere. When researchers at the Institute of Bioengineering and Nanotechnology (IBN) came up with the idea to create a contact lens that delivers drugs straight to the eye, it got coverage in The Economist, R&D Digest and international medical journals.

Patients suffering from eye ailments are often prescribed eye drops to treat illnesses or relieve discomfort. However it has been found that up to 95% of the medication drains through the nasal cavity and can seep into the blood stream of other organs. “Delivering medication through eye drops is not the most effective way – patients forget to apply their medication, eye drops are cumbersome, they lead to wastage and can enter the bloodstream,” says Dr Edwin Chow who is behind this IBN brainchild.

Chow and the IBN team of nano-engineers set their sights to create a highly effective, efficient and easy way to solve the problem. They created a time-release drug capsule encased in a contact lens. Chow is the first to mix oil-based materials and water components together to form the contact lens. By using a highly secretive special ingredient to gel the two, he’s proven that oil and water can mix!

The eye-opening technology works by adding medication into the lens solution. The solution contains a mixture of molecules, when set create a network of tiny channels that are 100,000 times smaller than the width of a strand of hair. These channels direct the drug to be released when the lens comes into contact with the eye. And by adjusting the channel size, dosages can be administered over the course of hours and even days.

Looking ahead, Chow has a great vision for this multi-tasking medical marvel that will change the way we view the humble contact lens. When probed…all he had to say was… Watch this space for more.”

We certainly will.

 
Mechanism:

Upon insertion into the eye, the drug-loaded lens will slowly release the drug into the pre-lens tear film - the film in between the air and the lens (PLTF) and the post lens film - the film in between the cornea and the lens (POLTF)

• Hydrophilic drugs
- Ciprofloxacin (antibiotic drug – treatment for bacterial infection)

• Hydrophilic drugs
- Timolol maleate (glaucoma medication)
- Chlorpheniramine maleate (antihistamine medication
– treatment for hay fever, allergy etc)
(research undergoing now)

• Artificial tears
(research undergoing now)

 
 
COPYRIGHT © Agency for Science, Technology and Research. You are most welcome to reproduce any part of this newsletter with acknowledgements except for material for which A*STAR does not hold the copyright. So please contact us first before reproduction in any form by emailing to:
a-star_contact@a-star.edu.sg
A*STAR © 2005 All Rights Reserved |Interactive Design by Apical