Research Areas

Nanomedicine and Biomaterials, where small molecule drugs, biologics, functionalized polymers and hydrogels are developed as therapeutics and carriers for the controlled release and targeted delivery of therapeutics to diseased cells and organs.

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Research > Nanomedicine and Biomaterials

Antiviral Polymers with Broad-Spectrum Activity, High Selectivity and Resistance Mitigation

Chuan Yang, Shujun Gao and Yi Yan Yang

Treatment of viral infections continues to be challenging due to the variance in viral structure (RNA, DNA, enveloped and non-enveloped viruses) and their ability to rapidly mutate and garner resistance. We have developed a general strategy to prevent viral infection using multi-functional macromolecules that were designed to have mannose moieties that compete with viruses for immune cells, and basic amine groups that block viral entry through electrostatic interactions and prevent viral replication by neutralizing the endosomal pH. These macromolecules effectively prevented dengue, influenza, Chikungunya, Enterovirus 71, Ebola, Marburg and herpes simplex infections at polymer concentrations as low as 0.2 mg/L with very high selectivity (> 5000) over mammalian cells. As the antiviral mechanism is based on non-specific supramolecular interactions between the amino acid residues and mannose/cationic moieties of the macromolecule, repeated use of the molecules did not induce drug resistance development. These macromolecules are being tested for in vivo efficacy.

CAR-Grafted Immune Cell Therapeutics for Cancer Immunotherapy

Jieming Zeng and Shu Wang

Chimeric antigen receptor (CAR)-modified immune cell therapy has achieved a significant advance in combating blood cancer and is highly promising for the treatment of solid tumors. Since CAR-grafted alpha beta T-cells concurrently express endogenous T cell receptors (TCRs) in the same T cells, uncontrolled graft-versus-host effects may be produced when used allogeneically. We aim to develop off-the-shelf, allogeneic CAR-grafted, anti-cancer cell therapeutics and focus on natural killer (NK) cells and gamma delta T-cells. Our goal is to translate the research findings in the laboratory into clinical products that can benefit patients.

Injectable Biodegradable Hydrogels for Drug Delivery and Tissue Engineering

Ki Hyun Bae, Atsushi Yamashita, Li Li, Shengyong Ng, Kun Liang, Joo Eun Chung and Motoichi Kurisawa

Hydrogels are soft materials with high water content. IBN researchers have developed a novel gel that can encapsulate therapeutic proteins, growth factors and cells for drug delivery and tissue regeneration. The hydrogels are biodegradable, made of non-toxic materials and can be injected into the body. They can regulate the rate of drug release in the body over a specific period, and reduce the need for frequent injections. These new materials show tremendous potential for improved treatment of cancer and neurological disorders. They can also be used as a scaffold to grow new tissues.

Macromolecular Antimicrobials to Combat Microbes

Chuan Yang, Shrinivas Venkataraman, Xin Ding, Shaoqiong Liu, Jeremy Tan, David Voo, Zhen Chang Liang, Eddy Tan, Shujun Gao, Yuan Yuan, Diane Lim, Hong Wu, Jackie Y. Ying, Yugen Zhang and Yi Yan Yang

The increasing prevalence of antibiotic-resistant infections, such as Methicillin-resistant Staphylococcus aureus (MRSA), has sparked off a pressing need for innovative antimicrobial treatments. IBN has developed a new class of antimicrobial polymers and peptides that can provide a new arsenal against superbugs. Most modern-day antibiotics act on specific molecular targets within the bacteria. While this yields therapeutic specificity, it also allows resistance development through mutation since the bacterial cell structure is generally preserved. The antimicrobial macromolecules are biodegradable and biocompatible, and have broad-spectrum antimicrobial activities against bacteria, yeast and fungi, to destroy multidrug-resistant microbes and prevent drug resistance development.

Polymeric Nanoparticles for Targeted Drug Delivery towards Cancer Cells and Cancer Stem Cells

Shaoqiong Liu, Ashlynn Lee, Chuan Yang, Shujun Gao and Yi Yan Yang

We aim to develop safe polymer-based nanocarriers with narrow size distribution, high drug loading capacity and in vivo stability to transport small molecular anti-cancer drugs to cancer cells and cancer stem cells that are responsible for tumor relapse and metastasis. Biodegradable polymer nanoparticles that can interact with the drugs have been synthesized. A number of platform technologies have been developed to deliver a variety of drugs, proteins and genes. In particular, the co-delivery of dual drugs has been demonstrated to effectively suppress tumor growth by eliminating both cancer cells and cancer stem cells. These co-delivery nanosized formulations have the potential to improve cancer therapy, and prevent relapse and metastasis.

Using Green Tea Nanocomplex to Fight Cancer

Joo Eun Chung, Kun Liang, Nunnarpas Yongvongsoontorn, Atsushi Yamashita, Ki Hyun Bae, Shengyong Ng, Lucky Swarnalatha Sasidharan, Min-Han Tan and Motoichi Kurisawa

Green tea has long been known for its anti-oxidant, anti-cancer, anti-aging and anti-microbial properties. IBN has taken the health benefits of green tea to the next level by using one of its key compounds, epigallocatechin gallate (EGCG), to develop micellar nanocomplexes for delivering anti-cancer protein drugs. The nanocarrier is formed by complexation of oligomerized EGCG with the protein drugs to form the core, followed by complexation of poly(ethylene glycol)–EGCG to form the shell. The micellar nanocomplexes protect the protein drugs from rapid proteolysis and renal clearance, while providing for tumor targeting. This green tea nanocarrier reduces tumor growth more effectively than using the drug by itself. We are also exploring the delivery of active ingredients in personal care and nutritional products using the micellar nanocomplexes.
  1. P. Yuan, X. Ding, Y. Y. Yang and Q. H. Xu , " Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection ," Advanced Healthcare Materials , (2018) DOI: 10.1002/adhm.201701392

  2. S. Obuobi, Z. X. Voo, M. W. Low, B. Czarny, V. Selvarajan, N. L. Ibrahim, Y. Y. Yang and P. L. R. Ee , " Phenylboronic Acid Functionalized Polycarbonate Hydrogels for Controlled Release of Polymyxin B in Pseudomonas Aeruginosa Infected Burn Wounds ," Advanced Healthcare Materials , (2018) DOI: 10.1002/adhm.201701388

  3. N. H. Park, W. Cheng, F. Lai, C. Yang, P. F. de Sessions, B. Periaswamy, C. W. Chu, S. Bianco, S. Liu, S. Venkataraman, Q. Chen, Y. Y. Yang and J. L Hedrick , " Addressing Drug Resistance in Cancer with Macromolecular Chemotherapeutic Agents ," Journal of the American Chemical Society , (2018) DOI: 10.1021/jacs.7b11468

  4. W. Chin, G. Zhong, Q. Pu, C. Yang, W. Lou, P. F. de Sessions, B. Periaswamy, A. Lee, Z. C. Liang, X. Ding, S. Gao, C. W. Chu, S. Bianco, C. Bao, Y. W. Tong, W. Fan, M. Wu, J. L. Hedrick and Y. Y. Yang , " A Macromolecular Approach to Eradicate Multidrug Resistant Bacterial Infections While Mitigating Drug Resistance Onset ," Nature Communications , 9 (2018) 917

  5. K. Liang, J. E. Chung, S. J. Gao, N. Yongvongsoontorn and M. Kurisawa , " Highly Augmented Drug Loading and Stability of Micellar Nanocomplexes Composed of Doxorubicin and Poly(ethylene glycol)–Green Tea Catechin Conjugate for Cancer Therapy ," Advanced Materials , (2018) DOI: 10.1002/adma.201706963

  6. K. H. Bae, S. Tan, A. Yamashita, W. X. Ang, S. Gao, S. Wang, J. E. Chung and M. Kurisawa , " Hyaluronic Acid-Green Tea Catechin Micellar Nanocomplex: Fail-Safe Cisplatin Nanomedicine for the Treatment of Ovarian Cancer Without Off-Target Toxicity ," Biomaterials , (2017) DOI: 10.1016/j.biomaterials.2017.09.027

  7. C. Liu, K. H. Bae, A. Yamashita, J. E. Chung and M. Kurisawa , " Thiol-Mediated Synthesis of Hyaluronic Acid-Epigallocatechin-3-O-Gallate Conjugates for the Formation of Injectable Hydrogels with Free Radical Scavenging Property and Degradation Resistance ," Biomacromolecules , 18 (2017) 3143-3155

  8. J. P. K. Tan, D. J. Coady, H. Sardon, A. Yuen, S. Gao, S. W. Lim, Z. C. Liang, E. W. Tan, S. Venkataraman, A. C. Engler, M. Fevre, R. On, Y. Y. Yang and J. L. Hedrick , " Broad Spectrum Macromolecular Antimicrobials with Biofilm Disruption Capability and In Vivo Efficacy ," Advanced Healthcare Materials , (2017) DOI: 10.1002/adhm.201601420

  9. Y. Yuan and Y. Zhang , " Enhanced Biomimic Bactericidal Surfaces by Coating with 2 Positively-Charged ZIF Nano-Dagger Arrays ," Nanomedicine: Nanotechnology, Biology and Medicine , (2017) DOI: 10.1016/j.nano.2017.06.003

  10. J. S. Khara, S. Obuobi, Y. Wang, M. S. Hamilton, B. D. Robertson, S. M. Newton, Y. Y. Yang, P. R. Langford and P. L. R. Ee , " Disruption of Drug-Resistant Biofilms Using De Novo Designed Short α-Helical Antimicrobial Peptides with Idealized Facial Amphiphilicity ," Acta Biomaterialia , 57 (2017) 103-114

  11. Z. Y. Ong, C. Yang, W. Cheng, Z. X. Voo, W.Chin, J. L. Hedrick and Y. Yan Yang , " Biodegradable Cationic Poly(carbonates): Effect of Varying Side Chain Hydrophobicity on Key Aspects of Gene Transfection ," Acta Biomaterialia , (2017) DOI: 10.1016/j.actbio.2017.03.027

  12. S. Liu, R. J. Ono, H. Wu, J. Y. Teo, Z. C. Liang, K. Xu, M. Zhang, G. Zhong, J. P.K. Tan, M. Ng, C. Yang, J. Chan, Z. Ji, C. Bao, K. Kumar, S. Gao, A. Lee, M. Fevre, H. Dong, J. Y. Ying, L. Li, W. Fan, J. L. Hedrick and Y. Y. Yang , " Highly Potent Antimicrobial Polyionenes with Rapid Killing Kinetics, Skin Biocompatibility and In Vivo Bactericidal Activity ," Biomaterials , 127 (2017) 36-48

  13. N. H. Park, Z. X. Voo, Y. Y. Yang and J. L. Hedrick , " Convergent Approach to Boronic Acid Functionalized Polycarbonates: Accessing New Dynamic Material Platforms ," ACS Macro Letters , 6[3] (2017) 252-256

  14. A. Bossion, G. O. Jones, D. Taton, D. Mecerreyes, J. L. Hedrick, Z. Y. Ong, Y. Y. Yang and H. Sardon , " Non-Isocyanate Polyurethane Soft Nanoparticles Obtained by Surfactant-Assisted Interfacial Polymerization ," Langmuir , 33[8] (2017) 1959-1968

  15. J. M. W. Chan, R. J. Wojtecki, H. Sardon, A. L. Z. Lee, C. E. Smith, A. Shkumatov, S. Gao, H. Kong, Y. Y. Yang and J. L. Hedrick , " Self-Assembled, Biodegradable Magnetic Resonance Imaging Agents: Organic Radical-Functionalized Diblock Copolymers ," ACS Macro Letters , 6[2] (2017) 176-180

  16. G. Zhong, J. Cheng, Z. C. Liang, L. Xu, W. Lou, C. Bao, Z. Y. Ong, H. Dong, Y. Y. Yang and W. Fan , " Short Synthetic β-Sheet Antimicrobial Peptides for the Treatment of Multidrug-Resistant Pseudomonas Aeruginosa Burn Wound Infections ," Advanced Healthcare Materials , 6 (2017) 1601134

  17. H. Wu, S. Liu, N. Wiradharma, Z. Y. Ong, Y. Li, Y. Y. Yang and J. Y. Ying , " Short Synthetic α-Helical-Forming Peptide Amphiphiles for Fungal Keratitis Treatment In Vivo ," Advanced Healthcare Materials , (2017) DOI: 10.1002/adhm.201600777

  18. W. X. Ang, Z. Li, Z. Chi, S.-H. Du, C. Chen, J. C. K. Tay, H. C. Toh, J. E. Connolly, X. H. Xu and S. Wang , " Intraperitoneal Immunotherapy with T Cells Stably and Transiently Expressing Anti-EpCAM CAR in Xenograft Models of Peritoneal Carcinomatosis ," Oncotarget , 8 (2017) 13545-13559

  19. S. Venkataraman, J. P. K. Tan, V. W. L. Ng, E. W. P. Tan, J. L. Hedrick and Y. Y. Yang , " Amphiphilic and Hydrophilic Block Copolymers from Aliphatic N-Substituted 8-Membered Cyclic Carbonates: A Versatile Macromolecular Platform for Biomedical Applications ," Biomacromolecules , 18 (2016) 178-188

  20. Y. Zu, M. H. Tan, E. C. Ren and J. Y. Ying , " Facile and Phase-Defined Determination of HLA Alleles with Morpholino-Functionalized Nanoparticle Probes ," Nanomedicine , (2016) DOI: 10.1016/j.nano.2016.09.009

  21. P. Yuan, X. Ding, N. Gao, H. Zhu, Y. Y. Yang and Q. H. Xua , " Au-Ag Core-Shell Nanoparticles for Simultaneous Bacterial Imaging and Synergistic Antibacterial Activity ," Nanomedicine: Nanotechnology, Biology and Medicine , (2016) DOI: 10.1016/j.nano.2016.09.003

  22. Y. S. Pek, H. Wu, S. T. Mohamed, and J. Y. Ying , " Long-Term Subconjunctival Delivery of Brimonidine Tartrate for Glaucoma Treatment Using a Microspheres/Carrier System ," Advanced Healthcare Materials , (2016) DOI: 10.1002/adhm.201600780

  23. C. Englert, M. Fevre, R. J. Wojtecki, W. Cheng, Q. Xu, C. Yang, X. Ke, M. Hartlieb, K. Kempe, J. M. García, R. J. Ono, U. S. Schubert, Y. Y. Yang and J. L. Hedrick , " Facile Carbohydrate-Mimetic Modifications of Poly(ethylene imine) Carriers for Gene Delivery Applications ," Polymer Chemistry , 7 (2016) 5862-5872

  24. Y. S. Pek, H. Wu, E. P. Y. Chow and J. Y. Ying , " Transparent Nanostructured Photochromic UV-Blocking Soft Contact Lenses ," Nanomedicine , 11[12] (2016) 1599-1610

  25. J. S. Khara, M. Priestman, I. Uhía, M. S. Hamilton, N. Krishnan, Y. Wang, Y. Y. Yang, P. R. Langford, S. M. Newton, B. D. Robertson and P. L. Ee , " Unnatural Amino Acid Analogues of Membrane-Active Helical Peptides with Anti-Mycobacterial Activity and Improved Stability ," Journal of Antimicrobial Chemotherapy , 71 (2016) 2181-2191

  26. C. Yang, S. Krishnamurthy, J. Liu, S. Liu, X. Lu, D. J. Coady, W. Cheng, G. D. Libero, A. Singhal, J. L. Hedrick and Y. Y. Yang , " Broad-Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells ," Advanced Healthcare Materials , 5[11] (2016) 1272-1281

  27. K. Ichiyama, C. Yang, L. Chandrasekaran, S. Liu, L. Rong, Y. Zhao, S. Gao, A. Lee, K. Ohba, Y. Suzuki, Y. Yoshinaka, K. Shimotohno, K. Miyakawa, A. Ryo, J. Hedrick, N. Yamamoto and Y. Y. Yang , " Cooperative Orthogonal Macromolecular Assemblies with Broad Spectrum Antiviral Activity, High Selectivity, and Resistance Mitigation ," Macromolecules , (2016) DOI: 10.1021/acs.macromol.6b00091

  28. J. M. W. Chan J. P. K. Tan, A. C. Engler, X. Ke, S. Gao, C. Yang, H. Sardon, Y. Y. Yang and J. L. Hedrick , " Organocatalytic Anticancer Drug Loading of Degradable Polymeric Mixed Micelles via a Biomimetic Mechanism ," Macromolecules , (2016) DOI: 10.1021/acs.macromol.5b02784

  29. Q. Xu, C. Yang, J. L. Hedrick and Y. Y. Yang , " Antimicrobial Silica Particles Synthesized via Ring-Opening Grafting of Cationic Amphiphilic Cyclic Carbonates: Effects of Hydrophobicity and Structure ," Polymer Chemistry , (2016) DOI: 10.1039/c6py00194g

  30. K. Liang, K. H. Bae, F. Lee, K. Xu, J. E. Chung, S. J. Gao and M. Kurisawa , " Self-Assembled Ternary Complexes Stabilized with Hyaluronic Acid-Green Tea Catechin Conjugates for Targeted Gene Delivery ," Journal of Controlled Release , 226 (2016) 205-216

  31. K. Liang, S. Ng, F. Lee, J. Lim, J. E. Chung, S. S. Lee and M. Kurisawa , " Targeted Intracellular Protein Delivery Based on Hyaluronic Acid–Green Tea Catechin Nanogels ," Acta Biomaterialia , 33 (2016) 142-152

  32. Z. X. Voo, M. Khan, Q. Xu, K. Narayanan, B. W. J. Ng, R. B. Ahmad, J. L. Hedrick and Y. Y. Yang , " Antimicrobial Coatings Against Biofilm Formation: The Unexpected Balance Between Antifouling and Bactericidal Behaviour ," Polymer Chemistry , 7 (2015) 656-668

  33. P. Y. Teo. W. Cheng, J. L. Hedrick, Y. Y. Yang , " Co-Delivery of Drugs and Plasmid DNA for Cancer Therapy ," Advanced Drug Delivery Reviews , (2015) DOI: 10.1016/j.addr.2015.10.014

  34. J.Zeng, C. Wu and S. Wang , " Antigenically Modified Human Pluripotent Stem Cells Generate Antigen-Presenting Dendritic Cells ," Scientific Reports , (2015) DOI: 10.1038/srep15262

  35. S. Venkataraman, V. W. L. Ng, D. J. Coady, H. W. Horn, G. O Jones, T. S. Fung, H. Sardón, R. M. Waymouth, J. L. Hedrick and Y. Y. Yang , " A Simple and Facile Approach to Aliphatic N-substituted Functional Eight-Membered Cyclic Carbonates and Their Organo-catalytic Polymerization ," Journal of the American Chemical Society , (2015) DOI: 10.1021/jacs.5b06355

  36. Y. Luo, D. Zhu, D. H. Lam, J. Huang, Y. Tang, X. Luo and S. Wang , " A Double-Switch Cell Fusion-Inducible Transgene Expression System for Neural Stem Cell-Based Antiglioma Gene Therapy ," Stem Cells International , (2015) DOI: 10.1155/2015/649080

  37. V. M. Prabhu, S. Venkataraman, Y. Y. Yang and J. L. Hedrick , " Equilibrium Self-Assembly, Structure, and Dynamics of Clusters of Star-Like Micelles ," ACS Macro Letters , 4 (2015) 1128-1133

  38. J. S. Khara, F. K. Lim, Y. Wanga, X. Ke, Z. X. Voo, Y. Y. Yang, R. Lakshminarayanan, P. L. R. Ee , " Designing α-Helical Peptides with Enhanced Synergism and Selectivity Against Mycobacterium Smegmatis: Discerning the Role of Hydrophobicity and Helicity ," Acta Biomaterialia , (2015) DOI: 10.1016/j.actbio.2015.09.015

  39. S. Krishnamurthy, V. W. L. Ng, S. Gao, M. H. Tan, J. L. Hedrick and Y. Y. Yang , " Codelivery of Dual Drugs from Polymeric Micelles for Simultaneous Targeting of Both Cancer Cells and Cancer Stem Cells ," Nanomedicine , 10 (2015) 2819-2832

  40. J. Cheng, W. Chin, H. Dong, L. Xu, G. Zhong, Y. Huang, L. Li, K. Xu, M. Wu, J. L. Hedrick, Y. Y. Yang and W. Fan , " Biodegradable Antimicrobial Polycarbonates with In Vivo Efficacy Against Multidrug-Resistant MRSA Systemic Infection ," Advanced Healthcare Materials , (2015) DOI: 10.1002/adhm.201500471

  41. Z. Yu, Q. Xu, C. B. Dong, S. S. Lee, L. Gao ,Y. Li, M. D'Ortenzio and J. Wu , " Self-Assembling Peptide Nanofibrous Hydrogel as a Versatile Drug Delivery Platform ," Current Pharmaceutical Design , 21[29] (2015) 4342-4354

  42. F. Lee, J. E. Chung, K. Xu and M. Kurisawa , " Injectable Degradation-Resistant Hyaluronic Acid Hydrogels Cross-Linked via the Oxidative Coupling of Green Tea Catechin ," ACS Macro Letters , 4 (2015) 957-960

  43. H. Sardon, J. P. Tan, J. M. Chan, D. Mantione, D. Mecerreyes, J. L. Hedrick and Y. Y. Yang , " Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery ," Macromolecular Rapid Communications , 36[19] (2015) 1761-1767

  44. R. J. Ono, A. L. Z. Lee, W. Chin, W. S. Goh, A. Y. L. Lee, Y. Y. Yang and J. L. Hedrick , " Biodegradable Block Copolyelectrolyte Hydrogels for Tunable Release of Therapeutics and Topical Antimicrobial Skin Treatment ," ACS Macro Letters , 4 (2015) 886-891

  45. K. Xu, F. Lee, S. Gao, M.-H. Tan and M. Kurisawa , " Hyaluronidase-Incorporated Hyaluronic Acid-Tyramine Hydrogels for the Sustained Release of Trastuzumab ," Journal of Controlled Release , 216 (2015) 47–55

  46. K. Xu, F. Lee, S. Gao, M. H. Tan and M. Kurisawa , " Hyaluronidase-Incorporated Hyaluronic Acid–Tyramine Hydrogels for the Sustained Release of Trastuzumab ," Journal of Controlled Release , (2015) DOI: 10.1016/j.jconrel.2015.08.015

  47. C. A. E. Hauser, Y. Loo, A. Lakshmanan, M. Ni, L. L. Toh, and S. Wang , " Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for 3D Organotypic Cultures ," Nano Letters , (2015) DOI: 10.1021/acs.nanolett.5b02859

  48. A. L. Z. Lee, S. Venkataraman, C. H. Fox, D. J. Coady, C. W. Frank, J. L. Hedrick and Y. Y. Yang , " Modular Composite Hydrogels from Cholesterol-Functionalized Polycarbonates for Antimicrobial Applications ," Journal of Materials Chemistry B , 3 (2015) 6953-6963

  49. J. H. Soh, Y. Lin, S. Rana, J. Y. Ying and M. M. Stevens , " Colorimetric Detection of Small Molecules in Complex Matrixes via Target-Mediated Growth of Aptamer-Functionalized Gold Nanoparticles ," Analytical Chemistry , (2015) DOI: 10.1021/acs.analchem.5b00875

  50. K. Xu, K. Narayanan, F. Lee, K. H. Bae, S. Gao and M. Kurisawa , " Enzyme-Mediated Hyaluronic Acid–Tyramine Hydrogels for the Propagation of Human Embryonic Stem Cells in 3D ," Acta Biomaterialia , (2015) DOI: 10.1016/j.actbio.2015.06.026

  51. K. H. Bae, F. Lee, K. Xu, C. T. Keng, S. Y. Tan, Y. J. Tan, Q. Chen and M. Kurisawa , " Microstructured Dextran Hydrogels for Burst-Free Sustained Release of PEGylated Protein Drugs ," Biomaterials , (2015) DOI: 10.1016/j.biomaterials.2015.06.008

  52. W. Cheng, C. Yang, X. Ding, A. C. Engler, J. L. Hedrick and Y. Y. Yang , " Broad-Spectrum Antimicrobial/Antifouling Soft Material Coatings Using Poly(ethylenimine) as a Tailorable Scaffold ," Biomacromolecules , (2015) DOI: 10.1021/acs.biomac.5b00359

  53. C. D. Ren, M. Kurisawa, J. E. Chung and J. Y. Ying , " Liposomal Delivery of Horseradish Peroxidase for Thermally Triggered Injectable Hyaluronic Acid-Tyramine Hydrogel Scaffold ," Journal of Materials Chemistry B , 3[23] (2015) 4663-4670

  54. S. George, S. S. Ho, E. S. P. Wong, T. T. Y. Tan, M. K. Verma, R. J. Aitken, M. Riediker, C. Cummings, L. Yu, Z. M. Wang, D. Zink, Z. Ng, S. C. J. Loo, and K. W. Ng , " The Multi-Facets of Sustainable Nanotechnology – Lessons from a Nanosafety Symposium ," Nanotoxicology , 9 (2015) 404-406

  55. F. Lee, J. Lim, M. R. Reithofer, S. S. Lee, J. E. Chung, C. A. E. Hauser and M. Kurisawa , " Synthesis and Bioactivity of a Conjugate Composed of Green Tea Catechins and Hyaluronic Acid ," Polymer Chemistry , 6 (2015) 4462-4472

  56. P. Y. Teo, C. Yang, L. M. Whilding, A. C. Parente-Pereira, J. Maher, A. J. George, J. L. Hedrick, Y. Y. Yang and S. Ghaem-Maghami , " Ovarian Cancer Immunotherapy Using PD-L1 siRNA Targeted Delivery from Folic Acid-Functionalized Polyethylenimine: Strategies to Enhance T Cell Killing ," Advanced Healthcare Materials , 4 (2015) 1180-1189

  57. C. Yang, S. Q. Liu, S. Venkataraman, S. J. Gao, X. Y. Ke, X. T. Chia, J. L. Hedrick and Y. Y. Yang , " Structure-Directing Star-Shaped Block Copolymers: Supramolecular Vesicles for the Delivery of Anticancer Drugs ," Journal of Controlled Release , (2015) DOI: 10.1016/j.jconrel.2015.03.027

  58. A. Pascual, J. P. K. Tan, A. Y. Yuen, J. M. W. Chan, D. J. Coady, D. Mecerreyes, J. L. Hedrick, Y. Y. Yang and H. Sardón , " Broad-Spectrum Antimicrobial Polycarbonate Hydrogels with Fast Degradability ," Biomacromolecules , (2015) DOI: DOI: 10.1021/bm501836z

  59. A. C. Engler, X. Ke, S. Gao, J. M. W. Chan, D. J. Coady, R. J. Ono, R. Lubbers, A. Nelson, Y. Y. Yang and J. L. Hedrick , " Hydrophilic Polycarbonates: Promising Degradable Alternatives to Poly(ethylene glycol)-Based Stealth Materials ," Macromolecules , (2015) DOI: 10.1021/acs.macromol.5b00156

  60. S. Tan, C. Gan, R. Li, Y. Ye, S. Zhang, X. Wu, Y. Y. Yang, W. Fan and M. Wu , " A Novel Chemosynthetic Peptide with β-Sheet Motif Efficiently Kills Klebsiella Pneumoniae in a Mouse Model ," International Journal of Nanomedicine , 10 (2015) 1045-1059

  61. Z. X. Voo, M. Khan, K. Narayanan, D. Seah, J. L. Hedrick, and Y. Y. Yang , " Antimicrobial/Antifouling Polycarbonate Coatings: Role of Block Copolymer Architecture ," Macromolecules , (2015) DOI: 10.1021/ma5022488

  62. A. L. Z. Lee, V. W. L. Ng, S. Gao, J. L. Hedrick and Y. Y. Yang , " Injectable Biodegradable Hydrogels from Vitamin D‑Functionalized Polycarbonates for the Delivery of Avastin with Enhanced Therapeutic Efficiency Against Metastatic Colorectal Cancer ," Biomacromolecules , (2015) DOI: 10.1021/bm5015206

  63. X. Liu, H. Li, L. Wu, J. Xing, Y. Poh, H. Cai and B. C. Cai , " Simultaneous Quantification of Chrysophanol and Physcion in Rat Plasma by Ultra Fast Liquid Chromatography-Tandem Mass Spectrometry and Application of the Technique to Comparative Pharmacokinetic Studies of Radix et Rhei Rhizoma Extract Alone and Dahuang Fuzi Decoction ," Journal of Chromatography B , 980 (2015) 88-93

  64. S. H. Du, J. C. Tay, C. Chen, F. C. Tay, W. K. Tan, Z. D. Li and S. Wang , " Human iPS Cell-Derived Fibroblast-Like Cells as Feeder Layers for iPS Cell Derivation and Expansion ," Journal of Bioscience and Bioengineering , (2015) DOI: 10.1016/j.jbiosc.2014.12.009

  65. Q. Xu, H. Sardon, J. M. W. Chan, J. L. Hedrick and Y. Y. Yang , " Polyurethane-Coated Silica Particles with Broad-Spectrum Antibacterial Properties ," Polymer Chemistry , (2015) DOI: 10.1039/C4PY01455C

  66. S. Krishnamurthy, X. Ke and Y. Y. Yang , " Delivery of Therapeutics Using Nanocarriers for Targeting Cancer Cells and Cancer Stem Cells ," Nanomedicine , 10[1] (2015) 143-160

  67. A. L. Z. Lee, V. W. L. Ng, S. Gao, J. L. Hedrick and Y. Y. Yang , " Injectable Biodegradable Hydrogels from Vitamin D-Functionalized Polycarbonates for the Delivery of Avastin with Enhanced Therapeutic Efficiency against Metastatic Colorectal Cancer ," Biomacromolecules , (2014) DOI: 10.1021/bm5015206

  68. H. Wu, Z. Y. Ong, S. Liu, Y. Li, N. Wiradharma, Y. Y. Yang and J. Y. Ying , " Synthetic β-Sheet Forming Peptide Amphiphiles for Treatment of Fungal Keratitis ," Biomaterials , 43 (2014) 44-49

  69. P. Yuan, X. Ding, Z. Guan, N. Gao, R. Ma, X. F. Jiang, Y. Y. Yang and Q. H. Xu , " Plasmon-Coupled Gold Nanospheres for Two-Photon Imaging and Photoantibacterial Activity ," Advanced Healthcare Materials , 4[5] (2014) 674-678

  70. R. J. Ono, S. Liu, S. Venkataraman, W. Chin, Y. Y. Yang and J. L. Hedrick , " Benzyl Chloride-Functionalized Polycarbonates: A Versatile Platform for the Synthesis of Functional Biodegradable Polycarbonates ," Macromolecules , (2014) DOI: 10.1021/ma501734y

  71. V. W.L. Ng, J. M.W. Chan, H. Sardon, R. J. Ono, J. M. García, Y. Y. Yang and J. L. Hedrick , " Antimicrobial Hydrogels: A New Weapon in the Arsenal Against Multidrug-Resistant Infections ," Advanced Drug Delivery Reviews , 78 (2014) 46-62

  72. J. E. Chung, S. Tan, S. J. Gao, N. Yongvongsoontorn, S. H. Kim, J. H. Lee, H. S. Choi, H. Yano, L. Zhuo, M. Kurisawa and J. Y. Ying , " Self-Assembled Micellar Nanocomplexes Comprising Green Tea Catechin Derivatives and Protein Drugs for Cancer Therapy ," Nature Nanotechnology , 9 (2014) 907-912

  73. C. Yang, X. Ding, R. J. Ono, H. Lee, L. Y. Hsu, Y. W. Tong, J. Hedrick and Y. Y. Yang , " Brush-Like Polycarbonates Containing Dopamine, Cations, and PEG Providing a Broad-Spectrum, Antibacterial, and Antifouling Surface via One-Step Coating ," Advanced Materials , (2014) DOI: 10.1002/adma.201402059

  74. Y. S. Pek, P. Pitukmanorom and J. Y. Ying , " Sustained Release of Bupivacaine for Post-Surgical Pain Relief Using Core–Shell Microspheres ," Journal of Materials Chemistry B , (2014) DOI: 10.1039/C4TB00948G

  75. S. Krishnamurthy, V. W.L. Ng, S. Gao, M. H. Tan and Y. Y. Yang , " Phenformin-Loaded Polymeric Micelles for Targeting Both Cancer Cells and Cancer Stem Cells In Vitro and In Vivo ," Biomaterials , 35[33] (2014) 9177-9186

  76. A. B. E. Attia, P. Oh, C. Yang, J. P. K. Tan, N. Rao, J. L. Hedrick, Y. Y. Yang and R. Ge , " Insights into EPR Effect versus Lectin-Mediated Targeted Delivery: Biodegradable Polycarbonate Micellar Nanoparticles With and Without Galactose Surface Decoration ," Small , (2014) DOI: 10.1002/smll.201401295

  77. X. Ke, V. W. L. Ng, R. J. Ono, J. M.W. Chan, S. Krishnamurthy, Y. Wang, J. L. Hedrick and Y. Y. Yang , " Role of Non-Covalent and Covalent Interactions in Cargo Loading Capacity and Stability of Polymeric Micelles ," Journal of Controlled Release , (2014) DOI: 10.1016/j.jconrel.2014.06.061

  78. S. Q. Liu, S. Venkataraman, Z. Y. Ong, J. M. W. Chan, C. Yang, J. L. Hedrick and Y. Y. Yang , " Overcoming Multidrug Resistance in Microbials Using Nanostructures Self-Assembled from Cationic Bent-Core Oligomers ," Small , 10[20] (2014) 4130-4135

  79. J. M. W. Chan, X. Ke, H. Sardon,A. C. Engler, Y. Y. Yang and J. L. Hedrick , " Chemically Modifiable N-heterocyclefunctionalized Polycarbonates as a Platform for Diverse Smart Biomimetic Nanomaterials ," Chemical Science , 5 (2014) 3294-3300

  80. F. C. Tay, J. K. Lim, H. Zhua, L. C. Hin and S. Wang , " Using Artificial MicroRNA Sponges to Achieve MicroRNA Loss-of-Function in Cancer Cells ," Advanced Drug Delivery Reviews , (2014) DOI: 10.1016/j.addr.2014.05.010

  81. L. S. Wang, F. Lee, J. Lim, C. Du, A.C.A. Wan, S. S. Lee and M. Kurisawa , " Enzymatic Conjugation of a Bioactive Peptide into an Injectable Hyaluronic Acid–Tyramine Hydrogel System to Promote the Formation of Functional Vasculature ," Acta Biomaterialia , (2014) DOI: 10.1016/j.actbio.2014.02.022

  82. V. W. L. Ng, J. P. K. Tan, J. Leong, Z. X. Voo, J. L. Hedrick and Y. Y. Yang , " Antimicrobial Polycarbonates: Investigating the Impact of Nitrogen-Containing Heterocycles as Quaternizing Agents ," Macromolecules , (2014) DOI: 10.1021/ma402641p

  83. X. Ke, D. J. Coady, C. Yang, A. C. Engler, J. L. Hedrick and Y. Y. Yang , " pH-Sensitive Polycarbonate Micelles for Enhanced Intracellular Release of Anticancer Drugs: A Strategy to Circumvent Multidrug Resistance ," Polymer Chemistry , (2014) DOI: 10.1039/C3PY01784B

  84. Y. Wang, X. Ke, J. S. Khara, P. Bahety, S. Liu and S. V. Seow, Y. Y. Yang and P. L. R. Ee , " Synthetic Modifications of the Immunomodulating Peptide Thymopentin to Confer Anti-Mycobacterial Activity ," Biomaterials , (2014) DOI: 10.1016/j.biomaterials.2013.12.049

  85. D. J. Coady, Z. Y. Ong, P. S. Lee, S. Venkataraman, W. Chin, A. C. Engler, Y. Y. Yang and J. L. Hedrick , " Enhancement of Cationic Antimicrobial Materials via Cholesterol Incorporation ," Advanced Healthcare Materials , (2013) DOI: 10.1002/adhm.201300554

  86. L. S. Wang. C. Du, W. S. Toh, A. C. A. Wan, S. J. Gao and M. Kurisawa , " Modulation of Chondrocyte Functions and Stiffness-Dependent Cartilage Repair Using an Injectable Enzymatically Crosslinked Hydrogel with Tunable Mechanical Properties ," Biomaterials , 35 (2014) 2207-2217

  87. K. Fukushima, S. Liu, H. Wu, A. C. Engler, D. J. Coady, H. Maune, J. Pitera, A. Nelson, N. Wiradharma, S. Venkataraman, Y. Huang, W. Fan, J. Y. Ying, Y. Y. Yang and J. L. Hedrick , " Supramolecular High Aspect Ratio Assemblies with Strong Antifungal Activity ," Nature Communications , (2013) DOI: 10.1038/ncomms3861

  88. J. S. Khara, Y. Wang, X. Y. Ke, S. Liu, S. M. Newton, P. R. Langford, Y. Y. Yang and P. L. R. Ee , " Anti-Mycobacterial Activities of Synthetic Cationic α-Helical Peptides and their Synergism with Rifampicin ," Biomaterials , 35[6] (2014) 2032-2038

  89. J. Zeng and S. Wang , " Human Dendritic Cells Derived From Embryonic Stem Cells Stably Modified with CD1d Efficiently Stimulate Antitumor Invariant Natural Killer T Cell Response ," Stem Cells Translational Medicine , 3[1] (2014) 69-80

  90. W. Chin, C. Yang, V. W. L. Ng, Y. Huang, J. Cheng, Y. W. Tong, D. J. Coady, W. Fan, J. L. Hedrick and Y. Y. Yang , " Biodegradable Broad-Spectrum Antimicrobial Polycarbonates: Investigating the Role of Chemical Structure on Activity and Selectivity ," Macromolecules , 46[22] (2013) 8797-8807

  91. A. C. Engler, J. P. K. Tan, D.J. Coady, V. W. L. Ng, Y. Yang and J. L. Hedrick , " Antimicrobial Polycarbonates: Investigating the Impact of Balancing Charge and Hydrophobicity Using a Same Centered Polymer Approach ," Biomacromolecules , 14 (2013) 4331-4339

  92. Z. Y. Ong, J. Cheng, Y. Huang, K. Xu, Z. Ji, W. Fan and Y. Y. Yang , " Effect of Stereochemistry, Chain Length and Sequence Pattern on Antimicrobial Properties of Short Synthetic β-Sheet Forming Peptide Amphiphiles ," Biomaterials , 35[4] (2014) 1315-1325

  93. X. Ke, V. W. L. Ng, S. Gao, Y. W. Tong, J. L. Hedrick and Y. Y. Yang , " Co-Delivery of Thioridazine and Doxorubicin Using Polymeric Micelles for Targeting Both Cancer Cells and Cancer Stem Cells ," Biomaterials , 35[3] (2014) 1096-1108

  94. A. L. Z. Lee, V. W. L. Ng, S. Gao, J. L Hedrick and Y. Y. Yang , " Injectable Hydrogels from Triblock Copolymers of Vitamin E-Functionalized Polycarbonate and Poly(ethylene glycol) for Subcutaneous Delivery of Antibodies for Cancer Therapy ," Advanced Functional Materials , (2013) DOI: 10.1002/adfm.201301307

  95. S. Venkataraman, J. L. Hedrick and Y. Y. Yang , " Fluorene-Functionalized Aliphatic Polycarbonates: Design, Syntheses and Aqueous Self-Assembly of Amphiphilic Block Copolymers ," Polymer Chemistry , (2013) DOI: 10.1039/C3PY01207G

  96. M. Reithofer, K. H. Chan, A. Lakshmanan, D. H. Lam, A. Mishra, B. Gopalan, M. Joshi, S. Wang, and C. A. E. Hauser , " Ligation of Anti-Cancer Drugs to Self-Assembling Ultrashort Peptides by Click Chemistry for Localized Therapy ," Chemical Science , 5 (2013) 625-630

  97. Z. Y. Ong, C. Yang, S. J. Gao, X. Y. Ke, J. L. Hedrick, Y. Y. Yang , " Galactose-Functionalized Cationic Polycarbonate Diblock Copolymer for Targeted Gene Delivery to Hepatocytes ," Macromolecular Rapid Communications , 34[21] (2013) 1714-1720

  98. A. L. Z. Lee, V. W. L. Ng, W. Wang, J. L. Hedrick and Y. Y. Yang , " Block Copolymer Mixtures as Antimicrobial Hydrogels for Biofilm Eradication ," Biomaterials , 34[38] (2013) 10278-10286

  99. V. W. L. Ng, X. Ke, A. L. Z. Lee, J. L. Hedrick and Y. Y. Yang , " Synergistic Co-Delivery of Membrane-Disrupting Polymers with Commercial Antibiotics against Highly Opportunistic Bacteria ," Advanced Materials , 25[46] (2013) 6730-6736

  100. H. Zhu, C.-H. Lau, S.-L. Goh, Q. Liang, C. Chen, S. Du, R.-Z. Phang, F. C. Tay, W.-K. Tan, Z. Li, J. C.-K. Tay, W. Fan and S. Wang , " Baculoviral Transduction Facilitates TALEN-Mediated Targeted Transgene Integration and Cre/LoxP Cassette Exchange in Human-Induced Pluripotent Stem Cells ," Nucleic Acids Research , 41[19] (2013) e180

  101. K. H. Bae, L. S. Wang and M. Kurisawa , " Injectable Biodegradable Hydrogels: Progress and Challenges ," Journal of Materials Chemistry B , 1[40] (2013) 5371-5388

  102. P. Y. Teo, C. Yang, J. L. Hedrick, A. C. Engler, D. J. Coady, S. Ghaem-Maghami, A. J. T. George and Y. Y. Yang , " Hydrophobic Modification of Low Molecular Weight Polyethylenimine for Improved Gene Transfection ," Biomaterials , 34[32] (2013) 7971-7979

  103. M. Shahbazi, T. W. X. Kwang, Y. I. Purwanti, W. Fan and S. Wang , " Inhibitory Effects of Neural Stem Cells Derived from Human Embryonic Stem Cells on Differentiation and Function of Monocyte-Derived Dendritic Cells ," Journal of the Neurological Sciences , 330[1] (2013) 85-93

  104. N. Han, Y. Y. Yang, S. Wang, S. Zheng and W. Fan , " Polymer-Based Cancer Nanotheranostics: Retrospectives of Multi-Functionalities and Pharmacokinetics ," Current Drug Metabolism , 14[6] (2013) 661-674

  105. R. Mathieu, J. A. De Toro, D. Salazar, S. S. Lee, J. L. Cheong and P. Nordblad , " Phase Transition in a Super Superspin Glass ," Europhysics Letters , 102 (2013) 67002

  106. D. Zhu, D. H. Lam, Y. I. Purwanti, S. L. Goh, C. Wu, J. Zeng, W. Fan and S. Wang , " Systemic Delivery of Fusogenic Membrane Glycoprotein-Expressing Neural Stem Cells to Selectively Kill Tumor Cells ," Molecular Therapy , 21 (2013) 1621-1630

  107. S. Venkataraman, A. L. Lee, H. T. Maune, J. L. Hedrick, V. M. Prabhu, and Y. Y. Yang , " Formation of Disk- and Stacked-Disk-like Self-Assembled Morphologies from Cholesterol-Functionalized Amphiphilic Polycarbonate Diblock Copolymers ," Macromolecules , (2013) DOI: 10.1021/ma400423b

  108. C. Q. Wang, L. Motoda, M. Satake, Y. Ito, I. Taniuchi, V. Tergaonkar and M. Osato , " Runx3 Deficiency Results in Myeloproliferative Disorder in Aged Mice ," Blood , 122 (2013) 562-566

  109. A. C. Engler, J. M. W. Chan, K. Fukushima, D. J. Coady, Y. Y. Yang and J. L. Hedrick , " Polycarbonate-Based Brush Polymers with Detachable Disulfide-Linked Side Chains ," ACS Macroletters , 2[4] (2013) 332-336

  110. D. J. Coady, H. W. Horn, G. O. Jones, H. Sardon, A. C. Engler, R. M. Waymouth, J. E. Rice, Y. Y. Yang and J. L. Hedrick , " Polymerizing Base Sensitive Cyclic Carbonates Using Acid Catalysis ," ACS Macroletters , 2[4] (2013) 306-312

  111. Y. Zhao, S. L. Lo, Y. Zheng, D. H. Lam, C. Wu, M. Y. Han and S. Wang , " Quantum Dot Coating of Baculoviral Vectors Enables Visualization of Transduced Cells and Tissues ," Biochemical and Biophysical Research Communications , 434 (2013) 110-116

  112. S. Venkataraman, N. Veronica, Z. X. Voo, J. L. Hedrick and Y. Y. Yang , " 2-Amino-1,3-Propane Diols: A Versatile Platform for the Syn-Theses of Aliphatic Cyclic Carbonate Monomers ," Polymer Chemistry , (2013) DOI: 10.1039/C3PY00318C

  113. H. Sardon, A. Engler, J. M. W. Chan, D. Coady, J. M. O'Brien, D. Mecerreyes, Y. Y. Yang and J. Hedrick , " Homogeneous Isocyanate- and Catalyst-Free Synthesis of Polyurethanes in Aqueous Media ," Green Chemistry , (2013) DOI: 10.1039/C3GC40319J

  114. L. Liu, J. Yang, J. Xie, Z. Luo, J. Jiang, Y. Y. Yang and S. Liu , " The Potent Antimicrobial Properties of Cell Penetrating Peptide-Conjugated Silver Nanoparticles with Excellent Selectivity for Gram-Positive Bacteria over Erythrocytes ," Nanoscale , (2013) DOI: 10.1039/c3nr34254a

  115. Z. Y. Ong, S. J. Gao and Y. Y. Yang , " Short Synthetic β-Sheet Forming Peptide Amphiphiles as Broad Spectrum Antimicrobials with Antibiofilm and Endotoxin Neutralizing Capabilities ," Advanced Functional Materials , 23[29] (2013) 3682-3692

  116. W. Cheng, C. Yang, J. L. Hedrick, D. F. Williams, Y. Y. Yang and P. G. Ashton-Rickardt , " Delivery of a Granzyme B Inhibitor Gene Using Carbamate-Mannose Modified PEI Protects Against Cytotoxic Lymphocyte Killing ," Biomaterials , 34[14] (2013) 3697-3705

  117. A. C. Engler, J. M. W. Chan, D. J. Coady, J. M. O'Brien, H. Sardon, A. Nelson, D. P. Sanders, Y. Y. Yang and J. L. Hedrick , " Accessing New Materials through Polymerization and Modification of a Polycarbonate with a Pendant Activated Ester ," Macromolecules , 46[4] (2013) 1283-1290

  118. A. B. E. Attia, C. Yang, J. P.K. Tan, S. Gao, D. F. Williams, J. L. Hedrick and Y. Yan Yang , " The Effect of Kinetic Stability on Biodistribution and Anti-Tumor Efficacy of Drug-Loaded Biodegradable Polymeric Micelles ," Biomaterials , 34[12] (2013) 3132-3140

  119. Y. Li, K. Fukushima, D. J. Coady, A. C. Engler, S. Liu, Y. Huang, J. S. Cho, Y. Guo, L. S. Miller, J. P. K. Tan, P. L. R. Ee, W. Fan, Y. Y. Yang, and J. L. Hedrick , " Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies ," Angewandte Chemie International Edition , (2012) DOI: 10.1002/anie.201206053

  120. Y. Choudhury, F. C. Tay, D. H. Lam, E. Sandanaraj, C. Tang, B. T. Ang and S. Wang , " Attenuated Adenosine-to-Inosine Editing of MicroRNA-376a* Promotes Invasiveness of Glioblastoma Cells ," Journal of Clinical Investigation , 122[11] (2012) 4059-4076

  121. J. Lin, S. Teo, D.H. Lam. K. Jeyaseelan and S. Wang , " MicroRNA-10b Pleiotropically Regulates Invasion, Angiogenicity and Apoptosis of Tumor Cells Resembling Mesenchymal Subtype of Glioblastoma Multiforme ," Cell Death and Disease , 3 (2012) e398

  122. S. Q. Liu, C. Yang, Y. Huang, X. Ding, Y. Li, W. M. Fan, J. L. Hedrick and Y. Y. Yang , " Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition ," Advanced Materials , (2012) DOI: 10.1002/adma.201202225

  123. K. Fukushima, J. P. K. Tan, P. A. Korevaar, Y. Y. Yang, J. Pitera, A. Nelson, H. Maune, D. J. Coady, J. E. Frommer, A. C. Engler, Y. Huang, K. Xu, Z. Ji, Y. Qiao, W. Fan, L. Li, N. Wiradharma, E. W. Meijer and J. L. Hedrick , " Broad-Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape ," ACS Nano , (2012) DOI: 10.1021/nn3035217

  124. Y. Huang, N. Wiradharma, K. Xu, Z. Ji, S. Bi, L. Li, Y.-Y. Yang, W. Fan , " Cationic Amphiphilic Alpha-Helical Peptides for the Treatment of Carbapenem-Resistant Acinetobacter Baumannii Infection ," Biomaterials , (2012) DOI: 10.1016/j.biomaterials.2012.08.026

  125. Y. Huang, N. Wiradharma, K. Xu, Z. Ji, S. Bi, L. Li, Y. Y. Yang and W. Fan , " Cationic Amphiphilic Alpha-Helical Peptides for the Treatment of Carbapenem-Resistant Acinetobacter Baumannii Infection ," Biomaterials , 33[34] (2012) 8841-8847

  126. L. Liu, Y. Huang, S. N. Riduan, S. Gao, Y. Yang, W. Fan, Y. Zhang , " Main-Chain Imidazolium Oligomer Material as a Selective Biomimetic Antimicrobial Agent ," Biomaterials , (2012) DOI: 10.1016/j.biomaterials.2012.08.006

  127. X. Ding, C. Yang, T. P. Lim, L. Y. Hsu, A. C. Engler, J. L. Hedrick and Y. Y. Yang , " Antibacterial and Antifouling Catheter Coatings Using Surface Grafted PEG-b-Cationic Polycarbonate Diblock Copolymers ," Biomaterials , (2012) DOI: 10.1016/j.biomaterials.2012.06.001

  128. Y. Li , C. Yang,M. Khan, S. Q. Liu, J. L. Hedrick, Y. Y. Yang and P-L. R. Ee , " Nanostructured PEG-Based Hydrogels with Tunable Physical Properties for Gene Delivery to Human Mesenchymal Stem Cells ," Biomaterials , (2012) DOI: 10.1016/j.biomaterials.2012.05.043

  129. M. Khan, Z. Y. Ong, N. Wiradharma, A. Bte Ebrahim Attia and Y. Y. Yang , " Advanced Materials for Co-Delivery of Drugs and Genes in Cancer Therapy ," Advanced Healthcare Materials , (2012) DOI: 10.1002/adhm.201200109

  130. X. D. Guo, N. Wiradharma, S. Q. Liu, L. J. Zhang, M. Khan, Y. Qian and Y. Y. Yang , " Oligomerized Alpha-Helical KALA Peptides with Pendant Arms Bearing Cell-Adhesion, DNA-Binding and Endosome-Buffering Domains as Efficient Gene Transfection Vectors ," Biomaterials , 33[26] (2012) 6284–6291

  131. J. Yang, G. Balasundaram, S.-L. Lo, E. C. S. Guang, J. M. Xue, J. Song, A. C. A. Wan, J. Y. Ying, and S. Wang , " Microfibers Fabricated by Non-Covalent Assembly of Peptide and DNA for Viral Vector Encapsulation and Cancer Therapy ," Advanced Materials , 24[24] (2012) 3280-3284

  132. A. C. Englera, N. Wiradharma, Z. Y. Ong, D. J. Coadya, J. L. Hedrick and Y. Y. Yang , " Emerging Trends in Macromolecular Antimicrobials to Fight Multi-Drug-Resistant Infections ," Nano Today , 7[3] (2012) 201–222

  133. S. L. Lo, S. Lua, J. Song, and S. Wang , " A β-Sheet Structure Interacting Peptide for Intracellular Protein Delivery into Human Pluripotent Stem Cells and their Derivatives ," Biochemical and Biophysical Research Communications , 421[3] (2012) 616-620

  134. M. Khan, C. Y. Ang, N. Wiradharma, L.-K. Yong, S. Liu, L. Liu, S. Gao, and Y.-Y. Yang , " Diaminododecane-based Cationic Bolaamphiphile as a Non-Viral Gene Delivery Carrier ," Biomaterials , 33[18] (2012) 4673-4680

  135. J. Zeng, M. Shahbazi, C. Wu and S. Wang , " Enhancing Immunostimulatory Function of Human Embryonic Stem Cell-Derived Dendritic Cells by CD1d Overexpression ," The Journal of Immunology , (2012) DOI: 10.4049/jimmunol.1102343

  136. W. S. Toh, T. C. Lim, M. Kurisawa, and M. Spector , " Modulation of Mesenchymal Stem Cell Chondrogenesis in a Tunable Hyaluronic Acid Hydrogel Microenvironment ," Biomaterials , 33[15] (2012) 3835-3845

  137. L.-S. Wang, C. Du, J. E. Chung, and M. Kurisawa , " Enzymatically Cross-Linked Gelatin-Phenol Hydrogels with a Broader Stiffness Range for Osteogenic Differentiation of Human Mesenchymal Stem Cells ," Acta Biomaterialia , 8[5] (2012) 1826-1837

  138. J. Yang, D. H. Lam, S. S. Goh, E. X. Lee, Y. Zhao, F. C. Tay, C. Chen, S. Du, G. Balasundaram, M. Shahbazi, C. K. Tham, W. H. Ng, H. C. Toh, and S. Wang , " Tumor Tropism of Intravenously Injected Human Induced Pluripotent Stem Cell-derived Neural Stem Cells and their Gene Therapy Application in a Metastatic Breast Cancer Model ," Stem Cells , 30[5] (2012) 1021-1029

  139. T. C. Lim, W. S. Toh, L.-S. Wang, M. Kurisawa, and M. Spector , " The Effect of Injectable Gelatin-Hydroxyphenylpropionic Acid Hydrogel Matrices on the Proliferation, Migration, Differentiation and Oxidative Stress Resistance of Adult Neural Stem Cells ," Biomaterials , 33[12] (2012) 3446-3455

  140. S. L. Lo and S. Wang , " Evaluation of the Use of Amphipathic Peptide-Based Protein Carrier for In Vitro Cancer Research ," Biochemical and Biophysical Research Communications , 419[2] (2012) 170-174

  141. K. Xu, F. Lee, S. J. Gao, J. E. Chung, H. Yano and M. Kurisawa , " Injectable Hyaluronic Acid-Tyramine Hydrogels Incorporating Interferon-α2a for Liver Cancer Therapy ," Journal of Controlled Release , 166[3] (2013) 203-210

  142. C. Yang, A. B. Ebrahim Attia, J. P. K. Tan, X. Ke, S. Gao, J. L. Hedrick and Y. Y. Yang , " The Role of Non-Covalent Interactions in Anticancer Drug Loading and Kinetic Stability of Polymeric Micelles ," Biomaterials , 33[10] (2012) 2971-2979

  143. N. Wiradharma, S. Q. Liu and Y. Y. Yang , " Branched and 4-Arm Starlike α-Helical Peptide Structures with Enhanced Antimicrobial Potency and Selectivity ," Small , 8[3] (2011) 362-366

  144. A. L. Z. Lee, S. Venkataraman, S. B. M. Sirata, S. Gao, J. L. Hedrick and Y. Y. Yang , " The Use of Cholesterol-Containing Biodegradable Block Copolymers to Exploit Hydrophobic Interactions for the Delivery of Anticancer Drugs ," Biomaterials , 33[6] (2011) 1921-1928

  145. C. Wu and S. Wang , " A pH-Sensitive Heparin-Binding Sequence from Baculovirus gp64 Protein Is Important for Binding to Mammalian Cells but Not to fSf9 Insect Cells ," Journal of Virology , 86 (2011) 484

  146. Y. Qiao, C. Yang, D. J. Coady, Z. Y. Ong, J. L. Hedrick and Y. Y. Yang , " Highly Dynamic Biodegradable Micelles Capable of Lysing Gram-Positive and Gram-Negative Bacterial Membrane ," Biomaterials , 33[4] (2011) 1146-1153

  147. K. Xu, H. Wang, L. Liu, W. Xu, J. Sheng, W. Fan, Y. Y. Yang and L. Li , " Efficacy of CG(3)R(6)TAT Nanoparticles Self-Assembled from a Novel Antimicrobial Peptide for the Treatment of Candida Albicans Meningitis ," Chemotherapy , 57[5] (2011) 417-425

  148. L. S. Wang, J. E. Chung and M. Kurisawa , " Controlling Fibroblast Proliferation with Dimensionality-Specific Response by Stiffness of Injectable Gelatin Hydrogels ," Journal of Biomaterials Science, Polymer Edition , 23[14] (2011) 1793-1806

  149. C. Yang, Z. Y. Ong, Y. Y. Yang, P. L. Ee and J .L. Hedrick , " Novel Biodegradable Block Copolymers of Poly(ethylene glycol) (PEG) and Cationic Polycarbonate: Effects of PEG Configuration on Gene Delivery ," Macromolecular Rapid Communications , 32 (2011) 1826-1833

  150. D. J. Coady, A. C. Englerand Y. Y. Yang and J. L. Hedrick , " Facile Routes to Star Polymers via an Organocatalytic Approach ," Polymer Chemistry , 2 (2011) 2619-2626

  151. N. Wiradharma, M. Khan, L-K. Yong, C. A. E. Hauser, S. V. Seow, S. Zhang and Y. Y. Yang , " The Effect of Thiol Functional Group Incorporation into Cationic Helical Peptides on Antimicrobial Activities and Spectra ," Biomaterials , 32[34] (2011) 9100-9108

  152. E.X. Lee, D. H Lam, C. Wu, J. Yang, C. K. Tham, W. H. Ng and S. Wang , " Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells ," Molecular Pharmaceutics , 8[5] (2011) 1515-1524

  153. S. Venkataraman, J. L. Hedrick, Z. Y. Ong, C. Yang, P. L. R. Ee, P. T. Hammond and Y. Y. Yang , " The Effects of Polymeric Nanostructure Shape on Drug Delivery ," Advanced Drug Delivery Reviews , 63 (2011) 1228-1246

  154. S.L. Lo, Y. Choudhury and S. Wang , " Peptide-Based Nanomaterials for siRNA Delivery: Design, Evaluation and Challenges ," Nanobiomaterials Handbook , (2011) DOI: 10.1201/b10970-10

  155. C. J. A. Ramachandra, M. Shahbazi, T. W. X. Kwang, Y. Choudhury, X. Y. Bak, J. Yang and S. Wang , " Efficient Recombinase-Mediated Cassette Exchange at the AAVS1 Locus in Human Embryonic Stem Cells Using Baculoviral Vectors ," Nucleic Acids Research , 39 (2011) e107

  156. Y. Zhao, D. H. Lam, J. Yang, C. K. Tham, W. H. Ng and S. Wang , " Targeted Suicide Gene Therapy for Glioma Using Human Embryonic Stem Cell-Derived Neural Stem Cells Genetically Modified by Baculorviral Vectors ," Gene Therapy , 19[2] (2011) 189-200

  157. S. H. Kim, J. P.K. Tan, K. Fukushima, F. Nederberg, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick , " Thermoresponsive Nanostructured Polycarbonate Block Copolymers as Biodegradable Therapeutic Delivery Carriers ," Biomaterials , 32[23] (2011) 5505-5514

  158. M. Sugai, K. Aoki, M. Osato, Y. Nambu, K. Ito, M. M. Taketo and A. Shimizu , " Runx3 is Required for Full Activation of Regulatory T Cells to Prevent Colitis-Associated Tumor Formation ," The Journal of Immunology , 186[11] (2011) 6515-6520

  159. T. Yokomizo, C. E. L. Ng, M. Osato and E. Dzierdzak , " Three-Dimensional Imaging of Whole Midgestation Murine Embryos Shows an Intravascular Localization for All Hematopoeitic Clusters ," Blood , 117 (2011) 6132-6134

  160. F. Nederberg, Y. Zhang, J. P. K. Tan, K. Xu, H. Wang, C. Yang, S. Gao, X. D. Guo, K. Fukushima, L. Li, J. L. Hedrick and Y. Y. Yang , " Biodegradable Nanostructures with Selective Lysis of Microbial Membranes ," Nature Chemistry , 3 (2011) 409-414

  161. X. Y. Bak*, H. L. Dang*, J. Yang, K. Ye, E. X. W. Lee, S. K. Lim and S. Wang , " Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma. ," Human Gene Therapy , 22[11] (2011) 1365-1377

  162. A. L. Z. Lee, S. H. K. Dhillon, Y. Wang, S. Pervaiz, W. Fan and Y. Y. Yang , " Synergistic Anti-Cancer Effects Via Co-Delivery of TNF-Related Apoptosis-Inducing Ligand (TRAIL/Apo2L) and Doxorubicin Using Micellar Nanoparticles ," Molecular BioSystems , 7[5] (2011) 1512-1522

  163. Z. Y. Ong, P. L. R. Ee, Y. Y. Yang, K. Fukushima, D. J. Coady and J. L. Hedrick , " Rational Design of Biodegradable Cationic Polycarbonates for Gene Delivery ," Journal of Controlled Release , 152[1] (2011) 120-126

  164. Y. F. Tan, P. Chandrasekharan, D. Maity, C. X. Yong, K. H. Chuang, Y. Zhao, S. Wang, J. Ding and S.-S. Feng , " Multimodal Tumor Imaging by Iron Oxides and Quantum Dots Formulated in Poly(lactic Acid)-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles ," Biomaterials , 32[11] (2011) 2969-2978

  165. J. C. M. Teo, R. R. G. Ng, C. P. Ng and A. W. H. Lin , " Surface Characteristics of Acrylic Modified Polysulfone Membranes Improves Renal Proximal Tubule Cell Adhesion and Spreading ," Acta Biomaterialia , 7[5] (2011) 2060-2069

  166. S. Venkataraman, W. L. Ong, Z. Y. Ong, S. C. J. Loo, P. L. R. Ee and Y. Y. Yang , " The Role of PEG Architecture and Molecular Weight in the Gene Transfection Performance of PEGylated Poly(dimethylaminoethyl methacrylate)-Based Cationic Polymers ," Biomaterials , 32[9] (2010) 2369-2378

  167. N. Wiradharma, U. Khoe, C. A. E. Hauser, S. V. Seow, S. Zhang and Y. Y. Yang , " Synthetic Cationic Amphiphilic α-Helical Peptides as Antimicrobial Agents ," Biomaterials , 32[8] (2010) 2204-2212

  168. A. L. Z. Lee, Y. Wang, S. Pervaiz and Y. Y. Yang , " Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles ," Macromolecular Bioscience , 11[2] (2010) 296-307

  169. H. Guo, Y. Choudhury, J. Yang, C. Chen, F. C. Tay, T. M. Lim and S. Wang , " Antiglioma Effects of Combined Use of a Baculoviral Vector Expressing Wild-Type p53 and Sodium Butyrate ," Journal of Gene Medicine , 13[1] (2010) 26-36

  170. C. Yang, J. P. K. Tan, W. Cheng, A. Bte Ebrahim Attia, C. Y. T. Tan, A. Nelson, J. L. Hedrick and Y. Y. Yang , " Supramolecular Nanostructures Designed for High Cargo Loading Capacity and Kinetic Stability ," Nano Today , 5[6] (2010) 515-523

  171. A. Bte Ebrahim Attia, Z. Y. Ong, J. L. Hedrick, P. P. Lee, R. P. L. Ee, P. T. Hammond and Y. Y. Yang , " Mixed Micelles Self-Assembled from Block Copolymers for Drug Delivery ," Current Opinion in Colloid & Interface Science , 16[3] (2010) 182-194

  172. E. L. C. Ng, Y. Yokomizo, N. Yamashita, B. Cirovic, H. Jin, Z. Wen, Y. Ito and M. Osato , " A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells ," Stem Cells , 28[10] (2010) 1869-1881

  173. J. Wang, S.-S. Feng, S. Wang and Z.-Y. Chen , " Evaluation of Cationic Nanoparticles of Biodegradable Copolymers as siRNA Delivery System for Hepatitis B Treatment ," International Journal of Pharmaceutics , 400[1-2] (2010) 194-200

  174. S. L. Lo and S. Wang , " Peptide-Based Nanocarriers for Intracellular Delivery of Biologically Active Proteins ," Organelle-Specific Pharmaceutical Nanotechnology , (2010) DOI: 10.1002/9780470875780.ch18

  175. Y. T. Wong, J. Gruber, A. M. Jenner, F. E. H. Tay and R. S. Ruan , " Chronic Resveratrol Intake Reverses Pro-Inflammatory Cytokine Profile and Oxidative DNA Damage in Ageing Hybrid Mice ," Age , 33[3] (2010) 229-246

  176. L. S. Wang, J. Boulaire, P. P. Y. Chan, J. E. Chung and M. Kurisawa , " The Role of Stiffness of Gelatin-Hydroxyphenylpropionic Acid Hydrogels Formed by Enzyme-Mediated Crosslinking on the Differentiation of Human Mesenchymal Stem Cell ," Biomaterials , 31[33] (2010) 8608-8616

  177. S. H. Kim, J. P. K. Tan, F. Nederberg, K. Fukushima, J. Colson, C. Yang, A. Nelson, Y. Y. Yang and J. L. Hedrick , " Hydrogen Bonding-Enhanced Micelle Assemblies for Drug Delivery ," Biomaterials , 31[31] (2010) 8063-8071

  178. S. Q. Liu, Q. Tian, J. L. Hedrick, J. H. P. Hui, P. L. R. Ee and Y. Y. Yang , " Biomimetic Hydrogels for Chondrogenic Differentiation of Human Mesenchymal Stem Cells to Neocartilage ," Biomaterials , 31[28] (2010) 7298-7307

  179. L. Li, H. Wang, Z. Y. Ong, K. Xu, P. L. R. Ee, S. Zheng, J. L. Hedrick and Y. Y. Yang , " Polymer- and Lipid-Based Nanoparticle Therapeutics for the Treatment of Liver Diseases ," Nano Today , 5[4] (2010) 296-312

  180. M. Khan, N. Wiradharma, G Beniah, N. M. Rafiq, S. Q. Liu, J. Au and Y. Y. Yang , " Branched Disulfide-Based Polyamidoamines Capable of Mediating High Gene Transfection ," Current Pharmaceutical Design , 16[21] (2010) 2341-2349

  181. J. P. K. Tan, S. H. Kim, F. Nederberg, K. Fukushima, D. J. Coady, A. Nelson, Y. Y. Yang and J. L. Hedrick , " Delivery of Anticancer Drugs Using Polymeric Micelles Stabilized by Hydrogen-Bonding Urea Groups ," Macromolecular Rapid Communications , 31[13] (2010) 1187-1192

  182. N. Wiradharma, Y. W. Tong and Y. Y. Yang , " Design and Evaluation of Peptide Amphiphiles with Different Hydrophobic Blocks for Simultaneous Delivery of Drugs and Genes ," Macromolecular Rapid Communications , 31[13] (2010) 1212-1217

  183. X. Y. Bak, J. Yang and S. Wang , " Baculovirus-Transduced Bone Marrow Mesenchymal Stem Cells for Systemic Cancer Therapy ," Cancer Gene Therapy , 17[10] (2010) 721-729

  184. S. Wang and G. Balasundaram , " Potential Cancer Gene Therapy by Baculoviral Transduction ," Current Gene Therapy , 10[3] (2010) 214-225

  185. S. Q. Liu, Q. Tian, L. Wang, J. L. Hedrick, J. H. P. Hui, Y. Y. Yang and P. L. R. Ee , " Injectable Biodegradable Poly(ethylene glycol)/RGD Peptide Hybrid Hydrogels for In Vitro Chondrogenesis of Human Mesenchymal Stem Cells ," Macromolecular Rapid Communications , 31[13] (2010) 1148-1154

  186. W. Y. Seow, Y. Y. Yang and A. J. T. George , " Novel Triblock Oligopeptides as Efficient Nonviral Vectors: Characterization and Further Insights ," Macromolecular Rapid Communications , 31[13] (2010) 1170-1174

  187. S. L. Lo and S. Wang , " Intracellular Protein Delivery Systems Formed by Noncovalent Bonding Interactions between Amphipathic Peptide Carriers and Protein Cargos ," Macromolecular Rapid Communications , 31[13] (2010) 1134-1141

  188. Y. Zhao and S. Wang , " Human NT2 Neural Precursor Derived Tumor Infiltrating Cells as Delivery Vehicles for Treatment of Glioblastoma ," Human Gene Therapy , 21[6] (2010) 683-694

  189. M. Kurisawa, F. Lee, L. S. Wang and J. E. Chung , " Injectable Enzymatically Crosslinked Hydrogel System with Independent Tuning of Mechanical Strength and Gelation Rate for Drug Delivery and Tissue Engineering ," Journal of Materials Chemistry , 20[26] (2010) 5371-5375

  190. Y. C. Wang, Y. Li, T. M. Sun, M. H. Xiong, J. Wu, Y. Y. Yang and J. Wang , " Core-Shell-Corona Micelle Stabilized by Reversible Cross-Linkage for Intracellular Drug Delivery ," Macromolecular Rapid Communications , 31[13] (2010) 1201-1206

  191. M. Khan, G. Beniah, N. Wiradharma, X. D. Guo and Y. Y. Yang , " Brush-Like Amphoteric Poly[isobutylene-alt-(maleic acid)-graft-oligoethyleneamine)]/DNA Complexes for Efficient Gene Transfection ," Macromolecular Rapid Communciations , 31[13] (2010) 1142–1147

  192. C. Q. Wang, B. Jacob, G. S. S. Nah and M. Osato , " Runx, Niche and Stem Cell Quiescence ," Blood Cells, Molecules and Diseases , 44[4] (2010) 275-286

  193. N. T. Zaman, Y. Y. Yang and J. Y. Ying , " Stimuli-Responsive Polymers for the Targeted Delivery of Paclitaxel to Hepatocytes ," Nano Today , 5[1] (2010) 9-14

  194. F. Suriano, R. Pratt, J. P. K. Tan, N. Wiradharma, A. Nelson, Y. Y. Yang, P. Dubois and J. L. Hedrick , " Synthesis of a Family of Amphiphilic Glycopolymers via Controlled Ring-Opening Polymerization of Functionalized Cyclic Carbonates and Their Application in Drug Delivery ," Biomaterials , 31[9] (2010) 2637-2645

  195. H. Wang, K. Xu, L. Liu, J. P. K. Tan , Y. Chen, Y. Li, W. Fan, Z. Wei, J. Sheng, Y. Y. Yang and L. Li , " The Efficacy of Self-Assembled Cationic Antimicrobial Peptide Nanoparticles Against Cryptococcus Neoformans for the Treatment of Meningitis ," Biomaterials , 31[10] (2009) 2874-2881

  196. S. Venkataraman, Y. Zhang, L. Liu and Y. Y. Yang , " Design, Syntheses and Evaluation of Hemocompatible Pegylated-Antimicrobial Polymers with Well-Controlled Molecular Structures ," Biomaterials , 31[7] (2009) 1751-1756

  197. S. Q. Liu, R. Tay, M. Khan, P. L. R. Ee, J. L. Hedrick and Y. Y. Yang , " Synthetic Hydrogels for Controlled Stem Cell Differentiation ," Soft Matter , 6[1] (2009) 67-81

  198. H. P. Song, J. Y. Yang, S. L. Luo, Y. Wang, W. M. Fan, X. S. Tang, J. M. Xue and S. Wang , " Gene Transfer Using Self-Assembled Ternary Complexes of Cationic Magnetic Nanoparticle, Plasmid DNA and Cell-Penetrating Tat Peptide ," Biomaterials , 31[4] (2010) 769-778

  199. C. X. Wu, J. K. Lin, M. Hong, D. Leung, Y. Choudhury, P. Balani, J. M. Zeng, J. Boulaire and S. Wang , " Combinatorial Control of Suicide Gene Expression by Tissue-Specific Promoter and microRNA Regulation for Cancer Therapy ," Molecular Therapy , 17[12] (2009) 2058-2066

  200. X. D. Guo, J. P. K. Tan, S. H. Kim, L. J. Zhang, Y. Zhang, J. L. Hedrick, Y. Y. Yang and Y. Qian , " Computational Studies on Self-Assembled Paclitaxel Structures: Templates for Hierarchical Block Copolymer Assemblies and Sustained Drug Release ," Biomaterials , 30[33] (2009) 6556-6563

  201. W. Y. Seow, Y. Y. Yang and A. George , " Oligopeptide-Mediated Gene Transfer into Mouse Corneal Endothelial Cells: Expression, Design Optimization, Uptake Mechanism and Nuclear Localization ," Nucleic Acids Research , 37[18] (2009) 6276-6289

  202. J. Zeng, J. Du, J. Boulaire, Y. Zhao and S. Wang , " The Combined Use of Viral Transcriptional and Post-Transcriptional Regulatory Elements to Improve Baculovirus-Mediated Transient Gene Expression in Human Embryonic Stem Cells ," Journal of Bioscience and Bioengineering , 109[1] (2009) 1-8

  203. Y. Yang, S. L. Lo, J. Y. Yang, J. Yang, S. S. L. Goh, C. X. Wu, S. S. Feng and S. Wang , " Polyethylenimine Coating to Produce Serum-Resistant Baculoviral Vectors for In Vivo Gene Delivery ," Biomaterials , 30[29] (2009) 5767-5774

  204. Nikken Wiradharma, Ying Zhang, Shrinivas Venkataraman, James L. Hedrick, and Yi Yan Yang , " Self-Assembled Polymer Nanostructures for Delivery of Anticancer Therapeutics ," Nano Today , 4[4] (2009) 302-317

  205. L. Liu, K. Xu, H. Wang, J. P. K. Tan, W. Fan, S. S. Venkatraman, L. Li and Y. Yang , " Self-Assembled Cationic Peptide Nanoparticles as an Efficient Antimicrobial Agent ," Nature Nanotechnology , 4 (2009) 457-463

  206. J. M. Zeng, J. Du, J. K. Lin, X. Y. Bak, C. X. Wu and S. Wang , " High-Efficiency Transient Transduction of Human Embryonic Stem Cell-Derived Neurons with Baculoviral Vectors ," Molecular Therapy , 17[9] (2009) 1585-1593

  207. J. Chen and R. S. Ruan , " Identifying Stable Reference Genes for Evaluation of Antioxidative Enzyme Gene Expression in Auditory Cortex and Cochlea of Young and Old Fischer 344 Rats ," Acta Octo-Laryngologica , 129[6] (2009) 644-650

  208. M. C. Tan, J. Y. Ying, and G. M. Chow , " Interfacial Properties and In Vitro Cytotoxic Effects of Surface?Modified Near Infrared Absorbing Au?Au2S Nanoparticles ," Journal of Materials Science: Materials in Medicine , 20[10] (2009) 2091-2103

  209. W. Y. Seow and Y. Y. Yang , " Functional Polycarbonates and Their Self-Assemblies as Promising Non-Viral Vectors ," Journal of Controlled Release , 139[1] (2009) 40-47

  210. S. H. Kim, F. Nederberg, R. Jakobs, J. P. K. Tan, K. Fukushima, A. Nelson, E. W. Meijer, Y. Y. Yang and J. L. Hedrick , " A Supramolecularly Assisted Transformation of Block Copolymer Micelles into Nanotubes ," Angewandte Chemie International Edition , 48[25] (2009) 4508-4512

  211. Y. Yan, J. Du, T. S. Chen, M. S. Yi, M. Y. Li, S. Wang, C. M. Li and Y. H. Hong , " Establishment of Medakafish as a Model for Stem Cell-based Gene Therapy: Efficient Gene Delivery and Potential Chromosomal Integration by Baculoviral Vectors ," Experimental Cell Research , 315[13] (2009) 2322-2331

  212. J. Boulaire, P. Balani and S. Wang , " Transcriptional Targeting to Brain Cells: Engineering Cell Type-Specific Promoter Containing Cassettes for Enhanced Transgene Expression ," Advanced Drug Delivery Reviews , 61[7-8] (2009) 589-602

  213. F. Nederberg, E. Appel, J. P. K. Tan, S. H. Kim, K. Fukushima, J. Sly, R. D. Miller, R. M. Waymouth, Y. Y. Yang and J. L. Hedrick , " A Simple Approach to Stabilized Micelles Employing Mikto-arm Terpolymers and Stereocomplexes with Application in Paclitaxel Delivery ," Biomacromolecules , 10[6] (2009) 1460-1468

  214. J. Boulaire, Y. Zhao and S. Wang , " Gene Expression Profiling to Define Host Response to Baculoviral Transduction in the Brain ," Journal of Neurochemistry , 109[5] (2009) 1203-1214

  215. X. D. Guo, J. P. K. Tan, L. J. Zhang, M. Khan, S. Q. Liu, Y. Y. Yang and Y. Qian , " Phase Behavior Study of Paclitaxel Loaded Amphiphilic Copolymer in Two Solvents by Dissipative Particle Dynamics Simulations ," Chemical Physics Letters , 473[4-6] (2009) 336-342

  216. N. Wiradharma, Y. W. Tong and Y. Y. Yang , " Self-Assembled Oligopeptide Nanostructures for Co-Delivery of Drug and Gene in Achieving Synergistic Therapeutic Effect ," Biomaterials , 30[17] (2009) 3100-3109

  217. M. Hu, M. Kurisawa, R. Deng, C. M. Teo, A. Schumacher, Y. X. Thong, L. Wang, K. M. Schumacher and J. Y. Ying , " Cell Immobilization in Gelatin-Hydroxyphenylpropionic Acid Hydrogel Fibers ," Biomaterials , 30[21] (2009) 3523-3531

  218. J. P. K. Tan, S. H. Kim, F. Nederberg, E. A. Appel, R. M. Waymouth, Y. Zhang, J. L. Hedrick and Y. Y. Yang , " Hierarchical Supermolecular Structures for Sustained Drug Release ," Small , 5[13] (2009) 1504-1507

  219. P. Balani, J. Boulaire, Y. Zhao, J. Zeng, J. K. Lin and S. Wang , " High Mobility Group Box2 Promoter-Controlled Suicide Gene Expression Enables Targeted Glioblastoma Treatment ," Molecular Therapy , 17[6] (2009) 1003-1011

  220. S. Q. Liu, P. L. R. Ee, C. Y. Ke, J. L. Hedrick and Y. Y. Yang , " Biodegradable Poly(ethylene glycol)-Peptide Hydrogels with Well-Defined Structure and Properties for Cell Delivery ," Biomaterials , 30[8] (2009) 1453-1461

  221. C. Beh, W. Y. Seow, Y. Wang, Y. Zheng and Y. Y. Yang , " Delivery of Bcl-2-Targeted siRNA Using Cationic Polymer Micelles: Downregulation ofmRNA Expression Level and Sensitization of Cancer Cells to Anticancer Drug ," Biomacromolecules , 10[1] (2009) 41-48

  222. S. H. Kim, F. Nederberg, J. Tan, K. Fukushima, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick , " Mixed Micelle Formation Through Stereocomplexation Between Enantiomeric Poly(lactide) Block Copolymers ," Macromolecules , 42[1] (2009) 25-29

  223. F. Lee, J. E. Chung and M. Kurisawa , " An Injectable Hyaluronic Acid-Tyramine System for Protein Delivery ," Journal of Controlled Release , 134[3] (2008) 186-193

  224. A. Lee, Y. Wang, H. Y. Cheng, S. Pervaiz and Y. Y. Yang , " Co-Delivery of Paclitaxel and Herceptin Using Cationic Micellar Nanoparticles: Achieving Enhanced Cytotoxicity and Targeting ," Biomaterials , 30[5] (2009) 919-927

  225. W. Y. Seow and Y. Y. Yang , " A Class of Triblock Cationic Oligopeptides as Efficient Gene Delivery Vectors ," Advanced Materials , 21[1] (2009) 86-90

  226. K. Fukushima, R. C. Pratt, F. Nederberg, J. Tan, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick , " Organocatalytic Approach to Amphiphilic Comb-Block Copolymers Capable of Stereocomplexation and Self-Assembly ," Biomacromolecules , 9[11] (2008) 3051-3056

  227. F. Tandiono, X. D. Guo, N. Wiradharma, D. Khor, C. G. Tan, M. Khan, Y. Qian and Y. Y. Yang , " Cationic Micelles Self-Assembled from Cholesterol-Conjugated Oligopeptides as an Efficient Gene Delivery Vector ," Biomaterials , 29[36] (2008) 4838-4846

  228. P. Pitukmanorom, T.-H. Yong and J. Y. Ying , " Tunable Release of Proteins with Polymer-Inorganic Nanocomposite Microspheres ," Advanced Materials , 20[18] (2008) 3504-3509

  229. J. Jurvansuu, Y. Zhao, S. Y. Leung, J. Boulaire, Y. H. Yu, S. Ahmed and S. Wang , " TMEM18 Enhances the Tropism of Neural Stem Cells for Glioma Cells ," Cancer Research , 68[12] (2008) 4614-4622

  230. C. X. Wu, S. L. Lo, J. Boulaire, M. L. W. Hong, H. M. Beh, S. Y. Leung and S. Wang , " A Peptide-based Carrier for Intracellular Delivery of Proteins into Malignant Glial Cells In Vitro ," Journal of Controlled Release , 130[2] (2008) 140-145

  231. L. H. Liu, S. S. Venkatraman, Y. Y. Yang, K. Guo, J. Lu, B. P. He, S. Moochhala and L. J. Kan , " Polymeric Micelles Anchored with TAT for Delivery of Antibiotics across the Blood-Brain Barrier ," Biopolymers , 90[5] (2008) 617-623

  232. N. Wiradharma, M. Khan, Y. W. Tong, S. Wang and Y. Y. Yang , " Self-Assembled Cationic Peptide Nanoparticles Capable of Inducing Efficient Gene Expression in vitro ," Advanced Functional Materials , 18[6] (2008) 943-951

  233. B. H. Liu, S. Wang, M. Brenner, J. F. R. Paton and S. Kasparov , " Enhancement of Cell-Specific Transgene Expression from a Tet-Off Regulatory System Using a Transcriptional Amplification Strategy in the Rat Brain ," Journal of Gene Medicine , 10[5] (2008) 583-592

  234. S. L. Lo and S. Wang , " An Endosomolytic TAT Peptide Produced by Incorporation of Histidine and Cysteine Residues as a New Nonviral Vector for Efficient DNA Transfection ," Biomaterials , 29[15] (2008) 2408-2414

  235. F. Lee, J. E. Chung and M. Kurisawa , " An Injectable Enzymatically Crosslinked Hyaluronic Acid-Tyramine Hydrogel System with Independent Tuning of Mechanical Strength and Gelation Rate ," Soft Matter , 4[4] (2008) 880-887

  236. A. Lee, Y. Wang, W. H. Ye, H. S. Yoon, S. Y. Chan and Y. Y. Yang , " Efficient Intracellular Delivery of Functional Proteins Using Cationic Polymer Core/Shell Nanoparticles ," Biomaterials , 29[9] (2008) 1224-1232

  237. M. C. Tan, J. Y. Ying and G. M. Chow , " Composition, Particle Size and NIR Irradiation Effects on Optical Properties of Au-Au2S Nanoparticles ," Journal of Materials Research , 23[1] (2008) 281-293

  238. L. H. Liu, K. Guo, J. Lu, S. S. Venkatraman, D. Luo, K. C. Ng, E. A. Ling, S. Moochhala and Y. Y. Yang , " Biologically Active Core/Shell Nanoparticles Self-Assembled from Cholesterol-Terminated PEG-TAT for Drug Delivery across the Blood-Brain Barrier ," Biomaterials , 29[10] (2007) 1509-1517

  239. Q. Y. Meng, C. N. Velalar and R. S. Ruan , " Effects of Epigallocatechin-3-Gallate on Mitochondrial Integrity and Antioxidative Enzyme Activity in Aging Process of Human Fibroblast ," Free Radical Biology and Medicine , 44[6] (2007) 1032-1041

  240. Z. Yue, S. B. M. Usuludn and H. Yu , " Bio-inspired Multifunctional Nanoassemblies for Intracellular Drug Delivery ," Proceedings of the International Conference on Cellular and Molecular Bioengineering , (2007) DOI: -

  241. S. Moudgil and J. Y. Ying , " Calcium-Doped Organosilicate Nanoparticles as Gene Delivery Vehicles for Bone Cells ," Advanced Materials , 19[20] (2007) 3130-3135

  242. B. Gopalan, M. Shanker, A. Scott, C. D. Branch, S. Chada and R. Ramesh , " MDA-7/IL-24, a Novel Tumor Suppressor/Cytokine is Ubiquitinated and Regulated by the Ubiquitin-Proteasome System, and Inhibition of MDA-7/IL-24 Degradation Enhances the Antitumor Activity ," Cancer Gene Therapy , 15[1] (2007) 1-8

  243. M. C. Tan, J. Y. Ying and G. M. Chow , " Structure and Microstructure of Near Infrared-Absorbing Au-Au2S Nanoparticles ," Journal of Materials Research , 22[9] (2007) 2531-2538

  244. Y. Wang, C. Y. Ke, C. W. J. Beh, S. Q. Liu, S. H. Goh and Y. Y. Yang , " The Self Assembly of Biodegradable Cationic Polymer Micelles as Vectors for Gene Transfection ," Biomaterials , 28[35] (2007) 5358-5368

  245. C. X. Wu, K. Y. Soh and S. Wang , " Ion-Exchange Membrane Chromatography Method for Rapid and Efficient Purification of Recombinant Baculovirus and Baculovirus gp64 Protein ," Human Gene Therapy , 18[7] (2007) 665-672

  246. G. Tresset, W. C. D. Cheong, Y. L. S. Tan, J. Boulaire and Y. M. Lam , " Phospholipid-based Artificial Viruses Assembled by Multivalent Cations ," Biophysical Journal , 93[2] (2007) 637-644

  247. J. M. Zeng, J. Du, Y. Zhao, N. Palanisamy and S. Wang , " Baculoviral Vector-mediated Transient and Stable Transgene Expression in Human Embryonic Stem Cells ," Stem Cells , 25[4] (2007) 1055-1061

  248. Y. Wang, L. S. Wang, S. H. Goh and Y. Y. Yang , " Synthesis and Characterization of Cationic Micelles Self-Assembled from A Biodegradable Copolymer for Gene Delivery ," Biomacromolecules , 8[3] (2007) 1028-1037

  249. K. S. Soppimath, L. H. Liu, W. Y. Seow, S. Q. Liu, R. Powell, P. Chan and Y. Y. Yang , " Multi-Functional Polymer Core-Shell Nanoparticles Self-Assembled from pH-Induced Thermally Responsive Polymer for Targeted Anticancer Drug Delivery ," Advanced Functional Materials , 17[3] (2007) 355-362

  250. Q. Y. Meng, Y. Wong, J. Chen and R. Ruan , " Age-related Changes in Mitochondrial Function and Antioxidative Enzyme Activity in Fischer 344 Rats ," Mechanisms of Ageing and Developments , 128[3] (2007) 286-292

  251. W. Y. Seow, J. M. Xue and Y. Y. Yang , " Targeted and Intracellular Delivery of Paclitaxel Using Multi-functional Polymeric Micelles ," Biomaterials , 28[9] (2006) 1730-1740

  252. J. Zeng, X. Wang and S. Wang , " Self-Assembled Ternary Complexes of Plasmid DNA, Low Molecular Weight Polyethylenimine and Targeting Peptide for Nonviral Gene Delivery into Neurons ," Biomaterials , 28[7] (2006) 1443-1451

  253. S. Q. Liu, N. Wiradharmaa, S. J. Gao, Y. W. Tong and Y. Y. Yang , " Bio-functional Micelles Self-Assembled from a Folate-Conjugated Block Copolymer for Targeted Intracellular Delivery of Anticancer Drugs ," Biomaterials , 28[7] (2006) 1423-1433

  254. P. Chan, M. Kurisawa, J. E. Chung and Y. Y. Yang , " Synthesis and Characterization of Chitosan-g-Poly(ethylene glycol)-Folate as a Non Viral Carrier for Tumor-Targeted Gene Delivery ," Biomaterials , 28[3] (2006) 540-549

  255. Y. Wang, S. J. Gao, H. Wen, H. S. Yoon and Y. Y. Yang , " Co-delivery of Drugs and DNA from Cationic Core-Shell Nanoparticles Self-Assembled from a Biodegradable Copolymer ," Nature Materials , 5[10] (2006) 791-796

  256. T. B. Bini, S. J.Gao, S. Wang and S. Ramakrishna , " Poly(l-lactide-co-glycolide) Biodegradable Microfibers and Electrospun Nanofibers for Nerve Tissue Engineering: An In Vitro Study ," Journal of Materials Science , 41[19] (2006) 6453-6459

  257. Z. Shang, D. N. Ting, Y. T. Wong, Y. C. Tan, B. Ying and Y. Mo , " A Study of DFT and Surface Enhanced Raman Scattering in Silver Colloids for Thymine ," Journal of Molecular Structure , 826[1] (2006) 64-67

  258. B. H. Liu, Y. Yang, J. F. R. Paton, F. Li, J. Boulaire, S. Kasparov and S. Wang , " GAL4-NF-κB Fusion Protein Augments Transgene Expression from Neuronal Promoters in the Rat Brain ," Molecular Therapy , 14[6] (2006) 872-882

  259. F. Alexis, S. L. Lo and S. Wang , " Covalent Attachment of Low Molecular Weight Polyethylenimine Improves Tat Peptide-Mediated Gene Delivery ," Advanced Materials , 18[16] (2006) 2174-2178

  260. G. P. Tang, H. Y. Guo, F. Alexis, X. Wang, S. Zeng, T. M. Lim, J. Ding, Y. Y. Yang and S. Wang , " Low Molecular Weight Polyethylenimines Linked by β-Cyclodextrin for Gene Transfer into the Nervous System ," Journal of Gene Medicine , 8[6] (2006) 736-744

  261. C. Y. Wang, F. Li, Y. Yang, H. Y. Guo, C. X. Wu and S. Wang , " Recombinant Baculovirus Containing the Diphtheria Toxin A Gene for Malignant Glioma Therapy ," Cancer Research , 66[11] (2006) 5798-806

  262. C. Y. Wang and S. Wang , " Astrocytic Expression of Transgene in the Rat Brain Mediated by Baculovirus Vectors Containing an Astrocyte-Specific Promoter ," Gene Therapy , 13[20] (2006) 1447-1456

  263. L. S. Wang, P. Y. Chow, T.-T. Phan, I. J. Lim and Y.Y. Yang , " Fabrication and Characterization of Nano-structured and Thermo-sensitive Membranes for Wound Healing and Cell Grafting ," Advanced Functional Materials , 16[9] (2006) 1171-1178

  264. Y. Y. Yang, Y. Wang, R. Powell and P. Chan , " Polymeric Core-Shell Nanoparticles for Therapeutics ," Clinical & Experimental Pharmacology and Physiology , 33[5-6] (2006) 557-562

  265. H. W. Yu, H. Chen, X. Wang, Y. Y. Yang and C. B. Ching , " Cross-Linked Enzyme Aggregates (CLEAs) with Controlled Particles: Application to Candida Rugosa Lipase ," Journal of Molecular Catalysis B-Enzymatic , 43[1-4] (2006) 124-127

  266. D. Tan, B. Zhao, S. Moochhala and Y. Y. Yang , " Pharmacokinetic Profile of a Sustained-Delivery System for Physostigmine in Rats ," Materials Science and Engineering B , 132[1-2] (2006) 155-158

  267. D. Tan, B. Zhao, S. Moochhala and Y. Y. Yang , " Sustained-Release of Caffeine from a Polymeric Tablet Matrix: An In Vitro and Pharmacokinetic Study ," Materials Science and Engineering B , 132[1-2] (2006) 143-146

  268. G. Tresset , " Ion-Induced Accumulation of DNA in Lipid Vesicles ," Proceedings of the 50th Biophysical Society Annual Meeting , (2006) DOI: -

  269. N. T. Zaman, F. E. Tan, S. M. Joshi and J. Y. Ying , " Targeted Stimuli-Responsive Dextran Conjugates for Doxorubicin Delivery to Hepatocytes ," Proceedings of the Singapore-MIT Alliance Symposium , (2006) DOI: -

  270. X. Jiang, H. Dai, K. W. Leong, S. H. Goh, H. Q. Mao and Y. Y. Yang , " Chitosan-g-PEG/DNA Complexes Deliver Gene to the Rat Liver via Intrabiliary and Intraportal Infusions ," Journal of Gene Medicine , 8[4] (2006) 477-487

  271. S. T. Ong, F. Li, J. Du, Y. W. Tan and S. Wang , " Hybrid Cytomegalovirus Enhancer-h1 Promoter-based Plasmid and Baculovirus Vectors Mediate Effective RNA Interference ," Human Gene Therapy , 16[12] (2005) 1404-1412

  272. W. M. Shu, W. N. Everett, Q. X. Zhang, M. H. H. Liu, A. Trigg, Y. X. Ma, S. M. Spearing, S. Wang, H. J. Sue and P. M. Moran , " Microheated Substrates for Patterning Cells and Controlling Development ," Journal of Microelectromechanical Systems , 14[5] (2005) 924-934

  273. C. Y. Wang and S. Wang , " Adeno-Associated Virus Inverted Terminal Repeats Improve Neuronal Transgene Expression Mediated by Baculoviral Vectors in Rat Brain ," Human Gene Therapy , 16[10] (2005) 1219-1226

  274. J. S. Wei, H. B. Zeng, S. Q. Liu, X. G. Wang, E. H. Tay and Y. Y. Yang , " Temperature- and pH-sensitive Core-Shell Nanoparticles Self-Assembled from Poly (N-isopropylacrylamide-co-acrylic acid-cocholesteryl acrylate) for Intracellular Delivery of Anticancer Drugs ," Frontiers in Bioscience , 10 (2005) 3058-3067

  275. L. M. Gan, P. Y. Chow, Z. L. Liu, M. Han and C. H. Quek , " The Zwitterion Effect in Proton Exchange Membranes as Synthesised by Polymerisation of Bicontinuous Microemulsions ," Chemical Communications , 35 (2005) 4459

  276. M. Kurisawa, J. E. Chung, Y. Y. Yang, S. J. Gao and H. Uyama , " Injectable Biodegradable Hydrogels Composed of Hyaluronic Acid-Tyramine Conjugates for Drug Delivery and Tissue Engineering ," Chemical Communications , 34 (2005) 4312-4314

  277. S. Q. Liu, Y. W. Tong and Y. Y. Yang , " Thermally Sensitive Micelles Self-Assembled from Poly(N-isopropylacrylamide-co-N, Ndimethylacrylamide)- b-poly (D,L-lactide-coglycolide) for Controlled Delivery of Paclitaxel ," Molecular BioSystems , 1[2] (2005) 158-165

  278. T. B. Bini, S. J. Gao, S. Wang and S. Ramakrishna , " Development of Fibrous Biodegradable Polymer Conduits for Guided Nerve Regeneration ," Journal of Materials Science: Materials in Medicine , 16[4] (2005) 367-375

  279. X. Wang, C. Y. Wang, J. M. Zeng, X. Y. Xu, P. Y. K. Hwang, W.C. Yee, Y. K. Ng and S. Wang , " Gene Transfer to Dorsal Root Ganglia by Intrathecal Injection: Effects on Regeneration of Peripheral Nerves ," Molecular Therapy , 12 (2005) 314-320

  280. C. Y. Wang, H. Y. Guo, T. M. Lim, Y. K. Ng, H. P. Neo, P. Y. K. Hwang, W.-C. Yee and S. Wang , " Improved Neuronal Transgene Expression from an AAV-2 Vector with a Hybrid CMV Enhancer/ PDGF-β Promoter ," Journal of Gene Medicine , 7[7] (2005) 945-955

  281. S. Q. Lu, Y. W. Tong and Y. Y. Yang , " Incorporation and In VitroRelease of Doxorubicin in Thermally Sensitive Micelles Made from Poly(N-isopropyl acrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactideco- glycolide) with Varying Compositions ," Biomaterials , 26[24] (2005) 5064-5074

  282. B. Li, Y. X. Ma, S. Wang and P. M. Moran , " Influence of Carboxyl Group Density on Neuron Cell Attachment and Differentiation Behavior: Gradient-Guided Neurite Outgrowth ," Biomaterials , 26[24] (2005) 4956-4963

  283. P. Y. Chow and L. M. Gan , " Microemulsion Polymerizations and Reactions ," Advances in Polymer Science , 175 (2005) 257-298

  284. M. Y. Wang, Y. Y. Yang and P. W. S. Heng , " Understanding of Fatty Acids as Chemical Enhancers for Transdermal Delivery of Physostigmine ," International Journal of Pharmaceutics , 290[2 Jan] (2005) 25-36

  285. Y. Li, Y. Yang and S. Wang , " Neuronal Gene Transfer by Baculovirus-Derived Vectors Accommodating a Neuron-Specific Promoter ," Experimental Physiology , 90[1] (2004) 39-44

  286. N. Wu, L. S. Wang, C. W. Tan, S. M. Moochhala and Y. Y. Yang , " Mathematical Modeling and In Vitro Study of Controlled Drug Release via a Highly Swellable and Dissoluble Polymer Matrix: Polyethylene Oxide (PEO) with High Molecular Weights ," Journal of Controlled Release , 102[3] (2004) 569-581

  287. F. Alexis , " Factors Affecting Degradation and Drug Release Mechanism of Bioerodible Polymers ," Polymer International: Critical Review Paper , 54[1] (2004) 36-46

  288. J. Y. Wu, S. Q. Liu, W. S. Heng and Y. Y. Yang , " Evaluating Proteins Release from and Their Interactions with Thermosensitive Poly (N-isopropylacrylamide) Hydrogels ," Journal of Controlled Release , 102[2] (2004) 361-372

  289. L. S. Wang, P. Y. Chow, C. W. Tan, W. D. Zhang and Y. Y. Yang , " Nano-Structured and Transparent Polymer Membranes with Thermo-Sensitivity for Wound Dressing and Cell Grafting ," Advanced Materials , 16[20] (2004) 1790-1794

  290. F. Yang, R. Murugan, S. Wang and S. Ramakrishna , " Electrospinning of Nano/Micro Scale Poly(L-lactic acid) Aligned Fibers and their Potential in Neural Tissue Engineering ," Biomaterials , 26[15] (2004) 2603-2610

  291. J. Zeng, H. P. Too, Y. Ma, E. S. Luo and S. Wang , " A Synthetic Peptide Containing Loop 4 of Nerve Growth Factor for Targeted Gene Delivery ," Journal of Gene Medicine , 6[11] (2004) 1247-1256

  292. X. Liu, J. A. Mohamed and R. S. Ruan , " Analysis of Differential Gene Expression in the Cochlea and Kidney of Mouse by cDNA Microarrays ," Hearing Research , 197[1-2] (2004) 35-43

  293. Z. Q. Chen, M. Ulfendahl, R. S. Ruan, L. Tan and M. L. Duan , " Protection of Auditory Function Against Noise Trauma with Local Caroverine Administration in Guinea Pigs ," Hearing Research , 197[1-2] (2004) 131-136

  294. Y. Li, X. Wang, H. Guo and S. Wang , " Axonal Transport of Recombinant Baculovirus Vectors ," Molecular Therapy , 10 (2004) 1121-1129

  295. B. Li, Y. X. Ma, S. Wang and P. M. Moran , " A Technique for Preparing Protein Gradients on Polymeric Surfaces: Effects on PC12 Pheochromocytoma Cells ," Biomaterials , 26[13] (2004) 1487-1495

  296. J. M. Zeng and S. Wang , " Enhanced Gene Delivery to PC12 Cells by a Cationic Polypeptide ," Biomaterials , 26[6] (2004) 679-686

  297. P. Y. Chow, L. M. Gan , " Microemulsion Processing of Silica-Polymer Nanocomposite ," Journal of Nanoscience and Nanotechnology , 4[1-2] (2004) 197-202

  298. M. Y. Wang, Y. Y. Yang, and W. S. Heng , " Role of Solvent in Interactions between Fatty Acid-based Formulations and Lipids in Porcine Stratum Corneum ," Journal of Controlled Release , 94[1] (2003) 207-216

  299. C. S. Chaw, K. W. Chooi, X. M. Liu, C. W. Tan, L. Wang, and Y. Y. Yang , " Thermally Responsive Core-Shell Nanoparticles Self-Assembled from Cholesteryl End-Capped and Grafted Polyacrylamides: Drug Incorporation and In Vitro Release ," Biomaterials , 25[18] (2004) 4297-4308

  300. L. Wang, C. S. Chaw, Y. Y. Yang, S. M. Moochhala, B. Zhao, S. Ng, and J. Heller , " Preparation, Characterization, and In Vitro Evaluation of Physostigmine-Loaded Poly(orthoester) and Poly(orthoester)/Poly (D,L-lactide-co-glycolide) Blend Microspheres Fabricated by Spray Drying ," Biomaterials , 25[16] (2004) 3275-3282

  301. N. Ma, S. S. Wu, Y. X. Ma, J. M. Zeng, G. P. Tang, Y. Huang, and S. Wang , " Nerve Growth Receptor-Mediated Gene Transfer ," Molecular Therapy , 9 (2003) 270-281

  302. S. Q. Liu, Y. Y. Yang, X. M. Liu, and T. Y. Wah , " Preparation and Characterization of Temperature-Sensitive Poly(N-isopropylacrylamide)-b-Poly(D.L-lactide) Microspheres for Protein Delivery ," Biomacromolecules , 4[6] (2003) 1784-1793

  303. X. M. Liu, Y. Y. Yang, and K. W. Leong , " Thermally Responsive Polymeric Micellar Nanoparticles Self- Assembled from Cholesteryl End-Capped Random Poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide): Synthesis, Temperature-Sensitivity, and Morphologies ," Journal of Colloid and Interfacial Science , 266[2] (2003) 295-303

  304. Y. Li, J. Wang, C. G. Lee, C. Y. Wang, S. J. Gao, G.P. Tong, Y. X. Ma, H. Yu, H. Q. Mao, K. W. Leong, and S. Wang , " CNS Gene Transfer Facilitated by A Novel Controlled Release System Based on DNA Complexes of Degradable Polycation PPE-EA: A Comparison with Polyethylenimine/DNA Complexes ," Gene Therapy , 11 (2003) 109-114

  305. B. H. Liu, X Wang, Y. X. Ma, and S. Wang , " CMV Enhancer/Human PDGF-b Promoter for Neuron-Specific Transgene Expression ," Gene Therapy , 11 (2003) 52-60

  306. C. S. Chaw, C. W. Tan, Y. Y. Yang, L. Wang, and S. M. Moochhala , " Design of Physostigmine-Loaded Polymeric Microparticles for Pretreatment against Exposure to Organophosphate Agents ," Biomaterials , 24[7] (2002) 1271-1277

Tissue and Organoid Models, where biomimicking materials, stem cell technology and bioimaging tools are combined to develop novel approaches for regenerative medicine, artificial organs and toxicology.

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Research > Tissue and Organoid Models

Biomaterials for Cell Reprogramming

Hongfang Lu and Andrew Wan 

Cell plasticity refers to the ability of cells to be reprogrammed to other cell types, including stem cells. Our research efforts are focused on two fronts. First, we are trying to replace the more conventional cell reprogramming method, which typically involves genetic modification of cells, with transgene-free and xeno-free methods that dispense with the use of animal products. Through this, we hope to develop a safer source of cells for use in regenerative medicine. Our second research focus is on investigating the role of the cellular microenvironment in the reprogramming of cancer cells. We have shown that the extracellular matrix and 3D environment combine to influence the stemness of glioma cells, which is typically associated with the cells’ self-renewal and drug-resistance properties. This information would be useful in developing new cancer therapies.

Digital Livers: Quantitative Analysis of the Dynamic Processes of Liver Regeneration and Chronic Liver Diseases

Ziwei Song, Yu Yang and Hanry Yu 

We have developed optical imaging modalities to quantify cellular and extracellular changes in tissues. The instruments and machine-learning based image-processing/feature analysis algorithms developed are used to automate and improve pathological examinations related to (i) liver fibrosis, (ii) cholestasis and (iii) non-alcoholic fatty liver diseases. This helps to shed light on the etiology of the diseases quantitatively. We have developed a high-throughput tissue imaging platform to quantify tissue/cell and matrix features of big blocks of tissue in mice or the entire biopsy sample at molecular and cellular resolutions for 3D characterization of disease progression. We have spun off an award-winning company, HistoIndex Pte Ltd, from this project, and licensed key technologies to another start-up company, InvitroCue Pte Ltd, to create an impact in the digital pathology and telemedicine landscape. The team is also investigating the fundamental process of liver regeneration by quantifying and modeling the mechanical and biochemical regulation of the cellular hypertrophy.

Drug Testing Platforms: Development of Robust, Inexpensive, Scalable and Predictive Assays for Safety Testing of Drugs and Chemicals

Farah Tasnim, Xiaozhong Huang and Hanry Yu 

Cell-based assays for in vitro toxicity evaluation are attracting increasing attention from institutions and companies involved in the development of drugs and industrial chemicals. The major bottlenecks are the lack of stable human primary cells, and cell-culture models that recapitulate the in vivo physiological responses to the tested compounds. So far, only the sandwich culture of liver cells is accepted by the Federal Drug Administration (FDA) for routine hepatotoxicity testing of drugs. To improve the cell-based assays, we have developed (i) a scalable aligned substrate on optical media, (ii) two improved spheroid models for acute and chronic toxicity testing, respectively, (iii) a co-culture model for idiosyncratic toxicity, (iv) three perfusion-based models for improved sensitivity to detect metabolites, (v) a developmental toxin based on morphogenic migration of human stem cells, and (vi) stable and robust cell sources from human stem or progenitor cells. We are validating these established models for hepatotoxicity and teratogen testing of compounds, and improving the performance of these platforms for robustness, predictive fidelity, scalability and cost. We are also extending the applications of these models to sub-acute/chronic hepatotoxicity in order to better mimic “in vivo-like” conditions.

Engineering Complex Tissues: Spatial and Temporal Control of Microenvironment

Zheng Liu (Justinian), Farah Tasnim and Hanry Yu 

Complex tissues with multiple cell types will be engineered by controlling cell-cell and cell-matrix interactions through (i) engineering inter-cellular linkers for 3D printing, (ii) engineering cellular response to the chemical and mechanical signals by developing ultra-soft macroporous sponges that are robust, transparent, degradable and enhancing compact spheroid formation, and (iii) fabricating relevant 3D microfluidics, micro-patterns and ultra-thin porous membranes incorporating mechanical compaction and multiple cell types for organ-on-a-chip applications, such as a liver cancer chip to aid chemotherapy testing. This project establishes the fundamental principles, toolboxes and devices to precision-engineer micro-tissue constructs of different cell types and inter-cellular tissue space (such as sinusoid and bile canaliculi in liver) for repeated dose testing of compounds that require mid-term (> 2-4 weeks) or long-term (up to 6 weeks) culture of micro-tissue constructs.

Fibrous Scaffolds for Tissue Engineering

Tze Chiun Lim, Chan Du, Yihua Loo, Wei Yang Seow, Benjamin Tai , Andrew Wan 

Tissue engineering requires the use of a framework or scaffold for cells to attach and grow. In addition, scaffolds may contain biological molecules, which control the rate of cell growth and propensity of stem cells to differentiate into cells of specific tissues and organs. Most of the current processes for the production of tissue scaffolds require high temperatures and organic solvents, which may denature the proteins and other biological molecules to be incorporated. In this project, we are fabricating scaffolds by encapsulating cells and the relevant biological molecules into fibers that are formed at the interface between two oppositely charged polyelectrolytes. These fibers are then combined to form 3D patterned tissue constructs.

New Alternative Methods for the Prediction of Chemical- and Nanomaterial-Induced Toxicities in Humans

Jacqueline Chuah, Faezah Hussain and Daniele Zink 

New alternative methods for toxicity prediction are required by the pharmaceutical, chemical, food and consumer care industries. Currently, there are no accepted alternative methods for the prediction of toxicities for human internal organs, such as the kidney and liver. We are developing robust screening platforms that predict toxicities to human internal organs with high sensitivity and accuracy (test balanced accuracy > 80%). Our methods include several novel technologies, such as the first in vitro assay that predicts nephrotoxicity in humans with high accuracy, the first stem cell-based predictive renal screening platforms, and the first predictive kidney-specific high-throughput platform. Our kidney-specific technologies have been awarded by the US Society of Toxicology (2015) and have won the Lush Prize (2016, Science category). The renal high-throughput platform is applied in collaboration with the US Environmental Protection Agency for the prediction of the human nephrotoxicity of ToxCast compounds. Our high-throughput technology is currently adapted for the prediction of other organ-specific toxicities. A liver-specific platform has been established, and a vasculature-specific platform is under development. Our methods can also be applied for the prediction of chemical- as well as nanomaterial-induced toxicities.

  1. Jieming Zeng, Shin Yi Tang, Lai Ling Toh and Shu Wang , " Generation of ‘‘Off-the-Shelf’’ Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells ," Stem Cell Reports , (2017) DOI: https://doi.org/10.1016/j.stemcr.2017.10.020

  2. Z. Song, K. Gupta, I. C. Ng, J. Xing, Y. A. Yang and H. Yu , " Mechanosensing in Liver Regeneration ," Seminars in Cell and Developmental Biology , (2017) DOI: 10.1016/j.semcdb.2017.07.041

  3. L. J. Y. Ong, L. H. Chong, L. Jin, P. K. Singh, P. S. Lee, H. Yu, A. Ananthanarayanan, H. L. Leo and Y.-C. Toh , " A Pump-Free Microfluidic 3D Perfusion Platform for the Efficient Differentiation of Human Hepatocyte-Like Cells ," Bioengineering & Biotechnology , (2017) DOI: 10.1002/bit.26341

  4. Y. Choudhury, Y. C Toh, J. Xing, Y. Qu, J. Poh, L. Huan, H. S. Tan, R. Kanesvaran, H. Yu and M-H. Tan , " Patient-Specific Hepatocyte-Like Cells Derived from Induced Pluripotent Stem Cells Model Pazopanib-Mediated Hepatotoxicity ," Scientific Reports , 7 (2017) 41238

  5. J. K. C. Chuah and D. Zink , " Stem Cell-Derived Kidney Cells and Organoids: Recent Breakthroughs and Emerging Applications ," Biotechnology Advances , (2017) DOI: 10.1016/j.biotechadv.2016.12.001

  6. M. F. Leong, H. F. Lu, T. C. Lim, C. Du, N. K. L. Ma and A. C. A. Wan , " Electrospun Polystyrene Scaffolds as a Synthetic Substrate for Xeno-Free Expansion and Differentiation of Human Induced Pluripotent Stem Cells ," Acta Biomaterialia , (2016) DOI: 10.1016/j.actbio.2016.09.032

  7. W. Y. Seow, G. Salgado, E. B. Lane and C. A. E. Hauser , " Transparent Crosslinked Ultrashort Peptide Hydrogel Dressing with High Shape-Fidelity Accelerates Healing of Full-Thickness Excision Wounds ," Scientific Reports , 6 (2016) 32670

  8. C. Du, K. Narayanan, M. F. Leong, M. S. Ibrahim, Y. P. Chua, V. M. H. Khoo and A. C. A. Wan , " Functional Kidney Bioengineering with Pluripotent Stem-Cell-Derived Renal Progenitor Cells and Decellularized Kidney Scaffolds ," Advanced Healthcare Materials , (2016) DOI: 10.1002/adhm.201600120

  9. G.Y. Chew, J.H.J. Tan, A.W. Bahta, B.S.-Y. Ho, X. Liu, T.C. Lim, Y.Y. Sia, P.L. Bigliardi, S. Heilmann, A.C.A. Wan, M.M. Nöthen, M.P. Philpott and Hillmer , " Differential Expression Between Human Dermal Papilla Cells from Balding and Nonbalding Scalps Reveals New Candidate Genes for Androgenetic Alopecia ," Journal of Investigative Dermatology , (2016) DOI: 10.1016/j.jid.2016.03.032

  10. A. C. A. Wan , " Recapitulating Cell–Cell Interactions for Organoid Construction – Are Biomaterials Dispensable? ," Trends in Biotechnology , (2016) DOI: 10.1016/j.tibtech.2016.02.015

  11. A. C. A. Wan, M. F. A. Cutiongco, B. C.U. Tai, M. F. Leong, H. F. Lu and E. K. F. Yim , " Fibers by Interfacial Polyelectrolyte Complexation – Processes, Materials and Applications ," Materials Today , (2016) DOI: 10.1016/j.mattod.2016.01.017

  12. S. Dorfmueller, H. C. Tan, Z. X. Ngoh, K. Y. Toh, G. Peh, H. P. Ang, X. Y. Seah, A. Chin, A. Choo, J. S. Mehta and W. Sun , " Isolation of a Recombinant Antibody Specific for a Surface Marker of the Corneal Endothelium by Phage Display ," Scientific Reports , (2016) DOI: 10.1038/srep21661

  13. Q. Li, Y. Zhang, P. Pluchon, J. Robens, K. Herr, M. Mercade, J-P. Thiery, H. Yu and V. Viasnoff , " Extracellular Matrix Scaffolding Guides Lumen Elongation by Inducing Anisotropic Intercellular Mechanical Tension ," Nature Cell Biology , (2016) DOI: 10.1038/ncb3310

  14. K. Narayanan, N. Erathodiyil, B. Gopalan, S. Chong, A. C. A. Wan and J. Y. Ying , " Targeting Warburg Effect in Cancers with PEGylated Glucose ," Advanced Healthcare Materials , (2016) DOI: 10.1002/adhm.201500613

  15. R. Su, S. Xiong, D. Zink and L.H. Loo , " High-Throughput Imaging-Based Nephrotoxicity Prediction for Xenobiotics with Diverse Chemical Structures ," Archives of Toxicology , (2015) DOI: 10.1007/s00204-015-1638-y

  16. N. K. L. Ma, J. K. Lim, M. F. Leong, E. Sandanaraj, B. T. Ang, C. Tang and A. C. A. Wan , " Collaboration of 3D Context and Extracellular Matrix in the Development of Glioma Stemness in a 3D Model ," Biomaterials , 78 (2016) 62–73

  17. Y. Loo, M. Goktas, A. B. Tekinay, M. O. Guler, C. A. E. Hauser and A. Mitraki , " Self-Assembled Proteins and Peptides as Scaffolds for Tissue Regeneration ," Advanced Healthcare Materials , 4[16] (2015) 2557-2567

  18. L. Qiu, H. Yu and F. Liang , " Multiple C2 Domains Transmembrane Protein 1 is Expressed in CNS Neurons and Possibly Regulates Cellular Vesicle Retrieval and Oxidative Stress ," Journal of Neurochemistry , (2015) DOI: 10.1111/jnc.13251

  19. F. Tasnim, D. Phan, Y. C. Toh and H. Yu , " Cost-Effective Differentiation of Hepatocyte-Like Cells from Human Pluripotent Stem Cells Using Small Molecules ," Biomaterials , 70 (2015) 115-125

  20. K. Kandasamy, J. K. C. Chuah, R. Su, P. Huang, K. G. Eng, S. Xiong, Y. Li, C. S. Chia, L.-H. Loo and D. Zink , " Prediction of Drug-Induced Nephrotoxicity and Injury Mechanisms with Human Induced Pluripotent Stem Cell-Derived Cells and Machine Learning Methods ," Scientific Reports , (2015) DOI: 10.1038/srep12337

  21. L. Xia, X. Hong, R. B. Sakban, Y. Qu, N. H. Singh, M. McMillian, S. Dallas, J. Silva, S. Zhao, H. K. Lim and H. Yu , " Cytochrome P450 Induction Response in Tethered Spheroids as a Three-Dimensional Human Hepatocyte In Vitro Model ," Journal of Applied Toxicology , (2015) DOI: 10.1002/jat.3189

  22. S. Xu, C. H. Kang, X. Gou, Q. Peng, J. Yan, S. Zhuo, C. L. Cheng, Y. He, Y. Kang, W. Xia, P. T. C. So, R. Welsch, J. C. Rajakse and H. Yu , " Quantification of Liver Fibrosis via Second Harmonic Imaging of the Glisson's Capsule from Liver Surface ," Journal of Biophotonics , (2015) DOI: 10.1002/jbio.201500001

  23. J. Xing, Y. C. Toh, S. Xu and H. Yu , " A Method for Human Teratogen Detection by Geometrically Confined Cell Differentiation and Migration ," Scientific Reports , (2015) DOI: 10.1038/srep10038

  24. Y. C. Toh, J. Xing and H. Yu , " Modulation of Integrin and E-Cadherin-Mediated Adhesions to Spatially Control Heterogeneity in Human Pluripotent Stem Cell Differentiation ," Biomaterials , 50 (2015) 87-97

  25. K. S. Chian, M. F. Leong and K. Kono , " Regenerative Medicine for Oesophageal Reconstruction after Cancer Treatment ," The Lancet Oncology , 16[2] (2015) e84–92

  26. C. Ren, S. Gao, M. Kurisawa and J. Y. Ying , " Cartilage Synthesis in Hyaluronic Acid-Tyramine Constructs ," Journal of Materials Chemistry B , 3 (2015) 1942-1956

  27. Z. Wang, X. Luo, C. Anene-Nzelu, Y. Yu, X. Hong, N. H. Singh, L. Xia, S. Liu and H. Yu , " HepaRG Culture in Tethered Spheroids as an In Vitro Three-Dimensional Model for Drug Safety Screening ," Journal of Applied Toxicology , (2014) DOI: 10.1002/jat.3090

  28. R. Su, Y. Li, D. Zink and L.-H. Loo , " Supervised Prediction of Drug-Induced Nephrotoxicity Based on Interleukin-6 and -8 Expression Levels ," BMC Bioinformatics , 15 (2014) S16

  29. A. Mehta, V. Verma, M. Nandihalli, C. J. A. Ramachandra, G. L. Sequiera, Y. Sudibyo, Y. Chung, W. Sun and W. Shim , " A Systemic Evaluation of Cardiac Differentiation from mRNA Reprogrammed Human Induced Pluripotent Stem Cells ," PLoS ONE , 9 (2014) e114771

  30. J. Yan, Y. Kang, S. Xu, S. L. L. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. So, I. R. Wanless and H. Yu , " In Vivo Label-Free Quantification of Liver Microcirculation Using Dual Modality Microscopy ," Journal of Biomedical Optics , 19 (2014) 11606

  31. N. Mittal and I. J. Domian , " Persistent Integration of Reprogramming Factors Impairs the In Vitro Cardiogenic Potential of Induced Pluripotent Stem Cells ," Circulation Cardiovascular Genetics , 7 (2014) 571-572

  32. B. Gopalan, K. Narayanan, Z. Ke, T. Lu, Y. Zhang and L. Zhuo , " Therapeutic Effect of a Multi-Targeted Imidazolium Compound in Hepatocellular Carcinoma ," Biomaterials , 35[26] (2014) 7479-7487

  33. J. W. Cha, V. R. Singh, K. H. Kim, J. Subramanian, Q. Peng, H. Yu, E. Nedivi, and P. T. C. So , " Reassignment of Scattered Emission Photons in Multifocal Multiphoton Microscopy ," Scientific Reports , 4 (2014) 5153

  34. M. Reithofer, A. Lakshmanan, A. T. K. Ping, J. M. Chin, C. A. E. Hauser , " In Situ Synthesis of Size-Controlled, Stable Silver Nanoparticles Within Ultrashort Peptide Hydrogels and their Anti-Bacterial Properties ," Biomaterials , 35[26] (2014) 7535-7542

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  40. A. Bartles, J. Muck, R. S. Dias, A. M. Carnerup, D. Zink and T. Nylander , " DNA Compaction Induced by a Cationic Polymer or Surfactant Impact Gene Expression and DNA Degradation ," PLOS ONE , 9[3] (2014) e92692

  41. Y. Loo, Y. Wong, E. Z. Cai, C. Ang, A. Raju, A. Lakshmanan, A. G. Koh, H. J. Zhou, T. Lim, S. M. Moochhala and C. A.E. Hauser , " Ultrashort Peptide Nanofibrous Hydrogels for the Acceleration of Healing of Burn Wounds ," Biomaterials , 35[17] (2014) 4805-4814

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  43. H. Y. Tiong, P. Huang, S. Xiong, Y. Li, A. Vathsala and D. Zink , " Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models ," Molecular Pharmaceutics , (2014) DOI: 10.1021/mp400720w

  44. Y. Li, K. Kandasamy, J. K. C. Chuah, Y. N. Lam, W. S. Toh, Z. Y. Oo and D. Zink , " Identification of Nephrotoxic Compounds with Embryonic Stem Cell-Derived Human Renal Proximal Tubular-Like Cells ," Molecular Pharmaceutics , (2014) DOI: 10.1021/mp400637s

  45. J. S. Kochhar, P. Anbalagan, S. B. Shelar, J. K. Neo, C. Iliescu and L. Kang , " Direct Microneedle Array Fabrication of a Photomask to Deliver Collagen Through Skin ," Pharmaceutical Research , (2014) DOI: 10.1007/s11095-013-1275-1

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  56. D. H. Zheng, G. V. Limmon, L. Yin, N. H. N. Leung, H. Yu, V. T. K. Chow and J. Z. Chen , " A Cellular Pathway Involved in Clara Cell to Alveolar Type II Cell Differentiation after Severe Lung Injury ," PLoS One , 8 (2013) e71028

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  58. K. Narayanan, S. K. Yen, Q. Dou, P. Padmanabhan, T. Sudhaharan, S. Ahmed, J. Y. Ying and S. T. Selvan , " Mimicking Cellular Transport Mechanism in Stem Cells Through Endosomal Escape of New Peptide-Coated Quantum Dots ," Scientific Reports , 3 (2013) 2184

  59. L. P. Saldutti, B. K. Beyer, W. Breslin, T. R. Brown, R. R. Chapin, S. Campion, B. Enright, E. Faustman, P. M. D. Foster, T. Hartung, W. Kelce, J. H. Kim, E. G. Loboa, A. H. Piersma, D. Seyler, K. J. Turner, H. Yu, X. Yu and J. C. Sasaki , " In Vitro Testicular Toxicity Models: Opportunities for Advancement via Biomedical Engineering Techniques ," ALTEX Alternatives to Animal Experimentation , 30[3] (2013) 353-377

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  61. A. Lim, M. F. Leong, H. Lu, D. Chan, S. Gao, A. Wan and J. Y. Ying , " Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers ," Biomaterials , (2013) DOI: 10.1016/j.biomaterials.2013.05.068

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  65. M. Khan, K. Narayanan, H. Lu, Y. Choo, C. Du, N. Wiradharma, Y. Y. Yang and A. C. A. Wan , " Delivery of Reprogramming Factors into Fibroblasts for Generation of Non-Genetic Induced Pluripotent Stem Cells Using a Cationic Bolaamphiphile as a Non-Viral Vector ," Biomaterials , 34[21] (2013) 5336-5343

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  76. H. F. Lu, S.-X. Lim, M. F. Leong, K. Narayanan, R. P.K. Toh, S. Gao and A. C. A. Wan , " Efficient Neuronal Differentiation and Maturation of Human Pluripotent Stem Cells Encapsulated in 3D Microfibrous Scaffolds ," Biomaterials , (2012) DOI: 10.1016/j.biomaterials.2012.09.006

  77. L. Xia, T. Arooz, S. Zhang, X. Tuo, G. Xiao, T. A. K. Susanto, J. Sundararajan, T. Cheng, Y. Kang, H. J. Poh, H. L. Leo and H. Yu , " Hepatocyte Function Within a Stacked Double Sandwich Culture Plate Cylindrical Bioreactor for Bioartificial Liver System ," Biomaterials , 33[32] (2012) 7925-7932

  78. J. S. Muck, K. Kandasamy, A. Englmann, M. Günther and D. Zink , " Perinuclear Positioning of the Inactive Human Cystic Fibrosis Gene Depends on CTCF, A-Type Lamins and an Active Histone Deacetylase ," Journal of Cellular Biochemistry , 113[8] (2012) 2607-2621

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  81. F. Tasnim and D. Zink , " Cross Talk Between Primary Human Renal Tubular Cells and Endothelial Cells in Cocultures ," American Journal of Physiology - Renal Physiology , 302[8] (2012) F1055-F1062

  82. A. Lakshmanan, S. Zhang and C. A. E. Hauser , " Short Self-Assembling Peptides as Building Blocks for Modern Nanodevices ," Trends in Biotechnology , 30[3] (2011) 155-165

  83. H. F. Lu, K. Narayanan, S-X Lim, S. Gao, M. F. Leong and A. C. A. Wan , " A 3D Microfibrous Scaffold for Long-Term Human Pluripotent Stem Cell Self-Renewal Under Chemically Defined Conditions ," Biomaterials , 33[8] (2012) 2419-2430

  84. E. C. Wu, S. Zhang and C. A. E. Hauser , " Self-Assembling Peptides as Cell-Interactive Scaffolds ," Advanced Functional Materials , 22[3] (2012) 456-468

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  86. A. C. A. Wan, M. F. Leong, J. K. C. Toh, Y. Zheng and J. Y. Ying , " Multicomponent Fibers by Multi-Interfacial Polyelectrolyte Complexation ," Advanced Healthcare Materials , 1[1] (2011) 101-105

  87. D. Choudhury, D. v. Noort, C. Iliescu, B. Zheng, K-L. Poon, S. Korzh, V. Korzh and H. Yu , " Fish and Chips: A Microfluidic Perfusion Platform For Monitoring Zebrafish Development ," Lab on a Chip , 12[5] (2011) 892-900

  88. T. M. Hsieh, A. C. A. Wan and J. Y. Ying , " Applications of Fabricated Micro- and Nanostructures in Biomedicine ," MRS Bulletin , 36[12] (2011) 990-997

  89. J Lin, F. Lu, W. Zheng, S. Xu, D. Tai, H. Yu and Z. Huang , " Assessment of Liver Steatosis and Fibrosis in Rats Using Integrated Coherent Anti-Stokes Raman Scattering and Multiphoton Imaging Technique ," Journal of Biomedical Optics , 16[11] (2011) 116024

  90. R. Magalhães, B. Nugraha, S. Pervaiz, H. Yu and L. L. Kuleshova , " Influence of Cell Culture Configuration on the Post-Cryopreservation Viability of Primary Rat Hepatocytes ," Biomaterials , 33[3] (2011) 829-836

  91. B. Zheng, L. Tan, X. Mo, W. Yu, Y. Wang, L.Tucker-Kellogg, R. E. Welsch, P. T. C. So and H. Yu , " Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis ," PLoS ONE , 6[11] (2011) e26230

  92. Y. C. Toh, K. Blagovic, H. Yu and J. Voldman , " Spatially Organized In Vitro Models Instruct Asymmetric Stem Cell Differentiation ," Integrative Biology , 3[12] (2011) 1179-1187

  93. F. Tasnim, K. Kandasamy, J. S. Muck, M. S. bin Ibrahim, J. Y. Ying and D. Zink , " Effects of BMPs on Primary Human Renal Cells and the Generation of BMP-7-Expressing Cells for Applications in Bioartificial Kidneys ," Tissue Engineering Part A , 18[3-4] (2011) 262-276

  94. F. Zhuang, K. Oglecka and C. A. E. Hauser , " Self-Assembling Peptide Surfactants A6K and A6D Adopt α-Helical Structures Useful for Membrane Protein Stabilization ," Membranes , 1[4] (2011) 314-326

  95. M. Ni, P. K. Zimmermann, K. Kandasamy, W. Lai, Y. Li, M. F. Leong, A. C. A. Wan and D. Zink , " The Use of a Library of Industrial Materials to Determine the Nature of Substrate-Dependent Performance of Primary Adherent Human Cells ," Biomaterials , 33[2] (2012) 353-364

  96. Y. Loo, S. Zhang and C. A. E. Hauser , " From Short Peptides to Nanofibers to Macromolecular Assemblies in Biomedicine ," Biotechnology Advances , 30[3] (2011) 593-603

  97. L. Venkatraman, H. Li, C. F. Dewey, J. K. White, S. S. Bhowmick, H. Yu and L. Tucker-Kellogg , " Steady States and Dynamics of Urokinase-Mediated Plasmin Activation In Silico and In Vitro ," Biophysical Journal , 101[8] (2011) 1825-1834

  98. A. Lakshmanan and C. A. E. Hauser , " Ultrasmall Peptides Self-Assemble into Diverse Nanostructures: Morphological Evaluation and Potential Implications ," International Journal of Molecular Sciences , 12[9] (2011) 5736-5746

  99. Y. O. Zay, R. Deng, M. Hu, M. Ni, K. Kandasamy, M. S. bin Ibrahim, J. Y. Ying and D. Zink , " The Performance of Primary Human Renal Cells in Hollow Fiber Bioreactors for Bioartificial Kidneys ," Biomaterials , 32[34] (2011) 8806-8815

  100. S. L. J. Ng, K. Narayanan, S. Gao and A. C. A. Wan , " Lineage Restricted Progenitors for the Repopulation of Decellularized Heart ," Biomaterials , 32[30] (2011) 7571-7580

  101. E. Tamariz, A. C. A. Wan, Y. S. Pek, M. Giordano, G. Hernández-Padrón, A. Varela-Echavarría, I. Velasco and V. M. Castaño , " Delivery of Chemotropic Proteins and Improvement of Dopaminergic Neuron Outgrowth Through a Thixotropic Hybrid Nano-Gel ," Journal of Materials Science: Materials in Medicine , 22[9] (2011) 2097-2109

  102. B. Nugraha, X. Hong, X. Mo, L. Tan, W. Zhang, P-M. Chan, C. H. Kang, Y. Wang, L. T. Beng, W. Sun, D. Choudhury, J. M. Robens, M. McMillian, J. Silva, S. Dallas, C-H. Tan, Z. Yue and H. Yu , " Galactosylated Cellulosic Sponge for Multi-Well Drug Safety Testing ," Biomaterials , 32[29] (2011) 6982-6994

  103. Y. S. Pek and A. C. A. Wan , " Characterization of Early Extracellular Matrix Secretions in a Three-Dimensional Thixotropic Cell Culture System ," Acta Biomaterialia , 7[11] (2011) 3981-3987

  104. D. Choudhury, X. Mo, C. Iliescu, L. L. Tan, W. H. Tong and H. Yu , " Exploitation of Physical and Chemical Constraints for Three-Dimensional Microtissue Construction in Microfluidics ," Biomicrofluidics , 5 (2011) 22203

  105. G. Maubach, M. C. C. Lim, J. Chen, H. Yang and L. Zhuo , " miRNA Studies in In Vitro and In Vivo Activated Hepatic Stellate Cells ," World Journal of Gastroenterology , 17[22] (2011) 2748-2773

  106. A. Mishra, Y. Loo, R. Deng, Y. J. Chuah, H. T. Hee, J. Y. Ying and C. A. E Hauser , " Ultrasmall Natural Peptides Self-Assemble to Strong Temperature-Resistant Helical Fibers in Scaffolds Suitable for Tissue Engineering ," Nano Today , 6 (2011) 232-239

  107. Y. Li, Y. Zheng, K. Zhang, J. Y. Ying and D. Zink , " Effects of Quantum Dots on Different Renal Proximal Tubule Cell Models and on Gel-Free Renal Tubules Generated In Vitro ," Nanotoxicology , 6[2] (2011) 121-133

  108. J. ZHou, C. Bi, W.-J. Chng, L.-L. Cheong, S.-C. Liu, S. Mahara, K.-G. Tay, Q. Zeng, J. Li, K. Guo, C. P. B. Tan, H. Yu, D. H. Albert and C.-S. Chen , " PRL-3, A Metastasis Associated Tyrosine Phosphatase, is Involved in FLT3-ITD Signaling and Implicated in Anti-AML Therapy ," PLoS ONE , 6 (2011) e19798

  109. B. Jakob, J, Splinter, S. Conrad, K.-O. Voss, D. Zink, M. Durante, M. Loebrich and G. Taucher-Scholz , " DNA Double-Strand Breaks in Heterochromatin Elicit Fast Repair Protein Recruitment, Histone H2AX Phosphorylation and Relocation to Euchromatin ," Nucleic Acids Research , 39 (2011) 6489-6499

  110. K. Subramaniam, K. Kandasamy, K. Joseph, E. K. Spicer and B. G. Tholanikunnel , " 3\'-Untranslated Region Length and AU-Rich RNA Location Modulate RNA-Protein Interaction and Translational Control of β2-Adrenergic Receptor mRNA ," Molecular and Cellular Biochemistry , 352[1-2] (2011) 125-141(17)

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  112. B. Gopalan, Z. Ke, C. Zhang, Y. Kng, N. A. Suhaimi, S. N. Riduan, Y. Zhang and L. Zhuo , " Metal-Free Imidazolium Salts Inhibit the Growth of Hepatocellular Carcinoma in a Mouse Model ," Laboratory Investigation , 91 (2011) 744-751

  113. S. Kumar and L. Zhuo , " Quantitative Analysis of Pupillary Light Reflex by Real-Time Autofluorescent Imaging in a Diabetic Mouse Model ," Experimental Eye Research , 92[3] (2011) 4-172

  114. D. Berchtold, S. Fesser, G. Bachmann, A. Kaiser, J. C. Eilert, F. Frohns, N. Sadoni, J. Muck, E. Kremmer, D. Eick, P. G. Layer and D. Zink , " Nuclei of Chicken Neurons in Tissues and Three-Dimensional Cell Cultures are Organized into Distinct Radial Zones ," Chromosome Research , 19[2] (2011) 165-182

  115. C. Anene-Nzelu, Y. Wang, H. Yu and H. L. Leo , " Liver Tissue Model for Drug Toxicity Screening ," Journal of Mechanics in Medicine and Biology , 11[2] (2011) 369-390

  116. M. Ni, J. C .M. Teo, M. S. bin Ibrahim, K. Zhang, F. Tasnim, P.-Y. Chow, D. Zink and J. Y. Ying , " Characterization of Membrane Materials and Membrane Coatings for Bioreactor Units of Bioartificial Kidneys ," Biomaterials , 32[6] (2010) 1465-1476

  117. C. A. E. Hauser, R. Deng, A. Mishra, Y. Loo, U. Khoe, F. Zhuang, D. W. Cheong, A. Accardo, M. B. Sullivan, C. Riekel, J. Y. Ying and U. A. Hauser , " Natural tri- to hexapeptides self-assemble in water to amyloid β-type fiber aggregates by unexpected α-helical intermediate structures ," Proceedings of the National Academy of Sciences , 108[4] (2011) 1361-1366

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  120. J. H. Song, K. Kandasamy, M. Zemskova, Y-W. Lin and A. S. Kraft , " The BH3 Mimetic ABT-737 Induces Cancer Cell Senescence ," Cancer Research , 71[2] (2010) 506-515

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  122. S. Zhang, W. H. Tong, B. Zheng, T. A. K. Susanto, L. Xia, C. Zhang, A. Ananthanarayanan, X. Tuo, R. B. Sakban, R. R. Jia, C. Iliescu, K. H. Chai, M. McMillian, S. Shen, H. L. Leo and H. Yu , " A Robust High-Throughput Sandwich Cell-Based Drug Screening Platform ," Biomaterials , 32[4] (2010) 1229-1241

  123. A. M. Raja, S. Xu, W. Sun, J. Zhou, D. C. S. Tai, C. S. Chen, J. C. Rajapakse, P. T. C. So and H. Yu , " Pulse-Modulated Second Harmonic Imaging Microscope Imaging Quantitatively Demostrates Marked Increase of Collagen in Tumor After Chemotherapy ," Journal of Biomedical Optics , 15[5] (2010) 056016

  124. C. Hauser and S. Zhang , " Designer Self-Assembling Peptide Materials for Diverse Applications ," Macromolecular Symposia , 295[1] (2010) 30-48

  125. Y. Wei, J. Yang, A. W. H. Lin and J. Y. Ying , " A Highly Reactive Se Precursor for the Phosphine-Free Synthesis of Metal Selenide Nanocrystals ," Chemistry of Materials , 22[20] (2010) 5672-5677

  126. Y. He, C. H. Kang, S. Xu, X. Tuo, S. L. Trasti, D. C. S. Tai, A. M. Raja, Q. Peng, P. T. C. So, J. C. Rajapakse, R. Welsch and H. Yu , " Towards Surface Quantification of Liver Fibrosis Progression ," Journal of Biomedical Optics , 15[5] (2010) 056007

  127. Z. Yue, F. Wen, S. Gao, M. Y. Ang, P. K. Pallathadka, L. Liu and H. Yu , " Preparation of Three-Dimensional Interconnected Macroporous Cellulosic Hydrogels for Soft Tissue Engineering ," Biomaterials , 31[32] (2010) 8141-8152

  128. F. Tasnim, R. Deng, M. Hu, S. Liour, Y. Li, M. Ni, J. Y. Ying and D. Zink , " Achievements and Challenges in Bioartificial Kidney Development ," Fibrogenesis and Tissue Repair , 3[14] (2010)

  129. T. M. Hsieh, C. W. B. Ng, K. Narayanan, A. C. A. Wan and J. Y. Ying , " Three-Dimensional Microstructured Tissue Scaffolds Fabricated by Two-Photon Laser Scanning Photolithography ," Biomaterials , 31[30] (2010) 7648-7652

  130. S. Kumar and L. Zhuo , " Longitudinal In Vivo Imaging of Retinal Gliosis in a Diabetic Mouse Model ," Experimental Eye Research , 91[4] (2010) 530-536

  131. K. Saravana, S. H. Ong and K. S. W. Tan , " Robust Contour Reconstruction of Red Blood Cells and Parasites in the Automated Identification of the Stages of Malarial Infection ," Machine Vision and Application , 22[3] (2010) 461-469

  132. X. Mo, Q. Li, L. W. Y. Lui, B. Zheng, C. H. Kang, B. Nugraha, Z. Yue, R. R. Jia, H. X. Fu, D. Choudhury, T. Arooz, J. Yan, C. T. Lim, S. Shen, C. H. Tan and H. Yu , " Rapid Construction of Mechanically-Confined Multi-Cellular Structures Using Dendrimeric Intercellular Linker ," Biomaterials , 31[29] (2010) 7455-7467

  133. H. Zhang, S. F.-T. Lau, B. F. Heng, P. Y. Teo, P. K. D. Thilini Alahakoon, M. Ni, F. Tasnim, J. Y. Ying and D. Zink , " Generation of Easily Accessible Human Kidney Tubules on Two-Dimensional Surfaces In Vitro ," Journal of Cellular and Molecular Medicine , 15[6] (2010) 1287-1298

  134. C. A. E. Hauser and S. Zhang , " Designer Self-Assembling Peptide Nanofiber Biological Materials ," Chemical Society Reviews , 39[8] (2010) 2780-2790

  135. X. Zhao, F. Pan, H. Xu, M. Yaseen, H. Shan, C. A. E. Hauser, S. Zhang and J. R. Lu , " Molecular Self-Assembly and Applications of Designer Peptide Amphiphiles ," Chemical Society Reviews , 39[9] (2010) 3480-3498

  136. B. C. U. Tai, A. C. A. Wan and J. Y. Ying , " Modified Polyelectrolyte Complex Fibrous Scaffold as a Matrix for 3D Cell Culture ," Biomaterials , 31[23] (2010) 5927-5935

  137. G. Ho, K. Saravana, Z. Y. Ke, H. N. Chan, N. Mohamed Suhaimi, Y. L. Kng, Y. Zhang and L. Zhuo , " Imidazolium Salt (DBZIM) Reduces Gliosis in Mice Treated with Neurotoxicant 2'-CH3-MPTP ," CNS Neuroscience & Therapeutics , 17[3] (2010) 148-157

  138. Y. Wei, J. Yang and J. Y. Ying , " Reversible Phase Transfer of Quantum Dots and Metal Nanoparticles ," Chemical Communications , 46[18] (2010) 3179-3181

  139. G. Xing, J. Jiang, J. Y. Ying and W. Ji , " Fe3O4-Ag Nanocomposites for Optical Limiting: Broad Temporal Response and Low Threshold ," Optics Express , 18[6] (2010) 6183-6190

  140. A. Rebuffat, C. O. Harding, Z. Ding and B. Thony , " Comparison of Adeno-Associated Virus Pseudotype 1, 2 and 8 Vectors Administered by Intramuscular Injection in the Treatment of Murine Phenylketonuria ," Human Gene Therapy , 21[4] (2010) 463-477

  141. W. Zhang, L. Tucker-Kellogg, B. C. Narmada, L. Venkatraman, S. Chang, L. Ying, N. Tan, J. K. White, R. R. Jia, S. S. Bhowmick, S. Shen, C. F. Dewey, Jr. and H. Yu , " Cell Delivery Therapeutics for Liver Regeneration ," Advanced Drug Delivery Reviews , 62[7-8] (2010) 814-826

  142. S. J. Tan, N. R. Jana, S. Gao, P. K. Patra and J. Y. Ying , " Surface Ligand-Dependent Cellular Interaction, Subcellular Localization and Cytotoxicity of Polymer-Coated Quantum Dots ," Chemistry of Materials , 22[7] (2010) 2239-2247

  143. A. C. A. Wan and J. Y. Ying , " Nanomaterials for In Situ Delivery and Tissue Regeneration ," Advanced Drug Delivery Reviews , 62[7-8] (2010) 731-740

  144. J. Yang and J. Y. Ying , " Diffusion of Gold from the Inner Core to the Surface of Ag2S Nanocrystals ," Journal of the American Chemical Society , 132[7] (2010) 2114-2115

  145. N. R. Jana. N. Erathodiyil, J. Jiang and J. Y. Ying , " Cysteine-Functionalized Polyaspartic Acid: A Polymer for Coating and Bioconjugation of Nanoparticles and Quantum Dots ," Langmuir , 26[9] (2010) 6503-6507

  146. R. Hortsch, E. Lee, N. Erathodiyil, S. Hebbar, S. Steinert, J. Y. Lee, D. S. K. Chua and R. Kraut , " Glycolipid Trafficking in Drosophila Undergoes Pathway Switching in Response to Aberrant Cholesterol Levels ," Molecular Biology of the Cell , 21[5] (2010) 778-790

  147. M. Ni, W.H. Tong, D. Choudhury, C. Iliescu and H. Yu , " Cell Culture on MEMS Platforms: A Review ," International Journal of Molecular Sciences , 10[12] (2009) 5411-5441

  148. L. S. Wang, J. E. Chung, P. Chan and M. Kurisawa , " Injectable Biodegradable Hydrogels with Tunable Mechanical Properties for the Stimulation of Neurogenesic Differentiation of Human Mesenchymal Stem Cells in 3D Culture ," Biomaterials , 31[6] (2009) 1148-1157

  149. S. M. Ong, Z. Zhao, T. Arooz, D. Zhao, S. Zhang, T. Du, M. Wasser, D. van Noort and H. Yu , " Engineering a Scaffold-Free 3D In Vitro Tumor Model for In Vitro Drug Penetration Studies ," Biomaterials , 31[6] (2009) 1180-1190

  150. M. Hu, R. Deng, K. M. Schumacher, M. Kurisawa, H. Ye, K. Purnamawati and J. Y. Ying , " Hydrodynamic Spinning of Hydrogel Fibers ," Biomaterials , 31[5] (2009) 863-869

  151. W. Xiang, Z. Ke, Y. Zhang, G. H. Cheng, I. D. Irwan, K. N. Sulochana, P. Potturi, Z. Wang, H. Yang, J. Wang, L. Zhuo, R. M. Kini and R. Ge , " Isthmin is a Novel Secreted Angiogenesis Inhibitor that Inhibits Tumor Growth in Mice ," Journal of Cellular and Molecular Medicine , 15[2] (2009) 359-374

  152. C. Zhang, D. Zhao, N. A. Abdul Rahim, D. van Noort and H. Yu , " Towards a Human-on-Chip: Culturing Multiple Cell Types on a Chip with Compartmentalized Microenvironments ," Lab on a Chip , 9[22] (2009) 3185-3192

  153. Y. S. Pek, A. C. A. Wan and J. Y. Ying , " The Effect of Matrix Stiffness on Mesenchymal Stem Cell Differentiation in a 3D Thixotropic Gel ," Biomaterials , 31[3] (2009) 385-391

  154. B. C. U. Tai, D. Chan, S. J. Gao, A. C. A. Wan and J. Y. Ying , " The Use of a Polyelectrolyte Fibrous Scaffold to Deliver Differentiated hMSCs to the Liver ," Biomaterials , 31[1] (2009) 48-57

  155. M. C. C. Lim, G. Maubach and L. Zhuo , " TGF-β1 Down-regulates Connexin 43 Expression and Gap Junction Intercellular Communication in Rat Hepatic Stellate Cells ," European Journal of Cell Biology , 88[12] (2009) 719-730

  156. J. Xu, D. Li, Z. Y. Ke, R. M. Liu, G. Maubach and L. Zhuo , " Cathepsin S is Aberrantly Overexpressed in Human Hepatocellular Carcinoma ," Molecular Medicine Reports , 2[5] (2009) 713-718

  157. Y. Wei, N. R. Jana, S. Tan, and J. Y. Ying , " Surface Coating Directed Cellular Delivery of TAT-Functionalized Quantum Dots ," Bioconjugate Chemistry , 20[9] (2009) 1752-1758

  158. C. Y. Zhang, Z. B. Ding, N. Mohamed Suhaimi, Y. L. Kng, Y. Zhang and L. Zhuo , " A Class of Imidazolium Salts is Anti-Oxidative and Anti-Fibrotic in Hepatic Stellate Cells ," Free Radical Research , 43[10] (2009) 899-912

  159. S. Kumar, S. H. Ong, S. Ranganath and F. T. Chew , " Invariant Texture Classification for Biomedical Cell Specimens via Non-Linear Polar Map Filtering ," Computer Vision and Image Understanding , 114[1] (2009) 44-53

  160. L. Xia, S. Ng, R. Han, X. Tuo, H. L. Leo and H. Yu , " Laminar-Flow Immediate-Overlay Hepatocyte Sandwich Perfusion System for Drug Hepatoxicity Testing ," Biomaterials , 30[30] (2009) 5927-5936

  161. D. Tai, N. Tan, S. Y. Xu, C. H. Kang, S. M. Chia, C. L. Cheng, A. Wee, L. W. Chiang, A. M. Raja, G. F. Xiao, J. C. Rajapakse, P. So and H. Yu , " Fibro-C-Index - A Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-Photon Microscopy ," Journal of Biomedical Optics , 14[4] (2009) 044013

  162. J. Muck and D. Zink , " Nuclear Organization and Dynamics of DNA Replication in Eukaryotes ," Frontiers in Bioscience , 14 (2009) 5361-5371

  163. R. Magalhaes, P. R. Anil Kumar, F. Wen, X. Zhao, H. Yu and L. L. Kuleshova , " The Use of Vitrification to Preserve Primary Rat Hepatocyte Monolayer on Collagen-Coated Poly(ethylene-terephthalate) Surfaces for a Hybrid Liver Support System ," Biomaterials , 30[25] (2009) 4136-4142

  164. K. Narayanan, K-J. Leck, S. Gao and A. C.A. Wan , " Three-Dimensional Reconstituted Extracellular Matrix Scaffolds for Tissue Engineering ," Biomaterials , 30[26] (2009) 4309-4317

  165. J. Yang and J. Y. Ying , " Room-Temperature Synthesis of Nanocrystalline Ag2S and Its Nanocomposites with Gold ," Chemical Communications , 1[22] (2009) 3187-3189

  166. C. Zhang, S. M. Chia, S. M. Ong, S. Zhang, Y. C. Toh, D. van Noort and H. Yu , " The Controlled Presentation of TGF-β1 to Hepatocytes in a 3D Microfludic Cell Culture System ," Biomaterials , 30[23-24] (2009) 3847-3853

  167. E. Fedorova and D. Zink , " Nuclear Genome Organization: Common Themes and Individual Patterns ," Current Opinion in Genetics and Development , 19[2] (2009) 166-171

  168. X. Pan, X. Shi, V. Korzh, H. Yu and T. Wohland , " Line Scan Fluorescence Correlation Spectroscopy for 3D Microfluidic Flow Velocity Measurements ," Journal of Biomedical Optics , 14[2] (2009) 024049

  169. H. Zhang, F. Tasnim, J. Y. Ying and D. Zink , " The Impact of Extracellular Matrix Coatings on the Performance of Human Renal Cells Applied in Bioartificial Kidneys ," Biomaterials , 30[15] (2009) 2899-2911

  170. W. E. Maalouf, Z. Liu, V. Brochard, J. P. Renard, P. Debey, N. Beaujean and D. Zink , " Trichostatin A Treatment of Cloned Mouse Embryos Improves Constitutive Heterochromatin Remodeling as Well as Developmental Potential to Term ," BMC Developmental Biology , 9:11 (2009)

  171. D. Van Noort, S. M. Ong, C. Zhang, S. Zhang, T. Arooz and H. Yu , " Stem Cells in Microfluidics ," Biotechnology Progress , 25[1] (2009) 52-60

  172. A. Lim and R. Kraut , " The Drosophila BEACH Family Protein, Blue Cheese, Links Lysosomal Axon Transport with Motorneuron Degeneration ," Journal of Neuroscience , 29[4] (2009) 951-963

  173. G. Ho, S. Kumar, X. S. Min, Y. L. Kng, M. Y. Loh, S. J. Gao, and L. Zhuo , " Molecular Imaging of Retinal Gliosis in Transgenic Mice Induced by Kainic Acid Neurotoxicity ," Investigative Opthalmology and Visual Science , 50[5] (2009) 2459-2464

  174. J. Zhou, C. Bi, J. Janakaumara, S. C. Liu, W. J. Chng, K. G. Tay, L. F. Poon, Z. Xie, P. Senthilnathan, H. Yu, K. B. Glaser, D. Albert, S. Davidsen and C. S. Chen , " Enhanced Activation of STAT Pathways and Overexpression of Survivin Confer Resistance to FLT3 Inhibitors and Could Be Therapeutic Targets in AML ," Blood , 113[17] (2009) 4052-4062

  175. G. Xing, W. Ji, Y. Zheng and J. Y. Ying , " Two- and Three-Photon Absorption of Semiconductor Quantum Dots in the Vicinity of Half of Lowest Excitation Energy ," Applied Physics Letters , 93[24] (2008) 241114-1-241114-3

  176. C. Y. Ang, L. Giam, Z. M. Chan, A. W. H. Lin, H. Gu, E. Devlin, G. C. Papaefthymiou, S. T. Selvan and J. Y. Ying , " Facile Synthesis of Fe2O3 Nanocrystals without Fe(CO)5 Precursor and One-Pot Synthesis of Highly Fluorescent Fe2O3-CdSe Nanocomposites ," Advanced Materials , 21[8] (2009) 869-873

  177. W. X. Sun, S. Chang, D. Tai, N. Tan, G. F. Xiao, H. H. Tang and H. Yu , " Non-Linear Optical Microscopy: Use of Second Harmonic Generation and Two-Photon Microscopy for Automated Quantitative Liver Fibrosis Studies ," Journal of Biomedical Optics , 13[6] (2008) 064010

  178. P. Liu, Y. W. Zhang, H. Yu, X. Zhang, Q. H. Cheng, C. Lu and W. Bonfield , " Spreading of an Anchorage-Dependent Cell on a Selectively Ligand-Coated Substrate Mediated by Receptor-Ligand Binding ," Journal of Biomedical Materials Research Part A , 91A[3] (2009) 806-813

  179. Y. S. Pek, M. Kurisawa, S. Gao, J. E. Chung and J. Y. Ying , " The Development of a Nanocrystalline Apatite Reinforced Crosslinked Hyaluronic Acid-Tyramine Composite as an Injectable Bone Cement ," Biomaterials , 30[5] (2009) 822-828

  180. S. Kumar, Y.Wang, V. Viswanathan and R. Kraut , " Multivariate Profiling of Neurodegeneration-Associated Changes in a Subcellular Compartment of Neurons via Image Processing ," BioData Mining , 1[10] (2008) 1-10

  181. J. Jiang, H. W. Gu, H. Shao, E. Devlin, G. C. Papaefthymiou and J. Y. Ying , " Bifunctional Fe3O4-Ag Heterodimer Nanoparticles for Two- Photon Fluorescence Imaging and Magnetic Manipulations ," Advanced Materials , 20[23] (2008) 4403-4407

  182. Y. S. Pek, A. C. A. Wan, A. Shekaran, L. Zhuo and J. Y. Ying , " Thixotropic Gels for Three Dimensional Cell Culture ," Nature Nanotechnology , 3 (2008) 671-675

  183. Y. Zheng, Z. Yang, Y. Li and J. Y. Ying , " From Glutathione Capping to Crosslinked, Phytochelatin-Like Coating of Quantum Dots ," Advanced Materials , 20[18] (2008) 3410-3415

  184. Y. S. Pek, S. Gao, M. S. Mohamed Arshad, K. J. Leck and J. Y. Ying , " Porous Collagen-Apatite Nanocomposite Foams as Bone Regeneration Scaffolds ," Biomaterials , 29[32] (2008) 4300-4305

  185. S. Steinert , E. Lee, G. Tresset, R. Wetzel, D. Zhang, S. Hebbar, R. Hortsch, J. R. Sundram, S. Kesavapany, E. Boschke and R. Kraut , " A Fluorescent Glycolipid-Binding Peptide Probe Traces Cholesterol Dependent Microdomain-Derived Trafficking Pathways ," PLoS-1 , 3[8] (2008) e2933

  186. E. Federova and D. Zink , " Nuclear Architecture and Gene Regulation ," Biochimica et Biophysica Acta - Molecular Cell Research , 1783[11] (2008) 2174-2184

  187. G. Maubach, M. C. C. Lim and L. Zhuo , " Nuclear Cathepsin F Regulates Activation Markers in Rat Hepatic Stellate Cells ," Molecular and Biology of the Cell , 19[10] (2008) 4238-4248

  188. G. Ho, S. Kumar, C. Y. Zhang, Y. L. Kng and L. Zhuo , " Molecular Imaging Reveals a Correlation Between 2\'-CH3-MPTP-Induced Neonatal Neurotoxicity and Dopaminergic Neurodegeneration in Adult Transgenic Mice ," International Journal of Developmental Neuroscience , 26[7] (2008) 673-681

  189. S. F. Zhang, X. Lei, S. M. Ong, Y. C. Toh, H. L. Leo, D. van Noort and H. Yu , " Microfabricated Silicon Nitride Membranes for Hepatocyte Sandwich Culture ," Biomaterials , 29[29] (2008) 3993-4002

  190. Z. Ding, G. Maubach, A. Masamune and L. Zhuo , " Glial Fibrillary Acidic Protein Promoter Targets Pancreatic Stellate Cells ," Digestive and Liver Disease , 41[3] (2009) 229-236

  191. D. Zhao, S. M. Ong, Z. Yue, Z. Jiang, Y. C. Toh, M. Khan, J. Shi, C. H. Tan, J. P. Chen and H. Yu , " Dendrimer Hydrazides as Multivalent Transient Inter-Cellular Linkers ," Biomaterials , 29[27] (2008) 3693-3702

  192. E. Federova, N. Sadoni, I. K. Dahlsveen, J. Koch, E. Kremmer, D. Eick, R. Paro and D. Zink , " The Nuclear Organization of Polycomb/Trithorax Group Response Elements in Larval Tissues of Drosophila Melanogaster ," Chromosome Research , 16[4] (2008) 649-673

  193. S. Kumar, G. Ho, K. M. Woo and L. Zhuo , " Achieving Cellular Resolution for In Vivo Retinal Images of Transgenic GFAP-GFP Mice via Image Processing ," Optics Express , 16[11] (2008) 8250-8262

  194. R. F. Luco, M. A. Maestro, N. Sadoni, D. Zink and J. Ferrer , " Targeted Deficiency of the Transcriptional Activator HNF1a Alters Subnuclear Positioning of Its Genomic Targets ," PLoS Genetics , 4[5] (2008) e1000079

  195. C. Earhart, N. R. Jana, N. Erathodiyil and J. Y. Ying , " Synthesis of Carbohydrate-Conjugated Nanoparticles and Quantum Dots ," Langmuir , 24[12] (2008) 6215-6219

  196. Y. Han, J. Jiang, S. S. Lee and J. Y. Ying , " Reverse Microemulsion Mediated Synthesis of Silica-Coated Gold and Silver Nanoparticles ," Langmuir , 24[11] (2008) 5842-5848

  197. S. M. Ong, C. Zhang, Y. C. Toh, S. H. Kim, H. L. Foo, C. H. Tan, D. van Noort, S. Park and H. Yu , " A Gel-Free 3D Microfluidic Cell Culture System ," Biomaterials , 29[22] (2008) 3237–3244

  198. N. Erathodiyil, N. R. Jana and J. Y. Ying , " Functionalization of Gold Nanospheres and Nanorods by Chitosan Oligosaccharide Derivatives ," Advanced Materials , 20[11] (2008) 2068-2073

  199. F.Wen, S. Chang, Y. C. Toh, T. Arooz, L. Zhuo, S. H. Teoh and H. Yu , " Development of Dual-Compartment Perfusion Bioreactor for Serial Co-Culture of Hepatocytes and Stellate Cells in Poly (Lactic-Co Glycolic Acid)-Collagen Scaffolds ," Journal of Biomedical Materials Research: Part B Applied Biomaterials , 87B[1] (2008) 154-162

  200. G. Xing, W. Ji, Y. G. Zheng and J. Y. Ying , " High Efficiency and Nearly Cubic Power Dependence of Below-Band-Edge Photoluminescence in Water-Soluble, Copper-Doped ZnSe/ZnS Quantum Dots ," Optics Express , 16[8] (2008) 5710-5715

  201. N. Sadoni, B.-S. Targosz, A. Englmann, S. Fesser, J. Koch, D. Schindelhauer and D. Zink , " Transcription-Dependent Spatial Arrangements of CFTR and Conserved Adjacent Loci are Not Conserved in Human and Murine Nuclei ," Chromosoma , 117[4] (2008) 381-397

  202. J. Corsi, M. K. Dymond, O. Ces, J. Muck, D. Zink and G. S. Attard , " DNA that is Dispersed in the Liquid Crystalline Phases of Phospholipids is Actively Transcribed ," Chemical Communications , (2008) DOI: 10.1039/B801199K

  203. M. C. C. Lim, G. Maubach and L. Zhuo , " Glial Fibrillary Acidic Protein Splice Variants in Hepatic Stellate Cells - Expression and Regulation ," Molecules and Cells , 25[3] (2008) 376-384

  204. H. L. Leo, A. W. L. Lim, X. Lei, D. M. Y. Ang, Z. Yue and H. Yu , " Development of a Perfusion-based Cellulosic Scaffold for In Vitro Drug Testing ," Proceedings of the 3rd MRS-S Conference on Advanced Materials , (2008) DOI: -

  205. A. C. A. Wan, B. C. U. Tai, K. M. Schumacher, A. Schumacher, S. Y. Chin and J. Y. Ying , " Polyelectrolyte Complex Membranes for Specific Cell Adhesion ," Langmuir , 24[6] (2008) 2611-2617

  206. Y. C. Toh, J. Zhang, Y. M. Khong, Y. Du, W. Sun and H. Yu , " Integrating Sensitive Quantification of Hepatic Metabolic Functions by Capillary Electrophoresis with Laser-Induced Fluorescence Detection ," The Analyst , 133[3] (2008) 326-330

  207. D.-K. Chang, S.-F. Cheng, E. A. B. Kantchev, Y.-T. Liu and C.-H. Lin , " Membrane Interaction and Structure of the Transmembrane Domain of Influenza Hemagglutinin and its Fusion Peptide Complex ," BMC Biology , 6[2] (2008)

  208. L. Xia, Y. Du, H. L. Leo and H. Yu , " The Relationship between Hepatocyte Density and Polarity in Synthetic Sandwich Culture ," Proceedings of the International Conference on Advances in Bioresorbable Biomaterials for Tissue Engineering , (2008) DOI: -

  209. J. Zhou, J. Khng, J. V. Janakakumara, C. Bi, S. Neo, M. Pan, L. F. Poon, Z. Xie, H. Yu, E. J. Yeoh, Y. Lu, K. Glaser, D. Albert, S. K. Davidsen and C. S. Chen , " In Vivo Activity of ABT-869, a Multi-Target Kinase Inhibitor, AgainstAcuteMyeloid Leukemia withWild-Type FLT3 Receptor ," Leukemia Research , 32[7] (2008) 1091-1100

  210. C. K. Sim and D. B. Forger , " Modeling the Electrophysiology of Suprachiasmatic Nucleus Neurons ," Journal of Biological Rhythms , 22[5] (2007) 445-453

  211. Y. Du, R. Han, F. Wen, S. Ng, L. Xia, T. Wohland, H. L. Leo and H. Yu , " Synthetic Sandwich Culture of 3D Hepatocyte Monolayer ," Biomaterials , 29[3] (2007) 290-301

  212. S. M. Ong, L. He, N. T. T. Linh, Y. H. Tee, T. Arooz, G. P. Tang, C. H. Tan and H. Yu , " Transient Inter-Cellular Polymeric Linker ," Biomaterials , 28[25] (2007) 3656-3667

  213. Y. Du, R. B. Han, S. Ng, J. Ni, W. X. Sun, T. Wohland, S. H. Ong, L. Kuleshova and H. Yu , " Identification and Characterization of a Novel Pre-Spheroid 3D Hepatocyte Monolayer on Galactosylated Substratum ," Tissue Engineering , 13[7] (2007) 1455-1468

  214. Y. N. Du, R. B. Han and H. Yu , " A Novel Synthetic Sandwich Configuration for Stabilizing and Culturing Pre-Spheroid Hepatocyte Monolayer ," Proceedings of Keystone Symposium on "Tissue Engineering and Developmental Biology" , (2007) DOI: -

  215. F. Wen, Y. M. Khong, Y. N. Du, Z. L. Yue, S. H. Teoh and H. Yu , " Surface Modification of Bulky Tissue Engineering Scaffold through Gamma Irradiation ," Proceedings of Keystone Symposium on "Tissue Engineering and Developmental Biology" , (2007) DOI: -

  216. S. M. Liu, L. Liu, Z. P. Xu, A. Yu, G. Q. Lu and J. C. D. da Costa , " Bioceramic Macrocapsules for Cell Immunoisolation ," Angewandte Chemie International Edition , 46[17] (2007) 3062-3065

  217. S. M. Chia, F. Y. Kuan and H. Yu , " Thrombospondin-1 is a Key TGF-β1 Activator for Hepatic Stellate Cells in Liver Fibrosis ," Proceedings of Keystone Symposium "Molecular Mechanisms in Fibrosis; From Bench to Bedside" , (2007) DOI: -

  218. G. Maubach, M. C. C. Lim, S. Kumar and L. Zhuo , " Expression and Upregulation of Cathepsin S and Other Early Molecules Required for Antigen Presentation in Activated Hepatic Stellate Cells upon IFN-γ Treatment ," Biochimica et Biophysica Acta - Molecular Cell Research , 1773[2] (2006) 219-231

  219. C. Y. Zhang and L. Zhuo , " EGCG and Genistein Attenuate GFAP Elevation Induced by Fibrogenic Cytokines in Hepatic Stellate Cells ," International Journal of Molecular Medicine , 18[6] (2006) 1141-1151

  220. X. T. Pan, Y. C. Toh, H. Yu and T. Wohland , " Characterization of Poly(acrylic acid) Diffusion Dynamics on the Grafted Surface of Poly(ethylene Terephthalate) Films by Fluorescence Correlation Spectroscopy ," Biophysical Review and Letters , 1[4] (2006) 433-441

  221. L. L. Ong, P. C. Lin, X. Zhang, S. M. Chia and H. Yu , " Kinectin-Dependent Assembly of Translation Elongation Factor-1 Complex on Endoplasmic Reticulum Regulates Protein Synthesis ," Journal of Biological Chemistry , 281[44] (2006) 33621-33634

  222. E. K. F. Yim, A. C. A. Wan, C. Le Visage, I. C. Liao and K. W. Leong , " Proliferation and Differentiation of Human Mesenchymal Stem Cell in Polyelectrolyte Complexation Fibrous Scaffold ," Biomaterials , 27[36] (2006) 6111-6122

  223. F. Wen, S. Chang, Y. C. Toh, S. H. Teoh and H. Yu , " Development of poly (lactic-co-glycolicacid)-collagenscaffolds for tissueengineering ," Materials Science and Engineering , 27[2] (2006) 285-292

  224. S. M. Chia, C. M. Tan and H. Yu , " Novel Cell Culture Supplements for Enhanced Hepatocyte Functions ," Proceedings of Regenerate World Congress on Tissue Engineering and Regenerative Medicine Pittsburgh , (2006) DOI: -

  225. A. C. A. Wan, B. C. U. Tai, K.-J. Leck and J. Y. Ying , " Silica-Incorporated Polyelectrolyte Complex Fibers as Tissue Engineering Scaffolds ," Advanced Materials , 18[5] (2006) 641-644

  226. G. Maubach, M. C. C. Lim, C. Y. Zhang and L. Zhuo , " Glial Fibrillary Acidic Protein Promoter Directs lacZ Expression Specifically in a Rat Hepatic Stellate Cell Line ," World Journal of Gastroenterology , 12[5] (2006) 723-730

  227. S. C. Wong, H. Yu and J. B. So , " Detection of Telomerase Activity in Gastric Lavage Fluid: A Novel Method to Detect Gastric Cancer ," Journal of Surgical Research , 131[2] (2006) 252-255

  228. H. F. Lu, W. S. Lim, P. C. Zhang, S. M. Chia, H. Yu, H.-Q. Mao and K. W. Leong , " Galactosylated PVDF Hollow Fiber Bioreactor for Hepatocyte Culture ," Tissue Engineering , 11[11-12] (2006) 1667-1677

  229. M. Lee and R. S. Ruan , " Malignant Transformation of Mammary Epithelial Cells under Prolonged Exposure to Oxidative Stress and Senescent Fibroblasts ," Proceedings of the 2nd International Conference on Tumor Progression and Therapeutic Resistance , (2005) DOI: -

  230. F. Wen, S. Chang, Y. C. Toh, S. H. Teoh and H. Yu , " Preparation of Biocompatible Poly (lactic-co-glycolic acid) Fiber Scaffolds for Rat Liver Cells Cultivation ," Materials Science and Engineering , (2005) DOI: -

  231. I. C. Liao, A. C. A. Wan, E. K. F. Yim and K. W. Leong , " Controlled Release from Fibers of Polyelectrolyte Complexes ," Journal of Controlled Release , 104[2] (2005) 347-358

  232. Y. C. Toh, S. Ng, Y. M. Khong, V. Samper and H. Yu , " A Configurable 3D Microenvironment in a Micro-Fluidic Channel for Primary Hepatocytes Culture Assay and Drug Development ," Technologies , 3[2] (2005) 169-176

  233. B. C. Heng, H. Yu, S. G. Lim, Y. J. Yin, and T. Cao , " Factors Influencing Stem Cell Differentiation into the Hepatic Lineage In Vitro ," Journal of Gastroenterology and Hepatology , 20[7] (2005) 975-987

  234. Y. Zhou, T. Sun, M. Chan, J. Zhang, Z. Han, X. Wang, Y. Toh, J. P. Chen and H. Yu , " Scalable Encapsulation of Hepatocytes by Electrostatic Spraying ," Journal of Biotechnology , 114 (2005) 99-109

  235. C. W. Tan and Y. Y. Yang , " pH-Triggered Thermally Responsive Polymer Core-Shell Nanoparticles for Targeted Drug Delivery ," Advanced Materials , 17[3] (2005) 318-323

  236. Y. C. Toh, S. T. Ho, Y. Zhou, D. W. Hutmacher and H. Yu , " Application of Polyelectrolyte Complex Coacervation to Improve the Seeding Efficiency of Bone Marrow Stromal Cells in 3D Scaffolds ," Biomaterials , 26[19] (2004) 4149-4160

  237. J. Zhang, H. P. Wei, C. H. Quek, S. M. Chia, and H. Yu , " Quantitative Measurement of Collagen Methylation by Capillary Electrophoresis ," Electrophoresis , 25[20] (2004) 3416-3421

  238. S. S. S. Ng, Y. N. Wu, Y. Zhou, Y. E. Toh, Z. Z. Ho, S. M. Chia, J. H. Zhu, H. Q. Mao and H. Yu , " Optimization of 3-D Hepatocyte Culture by Controlling the Physical and Chemical Properties of the Extra-Cellular Matrices ," Biomaterials , 26[16] (2005) 3153-3163

  239. N. Santama, P. N. Er, L. L. Ong, and H. Yu , " Kinectin Isoforms Exhibit Developmental, Cell-type and Organelle Specific Functions ," Journal of Cell Sciences , 117[19] (2004) 4537-4549

  240. L. L. Kuleshova, X. W. Wang, Y. N. Wu, Y. Zhou and H. Yu , " Vitrification of Encapsulated Hepatocytes with Reduced Cooling/Warming Rates ," Cryo Letters , 25[4] (2004) 241-254

  241. J. Wang, I. L. Lee, W. S. Lim, S. M. Chia, H. Yu, K. W. Leong, and H .Q. Mao , " Evaluation of Collagen and Methylated Collagen as Gene Carriers ," International Journal of Pharmaceutics , 279[1-4] (2004) 115-126

  242. T. Sun, L. H. Chan, C. H. Quek and H. Yu , " Improving Mechanical Stability and Density Distribution of Hepatocyte Microcapsules by Fibrin Clot and Gold Nano-particles ," Journal of Biotechnology , 111 (2004) 169-177

  243. A. C. A. Wan, H.-Q. Mao, S. Wang, S. H. Phua, G. P. Lee, J. H. Pan, S. Lu, J. Wang and K. W. Leong , " Poly(phosphoester) Ionomers as Tissue Engineering Scaffolds ," Journal of Biomedical Materials Research , 70B (2004) 91-102

  244. C. H. Quek, J. Li, T. Sun, M. L. H. Chan, H. Q. Mao, L. M. Gan, K. W. Leong and H. Yu , " Photo-Crosslinkable Microcapsules Formed by Polyelectrolyte Copolymer and Modified Collagen with Enhanced Mechanical Strength and Cellular Functions for Rat Hepatocyte Encapsulation ," Biomaterials , 25[17] (2004) 3531-3540

  245. B. C. Heng, H. Yu, and S. C. Ng , " Strategies for the Cryopreservation of Microencapsulated Cells ," Biotechnology and Bioengineering , 85[2] (2003) 202-213

  246. T. Sun, L. H. Chan, Y. Zhou, X. Xu, J. Zhang, C. H. Quek, X. J. Lao, J. P. Chen, K. W. Leong, H. Yu , " The Use of Ultra-Thin Shell Microcapsules of Hepatocytes in a Bio-Artificial Liver-Assisted Device ," Tissue Engineering , 9 Suppl 1 (2003) S65-75

  247. H. F. Lu, W. S. Lim, J. Wang, Z. Q. Tang, P. C. Zhang, K. W. Leong, S. M. Chia, H. Yu, and H.-Q. Mao , " Galactosylated PVDF Membrane Promotes Hepatocyte Attachment and Functional Maintenance ," Biomaterials , 24[27] (2003) 4893-4903

  248. S. C. H. Wong, L. L. Ong, P. N. Er, S. J. Gao, H. Yu, and B. Y. So , " Cloning of Rat Telomerase Catalytic Subunit Functional Domains, Reconstitution of Telomerase Activity and Enzymatic Profile of Pig and Chicken Tissues ," Life Sciences , 73[21] (2003) 2749-2760

  249. C. Iliescu, J. Miao and F. E. H. Tay , " Optimization of PECVD Amorphous Silicon Process for Deep Wet Etching of Pyrex Glass ," Surface Coatings Technology , (2003) DOI: -

  250. L. L. Ong, A. Ho, P. N. Er, H. Yu , " Kinectin Anchors Eukaryotic Elongation Factor, Delta to Endoplasmic Reticulum ," Journal of Biological Chemistry , 278[34] (2003) 32115-32123

  251. S. C. H. Wong, H. Yu, S. M. Moochhala, and B. Y. So , " Antisense Telomerase Induced Cell Growth Inhibition, Cell Cycle Arrest and Telomerase Activity Down-Regulation in Gastric and Colon Cancer Cells ," Anticancer Research , 23[1A] (2003) 465-469

  252. X. Y. Xu, W. C. Yee, P. Y. K. Hwang, H. Yu, A. C. A. Wan, S. J. Gao, K. L. Boon, H. Q. Mao, K. W. Leong, and S. Wang , " Peripheral Nerve Regeneration with Sustained Release of Poly(phosphoester) Microencapsulated Nerve Growth Factor within Nerve Guide Conduits ," Biomaterials , 24[13] (2003) 2405-2412

  253. C. Yin, S. M. Chia, C. H. Quek, H. Yu, R. X. Zhuo, K. W. Leong, H. Q. Mao , " Microcapsules With Improved Mechanical Stability For Hepatocyte Culture ," Biomaterials , 24[10] (2003) 1771-1780

Green and Safe Biomaterials, which encompass the synthesis of materials and pharmaceuticals such as anti-bacterial coatings and nanowires for a wide range of biotechnology and healthcare applications.

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Research > Green and Safe Biomaterials

Eco-Friendly Antimicrobial Materials and Antimicrobial Resistance Mitigation

Yuan Yuan, Diane Lim and Yugen Zhang 

Antimicrobial resistance (AMR) is one of the most critical challenges in our modern society. The overuse of antibiotics, including its use in non-therapeutic applications, such as agriculture and environmental disinfection, represents one of the main causes of antimicrobial resistance. IBN has developed a series of novel non-resistant, eco-friendly antimicrobial oligomers and polymers with broad-spectrum antimicrobial activities against bacteria, yeast and fungi. These have synergistic effect with small molecular antibiotics and prevent drug resistance development. Our novel antimicrobial materials will self-destruct after treatment, leaving no active residue that can lead to secondary environmental contamination. This is especially meaningful in the context of agricultural applications, topical use and environmental disinfection.

Green Synthesis, Care Chemicals and Functional Materials

Xiukai Li, Jinquan Wang, Diane Lim, Siew Ping Teong, Wei Lun Toh and Yugen Zhang 

IBN’s green synthesis research involves the use of sustainable resources for the environmentally friendly synthesis and investigation of green and benign chemical processes for the specialty chemicals industry. IBN researchers are developing green and safe chemicals for consumer care, healthcare and the food and nutrition industries. IBN is also creating functional materials for a broad range of applications including environmental, healthcare and medical applications.

Inorganic Nanomaterials for Antimicrobial Applications

Guangshun Yi, Siti Nurhanna Riduan, Yuan Yuan, Xiukai Li, Siew Ping Teong and Yugen Zhang 

IBN has developed inorganic and non-toxic antimicrobial materials specifically for surface disinfection and consumer care applications. Our antimicrobial technologies kill microbes either by physically rupturing their cell membranes or by a radical killing mechanism, which prevents the microbes from developing drug resistance and mutating into superbugs. Our nanomaterials are inexpensive to produce, environmentally friendly and safe. They are effective against a wide range of microbes and would be a powerful weapon against superbugs.

Phase-Selective Organogelators for Oil Spill Treatment

Changliang Ren and Huaqiang Zeng 

Marine oil spills can cause devastating and lasting damage to the environment and ecosystem, and are difficult to clean up using currently available oil-control techniques. We are developing cost-effective organogelators that can phase-selectively congeal oil from oily water, and allow easy separation of the gelled oil from water. It is made up of small organic molecules that can instantly self-assemble into nanofibers to form a 3D net that traps the oil molecules into clumps that can be skimmed off the water surface. This is a novel solution to clean up polluted water caused by oil spills.

Water Channel-Based Biomimetic Membranes for Water Desalination

Jie Shen, Feng Chen, Changliang Ren, Arundhati Roy and Huaqiang Zeng 

Commercial use of water-transporting aquaporins has been explored for wastewater reclamation and re-use as well as seawater desalination. However, significant challenges associated with manipulating channel proteins in terms of complexity, stability, scalability and activity reconstitution still remain. An alternative strategy is to design small molecule-based synthetic water channels that can mimic aquaporins in functionality for various water purification applications. Towards this goal, we are developing synthetic water channel-based membranes to desalinate seawater with higher salt rejection rates at much lower pressures than the current seawater reverse osmosis technology. These novel biomimetic membranes could form the basis for the next generation of water purification technology with less energy consumption and better performance. In addition, the low production cost of the membranes makes it attractive for other potential applications, such as pharmaceutical separations, artificial skin and kidney.

  1. C. Ren, X. Ding, A. Roy, J. Shen, S. Zhou, F. Chen, S. Fong, Y. Li, H. Ren, Y. Y. Yang and H. Zeng , " A Halogen Bond-Mediated Highly Active Artificial Chloride Channel with High Anticancer Activity ," Chemical Science , (2018) DOI: 10.1039/C8SC00602D

  2. Y. Zhang, R. Cao, J. Shen, C. S. F. Detchou, Y. Zhong, H. Wang, S. Zou, Q. Huang, C. Lian, Q. Wang, J. Zhu and B. Gong , " Hydrogen-Bonded Duplexes with Lengthened Linkers ," Organic Letters, , 20 (2018) 1555-1558

  3. G. Yi, Y. Yuan, X. Li and Y. Zhang , " ZnO Nanopillar Coated Surfaces with Substrate-Dependent Superbactericidal Property ," Small , (2018) DOI: 10.1002/smll.201703159

  4. J. Wang, K. Tee, Y. Lee, S. N. Riduan and Y. Zhang , " Hexaazatriphenylene Derivatives/GO Composites as Organic Cathodes for Lithium Ion Batteries ," Journal of Materials Chemistry A , (2018) DOI: 10.1039/C7TA10232A

  5. Y. Zhang, X. Li and J. Ko , " Highly Efficient Gas Phase Oxidation of Renewable Furfural to Maleic Anhydride over Plate VPO Catalyst ," ChemSusChem , (2017) DOI: 10.1002/cssc.201701866

  6. J. Wang, C. S. Chen and Y. Zhang , " Hexaazatrinaphthylene-Based Porous Organic Polymers as Organic Cathode Materials for Lithium Ion Battery ," ACS Sustainable Chemistry and Engineering , (2017) DOI: 10.1021/acssuschemeng.7b03165

  7. A. A. AbdelHamid, J. H. Soh, Y. Yu and J. Y. Ying , " Graphene Oxide-Templated Synthesis of Ternary Oxide Nanosheets for High Performance Li-ion Battery Anodes ," Nano Energy , 44 (2018) 399-410

  8. J. A. De Toro, M. Vasilakaki, S. S. Lee, M. S. Andersson, P. S. Normile, N. Yaacoub, P. Murray, E. H. Sanchez, P. Muniz, D. Peddis, R. Mathieu, K. Liu, J. Geshev, K. N. Trohidou and J. Nogues , " Remanence Plots as a Probe of Spin Disorder in Magnetic Nanoparticles ," Chemistry of Materials , (2017) DOI: 10.1021/acs.chemmater.7b02522

  9. Changliang Ren, Jie Shen and Huaqiang Zeng , " Combinatorial Evolution of Fast-Conducting Highly Selective K+- Channels via Modularly Tunable Directional Assembly of Crown Ethers ," Journal of the American Chemical Society , (2017) DOI: 10.1021/jacs.7b04335

  10. Y. Zhang, S. N. Riduan and J. Wang , " Redox Active Metal- and Covalent Organic Frameworks for Energy Storage: Balancing Porosity and Electrical Conductivity ," Chemistry: A European Journal , (2017) DOI: 10.1002/chem.201702919

  11. S. P. Teong, J. Lim and Y. Zhang , " Vinylation of Aryl Ether (Lignin β-O-4 Linkage) and Epoxides with Calcium Carbide via C-O Bond Cleavage ," ChemSusChem , 10 (2017) 3198-3120

  12. A. A. AbdelHamid, Y. Yu, J. Yang and J. Y. Ying , " Generalized Synthesis of Metal Oxide Nanosheets and Their Application as Li-Ion Battery Anodes ," Advanced Materials , (2017) DOI: 10.1002/adma.201701427

  13. X. W. Hu, X. Chen, Y. Zhu, H. Q. Zeng, H. F. Jiang and W. Zeng , " Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp2–H/Csp3–Csp3 Activation ," Organic Letters , 19 (2017) 3473-3477

  14. H. Zhao, J. Shen, C. Ren, W. Zeng and H. Zeng , " A Foldamer-Based Organocatalyst for Direct Arylations of Unactivated Arenes ," Organic Letters , 19[8] (2017) 2190-2193

  15. C. Ren, J. Shen, F. Chen and H. Zeng , " Rapid Room-Temperature Gelation of Crude Oils by a Wetted Powder Gelator ," Angewandte Chemie International Edition , (2017) DOI: 10.1002/anie.201611852

  16. S. P. Teong, A. Y. H. Chua, S. Deng, X. Li and Y. Zhang , " Direct Vinylation of Natural Alcohols and Derivatives with Calcium Carbide ," Green Chemistry , (2017) DOI: 10.1039/C6GC03579E

  17. D. Yu, F. Zhou, D. S. W. Lim, H. Su and Y. Zhang , " NHC-Ag/Pd Catalyzed Reductive Carboxylation of Terminal Alkyne with CO2 and H2, A Combined Experimental and Computational Study for Fine-Tuned Selectivity ," ChemSusChem , (2017) DOI: 10.1002/cssc.201601785

  18. J. Shen, C. Ren and H. Zeng , " Surprisingly High Selectivity and High Affinity in Mercury Recognition by H-Bonded Cavity-Containing Aromatic Foldarands ," Journal of the American Chemical Society , (2017) DOI: 10.1021/jacs.6b13342

  19. X. Li, B. Ho, D. S. W. Lim and Y. Zhang , " Highly Efficient Formic Acid-Mediated Oxidation of Renewable Furfural to Maleic Acid with H2O2 ," Green Chemistry , (2017) DOI: 10.1039/C6GC03020C

  20. X. Li and Y. Zhang , " Highly Selective Deoxydehydration of Tartaric Acid over Supported and Unsupported Rhenium Catalysts with Modified Acidities ," Highly Selective Deoxydehydration of Tartaric Acid over , (2016) DOI: 10.1002/cssc.201600865

  21. Y. Zhang, J. Wang and S. N. Riduan , " Strategies Toward Improving the Performance of Organic Electrodes in Rechargeable Lithium (Sodium) Battery ," Journal of Materials Chemistry A , (2016) DOI: 10.1039/C6TA05231B

  22. Jian Liang Cheong, Yaling Shao, Sherman J. R. Tan, Xiukai Li, Yugen Zhang and Su Seong Lee , " Highly Active and Selective Zr/MCF Catalyst for Production of 1,3-Butadiene from Ethanol in a Dual Fixed Bed Reactor System ," ACS Sustainable Chemistry & Engineering , (2016) DOI: 10.1021/acssuschemeng.6b01193

  23. J. Wang and Y. Zhang , " Facile Synthesis of N-Rich Porous Azo-Linked Frameworks for Selective CO2 Capture and Conversion ," Green Chemistry , (2016) DOI: 10.1039/C6GC01114D

  24. J. Wang and Y. Zhang , " Boronic Acids as Hydrogen Bond Donor Catalysts for Efficient Conversion of CO2 into Organic Carbonate in Water ," ACS Catalysis , 6 (2016) 4871-4876

  25. Ayman A. AbdelHamid, Xianfeng Yang, Jinhua Yang, Xiaojun Chen and Jackie Y. Ying , " Graphene-Wrapped Nickel Sulfide Nanoprisms with Improved Performance for Li-Ion Battery Anodes and Supercapacitors ," Nano Energy , 26 (2016) 425-437

  26. Y. Huo, H. Zeng and Y. Zhang , " Integrating Metabolic Engineering and Heterogeneous Chemocatalysis: New Opportunities for Biomass to Chemicals ," ChemSusChem , 9[10] (2016) 1078-1080

  27. C. Ren, G. H. B. Ng, H. Wu, K. H. Chan, J. Shen, C. Teh, J. Y. Ying and H. Zeng , " Instant Room-Temperature Gelation of Crude Oil by Chiral Organogelators ," Chemistry of Materials , (2016) DOI: 10.1021/acs.chemmater.6b0136

  28. S. P. Teong, D. Yu, Y. N. Sum and Y. Zhang , " Copper Catalysed Alkynylation of Tertiary Amines with CaC2 via sp3 C–H Activation ," Green Chemistry , (2016) DOI: 10.1039/C6GC00872K

  29. X. Li, B. Ho and Y. Zhang , " Selective Aerobic Oxidation of Furfural to Maleic Anhydride with Heterogeneous Mo-V-O Catalysts ," Green Chemistry , 18 (2016) 2976-2980

  30. X. Li and Y. Zhang , " Oxidative Dehydration of Glycerol to Acrylic Acid over Vanadium Substituted Cesium Salts of Keggin-type Heteropolyacids ," ACS Catalysis , (2016) DOI: 10.1021/acscatal.6b00213

  31. X. Cao and Y. Zhang , " Palladium Catalyzed Direct Benzylation/Allylation of Malonates with Alcohols -- in-situ C-O Bond Activation ," Green Chemistry , (2016) DOI: 10.1039/C6GC00163G

  32. S. N. Riduan, Y. Yuan, F. Zhou, J. Leong, H. Su and Y. Zhang , " Ultrafast Killing and Self-Gelling Antimicrobial Imidazolium Oligomers ," Small , (2016) DOI: 10.1002/smll.201600006

  33. J. Wang, L. Gao, Y. M. Lee, K. A. Kalesh, Y. S. Ong, J. Lim, J. E. Jee, H. Sun, S. S. Lee, Z. C. Hua and Q. Lin , " Target Identification of Natural and Traditional Medicines with Quantitative Chemical Proteomics Approaches ," Pharmacology & Therapeutics , (2016) DOI: 10.1016/j.pharmthera.2016.01.010

  34. D. S. W. Lim, T. T. S. Lew, and Y. Zhang , " Direct Amidation of N-Boc- and N-Cbz-Protected Amines via Rhodium-Catalyzed Coupling of Arylboroxines and Carbamates ," Organic Letters , 17[24] (2015) 6054-6057

  35. X. Li and Y. Zhang , " Highly Efficient Process for the Conversion of Glycerol to Acrylic Acid via Gas Phase Catalytic Oxidation of an Allyl Alcohol Intermediate ," ACS Catalysis , 6[1] (2016) 143–150

  36. S. N. Riduan, J. Y. Ying, Y. Zhang , " Solid Poly-N-Heterocyclic Carbene Catalyzed CO2 Reduction with Hydrosilanes ," Journal of Catalysis , (2015) DOI: 10.1016/j.jcat.2015.09.009

  37. G. Yi, S. P. Teong, Y. Zhang , " Base-Free Conversion of 5-hydroxymethylfurfural to 2,5-furandicarboxylic Acid Over a Ru/C Catalyst ," Green Chemistry , (2015) DOI: 10.1039/C5GC01584G

  38. R. Peltier, G. Chen, H, Lei, M. Zhang, L. Gao, S.S. Lee, Z. Wang and H. Sun , " Rational Design of Peptide-based Hydrogel Responsive to H2S ," Chemical Communications , (2015) DOI: 10.1039/C5CC06889D

  39. W. Ma, C. Wang, J. Li, K. Zhang, Y.-J. Lu, Y. Huo and H. Zeng , " The Dynamics, Energetics and Selectivity of Water Chain-Containing Aquapores Created by the Self-Assembly of Aquafoldamer Molecules ," Organic and Biomolecular Chemistry , (2015) DOI: 10.1039/c5ob01732g

  40. Y. Liu, J. Shen, C. Sun, C. Ren and H. Zeng , " Intramolecularly H-Bonded Aromatic Pentamers as Modularly Tunable Macrocyclic Receptors for Selective Recognition of Metal Ions ," Journal of the American Chemical Society , 137[37] (2015) 12055-12063

  41. X. Li and Y. Zhang , " The Conversion of 5-Hydroxymethyl furfural (HMF) to Maleic Anhydride with Vanadium-based Heterogeneous Catalysts ," Green Chemistry , (2015) DOI: 10.1039/C5GC01794G

  42. X. Li and Y. Zhang , " The Conversion of 5-Hydroxymethylfurfural (HMF) to Maleic Anhydride with Vanadium-Based Heterogeneous Catalysts ," Green Chemistry , (2015) DOI: 10.1039/C5GC01794G

  43. X. Li, B. Li, L. Chen, J. Hu, C. Wen, Q. Zheng, L. Wu, H. Zeng, B. Gong and L. Yuan , " Liquid-Crystalline Mesogens Based on Cyclo[6]aramides: Distinctive Phase Transitions in Response to Macrocyclic Host-Guest Interactions ," Angewandte Chemie International Edition , 54 (2015) 11147-11152

  44. X. Li, B. Li, L. Chen, J. Hu, C. Wen, Q. Zheng, L. Wu, H. Zeng, B. Gong and L. Yuan , " Liquid-Crystalline Mesogens Based on Cyclo[6]aramides: Distinctive Phase Transitions in Response to Macrocyclic Host–Guest Interactions ," Angewandte Chemie International Edition , (2015) DOI: 10.1002/anie.201505278

  45. T. T. Salim Lew, D. S. W. Lim and Y. Zhang , " Copper(I)-Catalyzed Amidation Reaction of Organoboronic Esters and Isocyanates ," Green Chemistry , (2015) DOI: 10.1039/c5gc01374g

  46. J. Wang, J. G. W. Yang, G. Yi and Y. Zhang , " Phosphonium Salt Incorporated Hypercrosslinked Porous Polymer for CO2 Capture and Conversion ," Chemical Communications , (2015) DOI: 10.1039/C5CC06295K

  47. M. H. Wong, Z. Zhang, X. Yang, X. Chen and J. Y. Ying , " One-Pot In Situ Redox Synthesis of Hexacyanoferrate/Conductive Polymer Hybrids as Lithium-Ion Battery Cathodes ," Chemical Communications , 51 (2015) 13674-13677

  48. Y. Zhang and D. S. W. Lim , " Synergistic Carbon Dioxide Capture and Conversion in Porous Materials ," ChemSusChem , 8[16] (2015) 2606-2608

  49. J. Wang, G. Yi, W. Sng Sng and Y. Zhang , " Imidazolium Salts-Modified Porous Hypercrosslinked Polymers for A Synergistic CO2 Capture and Conversion ," Chemical Communications , (2015) DOI: 10.1039/C5CC04702A

  50. S. P. Teong, G. Yi, H. Zeng and Y. Zhang , " The Effects of Emulsion on Sugar Dehydration to 5-Hydroxymethylfurfural in a Biphasic System ," Green Chemistry , (2015) DOI: 10.1039/C5GC00580A

  51. L. L. Chng, J. Yang and J. Y. Ying , " Efficient Synthesis of Amides and Esters from Alcohols under Aerobic Ambient Conditions Catalyzed by a Au/Mesoporous Al2O3 Nanocatalyst ," ChemSusChem , 8[11] (2015) 1916-1925

  52. J. Yang, X. F. Yang, Y. L. Zhong and J. Y. Ying , " Porous MnO/Mn3O4 Nanocomposites for Electrochemical Energy Storage ," Nano Energy , 13 (2015) 702-708

  53. Y. Zhang and J. Y. Ying , " Main-Chain Organic Frameworks with Advanced Catalytic Functionalities ," ACS Catalysis , 5 (2015) 2681-2691

  54. Guangshun Yi,* Siew Ping Teong, and Yugen Zhang* , " The Direct Conversion of Sugars into 2,5-Furandicarboxylic Acid in a Triphasic System ," ChemSusChem , (2015) DOI: 10.1002/cssc.201500118

  55. X. Cao, S. P. Teong, D. Wu, G. Yi, H. Su and Y. Zhang , " Enzyme Mimic Ammonium Polymer as a Single Catalyst for Glucose Dehydration to 5-Hydroxymethylfurfural ," Green Chemistry , (2015) DOI: 10.1039/C4GC02488E

  56. J. L. Cheong, J. Lim, J. K. C. Toh, J. E. Jee, L. L. Wong, S. Venkataraman, S. S. Lee and S-G. Lee , " Effects of Incorporation of Azido Moieties into the Hydrophobic Core of Coiled Coil Peptides ," Chemical Communications , (2015) DOI: 10.1039/c4cc09089f

  57. X. F. Yang, J.-H. Yang, K. Zaghrib, M. L. Trudeau and J. Y. Ying , " Synthesis of Phase-Pure Li2MnSiO4@C Porous Nanoboxes for High-Capacity Li-Ion Battery Cathodes ," Nano Energy , 12 (2015) 305-313

  58. L. Chen, S. Cai, J. Lim, S. S. Lee and S.-G. Lee , " Elucidating pH-Dependent Collagen Triple Helix Formation through Interstrand Hydroxyproline-Glutamic Acid Interactions ," ChemBioChem Communications , 16[3] (2015) 407-410

  59. J. L. Cheong, D. Wong, S. G. Lee, J. Lim and S. S. Lee , " Role of Grafted Alkoxybenzylidene Ligand in Silica-Supported Hoveyda–Grubbs-Type Catalysts ," Chemical Communications , 51 (2014) 1042-1045

  60. J. E. Jee, J. Lim, H. Hyun, J. Oon, Y. S. Ong, C. Massif, Y.T. Chang, H. S. Choi and S. S. Lee , " Investigating Fluorescent Dyes in Fluorescenceassisted Screenings ," Chemical Communications , 50 (2014) 15220-15223

  61. J. Liu, C. Sun, W. Ma, Y. J. Lu, L. Yu, K. Zhang and H. Zeng , " A Conformationally Switchable Fluorescent Oligophenol Foldamer for Selective Sensing of Copper(II) Ions ," RSC Advances , 4 (2014) 54469

  62. H. Zhao, S. Sheng, Y. Hong and H. Zeng , " Proton Gradient-Induced Water Transport Mediated by Water Wires inside Narrow Aquapores of Aquafoldamer Molecules ," Journal of the American Chemical Society , (2014) DOI: 10.1021/ja5077537

  63. D. Yu, S. P. Teong and Y. Zhang , " Transition Metal Complex Catalyzed Carboxylation Reactions with Carbon Dioxide ," Coordination Chemistry Reviews , (2014) DOI: 10.1016/j.ccr.2014.09.002

  64. Y. He, M. Xu, R. Gao, X. Li, F. Li, X. Wu, D. Xu, H. Zeng and L. Yuan , " Two-Component Supramolecular Gels Derived from Amphiphilic Shape-Persistent Cyclo[6]aramides for Specific Recognition of Native Arginine ," Angewandte Chemie International Edition , (2014) DOI: 10.1002/anie.201407092

  65. J. Shen, W. Ma, L. Yu, J. B. Li, H. C. Tao, K. Zhang and H. Zeng , " Size-Dependent Patterned Recognition and Extraction of Metal Ions by a Macrocyclic Aromatic Pyridone Pentamer ," Chemical Communications , (2014) DOI: 10.1039/c4cc05197a

  66. J. Wang, J. Leong and Y. Zhang , " Efficient Fixation of Carbon Dioxide into Cyclic Carbonates Catalysed by Silicon-Based Main Chain Poly-Imidazolium Salts ," Green Chemistry , 16 (2014) 4515-4519

  67. L. Gu, T. Lu, X. Li and Y. Zhang , " A Highly Efficient Thiazolylidene Catalyzed Acetoin Formation: Reaction, Tolerance and Catalyst Recycling ," Chemical Communications , 50 (2014) 12308-12310

  68. T. Lu, X. Li, L. Gu and Y. Zhang , " Vitamin B1-Catalyzed Acetoin Formation from Acetaldehyde: A Key Step for Upgrading Bioethanol to Bulk C4 Chemicals ," ChemSusChem , 7[9] (2014) 2423-2426

  69. L. L. Chng, J. Yang, Y. Wei and J. Y. Ying , " Palladium Nanomaterials in Catalytic Intramolecular C–H Amination Reactions ," Chemical Communications , (2014) DOI: 10.1039/c4cc03551h

  70. J.-E. Jee, Y. L. Ang, J. Cha, M. W. Ang, J. Ling, J. Lim and S. S. Lee , " Combinatorial Bead-Based Peptide Libraries Improved for Rapid and Robust Screenings ," Combinatorial Chemistry & High Throughput Screening , 17 (2014) 520-530

  71. S. Ping Teong, G. Yi, X. Cao and Y. Zhang , " Poly-benzylic Ammonium Chloride Resins as Solid Catalysts for Fructose Dehydration ," ChemSusChem , (2014) DOI: 10.1002/cssc.201402131

  72. G. Yi, S. P. Teong, X. Li and Y. Zhang , " Purification of Biomass-Derived 5-Hydroxymethylfurfural and Its Catalytic Conversion to 2,5-Furandicarboxylic Acid ," ChemSusChem , (2014) DOI: 0.1002/cssc.201402105

  73. D. Ling, L. Gao, J. Wang, M. Shokouhimehr, J. Liu, Y. Yu, M.J. Hackett, P.-K. So, B. Zheng, Z. Yao, J. Xia and T. Hyeon , " A General Strategy for Site-Directed Enzyme Immobilization by Using NiO Nanoparticle Decorated Mesoporous Silica ," Chemistry – A European Journal , 20 (2014) 7916-7921

  74. L. Gu, J. Lim, J. L. Cheong and S. S. Lee , " MCF-Supported Boronic Acids as Efficient Catalysts for Direct Amide Condensation of Carboxylic Acids and Amines ," Chemical Communications , 50 (2014) 7017-7019

  75. J. Hu, L. Chen, J. Shen, J. Luo, P. Deng, Y. Ren, H. Zeng, W. Feng and L. Yuan , " Convergent Heteroditopic Cyclo[6]aramides as Mmacrocyclic Ion-Pair Receptors for Constructing [2]Pseudorotaxanes ," Chemical Communications , (2014) DOI: 10.1039/C4CC02557A

  76. X. Yang, J. Yang, Y. L. Zhong, V. Gariepy, M. L. Trudeau, K. Zaghib and J. Y. Ying , " Hollow Melon-Seed-Shaped Lithium Iron Phosphate Micro-and Sub-Micrometer Plates for Lithium-Ion Batteries ," ChemSusChem , (2014) DOI: 10.1002/cssc.201400152

  77. X. Li, D. Wu, T. Lu, G. Yi, H. Su and Y. Zhang , " Highly Efficient Chemical Process To Convert Mucic Acid into Adipic Acid and DFT Studies of the Mechanism of the Rhenium-Catalyzed Deoxydehydration ," Angewandte Chemie International Edition , 53[16] (2014) 4200-4204

  78. H. Fu, H. Chang, J. Shen, L. Yu, B. Qin, K. Zhang and H. Zeng , " An Unusual Macrocyclization Reagent for Highly Selective One-Pot Synthesis of Strained Macrocyclic Aromatic Hexamers ," Chemical Communications , (2014) DOI: 10.1039/C3CC48576E

  79. S. P. Teong, G. Yi and Y. Zhang , " Hydroxymethylfurfural Production from Bioresources: Past, Present and Future ," Green Chemistry , (2014) DOI: 10.1039/C3GC42018C

  80. J. Yang, L. L. Chng, X. Yang, X. Chen and J. Y. Ying , " Multiply-Twinned Intermetallic AuCu Pentagonal Nanorods ," Chemical Communications , 50[9] (2013) 1141-1143

  81. M. X. Tan, Y. N. Sum, J. Y. Ying and Y. Zhang , " A Mesoporous Poly-Melamine-Formaldehyde Polymer as a Solid Sorbent for Toxic Metal Removal ," Energy & Environmental Science , 6[11] (2013) 3254-3259

  82. S. N. Riduan and Y. Zhang , " Imidazolium Salts and Their Polymeric Materials for Biological Applications ," Chemical Society Reviews , 42[23] (2013) 9055-9070

  83. Y. N. Sum, D. Yu and Y. Zhang , " Synthesis of Acetylenic Alcohols with Calcium Carbide as the Acetylene Source ," Green Chemistry , 15[10] (2013) 2718-2721

  84. Y. C. Teo, S. N. Riduan and Y. Zhang , " Iodine-Mediated Arylation of Benzoxazoles with Aldehydes ," Green Chemistry , 15[9] (2013) 2365-2368

  85. M. X. Tan, Y. Zhang and J. Y. Ying , " Mesoporous Poly(Melamine-Formaldehyde) Solid Sorbent for Carbon Dioxide Capture ," ChemSusChem , 6[7] (2013) 1186-1190

  86. M. Reithofer, Y. N. Sum and Y. Zhang , " Synthesis of Cyclic Carbonates with Carbon Dioxide and Cesium Carbonate ," Green Chemistry , (2013) DOI: 10.1039/C3GC40790J

  87. J. A. De Toro, S. S. Lee, D. Salazar, J. L. Cheong, P. S. Normile, P. Muñiz, J. M. Riveiro, M. Hillenkamp, F. Tournus, A. Tamion and P. Nordblad , " A Nanoparticle Replica of the Spin-Glass State ," Applied Physics Letter , 102[18] (2013) 183104

  88. J. A. De Toro, P. S. Normile, S. S. Lee, D. Salazar, J. L. Cheong, P. Muñiz, J. M. Riveiro, M. Hillenkamp, F. Tournus, A. Tamion and P. Nordblad , " Controlled Close-Packing of Ferrimagnetic Nanoparticles: An Assessment of the Role of Interparticle Superexchange Versus Dipolar Interactions ," Journal of Physical Chemistry C , 117 (2013) 10213-10219

  89. D. Yu, Y. N. Sum, A. C. E. Chng, M. P. Chin, and Y. Zhang , " Acetylide Ion as a Synthon to Link Electrophiles and Nucleophiles: A Simple Method for Enaminone Synthesis ," Angewandte Chemie International Edition , 52[19] (2013) 5125-5128

  90. L. Gu, T. Lu, M. Zhang, L. Tou and Y. Zhang , " Efficient Oxidative Chlorination of Aromatics on Saturated Sodium Chloride Solution ," Advanced Synthesis & Catalysis , 355[6] (2013) 1077-1082

  91. M. X. Tan, L. Gu, N. Li, J. Y. Ying and Y. Zhang , " Mesoporous Poly-Melamine-Formaldehyde (mPMF) – A Highly Efficient Catalyst for Chemoselective Acetalization of Aldehydes ," Green Chemistry , (2013) DOI: 10.1039/C3GC40297E

  92. Y. Wang, N. L. Ibrahim, J. Jiang, S. Gao, N. Erathodiyil, and J. Y. Ying , " Construction of Block Copolymers for the Coordinated Delivery of Doxorubicin and Magnetite Nanocubes ," Journal of Controlled Release , 169[3] (2013) 211-219

  93. S. N. Riduan, J. Y. Ying, and Y. Zhang , " Mechanistic Insights into the Reduction of Carbon Dioxide with Silanes over N-Heterocyclic Carbene Catalysts ," ChemCatChem , (2013) DOI: 10.1002/cctc.201200721

  94. Benjamin W. J. Chen, L. L. Chng, J. Yang, Y. Wei, J. Yang, and J. Y. Ying , " Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines ," ChemCatChem , (2012) DOI: 10.1002/cctc.201200496

  95. J. Y. Ying , " Cells Made of Silica ," Nature Nanotechnology , 7 (2013) 777-778

  96. L. Liu, H. Wu S. N. Riduan, J. Y. Ying and Y. Zhang , " Short Imidazolium Chains Effectively Clear Fungal Biofilm in Keratitis Treatment ," Biomaterials , (2012) DOI: 10.1016/j.biomaterials.2012.10.050

  97. J. Zhang, B. P. Ting and J. Y. Ying , " Theoretical Assessment of Binding and Mass-Transport Effects in Electrochemical Affinity Biosensors That Utilize Nanoparticle Labels for Signal Amplification ," Chemistry - A European Journal , (2012) DOI: 10.1002/chem.201201384

  98. F. Anariba, L. L. Chng, N. S. Abdullah and F. E. H. Tay , " Syntheses, Optical Properties, and Bioapplications of the Aggregation-Induced Emission of 2,3,4,5-Tetraphenylcyclopenta-2,4-Dienyl Benzene Derivatives ," Journal of Materials Chemistry , 22 (2012) 19303-19310

  99. J. Yang , X. Chen , X. Yang and J. Y. Ying , " Stabilization and Compressive Strain Effect of AuCu Core on Pt Shell for Oxygen Reduction Reaction ," Energy & Environmental Science , (2012) DOI: 10.1039/C2EE22172A

  100. G. Yi and Y. Zhang , " One-Pot Selective Conversion of Hemicellulose (Xylan) to Xylitol under Mild Conditions ," ChemSusChem , (2012) DOI: 10.1002/cssc.201200290

  101. H. Deng, W. Shen, Y. Peng, X. Chen, G. Yi, and Z. Gao , " Nanoparticulate Peroxidase/Catalase Mimetic and Its Application ," in Chemistry – A European Journal , 18[29] (2012) 8906- 8911

  102. D. Yu, S. Lee, Y. N. Sum and Y. Zhang , " Selective Formation of Formamidines or 7-Aminomethylbenzoxazoles from Unprecedented Couplings between Benzoxazoles and Amines ," Advanced Synthesis & Catalysis , 354[9] (2012) 1672-1678

  103. S. S. Lee, S. N. Riduan, N. Erathodiyil, J. Lim, J. L. Cheong, J. Cha, Y. Han, and J. Y. Ying , " Magnetic Nanoparticles Entrapped in Siliceous Mesocellular Foam: A New Catalyst Support ," Chemistry - A European Journal , 18[24] (2012) 7394-7403

  104. D. Yu, M. X. Tan, and Y. Zhang , " Carboxylation of Terminal Alkynes with Carbon Dioxide Catalyzed by Poly(N-Heterocyclic Carbene)-Supported Silver Nanoparticles ," Advanced Synthesis & Catalysis , 354[6] (2012) 969-974

  105. S. N. Riduan, J. Y. Ying, and Y. Zhang , " Carbon Dioxide Mediated Stereoselective Copper-Catalyzed Reductive Coupling of Alkynes and Thiols ," Organic Letters , 14[7] (2012) 1780-1783

  106. L. Bao, W.-L. Low, J. Jiang, and J. Y. Ying , " Colloidal Synthesis of Magnetic Nanorods with Tunable Aspect Ratios ," Journal of Materials Chemistry , 22[15] (2012) 7117-7120

  107. Z. Lin, D. Yu, Y. N. Sum, and Y. Zhang , " Synthesis of Functional Acetylene Derivatives from Calcium Carbide ," ChemSusChem , 5[4] (2012) 625-628

  108. J. Y. Ying , " Metamaterials: Turning a Negative into a Positive ," Nature Chemistry , 4[3] (2012) 159-160

  109. Q. Kang, and Y. Zhang , " Copper-Catalyzed Highly Efficient Aerobic Oxidative Synthesis of Imines From Alcohols and Amines ," Green Chemistry , 14[4] (2012) 1016-1019

  110. J. Cha, J. Lim, Y. Zheng, S. Tan, Y. L. Ang, J. Oon, M. W. Ang, J. Ling, M. Bode and S. S. Lee , " Process Automation Toward Ultra-High-Throughput Screening of Combinatorial One-Bead-One-Compound (OBOC) Peptide Libraries ," Journal of Laboratory Automation , 17[3] (2012) 186-200

  111. J. Garcia-Martinez, M. Johnson, J. Valla, K. Li and J. Y. Ying , " Mesostructured Zeolite Y – High Hydrothermal Stability and Superior FCC Catalytic Performance ," Catalysis, Science & Technology , 2 (2012) 987-994

  112. Y. Zhang and S. N. Riduan , " Functional Porous Organic Polymers for Heterogeneous Catalysis ," Chemical Society Reviews , 41[6] (2011) 2083-2094

  113. L. L. Chng, J. Zhang, J. Yang, M. Amoura and J. Y. Ying , " C-C Bond Formation via C-H Activation and C-N Bond Formation via Oxidative Amination Catalyzed by Palladium-Polyoxometalate Nanomaterials Using Dioxygen as the Terminal Oxidant ," Advanced Synthesis and Catalysis , 353 (2011) 2988-2998

  114. L. Lai and Y. Zhang , " The Production of 5-Hydroxymethyl-furfural from Fructose in iso-Propanol, A Green and Efficient System ," ChemSusChem , 4 (2011) 1745-1748

  115. J. Zhang, B. P. Ting, Y. T. Koh and J. Y. Ying , " Synthesis of Metallic Nanoparticles Using Electrogenerated Reduced Forms of [α-SiW12O40]4- as Both Reductants and Stabilizing Agents ," Chemistry of Materials , 23 (2011) 4688-4693

  116. S. W. Millward, R. K. Henning, G. A. Kwong, S. Pitram, H. D. Agnew, K. M. Deyle, A. Nag, J. Hein, S. S. Lee, J. Lim, J. A. Pfeilsticker, K. B. Sharpless and J. R. Heath , " Iterative In Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 ," Journal of the American Chemical Society , 133[45] (2011) 18280-18288

  117. N. Erathodiyil, H. Gu, H. Shao, J. Jiang and J. Y. Ying , " Enantioselective Hydrogenation of α-Ketoesters Over Alkaloid-Modified Platinum Nanowires ," Green Chemistry , 13 (2011) 3070-3074

  118. Z. Lin, D. Yu and Y. Zhang , " Propargylic Amines Constructed via Copper-Catalyzed Three Component-Coupling of Terminal Alkyne, Benzal Halide and Amine ," Tetrahedron Letters , 52[38] (2011) 4967-4970

  119. Q. Kang and Y. Zhang , " N-Heterocyclic Carbene-Catalyzed Aza-Michael Addition ," Organic and Biomolecular Chemistry , 9[19] (2011) 6715-6720

  120. Y. Zhang and S. N. Riduan , " Catalytic Hydrocarboxylation of Alkenes and Alkynes with CO2 ," Angewandte Chemie International Edition , 50 (2011) 6210-6212

  121. N. Erathodiyil and J. Y. Ying , " Functionalization of Inorganic Nanoparticles for Bioimaging Applications ," Accounts of Chemical Research , 44 (2011) 925-935

  122. Y. Zhang, M. X. Tan, H. Li, Y. Zheng, H. Zhang and J. Y. Ying , " Mesoscopic Organic Nanosheets Peeled from Stacked 2D Covalent Frameworks ," Chemical Communications , 47 (2011) 7365-7367

  123. A. W. H. Lin, C. Y. Ang, P. K. Patra, Y. Han, H. Gu, J.-M. Le Breton, J. Juraszek, H. Chiron, G. C. Papaefthymiou, S. T. Selvan and J. Y. Ying , " Seed-Mediated Synthesis, Properties and Application of λ-Fe2O3-CdSe Magnetic Quantum Dots ," Journal of Solid State Chemistry , 184[8] (2011) 2150-2158

  124. J. Yang, X. Chen, F. Ye, C. Wang, Y. Zheng and J. Yang , " Core-Shell CdSe@Pt Nanocomposites with Superior Electrocatalytic Activity Enhanced by Lateral Strain Effect ," Journal of Materials Chemistry , 21 (2011) 9088-9094

  125. Y. Zhang, L. Chen and T. Lu , " A Copper(II) Triflate-Catalyzed Tandem Friedel-Crafts Alkylation/Cyclization Process Towards Dihydroindenes ," Advanced Synthesis and Catalysis , 353 (2011) 1055-1060

  126. Y. Li, Y. Lu, H. Hong, Y. Chen, X. Ma, L. Guo, Z. Wang, J. Chen, M. Zhu, J. Ni, H. Gu, J. Lu and J. Y. Ying , " Synthesis of Pt@Fe2O3 Nanorods as MRI Probes for In Vivo Application ," Chemical Communications , 47 (2011) 6320-6322

  127. J. Yang and J. Y. Ying , " Nanocomposites of Ag2S and Noble Metals ," Angewandte Chemie International Edition , 50 (2011) 4637-4643

  128. J. Mao, X. Cao, J. Zhen, H. Shao, H. Gu, J. Lu and J. Y. Ying , " Facile Synthesis of Hybrid Nanostructures from Nanoparticles, Nanorods and Nanowires ," Journal of Materials Chemistry , 21 (2011) 11478-11481

  129. D. Y. Yu and Y. Zhang , " The Direct Carboxylation of Terminal Alkynes with Carbon Dioxide ," Green Chemistry , 13[5] (2011) 1275-1279

  130. L. Gu, B. S. Neo and Y. Zhang , " Gold-Catalyzed Direct Amination of Arenes with Azodicarboxylates ," Organic Letters , 13[7] (2011) 1872-1887

  131. D. Y. Yu and Y. Zhang , " Copper-Catalyzed Three-Component Coupling of Terminal Alkyne, Dihalomethane and Amine to Propargylic Amines ," Advanced Synthesis and Catalysis , 353[1] (2011) 163-169

  132. Y. Han, P. Pitukmanorom, L. Zhao and J. Y. Ying , " Generalized Synthesis of Mesoporous Shells on Zeolite Crystals ," Small , 7[3] (2010) 326-332

  133. M. X. Tan, L. Zhao and Y. Zhang , " Production of 5-Hydroxymethyl Furfural from Cellulose in CrCl2/Zeolite/BMIMCl System ," Biomass & Bioenergy , 35[3] (2010) 1367-1370

  134. J. Yang, J. Y. Lee and J. Y. Ying , " Phase Transfer and Its Applications in Nanotechnology ," Chemical Society Reviews , 40[3] (2010) 1672-1696

  135. D. Yu and Y. Zhang , " Copper- and Copper–N-Heterocyclic Carbene-Catalyzed C–H Activating Carboxylation of Terminal Alkynes with CO2 at Ambient Conditions ," Proceedings of the National Academy of Sciences , 107[47] (2010) 20184-20189

  136. L. Lai and Y. Zhang , " The Effect of Imidazolium Ionic Liquid for the Dehydration of Fructose to 5-Hydroxymethylfurfural and a Room Temperature Catalytic System ," ChemSusChem , 3[11] (2010) 1257-1259

  137. Y. Han, S. S. Lee and J. Y. Ying , " Siliceous Mesocellular Foam for High-Performance Liquid Chromatography: Effect of Morphology and Pore Structure ," Journal of Chromatography A , 1217[26] (2010) 4337-4343

  138. G. R. Peh, E. A. B. Kantchev, J. C. Er and J. Y. Ying , " Rational Exploration of N-Heterocyclic Carbene (NHC)-Palladacycle Diversity: A Highly Active and Versatile Precatalyst for Suzuki-Miyaura Couplings of Deactivated Aryl and Alkyl Substrates ," Chemistry – A European Journal , 16[13] (2010) 4010-4017

  139. S. N. Riduan and Y. Zhang , " Recent Developments in Carbon Dioxide Utilization Under Mild Conditions ," Dalton Transactions , 39[14] (2010) 3347-3357

  140. J. Lim, S. S. Lee and J. Y. Ying , " Mesoporous Silica-Supported Catalysts for Metathesis: Application to a Circulating Flow Reactor ," Chemical Communications , 46[5] (2009) 806-808

  141. L. L. Chng, J. Yang, Y. Wei and J. Y. Ying , " Semiconductor-Gold Nanocomposite Catalysts for the Efficient Three-Component Coupling of Aldehyde, Amine and Alkyne in Water ," Advanced Synthesis and Catalysis , 351[17] (2009) 2887-2896

  142. Y. Zhang and J. Y. G. Chan , " Sustainable Chemistry: Imidazolium Salts in Biomass Conversion and CO2 Fixation ," Energy and Environmental Science , 3[4] (2010) 408-417

  143. J. Y. G. Chan and Y. Zhang , " Selectively Converting Fructose to Hydroxymethylfurfural at Low Temperature Catalyzed by Tungsten Salts ," ChemSusChem , 2[8] (2009) 731-734

  144. J. Yang, E. H. Sargent, S. O. Kelly and J. Y. Ying , " A General Phase-Transfer Protocol for Metal Ions and Its Application in Nanocrystal Synthesis ," Nature Materials , 8 (2009) 683-689

  145. G. C. Papaefthymiou, E. Devlin, A. Simopoulos, D. K. Yi, S. N. Riduan, S. S. Lee and J. Y. Ying , " Interparticle Interactions in Magnetic Core/Shell Nanoarchitectures ," Physical Review B , 80[2] (2009) 024406-1-024406-10

  146. M. X. Tan and Y. Zhang , " An Efficient Metal-free Reduction Using Diphenylsilanes with (tris-perfluorophenyl)borane as Catalyst ," Tetrahedron Letters , 50[34] (2009) 4912-4915

  147. M. X. Tan, Y. Zhang and J. Y. Ying , " Hydrosilylation of Ketone and Imine over Poly-N-Heterocyclic Carbene Particles ," Advanced Synthesis and Catalysis , 351[9] (2009) 1390-1394

  148. P. Pitukmanorom and J. Y. Ying , " Selective Catalytic Reduction of Nitric Oxide by Propene over In2O3-Ga2O3/Al2O3 Nanocomposites ," Nano Today , 4[3] (2009) 220-226

  149. Y. Han, D. Zhang, L. L. Chng, J. Sun, L. Zhao, X. Zou and J. Y. Ying , " A Tri-Continuous Mesoporous Material IBN-9 with a Silica Pore Wall Following a Hexagonal Minimal Surface ," Nature Chemistry , 1 (2009) 123-127

  150. J. Lim, S. N. Riduan, S. S. Lee and J. Y. Ying , " Siliceous Mesocellular Foam-Supported Aza(bisoxazoline)- Copper Catalysts ," Advanced Synthesis and Catalysis , 350[9] (2008) 1295-1308

Synthetic Xenobiology and Biosystems, which is a new research area of synthetic biology using unnatural components (xeno-components) to generate new materials such as DNA and peptide aptamers and antibodies targeting toxins, proteins and cells; and develop new diagnostic and therapeutic tools.

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Research > Synthetic Xenobiology and Biosystems

Antibody Engineering for Rapid Diagnostic Tests

Thai Leong Yap, Huajing Wang, Shin Yee Hong and William Sun 

Rapid tests for the detection of infectious diseases can provide diagnosis at the point-of-care setting, enabling speedy and proper patient management. Rapid diagnostics, such as the lateral flow strip, require high-quality antibodies. We use a variety of engineering methods to isolate antibodies specific for pathogen proteins. These antibodies can then be incorporated into suitable assay platforms for the development of diagnostic tests. Our efforts are focused on generating rapid tests for diagnosing infections prevalent in Southeast Asia, such as dengue fever and Zika.

Biomimetic Ultrashort Peptide Hydrogel Scaffolds for Tissue Engineering

Yihua Loo, Wei Yang Seow and Andrew Wan 

IBN researchers have designed a unique class of ultrashort peptides of only 3 to 7 aliphatic amino acids that self-assemble into nanofibrous hydrogels in aqueous conditions. These hydrogels are attractive materials for tissue scaffolds, as their microarchitecture resembles extracellular matrix in the body. The hydrogels also possess mechanical strength that far exceeds that of soft tissue in the human body, but can be tuned to the desired strength, enabling the biofabrication of 3D organotypic constructs for disease modeling or implantation. Harnessing their propensity for self-assembly and taking advantage of their mechanical rigidity, these peptides are of interest as bioinks for 3D bioprinting, injectable scaffolds for regenerative medicine, synthetic 3D matrices for stem cell culture, and wound dressing for burn treatment.

Chemically Modified Glycomimetics as Molecular Scaffolds

Song-Gil Lee, Teck Chuan Lim and Su Seong Lee 

Although carbohydrates mediate important biological processes in the human body, their structural complexity and diversity have hindered efforts to understand their defined biological roles. Synthetic access to carbohydrate molecules of defined structure, in combination with biological studies, could provide unique tools for a systematic examination of structure-activity relationships. We are interested in developing structurally well-defined carbohydrate mimetics via synthetic approaches. These synthetic carbohydrate mimetics would pave the way for the development of carbohydrate-based drugs, vaccines, adjuvants, as well as novel biomaterials.

Circulating Tumor Cell Isolation for Non-Invasive Cancer Diagnosis and Prognosis

Min Hu, Jamie Mong, Jun-Li Shi, Min-Han Tan and Jackie Y. Ying 

Circulating tumor cells (CTCs) are cells that detach from a primary tumor and travel in the bloodstream to other locations, leading to the spread of tumor in the body. Catching and analyzing CTCs can further our understanding of cancer metastasis and enhance the treatment of cancer patients. However, CTCs are very rare compared to the large number of blood cells in the body, and there is a lack of universal cancer cell biomarkers to distinguish them from other circulating cells. Based on size and deformability selection, IBN’s microsieve devices enable the effective isolation of circulating tumor cells from patients’ blood samples in minutes without the use of costly reagents and complex instruments. The microsieve technology permits a simple workflow, with rapid separation and cell characterization on the same device. Intact and viable isolated CTCs can be easily eluted for molecular diagnosis, drug screening and assay development.

Development of Peptides with High Binding Affinity and High Specificity for Diagnostic and Therapeutic Applications

Joo-Eun Jee, Yong Siang Ong and Su Seong Lee 

Currently, antibodies are widely used for detecting protein biomarkers, but their high cost and chemical instability are major issues. Using synthetic peptides, IBN is developing high-affinity, highly specific capture agents for biomarkers of infectious diseases, such as dengue and Zika. The protein capture agents can be produced by screening bead-based D-peptide libraries in a high-throughput platform. Compared to antibodies, these synthetic peptides are highly stable and inexpensive, making them ideal as protein capture agents for in vitro diagnostic devices, immunohistochemistry and flow cytometry. These peptides can also be used for therapeutic purposes.

Genetic Alphabet Expansion using Unnatural Base Pair Systems

Michiko Kimoto, Itaru Okamoto, Kiyofumi Hamashima, Ken-ichiro Matsunaga and Ichiro Hirao 

The genetic information flow of the central dogma relies on only four nucleobases, which in turn constrains the Darwinian evolution of nucleic acids and proteins as functional molecules. IBN is developing a genetic alphabet expansion technology of DNA by creating extra base pairs, called unnatural base pairs. The unnatural base pairs exhibit high fidelity and efficiency in replication and/or transcription as a third base pair. The unnatural base pair systems can be used in a wide variety of biotechnology applications, such as PCR detection and aptamer generation.

High-Affinity DNA Aptamer Generation

Michiko Kimoto, Itaru Okamoto, Kiyofumi Hamashima, Nur-Afidah Binte Mohamed Suhaimi, Ken-ichiro Matsunaga and Ichiro Hirao 

IBN has successfully generated high-affinity DNA aptamers that bind to target proteins and cells by a new evolutionary engineering method called ExSELEX (genetic alphabet Expansion for Systematic Evolution of Ligands by EXponential enrichment) using our unnatural base pair technology. We have also created another technology, called mini-hairpin, to stabilize high-affinity DNA aptamers against heat and nucleases. We are developing diagnostic and therapeutic methods using these new technologies for cancer and infectious diseases.

Peptide Tags for Live Cell Imaging

Joo-Eun Jee and Su Seong Lee 

A universal tagging method for fluorescence probes is important for imaging complex biological events through live cell imaging. The current tagging methods employing fluorescence proteins, such as green fluorescent protein, have some disadvantages, including interference of the bulky fluorescence tags in the physiological activities of the target proteins. Many research groups have been developing smaller probes to overcome this problem. In this project, we aim to develop small peptide tags that can bind strongly and selectively to a specific fluorescence dye. The identified peptide tags can be genetically incorporated into target proteins and bind specifically to the fluorescent dyes for imaging purpose. In particular, we are targeting intracellular imaging using fluorescence dyes with cell-penetrating ability.

Practical Assays Predicting Diagnosis, Drug Response and Prognosis in Oncology

Michelle Pek, Jamie Mong, Jun Li Shi and Min-Han Tan 

We focus on developing practical assays that will be deployed in the clinic. We are interested in developing working assays for predicting outcomes in lung, breast, renal and colorectal cancers, as well as for adverse drug reactions in non-oncological settings. To support assay development, we work with patient-derived material and create customized animal models.

  1. J. Mong and M-H. Tan , " Size-Based Enrichment Technologies for Non-Cancerous Tumor-Derived Cells in Blood ," Trends in Biotechnology , (2018) DOI: doi.org/10.1016/j.tibtech.2018.02.010

  2. K. H. Lee and H. Zeng , " Aptamer-Based ELISA Assay for Highly Specific and Sensitive Detection of Zika NS1 Protein ," Analytical Chemistry , (2017) DOI: 10.1021/acs.analchem.7b02862

  3. M. Kimoto, A. J. Meyer, I. Hirao and A. D. Ellington , " Genetic Alphabet Expansion Transcription Generating Functional RNA Molecules Containing a Five-Letter Alphabet Including Modified Unnatural and Natural Base Nucleotides by Thermostable T7 RNA Polymerase Variants ," Chemcial Communications , (2017) DOI: 10.1039/c7cc06661a

  4. K. H. Lee, K. Hamashima, M. Kimoto and I. Hirao , " Genetic Alphabet Expansion Biotechnology by Creating Unnatural Base Pairs ," Current Opinion in Biotechnology , 51 (2018) 8-15

  5. M. Kimoto and I. Hirao , " Unique Thermal Stability of Unnatural Hydrophobic Ds Bases in Double-Stranded DNAs ," ACS Synthetic Biology , (2017) DOI: 10.1021/acssynbio.7b00165

  6. J. H. Soh, Y. Lin, M. R. Thomas, N. Todorova, C. Kallepitis, I. Yarovsky, J. Y. Ying and M. M. Stevens , " Distinct Bimodal Roles of Aromatic Molecules in Controlling Gold Nanorod Growth for Biosensing ," Advanced Functional Materials , (2017) DOI: 10.1002/adfm.201700523

  7. S. L. Kong, X. Liu, N-A. Mohamed Suhaimi, K. Koh, M. Hu, D. Lee, I. Cima, W. M. Phyo, E. Lee, J. A. Tai, Y. M. Foong, J. Vo, P. K. Koh, T. Zhang, J. Y. Ying, B. Lim, M. Han Tan and A. M. Hillmer , " Molecular Characterization of Circulating Colorectal Tumor Cells Defines Genetic Signatures for Individualized Cancer Care ," Oncotarget , (2017) DOI: 10.18632/oncotarget.19138

  8. K. H. Lee and H. Q. Zeng , " A General Double Library SELEX Strategy for Aptamer Selection Using Unmodified Nonimmobilized Targets ," Analytical and Bioanalytical Chemistry , (2017) DOI: 10.1007/s00216-017-0454-z

  9. A. Marx, K. Betz, M. Kimoto, K. Diederichs and I. Hirao , " Structural Basis for Expansion of the Genetic Alphabet by An Artificial Base Pair ," Angewandte Chemie International Edition , (2017) DOI: 10.1002/anie.201704190

  10. N.-A. Mohamed Suhaimi, W. M. Phyo, H. Y. Yap, S. Heng, X. Wei, Y. Choudhury, W. J. Tan, L. A. Peng, R. Foo, S. Tan, Z. Tiang, C. F. Wong, P. K. Koh and M. H. Tan , " Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient-Derived Xenografts ," Molecular Cancer Therapeutics , (2017) DOI: 10.1158/1535-7163.MCT-16-0793

  11. J. H. Vo, W. L. Nei, M. Hu, W. M. Phyo, F. Wang, K. W. Fong, T. Tan, Y. L. Soong, S. L. Cheah, K. Sommat, H. Low, B. Ling, J. Ng, W. L. Tan, K. S. Chan, L. Oon, J. Y. Ying and M.-H. Tan , " Comparison of Circulating Tumor Cells and Circulating Cell-Free Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma Undergoing Radiotherapy ," Scientific Reports , 6 (2016) 13

  12. K. Matsunaga, M. Kimoto and I. Hirao , " High-Affinity DNA Aptamer Generation Targeting von Willebrand Factor A1-Domain by Genetic Alphabet Expansion SELEX (ExSELEX) Using Two Types of Libraries Composed of Five Different Bases ," Journal of the American Chemical Society , (2016) DOI: 10.1021/jacs.6b10767

  13. J. Shen, C. Ren and H. Zeng , " Tuning Cation-Binding Selectivity and Capacity via Side Chain-Dependent Molecular Packing in the Solid State ," Chemical Communications , (2016) DOI: 10.1039/C6CC04526J

  14. M. Kimoto, M. Nakamura and I. Hirao , " Post-ExSELEX Stabilization of an Unnatural-Base DNA Aptamer Targeting VEGF165 Toward Pharmaceutical Applications ," Nucleic Acids Research , (2016) DOI: 10.1093/nar/gkw619

  15. I. Cima, S. L. Kong, D. Sengupta, I. B. Tan, W. M. Phyo, D. Lee, M. Hu, C. Iliescu, I. Alexander, W. L. Goh, M. Rahmani, N. A. Mohd Suhaimi, J. H. Vo, J. A. Tai, J. H. Tan, C. Chua, R. Ten, W. J. Lim, M. H. Chew, C. A. E. Hauser, R. M. van Dam, W. Y. Lim, S. Prabhakar, B. Lim, P. K. Koh, P. Robson, J. Y. Ying, A. M. Hillmer and M. H. Tan , " Tumor-Derived Circulating Endothelial Cell Clusters in Colorectal Cancer ," Science Translational Medicine , 8[345] (2016) 345ra89

  16. Y. Huo and H. Zeng , " “Sticky”-Ends-Guided Creation of Functional Hollow Nanopores for Guest Encapsulation and Water Transport ," Accounts of Chemical Research , 49[5] (2016) 922-930

  17. W. J. Tan, I. Cima, Y. Choudhury, X. Wei, J. C. T. Lim, A. A. Thike, M. H. Tan and P. H. Tan , " A Five-Gene Reverse Transcription-PCR Assay for Pre-Operative Classification of Breast Fibroepithelial Lesions ," Breast Cancer Research , (2016) DOI: 10.1186/s13058-016-0692-6

  18. N. Hong, M. Li, Y. Yuan, T. Wang, M. Yi, H. Xu, H. Zeng, J. Song, and Y. Hong , " Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish ," Stem Cell Reports , 6 (2016) 1-11

  19. L. Gao, S. S. Lee, J. Chen, H. Sun, Y. Zhao, Z. Chai, Y. Hu , " High-Throughput Screening of Substrate Specificity for Protein Tyrosine Phosphatases (PTPs) on Phosphopeptide Microarrays ," Methods in Molecular Biology , 1368 (2015) 181-196

  20. Y. Zhang and J. Y. Ying , " Homogeneous Immunochemical Assay on the Lateral Flow Strip for Measurement of DNase I Activity ," Analytical Chemistry , (2015) DOI: 10.1021/acs.analchem.5b02658

  21. Y. Zhang and J. Y. Ying , " Homogeneous Immunochemical Assay on the Lateral Flow Strip for Rapid Measurement of DNase I Activity ," Analytical Chemistry , (2015) DOI: 10.1021/acs.analchem.5b02658

  22. Z. Zheng, X. Wei, A. Hildebrandt and B. Schmidt , " A Computational Method for Studying the Relation Between Alternative Splicing and DNA Methylation ," Nucleic Acids Research , (2015) DOI: 10.1093/nar/gkv906

  23. S. Roy, J. H. Soh and J. Y. Ying , " A Microarray Platform for Detecting Disease-Specific Circulating miRNA in Human Serum ," Biosensors and Bioelectronics , 75 (2015) 238-246

  24. Y. H. Chu, H. Li, H. S. Tan, J. Lai, W. M. Phyo, Y. Choudhury, R. Kanesvaran, N. M. Chau, C. K. Toh, Q. S. Ng, P. H. Tan, B. Chowbay and M.-H. Tan , " Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma ," PLoS ONE , 10 (2015) e0134102

  25. W. J. Tan, J. Yan, S. Xu, A. A. Thike, B. H. Bay, H. Yu, M.-H. Tan and P. H. Tan , " Second Harmonic Generation Microcopy is a Novel Technique for Differential Diagnosis of Breast Fibroepithelial Lesions ," Journal of Clinical Pathology , (2015) DOI: 10.1136/jclinpath-2015-203231

  26. G. Marinaro, A. Accardo, N. Benseny-Cases, M. Burghammer, H. Castillo-Michel, M. Cotte, S. Dante, F. De Angelis, E. Di Cola, E. Di Fabrizio, C. Hauser and C. Riekel , " Probing Droplets with Biological Colloidal Suspensions on Smart Surfaces by Synchrotron Radiation Micro- and Nano-Beams ," Optics and Lasers in Engineering , (2015) DOI: 10.1016/j.optlaseng.2015.03.004i

  27. W. Wang, L. Qi, M.-H. Tan, Z. Zhang, J. Du, X. Wei and X. Yao , " Effect of Platelet-Derived Growth Factor-B on Renal Cell Carcinoma Growth and Progression ," Urologic Oncology , (2015) DOI: 10.1016/j.urolonc.2014.12.015

  28. Y. Zhang,J. Bai, H. Wu and J. Y.Ying , " Trapping Cells in Paper for White Blood Cell Count ," Biosensors and Bioelectronics , 69 (2015) 121-127

  29. P. Neuzil, W. Sun, T. Karasek and A. Manz , " Nanoliter-Sized Overheated Reactor ," Applied Physics Letters , 106 (2015) 024104

  30. Y. Zhang, J. Bai and J. Y. Ying , " A Stacking Flow Immunoassay for the Detection of Dengue-Specific Immunoglobins in Salivary Fluid ," Lab on a Chip , 15 (2015) 1465-1471

  31. N. A. Mohd Suhaimi, Y. M. Foong, D. Y. S. Lee, W. M. Phyo, I. Cima, E. X. W. Lee, W. L. Goh, W. Y. Lim, K. S. Chia, S. L. Kong, M. Gong, B. Lim, A. M. Hillmer, P. K. Koh, J. Y. Ying and M. H. Tan , " Non-Invasive Sensitive Detection of KRAS and BRAF Mutation in Circulating Tumor Cells of Colorectal Cancer Patients ," Molecular Oncology , (2015) DOI: 10.1016/j.molonc.2014.12.011

  32. Y. Zhang and T. Wang , " High-Resolution Quantification by Charge-Dominant Electrophoretic Mobility Shift of Quantum Dots ," Electrophoresis , (2014) DOI: 10.1002/elps.201400577

  33. H. S. Tan, H. Li, Y. W. Hong, C. K. Toh, A. Wong, G. Lopes, M. H. Tay, A. Chan, X. Yao, T. Tang, Q. S. Ng, R. Kanesvaran, N. M. Chau and M. H. Tan , " Efficacy and Safety of an Attenuated-Dose Sunitinib Regimen in Metastatic Renal Cell Carcinoma: Results from a Prospective Registry in Singapore ," Clinical Genitourinary Cancer , (2014) DOI: 10.1016/j.clgc.2014.11.004

  34. Y. Choudhury, X. Wei, Y. H. Chu, L. G. Ng, H. S. Ta, V. Koh, A. A. Thike, E. Poon, Q. S. Ng, C. K. Toh, R. Kanesvaran, P. H. Tan, M. H. Tan , " A Multigene Assay Identifying Distinct Prognostic Subtypes of Clear Cell Renal Cell Carcinoma with Differential Response to Tyrosine Kinase Inhibition ," European Urology , 67[1] (2014) 17-20

  35. Y. Zu, M. H. Tan, B. Chowbay, S. C. Lee, H. Yap, M. T. M. Lee, L-S. Lu, C-P. Chang and J. Y. Ying , " Nanoprobe-based Genetic Testing ," Nano Today , 9[2] (2014) 166-171

  36. C. A. E. Hauser, S. Maurer-Strohb and I. C. Martins , " Amyloid-Based Nanosensors and Nanodevices ," Chemical Society Reviews , 43 (2014) 5326-5345

  37. D. P. Poenar, C. Iliescu, J. Boulaire and H. Yu , " Label-Free Virus Identification and Characterization Using Electrochemical Impedance Spectroscopy ," Electrophoresis , (2014) DOI: 10.1002/elps.201300368

  38. F. C. Tay, W. K. Tan, S.-L. Goh, C. J. A. Ramachandra, C.-H. Lau, H. Zhu, C. Chen, S. Du, R. Z. Phang, M. Shahbazi, W. Fan and S. Wang , " Targeted Transgene Insertion into the AAVS1 Locus Driven by Baculoviral Vector-Mediated Zinc Finger Nuclease Expression in Human Induced Pluripotent Stem Cells ," The Journal of Gene Medicine , 15[10] (2013) 384-395

  39. T. T. Y. Tan, M. R. Reithofer, E. Y. Chen, A. G. Menon, T. S. A. Hor, J. Xu, and J. M. Chin , " Tuning Omniphobicity via Morphological Control of Metal-Organic Framework Functionalized Surfaces ," Journal of the American Chemical Society, , 135[44] (2013) 16272-16275

  40. Y. Zhang, D. J. Shin and T.-H. Wang , " Serial Dilution via Surface Energy Trap-Assisted Magnetic Droplet Manipulation ," Lab on a Chip , 13 (2013) 4827-4831

  41. D. Y. C. Heng, T. K. Choueiri, B. I. Rini, J. Lee, T. Yuasa, S. K. Pal, S. Srinivas, G. A. Bjarnason, J. J. Knox, M. MacKenzie, U. N. Vaishampayan, M. H. Tan, S. Y. Rha, F. Donskov, N. Agarwal, C. Kollmannsberger, S. North and L. A. Wood. , " Outcomes of Patients with Metastatic Renal Cell Carcinoma That Do Not Meet Eligibility Criteria for Clinical Trials ," Annals of Oncology , 25 (2013) 149-154

  42. B. Keeley, A. Stark, T. R. Pisanic II, R. Kwak, Y. Zhang, J. Wrangle, S. B. Baylin, J. G. Herman, N. Ahuja, M. V. Brock and T. H. Wang , " Extraction and Processing of Circulating DNA from Large Sample Volumes Using Methylation on Beads for The Detection of Rare Epigenetic Events ," Clinica Chimica Acta , 425 (2013) 169-175

  43. N. Kroeger, T. K. Choueiri, J. L. Lee, G. A. Bjarnason, J. J. Knox, M. J. Mackenzie, L. Wood, S. Srinivas, U. N. Vaishamayan, S. Y. Rha, S. K. Pal, T. Yuasa, F. Donskov, N. Agarwal, M. H. Tan, A. Bamias, C. K. Kollmannsberger, S. A. North, B. I. Rini and D. Y. Heng , " Survival Outcome and Treatment Response of Patients with Late Relapse from Renal Cell Carcinoma in the Era of Targeted Therapy ," European Urology , (2013) DOI: 10.1016/j.eururo.2013.07.031

  44. A. Mishra, K.-H. Chan, M. R. Reithofer and C. A. E. Hauser , " Influence of Metal Salts on the Hydrogelation Properties of Ultrashort Aliphatic Peptides ," RSC Advances , 3 (2013) 9985-9993

  45. N. Kroeger, W. Xie, J. L. Lee, G. A. Bjarnason, J. J. Knox, M. J. Mackenzie, L. Wood, S. Srinivas, U. N. Vaishamayan, S. Y. Rha, S. K. Pal, T. Yuasa, F. Donskov, N. Agarwal, C. K. Kollmannsberger, M. H. Tan, S. A. North, B. I. Rini, T. K. Choueiri and D. Y. Heng , " Metastatic Non-Clear Cell Renal Cell Carcinoma Treated with Targeted Therapy Agents: Characterization of Survival Outcome and Application of the International mRCC Database Consortium Criteria ," Cancer , 119 (2013) 2999-3006

  46. W. Y. Seow and C. A. E. Hauser , " A Convenient and Minimally-Invasive Method to Study Gel Formation by Surface Tension Measurements ," Journal of Chemical Science and Technology , 2[1] (2013) 5-9

  47. L. C. Harshman, W. Xie, G. A. Bjarnason, J. J. Knox, M. MacKenzie, L. Wood, S. Srinivas, U. N. Vaishampayan, M. H. Tan, S. Y. Rha, F. Donskov, N. Agarwal, C. Kollmannsberger, S. North, B. I. Rini, D. Y. C. Heng and Toni K. Choueiri , " Conditional Survival of Patients with Metastatic Renal-Cell Carcinoma Treated with VEGF-Targeted Therapy: A Population-Based Study ," Lancet Oncology , 13[9] (2012) 927-935

  48. X. Chen, A. Ying, Z. Gao , " Highly Sensitive and Selective Colorimetric Genotyping of Single-Nucleotide Polymorphisms Based on Enzyme-Amplified Ligation on Magnetic Beads ," Biosensors and Bioelectronics , 36[1] (2012) 89-94

  49. Y. Y. Lee, K. Narayanan, S. J. Gao, J. Y. Ying , " Elucidating Drug Resistance Properties in Scarce Cancer Stem Cells using Droplet Microarray ," Nano Today , 7[1] (2012) 29-34

  50. W. Y. Chay, W. S. Ong, P. H. Tan, N. Q. J. Leo, G. H. Ho, C. S. Wong, K. S. Chia, K. Y. Chow, M.-H. Tan, and P. Ang , " Validation of the Gail Model for Predicting Individual Breast Cancer Risk in a Prospective Nationwide Study of 28,104 Singapore Women ," Breast Cancer Research , 14[1] (2012) R19

  51. L. S. Lee, and M.-H. Tan , " Predictive Models for the Practical Management of Renal Cell Carcinoma ," Nature Reviews Urology , 9[2] (2012) 73-84

  52. D. Y. Heng, M. MacKenzie, U. Vaishampayan, J. J. Knox, G. A. Bjarnason, M. H. Tan, L. Wood, F. Donskov, C. Kollmannsberger, S. North, F. Donskov, B. I. Rini and T. K. Choueiri , " Primary Anti-Vascular Endothelial Growth Factor (VEGF)-Refractory Metastatic Renal Cell Carcinoma: Clinical Characteristics, Risk Factors and Subsequent Therapy ," The Annals of Oncology , (2011) DOI: 10.1093/annonc/mdr533

  53. P. H. Tan, A. A. Thike, W. J. Tan, M. M. Thu, I. Busmanis, H. Li, W. Y. Chay and M. H. Tan , " Predicting Clinical Behavior of Breast Phyllodes Tumors: A Nomogram Based on Histological Criteria and Surgical Margins ," Journal of Clinical Pathology , 65[1] (2011) 69-76

  54. G. Xu, D. Y. S. Lee, H. Xie, D. Chiew, T.-M. Hsieh, E. Mohamed Ali, X. L. Looi, M.-H. Li and J. Y. Ying , " A Self-Contained Polymeric Cartridge for Automated Biological Sample Preparation ," Biomicrofluidics , 5 (2011) 34107

  55. J. Zhang, M. C. Pearce, B. P. Ting and J. Y. Ying , " Ultrasensitive Electrochemical Immunosensor Employing Glucose Oxidase Catalyzed Deposition of Gold Nanoparticles for Signal Amplification ," Biosensors and Bioelectronics , 27[1] (2011) 53-57

  56. G. Yi, Y. F. Peng and Z. Gao , " Strong Red-Emitting Near-Infrared-to-Visible Upconversion Fluorescent Nanoparticles ," Chemistry of Materials , 23 (2011) 2729-2734

  57. Y. Zu, A. L. Ting, G. Yi and Z. Gao , " Sequence-Selective Recognition of Nucleic Acids Under Extremely Low Salt Conditions Using Nanoparticle Probes ," Analytical Chemistry , 83 (2011) 4090-4094

  58. S. Roy, J. H. Soh and Z. Gao , " A Microfluidic-Assisted Microarray for Ultrasensitive Detection of miRNA Under an Optical Microscope ," Lab on a Chip , 11 (2011) 1886-1894

  59. H. Taylor, D. Boning and C. Iliescu , " A Razor-Blade Test of the Demolding Energy in a Thermoplastic Embossing Process ," Journal of Micromechanics and Microengineering , 21[6] (2011) 67002

  60. X. Chen, Y. Zu, H. Xie, A. Muhammad Kemas and Z. Gao , " Coordination of Mercury(II) to Gold Nanoparticle Associated Nitrotriazole Towards Sensitive Colorimetric Detection of Mercuric Ion with Tunable Dynamic Range ," Analyst , 136[8] (2011) 1690-1696

  61. C. Iliescu, M. Avram, B. Chen, A. Popescu, V. Dumitrescu, D. P. Poenar, A. Sterian, D. Vrtacnik, S. Amon and P. Sterian , " Residual Stress in Thin Films PECVD Depositions: A Review ," Journal of Optoelectronics and Advanced Materials , 13 (2011) 387-394

  62. Z. Gao and Y. F. Peng , " A Highly Sensitive and Specific Biosensor for Ligation- and PCR-Free Detection of MicroRNAs ," Biosensors and Bioelectronics , 26[9] (2011) 3768-3773

  63. Y. F. Peng, X. J. Chen, G. S. Yi and Z. Q. Gao , " Mechanism of the Oxidation of Organic Dyes in the Presence of Nanoceria ," Chemical Communications , 47 (2011) 2916-2918

  64. Y. F. Peng and Z. Q. Gao , " Amplified Detection of MicroRNA Based on RuO2 Nanoparticle-Initiated Deposition of an Insulating Film ," Analytical Chemistry , 83[3] (2011) 820-827

  65. Y. Zu, A. L. Ting and Z. Gao , " Visualizing Low-Level Point Mutations: Enzyme-Like Selectivity Offered by Nanoparticle Probes ," Small , 7[3] (2010) 306-310

  66. G. L. Xu, F. E. H. Tay, G. Tresset, F. S. Iliescu, A. Avram and C. Iliescu , " Recent Trends in Dielectrophoresis ," Informacije Midem - Journal of Microelectronics Electronic Components and Materials , 40 (2010) 253-262

  67. K.-J. Leck, S. Zhang and C. Hauser , " Study of Bioengineered Zebra Fish Olfactory Receptor 131-2: Receptor Purification and Secondary Structure Analysis ," PLoS ONE , 5[11] (2010) 2780-2790

  68. N. C. Tansil, E. A. B. Kantchev, Z. Gao and H.-h. Yu , " Electropolymerization of Intercalator-Grafted Conducting Polymer for Direct and Amplified DNA Detection ," Chemical Communications , 47[5] (2010) 1533-1535

  69. Y. Peng, G. Yi and Z. Gao , " A Highly Sensitive MicroRNA Biosensor Based on Ruthenium Oxide Nanoparticle-Initiated Polymerization of Aniline ," Chemical Communications , 46[48] (2010) 9131-9133

  70. G. Xu, T.-M. Hsieh, D. Y. S. Lee, E. Mohamed Ali, H. Xie, X. L. Looi, E. S.-C. Koay, M.-H. Li and J. Y. Ying , " A Self-Contained All-in-One Cartridge for Sample Preparation and Real-Time PCR in Rapid Influenza Diagnosis ," Lab on a Chip , 10[22] (2010) 3103-3111

  71. Y. Peng, X. Chen and Z. Gao , " Determination of Trace Amounts of Mercury Using Hierarchically Nanostructured Europium Oxide ," Talanta , 82[5] (2010) 1924-1928

  72. J. Zhang, B. P. Ting, M. Khan, M. C. Pearce, Y. Yang, Z. Gao and J. Y. Ying , " Pt Nanoparticle Label-Mediated Deposition of Pt Catalyst for Ultrasensitive Electrochemical Immunosensors ," Biosensors and Bioelectronics , 26[2] (2010) 418-423

  73. P. Neuzil, L. Novak, J. Pipper, S. Lee, L. F.-P. Ng and C. Zhang , " Rapid Detection of Viral RNA by a Pocket-Size Real-Time PCR System ," Lab on a Chip , 10[19] (2010) 2632-2634

  74. W. C. Cheong, L. S. Lim, M. C. Huang, M. Bode and M.-H. Li , " New Insights into the De Novo Gene Synthesis Using the Automatic Kinetic Switch Approach ," Analytical Biochemistry , 406[1] (2010) 51-60

  75. X. Chen, S. Roy, Y. Peng and Z. Gao , " Electrical Sensor Array for Polymerase Chain Reaction-Free Messenger RNA Expression Profiling ," Analytical Chemistry , 82[14] (2010) 5958-5964

  76. C. Iliescu, G. Tresset, L. Yu and G. Xu , " 3D Dielectrophoretic Chips: Trapping and Separation of Cell Populations ," Romanian Journal of Information Science and Technology , 13[1] (2010) 49-64

  77. S. Roy and Z. Gao , " Direct-Write Fabrication of a Nanoscale Digital Logic Element on a Single Nanowire ," Nanotechnology , 21[24] (2010) 245306

  78. S.-C. Luo, S.S. Liour and H.-H. Yu , " Perfluoro-Functionalized PEDOT Films with Controlled Morphology as Superhydrophobic Coatings and Biointerfaces with Enhanced Cell Adhesion ," Chemical Communications , 46 (2010) 4731-4733

  79. C. Iliescu, G. Tresset, F. S. Iliescu and P. E. Sterian , " Live/Dead Cell Assay Based on Dielectrophoresis on a Chip ," UPB Scientific Bulletin Series A - Applied Mathematics and Physics , 72[1] (2010) 33-44

  80. D. Lee, P. Sukumar, A. Mahyuddin, M. Choolani and G. Xu , " Separation of Model Mixtures of Epsilon-Globin Positive Fetal Nucleated Red Blood Cells and Anucleate Erythrocytes Using a Microfluidic Device ," Journal of Chromatography A , 1217[11] (2010) 1862-1866

  81. J. Xie, Y. Zheng and J. Y. Ying , " Highly Selective and Ultrasensitive Detection of Hg2+ Based on Fluorescence Quenching of Au Nanoclusters by Hg2+-Au+ Interactions ," Chemical Communications , 46[6] (2009) 961-963

  82. C. Iliescu, D. P. Poenar and S. T. Selvan , " Frequency Dependence on the Accuracy of Electrical Impedance Spectroscopy Measurements in Microfluidic Devices ," Journal of Micromechanics and Microengineering , 20[2] (2009) 022001

  83. F. S. Iliescu, A. R. Sterian, E. Barbarini, M. Avram and C. Iliescu , " Continuous Separation of White Blood Cells from Blood in a Microfluidic Device UPB ," UPB Scientific Bulletin Series A – Applied Mathematics and Physics , 71[4] (2009) 21-30

  84. Z. F. Chen and Y. Zu , " Electrogenerated Chemiluminescence of the Tris(2,2\'-bipyridine)ruthenium(II)/Tertiary Amine Systems: Effects of Electrode Surface Hydrophobicity on the Low-Oxidation-Potential Emission ," Journal of Physical Chemistry C , 113[52] (2009) 21877-21882

  85. B. T. Chen, J. S. Wei and C. Iliescu , " Sonophoretic Enhanced Microneedle Array - Improving the Efficiency of Transdermal Drug Delivery ," Sensors and Actuators B: Chemical , 145[1] (2009) 54-60

  86. X. J. Chen, H. Xie, Z. Y. Seow and Z. Q. Gao , " An Ultrasensitive DNA Biosensor Based on Enzyme-Catalyzed Deposition of Cupric Hexacyanoferrate Nanoparticles ," Biosensors and Bioelectronics , 25[6] (2010) 1420-1426

  87. F. E. H. Tay, L. Yu and C. Iliescu , " Particle Manipulation by Miniaturized Dielectrophoretic Devices ," Defence Science Journal , 59[6] (2009) 595-604

  88. C. Iliescu, G. Tresset and G. L. Xu , " Dielectrophoretic Field-Flow Method for Separating Particle Populations in a Chip with Asymmetric Electrodes ," Biomicrofluidics , 3[4] (2009) 044104

  89. Y. B. Zu and Z. Q. Gao , " Facile and Controllable Loading of Single-Stranded DNA on Gold Nanoparticles ," Analytical Chemistry , 81[20] (2009) 8523-8528

  90. H. Xie, S. C. Luo and H. H. Yu , " Electric-Field-Assisted Growth of Functionalized Poly(3,4-ethylenedioxythiophene) Nanowires for Label-Free Protein Detection ," Small , 5[22] (2009) 2611-2617

  91. J. Wei, K. J. Leck, P. Gaughwin, M. Avram and C. Iliescu , " Low Stress Nanoporous SiNx Membrane for Cell Culture ," Journal of Computational Materials Science and Surface Engineering , 2[3-4] (2009) 268-281

  92. B. P. Ting, J. Zhang, M. Khan, Y. Y. Yang, and J. Y. Ying , " The Solid-State Ag/AgCl Process as a Highly Sensitive Detection Mechanism for an Electrochemical Immunosensor ," Chemical Communications , 41 (2009) 6231-6233

  93. S. Roy, X. J. Chen, M. H. Li, Y. F. Peng, F. Anariba and Z. Q. Gao , " Mass-Produced Nanogap Sensor Arrays for Ultrasensitive Detection of DNA ," Journal of American Chemical Society , 131[34] (2009) 12211-12217

  94. B. P. Ting, J. Zhang, Z. Gao, and J. Y. Ying , " A DNA Biosensor Based on the Detection of Doxorubicin-Conjugated Ag Nanoparticle Labels Using Solid-State Voltammetry ," Biosensors and Bioelectronics , 25 (2009) 282-287

  95. S. Roy and Z. Q. Gao , " Nanostructure-Based Electrical Biosensors ," Nano Today , 4[4] (2009) 318-334

  96. F. Anariba , " Fabrication and Electrical Characterization of Molecular Junctions; A Robust Platform for Electron Transport Studies in Molecular Electronics ," Verlag Dr. Mueller , (2009) DOI: -

  97. S. C. Luo, H. Xie, N. Y. Chen and H. H. Yu , " Trinity DNA Detection Platform by Ultrasmooth and Functionalized PEDOT Biointerfaces ," ACS Applied Materials and Interfaces , 1[7] (2009) 1414-1419

  98. M. Bode, S. Khor, H. Ye, M.-H. Li and J. Y. Ying , " TmPrime: Fast, Flexible Oligonucleotide Design Software for Gene Synthesis ," Nucleic Acids Research , 37 (2009) W214-W221

  99. Y. Zu , " Molecular and Nanoparticle Postcolumn Reagents for Assay of Low-Molecular-Mass Biothiols Using High-Performance Liquid Chromatograph ," Journal of Chromatography B , 877[28] (2009) 3358-3365

  100. Y.-C. Toh, T. C. Lim, D. Tai, G. Xiao, D. van Noort and H. Yu , " A Microfluidic 3D Hepatocyte Chip for Drug Toxicity Testing ," Lab on a Chip , 9[14] (2009) 2026-2035

  101. S.-C. Luo, J. Jiang, S. Liour, S. Gao, J. Y. Ying and H.-h. Yu , " Magnetic PEDOT Hollow Capsules with Single Holes ," Chemical Communications , 19 (2009) 2664-2666

  102. J. Zhang, B. P. Ting, N. R. Jana, Z. Q. Gao and J. Y. Ying , " Ultrasensitive Electrochemical DNA Biosensors Based on the Detection of a Highly Characteristic Solid-State Process ," Small , 5[12] (2009) 1414-1417

  103. H. Ye, M. C. Huang, M.-H. Li and J. Y. Ying , " Experimental Analysis of Gene Assembly with TopDown One-Step Real-Time Gene Synthesis ," Nucleic Acids Research , 37[7] (2009) e51

  104. J. Xie, Y. Zheng and J. Y. Ying , " Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters ," Journal of the American Chemical Society , 131[3] (2009) 888-889

  105. C. Fang, Y. Fan, J. Kong, Z. Q. Gao and N. Balasubramanian , " Electrical Detection of Oligonucleotide Using an Aggregate of Gold Nanoparticles as a Conductive Tag ," Analytical Chemistry , 80[24] (2008) 9387-9394

  106. C. Iliescu, G. L. Xu, E. Barbarini, M. Avram and A. Avram , " Microfluidic Device for Continuous Magnetophoretic Separation of White Blood Cells ," Microsystem Technologies , 15[8] (2008) 1157-1162

  107. S.-C. Luo, H.-h. Yu, A. C. A. Wan, Y. Han and J. Y. Ying , " A General Synthesis for PEDOT-Coated Nonconductive Materials and PEDOT Hollow Particles by Aqueous Chemical Polymerization ," Small , 4[11] (2008) 2051-2058

  108. M. C. Huang, H. Ye, Y. K. Kuan, M.-H. Li and J. Y. Ying , " Integrated Two-Step Gene Synthesis in a Microfluidic Device ," Lab on a Chip , 9[2] (2008) 276-285

  109. H. H. Yu, M. K. F. Wong, E. Mohamed Ali and J. Y. Ying , " Photostable and Luminescent ZnO Films: Synthesis and Application as Fluorescence Resonance Energy Transfer Donors ," Chemical Communications , 40 (2008) 4912-4914

  110. C. Fang, Y. Fan, J. Kong, Z. Q. Gao and N. Balasubramanian , " Preparation of Nanochain and Nanosphere by Self-Assembly of Gold Nanoparticles ," Applied Physics Letters , 92[26] (2008) 263108

  111. A. Gole, N. R. Jana, S. T. Selvan and J. Y. Ying , " Langmuir-Blodgett Thin Films of Quantum Dots: Synthesis, Surface Modification and Fluorescence Resonance Energy Transfer (FRET) Studies ," Langmuir , 24[15] (2008) 8181-8186

  112. S.C. Luo, E. Mohamed Ali, N. C. Tansil, H.-h. Yu, S. Gao, E. A. B. Kantchev and J. Y. Ying , " PEDOT Nanobiointerfaces: Thin, Ultrasmooth and Functionalized Poly(3,4-Ethylenedioxythiophene) Films with In Vitro and In Vivo Biocompatibility ," Langmuir , 24[15] (2008) 8071-8077

  113. M. Avram, A. M. Avram, A Bragaru, A. Ghiu and C. Iliescu, , " Plasma Surface Modification for Selective Hydrophobic Control ," Romanian Journal of Information Science and Technology , 11[4] (2008) 409-422

  114. C. Iliescu, J. Wei, B. Chen and P. L. Ong , " Silicon Nitride Membrane for Cell Culturing ," Romanian Journal of Information Science and Technology , 11[2] (2008) 167-176

  115. Y. Shi, S.-C. Luo, W. Fang, K. Zhang, E. Mohamed Ali, F. Y. C. Boey, J. Y. Ying, J. Wang, H.-h. Yu and L. Li , " Work Function Engineering of Electrodes via Electropolymerization of Ethylenedioxythiophenes and Its Derivatives ," Organic Electronics , 9[5] (2008) 859-863

  116. A. P. O'Mullane, J. Zhang, A. Brajter-Toth and A. M. Bond , " Higher Harmonic Large-Amplitude Fourier Transformed Alternating Current Voltammetry: Analytical Attributes Derived from Studies of the Oxidation of Ferrocenemethanol and Uric Acid at a Glassy Carbon Electrode ," Analytical Chemistry , 80[12] (2008) 4614-4626

  117. J. Pipper, Y. Zhang, P. Neuzil and T. M. Hsieh , " Clockwork PCR Including Sample Preparation ," Angewandte Chemie International Edition , 47[21] (2008) 3900-3904

  118. K. M. Schumacher, S. C. Phua, A. Schumacher and J. Y. Ying , " Controlled Formation of Biological Tubule Systems in Extracellular Matrix Gels In Vitro ," Kidney International , 73[10] (2008) 1187-1192

  119. H. Taylor, D. Boning, C. Iliescu and B. Chen , " Computationally Efficient Modelling of Pattern Dependencies in the Micro-Embossing of Thermoplastic Polymers ," Microelectronic Engineering , 85[5-6] (2008) 1453-1456

  120. S. F. Zhang, H. L. Leo, S. H. Kan and H. Yu , " Synthetic Collagen-free Sandwich Culture of Primary Hepatocytes based on Micro-fabrication Technology ," Proceedings of the International Conference on Advances in Bioresorbable Biomaterials for Tissue Engineering , (2008) DOI: -

  121. Y. M. Khong, J. Zhang, S. B. Zhou, C. Cheung, K. Doberstein, V. Samper and H. Yu , " Novel Intra-Tissue Perfusion System for Culturing Thick Liver Tissue ," Tissue Engineering , 13[9] (2007) 2345-2356

  122. Y. Han, L. Zhao and J. Y. Ying , " Entropy-Driven Helical Mesostructure Formation with Achiral Cationic Surfactant Templates ," Advanced Materials , 19[18] (2007) 2454-2459

  123. Y. Zhang, K. C. Ngeow and J. Y. Ying , " The First N-Heterocyclic Carbene (NHC)-based Nickel Catalyst for C-S Coupling ," Organic Letters , 9[18] (2007) 3495-3498

  124. J. Wei, P. L. Ong, F. E. H. Tay and C. Iliescu , " A New Fabrication Method of Low Stress PECVD SiNx Layers for Biomedical Application ," Thin Solid Films , 516[16] (2008) 5181-5188

  125. C. Iliescu, B. T. Chen, J. Wei and A. J. Pang , " Characterization of Silicon Carbide Films Deposited by Plasma Enhanced Chemical Vapor Deposition ," Thin Solid Films , 516[16] (2008) 5189-5193

  126. L. Kim, Y. C. Toh, J. Voldman and H. Yu , " A Practical Guide to Microfluidic Perfusion Culture of Adherent Mammalian Cells ," Lab on a Chip , 7[6] (2007) 681-694

  127. G. Tresset and C. Iliescu , " Electrical Control of Loaded Biomimetic Femtoliter Vesicles in Microfluidic System ," Applied Physics Letters , 90[17] (2007) 173901-1-173901-3

  128. K. Schumacher, Y. M. Khong, S. Chang, J. Ni, W. X. Sun and H. Yu , " Perfusion Culture Improves the Maintenance of Cultured Liver Tissue Slices ," Tissue Engineering , 13[1] (2007) 197-205

  129. Y. C. Toh, C. Zhang, J. Zhang, Y. M. Khong, S. Chang, V. D. Samper, D. V. Noort, D. W. Hutmacher and H. Yu , " A Novel 3D Mammalian Cell Perfusion-Culture System in Microfluidic Channels ," Lab on a Chip , 7[3] (2007) 302-309

  130. S. S. S. Ng, R. B. Han, J. Ni, S. Chang, W. Hunziker, A. B. Goryachev, S. H. Ong and H. Yu , " Improved Hepatocyte Excretory Function by Immediate Presentation of Polarity Cues ," Tissue Engineering , 12[8] (2006) 2181-2191

  131. Y. N. Du, S. M. Chia and H. Yu , " 3D Hepatocyte Monolayer on Hybrid RGD/Galactose Substratum ," Biomaterials , 27[33] (2006) 5669-5680

  132. Y. C. Toh, S. S. S. Ng, Y. M. Khong, X. Zhang, Y. J. Zhu, P. C. Lin, C. M. Ten, W. X. Sun and H. Yu , " Cellular Responses to a Nanofibrous Environment ," Nano Today , 1[3] (2006) 34-43

  133. H. L. Foo, A. Taniguchi, H. Yu, T. Okano and S. H. Teoh , " Catalytic Surface Modification of Roll-milled poly(ε-caprolactone) Biaxially Stretched to Ultra-thin Dimension ," Materials Science and Engineering: C , 27[2] (2006) 299-303

  134. B. Annaz, K. A. Hing, M. V. Kayser, T. Buckland, and L. Di Silvio , " An Ultra-Structural Study of Cellular Response to Variation in Porosity in Phase-Pure Hydroxyapatite ," Journal of Microscopy , 216[2] (2004) 97-109

  135. P. L. Mao, T. F. Liu, K. Kueh and P. Wu , " Predicting the Efficiency of UAG Translational Stop Signal Through Studies of Physicochemical Properties of its Composite Mono- and Di-Nucleotides ," Computational Biology and Chemistry , 28[4] (2004) 245-256

  136. T. S. Pek, M. Spector, I. V. Yannas, and L. J. Gibson , " Degradation of a Collagen-Chondroitin-6-Sulfate Matrix by Collagenase and by Chondroitinase ," Biomaterials , 25[3] (2003) 473-482

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