SIgN hosts three core research programs in Infection and Immunity, Cancer Immunology and Immune
Dysfunctions.
All research groups within these programs benefit from access to the SIgN Immunomonitoring Platform that
provides world-leading expertise and state-of-the-art technologies for flow cytometry/cell sorting,
Cytometry by Time-of-Flight (CyTOF), multiplexed soluble protein assays, immunogenomics, single-cell
analytics and Bioinformatics. SIgN researchers also have access to high-class functional immune imaging
facilities, an animal facility and preclinical mouse models of human disease and a human monoclonal antibody
platform. Together, these technologies enable our researchers to build a complete research picture from the
DNA and molecular level, through to models of human diseases and human clinical cohort
studies.
The
SIgN Immunomonitoring Platform actively
supports clinical trial monitoring, cohort and clinical studies, in collaboration with multiple research,
clinical and industrial partners. Some current examples include:
- A Phase IV clinical trial on the immune responsiveness in Flu-vaccinated Elderly
- Oncology studies in mouse and man aimed at biomarker discovery
- A large-scale clinical study of heart failure
- The Singapore Longitudinal Aging Study
- The Cohort Study of Atopy and Allergy
- The Growing Up Towards Healthy Outcomes (GUSTO) study
- The SG90 Nonagenarian Study
- Various clinical studies in areas of dengue virus, hepatitis B virus, irritable bowel disease, cancer and heart failure