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2015


Analysis of dual MNK/BCR-ABL inhibitor induced changes in Proteome Phosphorylation for Companion Diagnostics Development
Targeting the central pocket in human transcription factor TEAD as a potential cancer therapeutic strategy
Discovery of an ultra-short linear antibacterial tetrapeptide with anti-MRSA activity from a structure-activity relationship study
Peptidomimetic ethyl propenoate covalent inhibitors of the Enterovirus 71 3C protease: a P2 – P4 study
Journal of Enzyme Inhibition and Medicinal Chemistry
Melgious J. Y. Ang, Qiu Ying Lau, Fui Mee Ng, Siew Wen Then, Anders Poulsen, Yuen Kuen Cheong, Zi Xian Ngoh, Yong Wah Tan, Jianhe Peng, Thomas H. Keller, Jeffrey Hill, Justin J. H. Chu, C. S. Brian Chia
Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay
Antiviral Research
Justin Jang Hann Chu, Regina Ching Hua Lee, Melgious Jin Yan Ang, Wei-Ling Wang, Huichang Annie Lim, John Liang Kuan Wee, Joma Joy, Jeffrey Hill, C.S. Brian Chia
Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria
mBio
Wilfried Moreira, Grace J. Y. Ngan, Jian Liang Low, Anders Poulsen, Brian C. S. Chia, Melgious J. Y. Ang, Amelia Yap, Justina Fulwood, Umayal Lakshmanan, Jolander Lim, Audrey Y. T. Khoo, Horst Flotow, Jeffrey Hill, Ravikiran M. Raju, Eric J. Rubin, Thomas Dick
Targeting dengue virus NS4B protein for drug discovery
Journal of Virology
Wang QY, Dong H, Zou B, Karuna R, Wan KF, Zou J, Susila A, Yip A, Shan C, Yeo KL, Xu H, Ding M, Chan WL, Gu F, Seah PG, Liu W, Lakshminarayana SB, Kang C, Lescar J, Blasco F, Smith PW, Shi PY..
Pharmacophore Model for Wnt\/Porcupine Inhibitors and Its Use in Drug Design
Journal of Chemical Information and Modeling
Anders Poulsen, Soo Yei Ho, Weiling Wang, Jenefer Alam, Duraiswamy A. Jeyaraj, Shi Hua Ang, Eldwin Sum Wai Tan, Grace Ruiting Lin, Vivien Wei Wen Cheong, Zhiyuan Ke, May Ann Lee, Thomas H. Keller
Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport.
Scientific Reports
Rajan S, Choi M, Nguyen QT, Ye H, Liu W, Toh HT, Kang C, Kamariah N, Li C, Huang H, White C, Baek K, Grüber G, Yoon HS.
Determinants of Dengue Virus NS4A Protein Oligomerization
Journal of Virology
Chia Min Lee, Xuping Xie, Jing Zou, Shi-Hua Li, Michelle Yue Qi Lee, Hongping Dong, Cheng-Feng Qin, Congbao Kang, Pei-Yong Shi
Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy
Biochimica et Biophysica Acta (BBA) - Biomembranes
Yan Li, Qingxin Li, Ying Lei Wong, Lynette Sin Yee Liew, CongBao Kang
Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles.
Angew Chem Int Ed Engl. 2016 Sep 19;55(39):12068-72.
Li Y, Wong YL, Lee MY, Li Q, Wang QY, Lescar J, Shi PY, Kang C.
An FDA-drug library screen for compounds with bioactivities against meticillin-resistant Staphylococcus aureus (MRSA)
Antibiotics
Lau, Q.Y., Tan, Y.Y.F., Goh, V.C.C., Lee, D.J.Q., Ng, F.M., Ong, E.H.Q., Hill, J., Chia, C.S.B.