Post Doctoral Fellow (Wan Yue’s lab)

Position Code: SC10305

Dr. Wan Yue’s laboratory at the Genome Institute of Singapore is look for a suitable candidate to join the research team. The lab is broadly interested in using biochemical and genomics approaches to study how RNA structures impact RNA function in the cell. How an RNA folds into its secondary and tertiary structure is crucial for its function. While traditionally RNA structures are studied in a low throughput manner, recent advances in high throughput sequencing has enabled the simultaneous determination of thousands of RNA secondary structures in solution. This greatly expands the ability to study RNA structural organization in the cell and how this organization impacts gene regulation. Being one of the first to develop high throughput RNA structure probing, the lab is highly interested in utilizing and extending existing high throughput approaches to understand how RNAs function in microbial and mammalian systems(Kertesz et al., 2010; Wan et al., 2011; Wan et al., 2012; Wan et al., 2014).

Requirements :

We are seeking a highly motivated and independent postdoctoral fellow with a proven academic track record and interest in interdisciplinary research. The successful candidate should have a Ph.D in molecular and cellular biology, biochemistry, genetics or related field and have rich experience in RNA biology, cell biology and genomics. The postdoc will have opportunities to interact closely with bioinformaticians and other research groups in the Genome Institute of Singapore.

Interested candidates should submit a detailed CV to Dr. Wan Yue ( and a research statement of why you are interested in joining us. Shortlisted candidates will be required to submit three reference letters.

Reference List

Kertesz, M.*, Wan, Y.*, Mazor, E., Rinn, J.L., Nutter, R.C., Chang, H.Y., and Segal, E. (2010). Genome-wide measurement of RNA secondary structure in yeast. Nature 467, 103-107. *equal contribution Wan, Y., Kertesz, M., Spitale, R.C., Segal, E., and Chang, H.Y. (2011). Understanding the transcriptome through RNA structure. Nat. Rev. Genet. 12, 641-655. Wan, Y., Qu, K., Ouyang, Z., Kertesz, M., Li, J., Tibshirani, R., Makino, D.L., Nutter, R.C., Segal, E., and Chang, H.Y. (2012). Genome-wide Measurement of RNA Folding Energies. Mol. Cell 48, 169-181. Wan, Y.*, Qu, K.*, Zhang, Q.C., Flynn, R.A., Manor, O., Ouyang, Z., Zhang, J., Spitale, R.C., Snyder, M.P., Segal, E., and Chang, H.Y. (2014). Landscape and variation of RNA secondary structure across the human transcriptome. Nature 505, 706-709. *equal contribution

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice.

* We regret that only shortlisted candidates will be notified.

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