Yun Shen Winston Chan, Ph.D.
Programme Manager
chanysw@gis.a-star.edu.sg
RESEARCH FOCUS
 

Stem cells are prized for their self-renewing capacity and their ability to generate progeny cells. This invaluable cell tool allows scientist to generate cell types of interest for broad applications from disease modeling and replacement therapy to drug screening and toxicological studies. The central goal of our study is to utilize stem cells to generate in vitro models of various human diseases to identify molecular cornerstones for drug discovery. We aim to utilize both adult and pluripotent stem cells to generate mini organ-like cultures known as organoids. Coupled with genome editing tools such as the CRISPR-CAS system, we aim to generate organoid models for various human diseases in a dish. We will perform high throughput genetic and small molecule screens with these human models to identify key modulators of human diseases. This knowledge will establish the foundations for future development of therapeutic approaches.

**Postdocs, Bioinformaticians and Students with an interest in Stem Cell biology and Metabolic Diseases are welcome to contact for opportunities**

COMPLETE PUBLICATION LIST

Göke J, Lu X, Chan YS, Ng HH, Ly LH, Sachs F, Szczerbinska I "Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells." Cell Stem Cell 2015 Feb 05 ; 16(2) : 135-41
Abstract
 
Ho L, Tan SY, Wee S, Wu Y, Tan SJ, Ramakrishna NB, Chng SC, Nama S, Szczerbinska I, Sczerbinska I, Chan YS, Avery S, Tsuneyoshi N, Ng HH, Gunaratne J, Dunn NR, Reversade B "ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway." Cell Stem Cell 2015 Oct 01 ; 17(4) : 435-47
Abstract
 
Gonzales KA, Liang H, Lim YS, Chan YS, Yeo JC, Tan CP, Gao B, Le B, Tan ZY, Low KY, Liou YC, Bard F, Ng HH "Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways." Cell 2015 Jul 30 ; 162(3) : 564-79
Abstract
 
Chan YS, Göke J, Lu X, Venkatesan N, Feng B, Su IH, Ng HH "A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming." Stem Cells 2013 Apr ; 31(4) : 682-92
Abstract
 
Göke J, Chan YS, Yan J, Vingron M, Ng HH "Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells." Mol Cell 2013 Jun 27 ; 50(6) : 844-55
Abstract
 
Chan YS, Göke J, Ng JH, Lu X, Gonzales KA, Tan CP, Tng WQ, Hong ZZ, Lim YS, Ng HH "Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast." Cell Stem Cell 2013 Dec 05 ; 13(6) : 663-75
Abstract
 
Chan YS, Yang L, Ng HH "Transcriptional regulatory networks in embryonic stem cells." Prog Drug Res 2011 ; 67 : 239-52
Abstract
 
Kunarso G, Chia NY, Jeyakani J, Hwang C, Lu X, Chan YS, Ng HH, Bourque G "Transposable elements have rewired the core regulatory network of human embryonic stem cells." Nat Genet 2010 Jul ; 42(7) : 631-4
Abstract
 
Chia NY, Chan YS, Feng B, Lu X, Orlov YL, Moreau D, Kumar P, Yang L, Jiang J, Lau MS, Huss M, Soh BS, Kraus P, Li P, Lufkin T, Lim B, Clarke ND, Bard F, Ng HH "A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity." Nature 2010 Nov 11 ; 468(7321) : 316-20
Abstract
 
Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, Robson P, Zhong S, Ng HH "A core Klf circuitry regulates self-renewal of embryonic stem cells." Nat Cell Biol 2008 Mar ; 10(3) : 353-60
Abstract