Kern Rei Chng, Ph.D.
Programme Manager
CHNG_Kern_Rei@gis.a-star.edu.sg
RESEARCH FOCUS
 

The human body is constantly challenged with trillions of microbes and their metabolic outputs. Microbial life has co-evolved with human host since prehistory. This deep symbiotic relationship clearly meant that microbiome status will have an outstanding impact on human health and well-being. I am interested in the development and the application of experimental tools for generating and analyzing high throughput datasets to inform the biology of this noteworthy relationship, ultimately enabling rational interventions that modify and modulate microbiome to improve human health.
COMPLETE PUBLICATION LIST

Zhang Z#, Chng KR#, Lingadahalli S#, Chen Z, Liu MH, Do HH, Cai S, Rinaldi N, Poh HM, Li G, Sung Y, Heng CL, Core LJ, Tan SK, Ruan XA, Lis JT, Kellis M, Ruan Y, Sung WK, Cheung E "An AR-ERG transcriptional signature defined by long range chromatin interactomes in prostate cancer cells." Genome Res 2019 Jan 03 #Equal Contributions
Abstract
 
Yip LY, Aw CC, Lee SH, Hong YS, Ku HC, Xu WH, Chan JMX, Cheong EJY, Chng KR, Ng AHQ, Nagarajan N, Mahendran R, Lee YK, Browne ER, Chan ECY "The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat." Hepatology 2018 01 ; 67(1) : 282-295
Abstract
 
Chng KR, Tay AS, Li C, Ng AH, Wang J, Suri BK, Matta SA, McGovern N, Janela B, Wong XF, Sio YY, Au BV, Wilm A, De Sessions PF, Lim TC, Tang MB, Ginhoux F, Connolly JE, Lane EB, Chew FT, Common JE, Nagarajan N "Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare." Nat Microbiol 2016 Jul 11 ; 1(9) : 16106
Abstract
 
Chng KR, Chan SH, Ng AHQ, Li C, Jusakul A, Bertrand D, Wilm A, Choo SP, Tan DMY, Lim KH, Soetinko R, Ong CK, Duda DG, Dima S, Popescu I, Wongkham C, Feng Z, Yeoh KG, Teh BT, Yongvanit P, Wongkham S, Bhudhisawasdi V, Khuntikeo N, Tan P, Pairojkul C, Ngeow J, Nagarajan N "Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma." EBioMedicine 2016 Jun ; 8 : 195-202
Abstract
 
Li C#, Chng KR#, Boey EJ, Ng AH, Wilm A, Nagarajan N "INC-Seq: accurate single molecule reads using nanopore sequencing." Gigascience 2016 08 02 ; 5(1) : 34 #Equal Contributions
Abstract
 
Li C, Lim KM, Chng KR, Nagarajan N "Predicting microbial interactions through computational approaches." Methods 2016 06 01 ; 102 : 12-9
Abstract
 
Lim KM, Li C, Chng KR, Nagarajan N "@MInter: automated text-mining of microbial interactions." Bioinformatics 2016 10 01 ; 32(19) : 2981-7
Abstract
 
Bertrand D#, Chng KR#, Sherbaf FG#, Kiesel A, Chia BK, Sia YY, Huang SK, Hoon DS, Liu ET, Hillmer A, Nagarajan N "Patient-specific driver gene prediction and risk assessment through integrated network analysis of cancer omics profiles." Nucleic Acids Res 2015 Apr 20 ; 43(7) : e44 #Equal Contributions
Abstract
 
Wang S, Chng KR, Chen C, Bedard DL, He J "Genomic Characterization of Dehalococcoides mccartyi Strain JNA That Reductively Dechlorinates Tetrachloroethene and Polychlorinated Biphenyls." Environ Sci Technol 2015 Dec 15 ; 49(24) : 14319-25
Abstract
 
Wang S#, Chng KR#, Wilm A, Zhao S, Yang KL, Nagarajan N, He J "Genomic characterization of three unique Dehalococcoides that respire on persistent polychlorinated biphenyls." Proc Natl Acad Sci U S A 2014 Aug 19 ; 111(33) : 12103-8 #Equal Contributions
Abstract
 
Wang S, Chng KR, Wu C, Wilm A, Nagarajan N, He J "Draft Genome Sequence of Polychlorinated Biphenyl-Dechlorinating Dehalococcoides mccartyi Strain SG1, Which Carries a Circular Putative Plasmid." Genome Announc 2014 Oct 02 ; 2(5) :
Abstract
 
Chng KR, Cheung E "Sequencing the transcriptional network of androgen receptor in prostate cancer." Cancer Lett 2013 Nov 01 ; 340(2) : 254-60
Abstract
 
Chng KR, Chang CW, Tan SK, Yang C, Hong SZ, Sng NY, Cheung E "A transcriptional repressor co-regulatory network governing androgen response in prostate cancers." EMBO J 2012 Jun 13 ; 31(12) : 2810-23
Abstract
 
Tan PY, Chang CW, Chng KR, Wansa KD, Sung WK, Cheung E "Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival." Mol Cell Biol 2012 Jan ; 32(2) : 399-414
Abstract
 
Tan SK#, Lin ZH#, Chang CW, Varang V, Chng KR, Pan YF, Yong EL, Sung WK, Sung WK, Cheung E "AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription." EMBO J 2011 May 13 ; 30(13) : 2569-81 #Equal Contributions
Abstract