FACULTY MEMBER

Jonathan GÖKE

Senior Research Scientist

RESEARCH


➡️Visit the lab website of Jonathan Göke for latest news on publications, preprints, conference talks and job offers.



Even though all cells of the human body essentially share the same genetic information, the cell types that form the organs and tissues appear very diverse and have distinct properties. The central question of our research is what determines the identity of mammalian cells during development and differentiation; and how cellular identity is impaired in disease. We investigate transcript diversity, alternative splicing, gene regulation, and epigenetics to identify key elements and mechanisms involved in maintenance and conversion of cellular identities. Using machine learning techniques, we study the role of DNA sequence in regulation of cell-type specific expression signatures. We are closely collaborating with wet labs to translate computational models to cellular phenotypes.

PhD projects available starting in August 2018. Highly motivated students with a background in bioinformatics, statistics or computer science are welcome to contact Jonathan Göke.


In the Media
PBS Nova Next (10/2016): The Viruses That Made Us Human
Inside Science (2/2015): Ancient Viral Invaders May Affect Modern Human Embryo Development
National Geographic (4/2014): Ancient Virus DNA Gives Stem Cells the Power to Transform
A*STAR Research (1/2014): Regulating stem cell behavior
Channel News Asia (12/2013): Singapore scientists make breakthrough in regenerative medicine
Today (12/2013): A*STAR scientists find better way to engineer human stem cells
Asian Scientist (12/2013): Researchers Convert Human Embryonic Stem Cells Into Blastocyst-Like Cells

KEY ACHIEVEMENTS

  • 2014 GIS Fellow

    2013 Best Poster Award, EMS Autumn School on Computational Aspects of Gene Regulation

    2012-2014 Postdoctoral Fellowship, German Academic Exchange Service (DAAD), Genome Institute of Singapore

    2007 Research Fellowship, German Academic Exchange Service (DAAD), Stanford University

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