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SMCHD1 gene identified as a key player in nasal development | 11 Jan 2017
The absence of the development of a nose has been linked to loss-of-function mutations in the epigenetic regulator gene SMCHD1. As part of an international collaboration, a team of A*STAR scientists from the Institute of Medical Biology, Institute of Molecular and Cell Biology, Genome Institute of Singapore collaborated with researchers from the Institut Imagine, University Medical Center Göttingen and The Walter and Eliza Hall Institute of Medical Research. This discovery has the potential to develop into therapeutics for facioscapulohumeral muscular dystrophy (FSHD) type 2.
Cell-ebrate Science Imaging Contest | 07 Mar 2017
Staff from the IMB Microscopy Unit (IMU), Jaron Liu (alumni) and Sudha Thankiah, have won the ThermoFisher Scientific Cell-ebrate Science Imaging Contest with their superresolution microscopy image of filopodia-like protrusions in N!E-115 neuroblastoma cells, acquired on the DeltaVision OMX microscope.
Real-time imaging in zebrafish embryos reveal Pou5f3–Nanog complexes driving dorsoventral mesendoderm organization | 12 May 2017
Using latest imaging technologies, a team from A*STAR’s Institute of Medical Biology and Institute of Molecular and Cell Biology show how the gene-regulating proteins Pou5f3 and Nanog regulates mesendoderm differentiation at the blastula stage. Their work highlights the precise intricacies of molecular events behind the initiation of embryonic differentiation in zebrafish.
GASTRIC CANCER DRIVEN BY LGR5-EXPRESSING CHIEF CELLS | 07 Jun 2017
A breakthrough discovery by Nick Barker's group at Institute of Medical Biology, A*STAR found that LGR5-expressing chief cells are a major source of gastric cancer. A new population of Lgr5-labeled cells were identified in the corpus of the stomach and found to be recruited to function as stem cells during injury repair. However, with mutations these same cells can lead to gastric cancer. Featured in the news and highlighted in Nature Cell BiologyNature Reviews Gastroenterology & Hepatology, EMBO JournalThe Scientists and Stem Cells Daily.
Preeclampsia hormone discovered | 03 Jul 2017
Bruno Reversade’s research team at the Institute of Medical Biology, A*STAR, have made an exciting new discovery on the importance of the ELABELA micropeptide in preventing preeclampsia. The study, published in the journal Science, shows that ELABELA protects against proteinuria and hypertension, two hallmarks of preeclampsia. Featured as a Perspective in Science, in The Scientist, MedicalXpress and PharmaAsia.
Beautiful Science - Straits Times | 18 Aug 2017
An image from Nick Barker's recent Nature Cell Biology paper has been featured as the Straits Times 'Beautiful Science' image.