Publications

Publications

GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation.

Chia CY, Madrigal P, Denil SLIJ, Martinez I, Garcia-Bernardo J, El-Khairi R, Chhatriwala M, Shepherd MH, Hattersley AT, Dunn NR, Vallier L. Stem Cell Reports. 2019 Jan 8;12(1):57-70. doi: 10.1016/j.stemcr.2018.12.003.

Insights into atopic dermatitis gained from genetically defined mouse models.

Nakajima S, Nomura T, Common J, Kabashima K. J Allergy Clin Immunol. 2019 Jan;143(1):13-25. doi: 10.1016/j.jaci.2018.11.014.

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding.

Zhong FL, Robinson K, Teo DET, Tan KY, Lim C, Harapas CR, Yu CH, Xie WH, Sobota RM, Au VB, Hopkins R, D'Osualdo A, Reed JC, Connolly JE, Masters SL, Reversade B. J Biol Chem. 2018 Dec 7;293(49):18864-18878. doi: 10.1074/jbc.RA118.004350.

Cancer: the dark side of wound healing.

Sundaram GM, Quah S, Sampath P. FEBS J. 2018 Dec;285(24):4516-4534. doi: 10.1111/febs.14586.

Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation.

Corley SM, Mendoza-Reinoso V, Giles N, Singer ES, Common JE, Wilkins MR, Beverdam A. Cell Death Dis. 2018 Oct 31;9(11):1106. doi: 10.1038/s41419-018-1141-5.

Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction.

Tamborrini D, Juanes MA, Ibanes S, Rancati G, Piatti S. Nat Commun. 2018 Oct 17;9(1):4308. doi: 10.1038/s41467-018-06767-0

Novel mutations in the ciliopathy-associated gene CPLANE1 (C5orf42) cause OFD syndrome type VI rather than Joubert syndrome.

Bonnard C, Shboul M, Tonekaboni SH, Ng AYJ, Tohari S, Ghosh K, Lai A, Lim JY, Tan EC, Devisme L, Stichelbout M, Alkindi A, Banu N, Yüksel Z, Ghoumid J, Elkhartoufi N, Boutaud L, Micalizzi A, Brett MS, Venkatesh B, Valente EM, Attié-Bitach T, Reversade B, Kariminejad A. Eur J Med Genet. 2018 Oct;61(10):585-595. doi: 10.1016/j.ejmg.2018.03.012.

A user-interactive algorithm quantifying nuclear pore complex distribution within the nuclear lamina network in single molecular localization microscopic image

Lim JSY, Wright GD, Burke B, Xie W. Methods. 2018 Sep 27. pii: S1046-2023(18)30137-3. doi: 10.1016/j.ymeth.2018.09.006

Carcinoma Cells Reprogram a Wound-healing Switch to Promote Metastasis.

Sundaram GM, Sampath P. Mol Cell Oncol. 2018 Sep 20;5(6):e1432255. doi: 10.1080/23723556.2018.1432255.

Low-dose calcipotriol can elicit wound closure, anti-microbial, and anti-neoplastic effects in epidermolysis bullosa keratinocytes.

Guttmann-Gruber C, Tockner B, Scharler C, Hüttner C, Common JE, Tay ASL, Denil SLIJ, Klausegger A, Trost A, Breitenbach J, Schnitzhofer P, Hofbauer P, Wolkersdorfer M, Diem A, Laimer M, Strunk D, Bauer JW, Reichelt J, Lang R, Piñón Hofbauer J. Sci Rep. 2018 Sep 7;8(1):13430. doi: 10.1038/s41598-018-31823-6.

Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects.

He Q, Au B, Kulkarni M, Shen Y, Lim KJ, Maimaiti J, Wong CK, Luijten MNH, Chong HC, Lim EH, Rancati G, Sinha I, Fu Z, Wang X, Connolly JE, Crasta KC. Oncogenesis. 2018 Aug 15;7(8):62. doi: 10.1038/s41389-018-0072-4

Polyamine regulator AMD1 promotes cell migration in epidermal wound healing

Kheng LH, Rahim AB, Leo VI, Shatarupa D, Lim TC, Uemura T, Igarashi K, Common J, Vardy LA. J Invest Dermatol. 2018 Jun 12. pii: S0022-202X(18)32058-X. doi: 10.1016/j.jid.2018.05.029

Cancer: a CINful evolution.

Targa A, Rancati G. Curr Opin Cell Biol. 2018 Jun;52:136-144. doi: 10.1016/j.ceb.2018.03.007

Exome sequencing and rare variant analysis reveals multiple filaggrin mutations in Bangladeshi atopic eczema families and additional risk genes

Pigors M, Common JEA, Wong XFCC, Malik S, Scott CA, Tabarra N, Liany H, Liu J, Limviphuvadh V, Maurer-Stroh S, Tang MB, Lench N, Margolis DJ, van Heel DA, Mein CA, Novak N, Baurecht H, Weidinger S, McLean WHI, Irvine AD, O'Toole EA, Simpson MA, Kelsell DP. J Invest Dermatol. 2018 May 29. pii: S0022-202X(18)31990-0. doi: 10.1016/j.jid.2018.05.013

Tiled array-based sequencing identifies enrichment of loss-of-function variants in the highly homologous filaggrin gene in African American children with severe atopic dermatitis

Mathyer ME, Quiggle AM, Wong XFCC, Denil SLIJ, Kumar MG, Ciliberto HM, Bayliss SJ, Common JE, de Guzman Strong C. Exp Dermatol. 2018 May 23. doi: 10.1111/exd.13691

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaeminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B. Nature. 2018 May 16. doi: 10.1038/s41586-018-0118-y

Role of Lgr5-Expressing Stem Cells in Epithelial Renewal and Cancer in the Reproductive Tract.

Ng A, Barker N. Cell Biology of the Ovary. 2018 May;45-59. doi: 10.1007/978-981-10-7941-2_4.

Reduced microbial diversity is a feature of recessive dystrophic epidermolysis bullosa involved skin and wounds

Fuentes I, Guttmann-Gruber C, Ling Tay AS, Hofbauer JP, Denil SLIJ, Reichelt J, Palisson F, Common JEA, South AP. J Invest Dermatol. 2018 May 10. pii: S0022-202X(18)31963-8. doi: 10.1016/j.jid.2018.04.026

Recent Advances in Lgr5(+) Stem Cell Research

Leung C, Tan SH, Barker N. Trends Cell Biol. 2018 May;28(5):380-391. doi: 10.1016/j.tcb.2018.01.010

Directed differentiation of periocular mesenchyme from human embryonic stem cells.

Lovatt M, Yam GH, Peh GS, Colman A, Dunn NR, Mehta JS. Differentiation. 2018 Jan - Feb;99:62-69. doi: 10.1016/j.diff.2017.11.003

MINDY1 is a Downstream Target of the Polyamines and Promotes Embryonic Stem Cell Self-Renewal

James C, Zhao TY, Rahim A, Saxena P, Muthalif NA, Uemura T, Tsuneyoshi N, Ong S, Igarashi K, Lim CY, Dunn NR, Vardy LA. Stem Cells. 2018 Apr 12. doi: 10.1002/stem.2830

Dual Role of the Anaphase Promoting Complex/Cyclosome in Regulating Stemness and Differentiation in Human Primary Keratinocytes.

Quek LS, Grasset N, Jasmen JB, Robinson KS, Bellanger S. J Invest Dermatol. 2018 Mar 8. pii:S0022-202X(18)30214-8. doi: 10.1016/j.jid.2018.02.033

Xanthine Oxidoreductase: A Novel Therapeutic Target for the Treatment of Chronic Wounds?

Fernandez ML, Stupar D, Croll T, Leavesley D, Upton Z. Adv Wound Care (New Rochelle). 2018 Mar 1;7(3):95-104. doi: 10.1089/wound.2016.0724

Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells

Ong ST, Chalasani MLS, Fazil, MHUT, Prasannan P, Kizhakeyil A, Wright GD, Kelleher, D, Verma NK. Frontiers in Immunology 2018 9:397

Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis.

Tan Z, Chu ZV, Chan YJA, Lu YE, Rancati G. Scientific Reports. 2018 Feb 13;8(1):2890. doi:10.1038/s41598-018-20186-7

Imaging of native transcription factors and histone phosphorylation at high resolution in live cells

Conic S, Desplancq D, Ferrand A, Fischer V, Heyer V, Reina San Martin B, Pontabry J, Oulad-Abdelghani M, Babu N K, Wright GD, Molina N, Weiss E, Tora L. J Cell Biol. 2018 Feb 12. pii: jcb.201709153. doi: 10.1083/jcb.201709153.

Stem cells in 2017: Digesting recent stem cell advances in the gut.

Barker N. Nat Rev Gastroenterol Hepatol. 2018 Feb;15(2):78-80. doi: 10.1038/nrgastro.2017.176

Wnt Signaling in Adult Epithelial Stem Cells and Cancer

Tan SH, Barker N. Prog Mol Biol Transl Sci. 2018 Jan;153:21-79. doi: 10.1016/bs.pmbts.2017.11.017

Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer.

Huang KK, Ramnarayanan K, Zhu F, Srivastava S, Xu C, Tan ALK, Lee M, Tay S, Das K, Xing M, Fatehullah A, Alkaff SMF, Lim TKH, Lee J, Ho KY, Rozen SG, Teh BT, Barker N, Chia CK, Khor C, Ooi CJ, Fock KM, So J, Lim WC, Ling KL, Ang TL, Wong A, Rao J, Rajnakova A, Lim LG, Yap WM, Teh M, Yeoh KG, Tan P. Cancer Cell. 2018 Jan 8;33(1):137-150.e5. doi: 10.1016/j.ccell.2017.11.018

KIAA1109 Variants Are Associated with a Severe Disorder of Brain Development and Arthrogryposis

Gueneau L, Fish RJ, Shamseldin HE, Voisin N, Tran Mau-Them F, Preiksaitiene E,Monroe GR, Lai A, Putoux A, Allias F, Ambusaidi Q, Ambrozaityte L, Cimbalistienė L, Delafontaine J, Guex N, Hashem M, Kurdi W, Jamuar SS, Ying LJ, Bonnard C, Pippucci T, Pradervand S, Roechert B, van Hasselt PM, Wiederkehr M, Wright CF; DDD Study, Xenarios I, van Haaften G, Shaw-Smith C, Schindewolf EM, Neerman-Arbez M, Sanlaville D, Lesca G, Guibaud L, Reversade B, Chelly J, Kučinskas V, Alkuraya FS, Reymond A. Am J Hum Genet. 2018 Jan 4;102(1):116-132. doi: 10.1016/j.ajhg.2017.12.002

The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy

Vincan E, Schwab RHM, Flanagan DJ, Moselen JM, Tran BM, Barker N, Phesse TJ. Prog Mol Biol Transl Sci. 2018 Jan;153:299-319. doi: 10.1016/bs.pmbts.2017.11.009

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.

Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B. Science. 2017 Aug 18;357(6352):707-713. doi: 10.1126/science.aam6607

Retention of the Structure and Function of Heparan Sulfate Biomaterials After Gamma Irradiation

Smith RAA, Chua RJE, Carnachan SM, Tan CLL, Sims IM, Hinkley SFR, Nurcombe V, Cool SM. Tissue Eng Part A. 2017 Nov 30. doi: 10.1089/ten.TEA.2017.0263.

The flexibility and dynamics of the tubules in the endoplasmic reticulum

Georgiades P, Allan VJ, Wright GD, Woodman PG, Udommai P, Chung MA, Waigh TA. Sci Rep. 2017 Nov 28;7(1):16474. doi: 10.1038/s41598-017-16570-4

Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin

Wang AS, Ong PF, Chojnowski A, Clavel C, Dreesen O. Sci Rep. 2017 Nov 15;7(1):15678. doi: 10.1038/s41598-017-15901-9

C/EBPβ mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas

Di Pascale F, Nama S, Muhuri M, Quah S, Ismail HM, Chan XHD, Sundaram GM, Ramalingam R, Burke B, Sampath P. Nucleic Acids Res. 2017 Nov 10. doi: 10.1093/nar/gkx1105

5-Methylcytosine RNA Methylation in Arabidopsis Thaliana

Cui X, Liang Z, Shen L, Zhang Q, Bao S, Geng Y, Zhang B, Leo V, Vardy LA, Lu T, Gu X, Yu H. Mol Plant. 2017 Nov 6;10(11):1387-1399. doi: 10.1016/j.molp.2017.09.013

Emerging and evolving concepts in gene essentiality

Rancati G, Moffat J, Typas A, Pavelka N. Nat Rev Genet. 2018 Jan;19(1):34-49. doi: 10.1038/nrg.2017.74

Genetic and Epigenetic Profiling Reveals EZH2-mediated Down Regulation of OCT-4 Involves NR2F2 during Cardiac Differentiation of Human Embryonic Stem Cells

Pursani V, Pethe P, Bashir M, Sampath P, Tanavde V, Bhartiya D. Sci Rep. 2017 Oct 12;7(1):13051. doi: 10.1038/s41598-017-13442-9

Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells

Gimpel P, Lee YL, Sobota RM, Calvi A, Koullourou V, Patel R, Mamchaoui K, Nédélec F, Shackleton S, Schmoranzer J, Burke B, Cadot B, Gomes ER. Curr Biol. 2017 Oct 9;27(19):2999-3009.e9. doi: 10.1016/j.cub.2017.08.031

Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants.

Wong XFCC, Denil SLIJ, Foo JN, Chen H, Tay ASL, Haines RL, Tang MBY, McLean WHI, Sandilands A, Smith FJD, Lane EB, Liu J, Common JEA. J Allergy Clin Immunol. 2017 Oct 19. pii: S0091-6749(17)31588-9. doi: 10.1016/j.jaci.2017.10.001.

High-Performance Nano-Photoinitiators with Improved Safety for 3D Printing

Han Y, Wang F, Lim CY, Chi H, Chen D, Wang F, Jiao X. ACS Appl Mater Interfaces. 2017 Sep 27;9(38):32418-32423. doi: 10.1021/acsami.7b08399

ENPP1 Mutation Causes Recessive Cole Disease by Altering Melanogenesis

Chourabi M, Liew MS, Lim S, H'mida-Ben Brahim D, Boussofara L, Dai L, Wong PM, Foo JN, Sriha B, Robinson KS, Denil S, Common JE, Mamaï O, Ben Khalifa Y, Bollen M, Liu J, Denguezli M, Bonnard C, Saad A, Reversade B. J Invest Dermatol. 2017 Sep 27. pii: S0022-202X(17)32982-2. doi: 10.1016/j.jid.2017.08.045

Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells

Yap L, Murali S, Bhakta G, Titmarsh DM, Chen AK, Chiin Sim L, Bardor M, Lim YM, Goh JCH, Oh SKW, Choo ABH, van Wijnen AJ, Robinson DE, Whittle JD, Birch WR, Short RD, Nurcombe V, Cool SM. J Biomed Mater Res B Appl Biomater. 2017 Sep 20. doi: 10.1002/jbm.b.33999.

Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma

Tan DSW, Chong FT, Leong HS, Toh SY, Lau DP, Kwang XL, Zhang X, Sundaram GM, Tan GS, Chang MM, Chua BT, Lim WT, Tan EH, Ang MK, Lim TKH, Sampath P, Chowbay B, Skanderup AJ, DasGupta R, Iyer NG. Nat Med. 2017 Oct;23(10):1167-1175. doi: 10.1038/nm.4401

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.

Windpassinger C, Piard J, Bonnard C, Alfadhel M, Lim S, Bisteau X, Blouin S, Ali NB, Ng AYJ, Lu H, Tohari S, Talib SZA, van Hul N, Caldez MJ, Van Maldergem L, Yigit G, Kayserili H, Youssef SA, Coppola V, de Bruin A, Tessarollo L, Choi H, Rupp V, Roetzer K, Roschger P, Klaushofer K, Altmüller J, Roy S, Venkatesh B, Ganger R, Grill F, Ben Chehida F, Wollnik B, Altunoglu U, Al Kaissi A, Reversade B, Kaldis P. Am J Hum Genet. 2017 Sep 7;101(3):391-403. doi: 10.1016/j.ajhg.2017.08.003

A fence barrier method of leading edge cell capture for explorative biochemical research

Wager LJ, Murray RZ, Thompson EW, Leavesley DI. Cell Adh Migr. 2017 Sep 3;11(5-6):496-503. doi: 10.1080/19336918.2016.1269997

Myeloid-epithelial cross talk coordinates synthesis of the tissue-protective cytokine leukemia inhibitory factor during pneumonia

Traber KE, Symer EM, Allen E, Kim Y, Hilliard KL, Wasserman GA, Stewart CL, Jones MR, Mizgerd JP, Quinton LJ. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L548-L558. doi: 10.1152/ajplung.00482.2016

MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease

Martinez EC, Lilyanna S, Wang P, Vardy LA, Jiang X, Armugam A, Jeyaseelan K, Richards AM. J Mol Cell Cardiol. 2017 Nov;112:27-39. doi: 10.1016/j.yjmcc.2017.08.013

Modeling the Structure of Keratin 1 and 10 Terminal Domains and their Misassembly in Keratoderma.

Badowski C, Sim AYL, Verma C, Szeverényi I, Natesavelalar C, Terron-Kwiatkowski A, Harper J, O'Toole EA, Lane EB. J Invest Dermatol. 2017 Sep;137(9):1914-1923. doi: 10.1016/j.jid.2017.03.038

Human reconstructed skin xenografts on mice to model skin physiology

Salgado G, Ng YZ, Koh LF, Goh CSM, Common JE. Differentiation. 2017 Sep 14;98:14-24. doi: 10.1016/j.diff.2017.09.004.

PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling

Mzoughi S, Zhang J, Hequet D, Teo SX, Fang H, Xing QR, Bezzi M, Seah MKY, Ong SLM, Shin EM, Wollmann H, Wong ESM, Al-Haddawi M, Stewart CL, Tergaonkar V, Loh YH, Dunn NR, Messerschmidt DM, Guccione E. Nat Genet. 2017 Sep;49(9):1354-1363. doi: 10.1038/ng.3922

Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts

Sharma B, Ho L, Ford GH, Chen HI, Goldstone AB, Woo YJ, Quertermous T, Reversade B, Red-Horse K. Dev Cell. 2017 Aug 31. pii: S1534-5807(17)30636-6. doi: 10.1016/j.devcel.2017.08.008

EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis

Sundaram GM, Ismail HM, Bashir M, Muhuri M, Vaz C, Nama S, Ow GS, Vladimirovna IA, Ramalingam R, Burke B, Tanavde V, Kuznetsov V, Lane EB, Sampath P. J Exp Med. 2017 Oct 2;214(10):2889-2900. doi: 10.1084/jem.20170354

Physiological Doses of Red Light Induce IL-4 Release in Cocultures between Human Keratinocytes and Immune Cells.

Leong C, Bigliardi PL, Sriram G, Au VB, Connolly J, Bigliardi-Qi M. Photochem Photobiol. 2017 Aug 1. doi: 10.1111/php.12817

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.

Flanagan DJ, Barker N, Nowell C, Clevers H, Ernst M, Phesse TJ, Vincan E. Dis Model Mech. 2017 Aug 1;10(8):971-980. doi: 10.1242/dmm.029876

Povidone iodine in wound healing: A review of current concepts and practices.

Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA. Int J Surg. 2017 Aug;44:260-268. doi: 10.1016/j.ijsu.2017.06.073

Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles.

Reiner AT, Witwer KW, van Balkom BWM, de Beer J, Brodie C, Corteling RL, Gabrielsson S, Gimona M, Ibrahim AG, de Kleijn D, Lai CP, Lötvall J, Del Portillo HA, Reischl IG, Riazifar M, Salomon C, Tahara H, Toh WS, Wauben MHM, Yang VK, Yang Y, Yeo RWY, Yin H, Giebel B, Rohde E, Lim SK. Stem Cells Transl Med. 2017 Aug;6(8):1730-1739. doi: 10.1002/sctm.17-0055

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice

Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B. Science. 2017 Aug 18;357(6352):707-713. doi: 10.1126/science.aam6607

Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire

Lemasters JJ, Ramshesh VK, Lovelace GL, Lim J, Wright GD, Harland D, Dawson TL Jr. J Invest Dermatol. 2017 Jul;137(7):1434-1444. doi: 10.1016/j.jid.2017.02.983

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease

Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C. Nat Genet. 2017 Jul;49(7):1025-1034. doi: 10.1038/ng.3871

Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis

Kwan R, Brady GF, Brzozowski M, Weerasinghe SV, Martin H, Park MJ, Brunt MJ, Menon RK, Tong X, Yin L, Stewart CL, Omary MB. Cell Mol Gastroenterol Hepatol. 2017 Jul 6;4(3):365-383. doi: 10.1016/j.jcmgh.2017.06.005

Nuclear networking

Xie W, Burke B. Nucleus. 2017 Jul 4;8(4):323-330. doi: 10.1080/19491034.2017.1296616

A Versatile Protocol for Studying Calvarial Bone Defect Healing in a Mouse Model.

Samsonraj RM, Dudakovic A, Zan P, Pichurin O, Cool SM, van Wijnen AJ. Tissue Eng Part C Methods. 2017 Nov;23(11):686-693. doi: 10.1089/ten.TEC.2017.0205.

Endogenous regeneration: Engineering growth factors for stroke.

Chan SJ, Love C, Spector M, Cool SM, Nurcombe V, Lo EH. Neurochem Int. 2017 Jul;107:57-65. doi: 10.1016/j.neuint.2017.03.024

Keratin gene mutations influence the keratinocyte response to DNA damage and cytokine induced apoptosis.

Zupancic T, Sersa G, Törmä H, Lane EB, Herrmann H, Komel R, Liovic M. Arch Dermatol Res. 2017 Jun 24. doi: 10.1007/s00403-017-1757-9

Aging in hair follicle stem cells and niche microenvironment.

Ji J, Ho BS, Qian G, Xie XM, Bigliardi PL, Bigliardi-Qi M. J Dermatol. 2017 Oct;44(10):1097-1104. doi: 10.1111/1346-8138.13897

Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells

Trott, J, Ee KT, Ong S, Titmarsh DM, Denil SLIJ, Giam M, Wong CK, Wang J, Shboul M, Eio M, Cooper-White J, Cool SM, Rancati G, Stanton LW, Reversade R, Dunn NR. Stem Cell Reports 2017 8:1675-1688. DOI: 10.1016/j.stemcr.2017.05.019

Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach

Leushacke M, Tan SH, Wong A, Swathi Y, Hajamohideen A, Tan LT, Goh J, Wong E, Denil SLIJ, Murakami K, Barker N. Nat Cell Biol. 2017 Jun 5. doi: 10.1038/ncb3541.

Investigating the potential of Oxymatrine as a psoriasis therapy

Chen Q, Zhou H, Yang Y, Chi M, Xie N, Zhang H, Deng X, Leavesley D, Shi H, Xie Y. Chem Biol Interact. 2017 Jun 1;271:59-66. doi: 10.1016/j.cbi.2017.04.020

Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure.

Cheng J, Rosario G, Cohen TV, Hu J, Stewart CL. Endocrinology. 2017 Jun 1;158(6):1916-1928. doi: 10.1210/en.2017-00103

ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.

Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K. Cardiovasc Res. 2017 Jun 1;113(7):760-769. doi: 10.1093/cvr/cvx061

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Induced by Fexofenadine.

Teo SL, Santosa A, Bigliardi PL. J Investig Allergol Clin Immunol. 2017 Jun;27(3):191-193. doi: 10.18176/jiaci.0158

EV-Associated MMP9 in High-Grade Serous Ovarian Cancer Is Preferentially Localized to Annexin V-Binding EVs

Reiner AT, Tan S, Agreiter C, Auer K, Bachmayr-Heyda A, Aust S, Pecha N, Mandorfer M, Pils D, Brisson AR, Zeillinger R, Lim SK. Dis Markers. 2017;2017:9653194. doi: 10.1155/2017/9653194

An expedient multiple information processing pattern-generating chromophore

Rout B, Bigliardi-Qi M, Bigliardi PL (2017). Sensors and Actuators, B: Chemical, 251, 164-170. DOI: 10.1016/j.snb.2017.05.046

Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing

Than UTT, Guanzon D, Leavesley D, Parker T. Int J Mol Sci. 2017 May 1;18(5). pii: E956. doi: 10.3390/ijms18050956

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes.

Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP, Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sudhaharan T, Ishiwata S, Lane EB, Chang YT, Tseng YH, Suzuki M, Raghunath M. Sci Rep. 2017 May 3;7(1):1383. doi: 10.1038/s41598-017-00291-9

Down-Regulation of PER2 Increases Apoptosis of Gliomas after X-Ray Irradiation

Yin L, Liu W, Xia H, Jia X, Leavesley D. (2017). Chemo Open Access 6:228. doi: 10.4172/2167-7700.1000228

Growth Differentiation Factor 5-Mediated Enhancement of Chondrocyte Phenotype Is Inhibited by Heparin: Implications for the Use of Heparin in the Clinic and in Tissue Engineering Applications.

Ayerst BI, Smith RA, Nurcombe V, Day AJ, Merry CL, Cool SM. Tissue Eng Part A. 2017 Apr;23(7-8):275-292. doi: 10.1089/ten.TEA.2016.0364

Affinity Selection of FGF2-Binding Heparan Sulfates for Ex Vivo Expansion of Human Mesenchymal Stem Cells.

Wijesinghe SJ, Ling L, Murali S, Qing YH, Hinkley SF, Carnachan SM, Bell TJ, Swaminathan K, Hui JH, van Wijnen AJ, Nurcombe V, Cool SM. J Cell Physiol. 2017 Mar;232(3):566-575. doi: 10.1002/jcp.25454

On the TRAIL to truth, or on a road to nowhere?

van Steensel MA. Exp Dermatol. 2017 Mar;26(3):225-226. doi: 10.1111/exd.13231

Pushing the boundaries of high content imaging

Wright GD, Ward AM, Bard F, Calvert ME. Cytometry A. 2017 Feb;91(2):113-114. doi: 10.1002/cyto.a.23063

A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus

Kumar D, Puan KJ, Andiappan AK, Lee B, Westerlaken GH, Haase D, Melchiotti R, Li Z, Yusof N, Lum J, Koh G, Foo S, Yeong J, Alves AC, Pekkanen J, Sun LD, Irwanto A, Fairfax BP, Naranbhai V, Common JE, Tang M, Chuang CK, Jarvelin MR, Knight JC, Zhang X, Chew FT, Prabhakar S, Jianjun L, Wang Y, Zolezzi F, Poidinger M, Lane EB, Meyaard L, Rötzschke O. Genome Med. 2017 Feb 20;9(1):18. doi: 10.1186/s13073-017-0404-6

Pattern-Generating Unimolecular Sensors: For Future Differential Sensing and Molecular Computing

Rout B, Bigliardi PL (2017). Synlett. 2017 Feb 16; 28(9). doi: 10.1055/s-0036-1588721

Microfluidic Screening Reveals Heparan Sulfate Enhances Human Mesenchymal Stem Cell Growth by Modulating Fibroblast Growth Factor-2 Transport

Titmarsh DM, Tan CL, Glass NR, Nurcombe V, Cooper-White JJ, Cool SM. Stem Cells Transl Med. 2017 Feb 16. doi: 10.1002/sctm.16-0343

Review of familial cerebral cavernous malformations and report of seven additional families.

de Vos IJ, Vreeburg M, Koek GH, van Steensel MA. Am J Med Genet A. 2017 Feb;173(2):338-351. doi: 10.1002/ajmg.a.38028

Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells

Havlicek S, Shen Y, Alpagu Y, Bruntraeger MB, Zufir NB, Phuah ZY, Fu Z, Dunn NR, Stanton LW. Mol Ther. 2017 Feb 1;25(2):342-355. doi: 10.1016/j.ymthe.2016.11.007.

De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development

Gordon CT, Xue S, Yigit G, Filali H, Chen K, Rosin N, Yoshiura KI, Oufadem M, Beck TJ, McGowan R, Magee AC, Altmüller J, Dion C, Thiele H, Gurzau AD, Nürnberg P, Meschede D, Mühlbauer W, Okamoto N, Varghese V, Irving R, Sigaudy S, Williams D, Ahmed SF, Bonnard C, Kong MK, Ratbi I, Fejjal N, Fikri M, Elalaoui SC, Reigstad H, Bole-Feysot C, Nitschké P, Ragge N, Lévy N, Tunçbilek G, Teo AS, Cunningham ML, Sefiani A, Kayserili H, Murphy JM, Chatdokmaiprai C, Hillmer AM, Wattanasirichaigoon D, Lyonnet S, Magdinier F, Javed A, Blewitt ME, Amiel J, Wollnik B, Reversade B. Nat Genet. 2017 Jan 9. doi: 10.1038/ng.3765.

Performing Skin Microbiome Research: A Method to the Madness.

Kong HH, Andersson B, Clavel T, Common JE, Jackson SA, Olson ND, Segre JA, Traidl-Hoffmann C. J Invest Dermatol. 2017 Jan 4. pii: S0022-202X(16)32621-5. doi: 10.1016/j.jid.2016.10.033.

Do shoot the messenger: Taking aim at RNA to treat genetic skin disorders.

van Steensel MA. Exp Dermatol. 2017 Jan;26(1):22-23. doi: 10.1111/exd.13218

Synthetic Peptide Drugs for Targeting Skin Cancer: Malignant Melanoma and Melanotic Lesions

Eberle AN, Rout B, Qi MB, Bigliardi PL. Curr Med Chem. 2017;24(17):1797-1826. doi: 10.2174/0929867324666170605105942.

GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells

Fazil MH, Ong ST, Chalasani ML, Low JH, Kizhakeyil A, Mamidi A, Lim CF, Wright GD, Lakshminarayanan R, Kelleher D, Verma NK. Sci Rep. 2016 Nov 24;6:37721. doi: 10.1038/srep37721.

Quantitative imaging reveals real-time Pou5f3-Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish

Perez-Camps M, Tian J, Chng SC, Sem KP, Sudhaharan T, Teh C, Wachsmuth M, Korzh V, Ahmed S, Reversade B. Elife. 2016 Sep 29;5. pii: e11475. doi: 10.7554/eLife.11475

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation.

Zhong FL, Mamaï O, Sborgi L, Boussofara L, Hopkins R, Robinson K, Szeverényi I, Takeichi T, Balaji R, Lau A, Tye H, Roy K, Bonnard C, Ahl PJ, Jones LA, Baker P, Lacina L, Otsuka A, Fournie PR, Malecaze F, Lane EB, Akiyama M, Kabashima K, Connolly JE, Masters SL, Soler VJ, Omar SS, McGrath JA, Nedelcu R, Gribaa M, Denguezli M, Saad A, Hiller S, Reversade B. Cell. 2016 Sep 22;167(1):187-202.e17. doi: 10.1016/j.cell.2016.09.001.

New developments and novel applications in high throughput and high content imaging

Calvert ME, Ward AM, Wright GD, Bard F. Cytometry Part A (2016) 89: 705-707. doi: 10.1002/cyto.a.22921

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, Sapkota GP, Purdie KJ, Proby CM, Harwood CA, Leigh IM, Clevers H, Barker N, Karlsson S, Pritchard C, Marais R, Chelala C, South AP, Sansom OJ, Inman GJ. Nat Commun. 2016 Aug 25;7:12493. doi: 10.1038/ncomms12493.

Characterization of a panARS-based episomal vector in the methylotrophic yeast Pichia pastoris for recombinant protein production and synthetic biology applications

Camattari A, Goh A, Yip LY, Tan AH, Ng SW, Tran A, Liu G, Liachko I, Dunham MJ, Rancati G. Microb Cell Fact. 2016 Aug 11;15(1):139. doi: 10.1186/s12934-016-0540-5

Loss-of-Function Mutations in ELMO2 Cause Intraosseous Vascular Malformation by Impeding RAC1 Signaling

Cetinkaya A, Xiong JR, Vargel İ, Kösemehmetoğlu K, Canter Hİ, Gerdan ÖF, Longo N, Alzahrani A, Camps MP, Taskiran EZ, Laupheimer S, Botto LD, Paramalingam E, Gormez Z, Uz E, Yuksel B, Ruacan Ş, Sağıroğlu MŞ, Takahashi T, Reversade B, Akarsu NA. Am J Hum Genet. 2016 Aug 4;99(2):299-317. doi: 10.1016/j.ajhg.2016.06.008

Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare

Kern Rei Chng, Angeline Su Ling Tay, Chenhao Li, Amanda Hui Qi Ng, Jingjing Wang, Bani Kaur Suri, Sri Anusha Matta, Naomi McGovern, Baptiste Janela, Xuan Fei Colin C. Wong, Yang Yie Sio, Bijin Veonice Au, Andreas Wilm, Paola Florez De Sessions, Thiam Chye Lim, Mark Boon Yang Tang, Florent Ginhoux, John E. Connolly, E. Birgitte Lane, Fook Tim Chew, John E. A. Common & Niranjan Nagarajan. Nature Microbiology 2016;1:16106. doi:10.1038/nmicrobiol.2016.106

Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells

Carlevaro-Fita J, Rahim A, Guigó R, Vardy LA, Johnson R.RNA. 2016 Jun;22(6):867-82. doi: 10.1261/rna.053561.115.

Superresolution Microscopy of the Nuclear Envelope and Associated Proteins.

Xie W, Horn HF, Wright GD. Methods Mol Biol. 2016;1411:83-97. doi: 10.1007/978-1-4939-3530-7_4

The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development

Deshwar AR, Chng SC, Ho L, Reversade B, Scott IC. Elife. 2016 Apr 14;5. pii: e13758. doi: 10.7554/eLife.13758

Organoids as an in vitro model of human development and disease

Fatehullah A, Tan SH, Barker N. Nat Cell Biol. 2016 Mar;18(3):246-54. doi: 10.1038/ncb3312.

Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium

Leushacke M, Barker N, Pin C. Sci Rep. 2016 Feb 26;6:21923. doi: 10.1038/srep21923

Adaptive Evolution: Don't Fix What's Broken

Liu G, Rancati G. Curr Biol. 2016 Feb 22;26(4):R169-71. doi: 10.1016/j.cub.2015.12.029

Analysis of mRNA Translation Rate in Mouse Embryonic Stem Cells

Rahim AB, Vardy LA. Methods Mol Biol. 2016;1341:143-55. doi: 10.1007/7651_2015_233.

Assays to Study Consequences of Cytoplasmic Intermediate Filament Mutations: The Case of Epidermal Keratins

Tan TS, Ng YZ, Badowski C, Dang T, Common JE, Lacina L, Szeverényi I, Lane EB. Methods Enzymol. 2016;568:219-53.

Direct organelle thermometry with fluorescence lifetime imaging microscopy in single myotubes

Itoh H, Arai S, Sudhaharan T, Lee SC, Chang YT, Ishiwata S, Suzuki M and Lane EB. Chem. Commun. (2016) DOI: 10.1039/C5CC09943A

Three-dimensional image analysis of the mouse cochlea.

Wright GD, Horn HF. Differentiation. 2016 Jan 16. pii: S0301-4681(16)30001-9. doi: 10.1016/j.diff.2016.01.002

Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells

Ling L, Camilleri ET, Helledie T, Samsonraj RM, Titmarsh DM, Chua RJ, Dreesen O, Dombrowski C, Rider DA, Galindo M, Lee I, Hong W, Hui JH, Nurcombe V, vanWijnen AJ, Cool SM. Gene. 2016 Jan 15;576(1 Pt 2):292-303. doi: 10.1016/j.gene.2015.10.039.

Embryonic Stem Cells Exhibit mRNA Isoform Specific Translational Regulation

Wong QW, Vaz C, Lee QY, Zhao TY, Luo R, Archer SK, Preiss T, Tanavde V, Vardy LA. PLoS One. 2016 Jan 22;11(1):e0143235. doi: 10.1371/journal.pone.0143235.

Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability

Liu G, Yong MY, Yurieva M, Srinivasan KG, Liu J, Lim JS, Poidinger M, Wright GD, Zolezzi F, Choi H, Pavelka N, Rancati G. Cell. 2015 Dec 3;163(6):1388-99. doi:10.1016/j.cell.2015.10.069

ELABELA Is an Endogenous Growth Factor that Sustains hESCSelf-Renewal via the PI3K/AKT Pathway.

Ho L, Tan SY, Wee S, Wu Y, Tan SJ, Ramakrishna NB, Chng SC, Nama S, Sczerbinska I, Chan YS, Avery S, Tsuneyoshi N, Ng HH, Gunaratne J, Dunn NR,Reversade B. Cell Stem Cell. 2015 Oct 1;17(4):435-47. doi: 10.1016/j.stem.2015.08.010.

SUN4 is essential for nuclear remodeling during mammalian spermiogenesis

Calvi A, Wong AS, Wright G, Wong ES, Han Loo T, Stewart CL, Burke B. Dev Biol. 2015 Sep 25. pii: S0012-1606(15)30200-1. doi: 10.1016/j.ydbio.2015.09.010. PubMed PMID: 26417726.

Nuclear envelope-associated endosomes deliver surface proteins to the nucleus

Chaumet A, Wright GD, Seet SH, Tham KM, Gounko NV, Bard F. Nature Communications. 2015;6:8218. doi: 10.1038/ncomms9218.

Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

Chojnowski A, Ong PF, Wong ESM, Lim JSY, Mutalif RA, Navasankari R, Dutta B, Yang H, Liow YY, Sze SK, Boudier T, Wright GD, Colman A, Burke B, Stewart CL, Dreesen O. eLife. 2015 Aug 27; 10.7554/eLife.07759

Recurrent de novo mutations affecting residue p.Arg138 of pyrroline-5-carboxylate synthase cause a novel progeroid form of autosomal dominant cutis laxa

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Intellectual disability, muscle weakness and characteristic face in three siblings: A newly described recessive syndrome mapping to 3p24.3-p25.3

Kariminejad A, Nafissi S, Nilipoor Y, Tavasoli A, Van Veldhoven PP, Bonnard C, Ng YT, Majoie CB, Reversade B, Hennekam RC. Am J Med Genet A. 2015 Jul 20. doi: 10.1002/ajmg.a.37248.

The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis

Helker CS, Schuermann A, Pollmann C, Chng SC, Kiefer F, Reversade B, Herzog W. Elife. 2015 May 27;4. doi: 10.7554/eLife.06726.

Leveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders

Brown R, Lee H, Eskin A, Kichaev G, Lohmueller KE, Reversade B, Nelson SF, Pasaniuc B. Eur J Hum Genet. 2015 Apr 22. doi: 10.1038/ejhg.2015.68

Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy

Tan CL, Teissier S, Gunaratne J, Quek LS, Bellanger S. Cell Cycle. 2015;14(9):1459-70. doi:10.1080/15384101.2015.1021519.

Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration

Bigliardi PL, Neumann C, Teo YL, Pant A, Bigliardi-Qi M. Br J Pharmacol. 2015 Jan;172(2):501-14. doi: 10.1111/bph.12687. Epub 2014 Jul 1. PubMed PMID: 24628261

A unique role for p53 in the regulation of M2 macrophage polarization

Li L, Ng DS, Mah WC, Almeida FF, Rahmat SA, Rao VK, Leow SC, Laudisi F, Peh MT, Goh AM, Lim JS, Wright GD, Mortellaro A, Taneja R, Ginhoux F, Lee CG, Moore PK, Lane DP. Cell Death Differ. 2015 Jul;22(7):1081-93. doi: 10.1038/cdd.2014.212.

Multiple self-healing palmoplantar carcinoma: a familial predisposition to skin cancer with primary palmoplantar and conjunctival lesions

Mamaï O, Boussofara L, Denguezli M, Escande-Beillard N, Kraeim W, Merriman B, Ben Charfeddine I, Stevanin G, Bouraoui S, Amara A, Mili A, Nouira R, H'mida D, Sriha B, Gribaa M, Saad A, Reversade B. J Invest Dermatol. 2015 Jan;135(1):304-8. doi: 10.1038/jid.2014.311.

PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells

Teo AK, Tsuneyoshi N, Hoon S, Tan EK, Stanton LW, Wright CV, Dunn NR. Stem Cell Reports. 2015 Apr 14;4(4):578-90. doi: 10.1016/j.stemcr.2015.02.015.

Pyoderma gangrenosum mimicking early acute infection following total knee arthroplasty

Yik JH, Bigliardi PL, Sebastin SJ, Cabucana NJ, Venkatachalam I, Krishna L. Ann Acad Med Singapore. 2015 Apr;44(4):150-1.

Zebrafish Rnf111 is encoded by multiple transcripts and is required for epiboly progression and prechordal plate development

Bessarab DA, Mathavan S, Jones CM, Ray Dunn N (22 Jan 2015) Differentiation. 2015 Jan 22. pii: S0301-4681(14)00099-1. doi: 10.1016/j.diff.2014.12.004.

The role of opioid receptors in migration and wound recovery in vitro in cultured human keratinocytes and fibroblasts

Bigliardi-Qi M1, Bigliardi PL. (2015) Methods Mol Biol. 2015;1230:273-7. doi: 10.1007/978-1-4939-1708-2_23.

Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration

Bigliardi PL, Neumann C, Teo YL, Pant A, Bigliardi-Qi M. (Jan 2015) Br J Pharmacol. 2015 Jan;172(2):501-14. doi: 10.1111/bph.12687.

Nuclear lamina remodelling and its implications for human disease

Chojnowski A, Ong PF, Dreesen O. (24 Dec 2014) Cell Tissue Res. 2014 Dec 24.

Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number.
Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number.

Hu WF, Pomp O, Ben-Omran T, Kodani A, Henke K, Mochida GH, Yu TW, Woodworth MB, Bonnard C, Raj GS, Tan TT, Hamamy H, Masri A, Shboul M, Al Saffar M, Partlow JN, Al-Dosari M, Alazami A, Alowain M, Alkuraya FS, Reiter JF, Harris MP, Reversade B, Walsh CA. Neuron. 2014 Dec 17;84(6):1240-57. doi: 10.1016/j.neuron.2014.12.017. PubMed PMID: 25521379.

Selective susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection

Cerny D, Shin A, Haniffa M, Bigliardi PL, Tan BK, Lee B, Poidinger M, Tan EY, Ginhoux F and Fink K (4 Dec 2014) PLoS Pathog. 2014 Dec 4;10(12):e1004548. doi: 10.1371/journal.ppat.1004548.

Nuclear Arc Interacts with the Histone Acetyltransferase Tip60 to Modify H4K12 Acetylation

Caroline L. Wee, Shaun Teo, Nicodemus E. Oey, Graham D. Wright, Hendrika M.A. VanDongen, Antonius M.J. VanDongen eneuro Nov 2014,DOI: 10.1523/ENEURO.0019-14.2014

Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma

Brinkhuizen T, Reinders MG, van Geel M, Hendriksen AJ, Paulussen AD, Winnepenninckx VJ, Keymeulen KB, Soetekouw PM, van Steensel MA, Mosterd K.(4 Sep 2014) J Am Acad Dermatol 71(5):1005-8. doi: 10.1016/j.jaad.2014.08.001

Immunohistochemical analysis of the mechanistic target of rapamycin and hypoxia signalling pathways in Basal cell carcinoma and trichoepithelioma

Brinkhuizen T, Weijzen CA, Eben J, Thissen MR, van Marion AM, Lohman BG, Winnepenninckx VJ, Nelemans PJ, van Steensel MA (Sep 2014). PLoS One 9(9):e106427. doi: 10.1371/journal.pone.0106427.

The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish

Young T, Poobalan Y, Tan EK, Tao S, Ong S, Wehner P, Schwenty-Lara J, Lim CY, Sadasivam A, Lovatt M, Wang ST, Ali Y, Borchers A, Sampath K, Dunn NR. 2014 Sep;141(18):3505-16.

Dynamin1 is a novel target for IRSp53 protein and works with mammalian enabled (Mena) protein and Eps8 to regulate filopodial dynamics

Chou AM, Sem KP, Wright GD, Sudhaharan T, Ahmed S.(29 Aug 2014) J Biol Chem. 2014 Aug 29;289(35):24383-96. doi: 10.1074/jbc.M114.553883.

Multiple Self-Healing Palmoplantar Carcinoma: A Familial Predisposition to Skin Cancer with Primary Palmoplantar and Conjunctival Lesions.
Multiple Self-Healing Palmoplantar Carcinoma: A Familial Predisposition to Skin Cancer with Primary Palmoplantar and Conjunctival Lesions.

Mamaï O, Boussofara L, Denguezli M, Escande-Beillard N, Kraeim W, Merriman B, Ben Charfeddine I, Stevanin G, Bouraoui S, Amara A, Mili A, Nouira R, H'mida D, Sriha B, Gribaa M, Saad A, Reversade B. J Invest Dermatol. 2014 Jul 22.

Mesenchymal stem cells secrete immunologically active exosomes

Zhang B, Yin Y, Lai RC, Tan SS, Choo AB, Lim SK. Stem Cells Dev. 2014. 23:1233-44. doi: 10.1089/scd.2013.0479.

Interaction of Fixed Number of Photons with Retinal Rod Cells.

Phan NM, Cheng MF, Bessarab DA, Krivitsky LA. Phys. Rev. Lett. 2014;112:213601

In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.

Rinkevich Y, Montoro DT, Contreras-Trujillo H, Harari-Steinberg O, Newman AM, Tsai JM, Lim X, Van-Amerongen R, Bowman A, Januszyk M, Pleniceanu O, Nusse R, Longaker MT, Weissman IL, Dekel B. Cell Rep. 2014 May 22;7(4):1270-83.

Divergent LIN28-mRNA associations result in translational suppression upon the initiation of differentiation

Tan SM, Altschuler G, Zhao TY, Ang HS, Yang H, Lim B, Vardy L, Hide W, Thomson AM, Lareu RR. Nucleic Acids Res. 2014;42(12):7997-8007.

Using dSTORM to probe the molecular architecture of filopodia

Ahmed S, Chou AM, Sem K. P., Thankiah S, Wright GD, Lim J; Srivats H (4 Mar 2014) Proceedings of SPIE: Single Molecule Spectroscopy and Superresolution Imaging VII 8950. doi:10.1117/12.2058123

E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-κ transcription in keratinocytes.

Sunthamala N, Thierry F, Teissier S, Pientong C, Kongyingyoes B, Tangsiriwatthana T, Sangkomkamhang U, Ekalaksananan T. PLoS One. 2014 Mar 10;9(3):e91473

Pruritus im Alter (Pruritus senilis)

Bigliardi PL (2014) Dermatologie Praxis, Vol 24, No2

'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing.

Sundaram GM, Common JE, Gopal FE, Srikanta S, Lakshman K, Lunny DP, Lim TC, Tanavde V, Lane EB, Sampath P. Nature. 2013 Mar 7;495(7439):103-6. doi: 10.1038/nature11890.

The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells
The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells

The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells

Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls
Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls

Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls

Neural differentiation of umbilical cord blood derived cells and applications in neurological disorders
Neural differentiation of umbilical cord blood derived cells and applications in neurological disorders

Umbilical cord blood, previously discarded, has emerged as a new source of stem cells for hematologic reconstitution, bone marrow failures and other hematologic deficiencies.

Stem Cells in Human Skin: Basic Science and Applications
Stem Cells in Human Skin: Basic Science and Applications

Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases.

From Stem cells to neurons: translating basic science into preclinical animal validation
From Stem cells to neurons: translating basic science into preclinical animal validation

Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today.

Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia
Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia

Barrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinoma. T

Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1
Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1

Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1

Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells
Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria
Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria

The segmental premature aging disease Hutchinson-Gilford Progeria (HGPS) is caused by a truncated and farnesylated form of Lamin A. In a mouse model for HGPS, a similar Lamin A variant causes the proliferative arrest and death of postnatal, but not embryonic, fibroblasts.

Viable rat-mouse chimeras: where do we go from here?
Viable rat-mouse chimeras: where do we go from here?

Viable Rat-Mouse Chimeras: Where Do We Go from Here?

A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1
A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1

Loss of fragile X mental retardation protein FMR1 is the most common genetic cause of mental deficiency in man.

A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.
A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.

Inhibition of apoptotic response of host cells during an early phase of infection is a strategy used by many enteroinvasive bacterial pathogens to enhance their survival.