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Scientist II


Soft Materials (SOF) Department

(+65) 6319 4869

2 Fusionopolis Way. Innovis, #08-03, Singapore 138634

Research Details

Food Safety technologies, e.g., portable food contamination and fraud detection systems
Translation of nanotechnologies to biomedical applications
Nanoparticle-based contrast agents for in vivo clinical imaging (e.g., MRI, CT, PET)
Nanoprobes for in vitro imaging (e.g., photothermal imaging)
Surface coating and functionalisation of nanoparticles (e.g., metal oxides, noble metals)
Organic-inorganic hybrid nanoparticles design
Biomolecular chemistry (e.g., peptide and protein chemistry)

Self-assembled monolayers (SAM) for nanoparticles coating

Nanoparticles functionalisation

Biomolecule engineering

Peptide and protein chemistry

Mass spectrometry

Electron microscopy

Peptide Coated Biocompatible and Highly Stable Superparamagnetic Iron Oxide Nanoparticles Conjugated with Anti-HER2 Antibodies for Targeted In Vivo Therapy and Diagnostic of Breast Cancer

in collaboration with SBIC, SIgN, NUH, University of Liverpool

Funding: Career Development Award Joint Council Office - A*STAR

Development of biocompatible metal nanoparticle markers for high throughput analysis of immune cells at single-cell level by mass cytometry

in collaboration with SIgN

Protein cage hybrid nanoparticles preparation and their applications

in collaboration with NTU

2014 - To-date Scientist II, Institute of Materials Research and Engineering (IMRE), A*STAR, Singapore

2010 - 2014 Scientist I, Institute of Materials Research and Engineering (IMRE), A*STAR, Singapore

2009 - 2010 Research Engineer, Max Mousseron Institute of Biomolecules (IBMM), University of Montpellier I, France

PhD in Biomolecular Engineering (Honours), University of Montpellier II, France, 2009

M.Sc in Biomolecular Chemistry (Honours), University of Montpellier II, France, 2005

B.Sc in Molecular Chemistry, University of Montpellier II, France, 2003

BTEC Higher National Diploma in Chemistry, University of Paul Sabatier, France, 2002

A*STAR Career Development Award, from A*STAR Joint Council Office, 2014

National Ph.D Scholardship, from the French Ministry of National Education, Research and Technology (MENRT), 2005

Master Merit Scholarship from the French State Higher Education Scholarship (CROUS), 2004

Member of IMRE Talent Development Committee
Member of the organisational committee of 5th Molecular Materials Meeting, Singapore, 2015
Member of the organisational committee of Asian Nano Forum, Singapore, 2015
Member of the organisational committee of IMRE Scientific Forum 2013, Singapore
Member of the Materials Research Society of Singapore (MRS-S) since 2011
Member of the Asian and Oceanian Photochemistry Association since 2011
Member of the local organizational committee, ICMAT, International Conference on Materials for advanced Technologies 2011, Singapore
Member of IMRE Social Committee

  1. Chee, H.L.; Gan, C.R.R.; Ng, M.; Low, L.; Fernig, D.G.; Bhakoo, K.; Paramelle, D.* Biocompatible Peptide Coated Ultra-Small Superparamagnetic Iron Oxide Nanoparticles for in vivo Contrast-Enhanced Magnetic Resonance Imaging. ACS Nano 2017, 10.1021/acsnano.7b07572.  
  2. Colangelo, E.; Chen, Q.; Davidson, A. M.; Paramelle, D.; Sullivan, M. B.; Volk, M.; Lévy, R. Computational and Experimental Investigation of the Structure of Peptide Monolayers on Gold Nanoparticles. Langmuir 2017, 33, 438–449.
  3. Colangelo, E.; Comenge, J.; Paramelle, D.; Volk, M.; Chen, Q.; Lévy, R. Characterizing Self-Assembled Monolayers on Gold Nanoparticles. Bioconjug. Chem. 2017, 28, 11–22.
  4. Paramelle, D.*; Peng, T.; Free, P.; Fernig, D. G.; Lim, S.*; Tomczak, N.* Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding. PLoS One 2016, 11, e0162848.
  5. Paramelle, D.; Gorelik, S.; Liu, Y.; Kumar, J. Photothermally Responsive Gold Nanoparticle Conjugated Polymer-Grafted Porous Hollow Silica Nanocapsules. Chem. Commun. 2016, 52, 9897–9900.
  6. Paramelle, D.*; Nieves, D.; Brun, B.; Kraut, R. S.; Fernig, D. G. Targeting Cell Membrane Lipid Rafts by Stoichiometric Functionalization of Gold Nanoparticles with a Sphingolipid-Binding Domain Peptide. Adv. Healthc. Mater. 2015, 4, 911–917.
  7. Paramelle, D.; Sadovoy, A.; Gorelik, S.; Free, P.; Hobley, J.; Fernig, D. G. A Rapid Method to Estimate the Concentration of Citrate Capped Silver Nanoparticles from UV-Visible Light Spectra. Analyst 2014, 139, 4855–4861.
  8. Paramelle, D.; Martinez, J.; Subra, G. Agents Chimiques Pour La Determination de Structures de Proteines; Omn.Pres.F.; Presses Académiques Francophones, 2014.
  9. Peng, T.; Paramelle, D.; Sana, B.; Lee, C. F.; Lim, S. Designing Non-Native Iron-Binding Site on a Protein Cage for Biological Synthesis of Nanoparticles. Small 2014, 10, 3131–3138.
  10. Paramelle, D.; Miralles, G.; Subra, G.; Martinez, J. Chemical Cross-Linkers for Protein Structure Studies by Mass Spectrometry. Proteomics 2013, 13, 438–456.
  11. Qiu, H.; Dong, X.; Sana, B.; Peng, T.; Paramelle, D.; Chen, P.; Lim, S. Ferritin-Templated Synthesis and Self-Assembly of Pt Nanoparticles on a Monolithic Porous Graphene Network for Electrocatalysis in Fuel Cells. ACS Appl. Mater. Interfaces 2013, 5, 782–787.
  12. Chen, X.; Qoutah, W. W.; Free, P.; Hobley, J.; Fernig, D. G.; Paramelle, D.* Features of Thiolated Ligands Promoting Resistance to Ligand Exchange in Self-Assembled Monolayers on Gold Nanoparticles. Aust. J. Chem. 2012, 65, 266.
  13. Hobley, J.; Paramelle, D.; Free, P.; Fernig, D. G.; Kajimoto, S.; Gorelik, S. Photothermal Laser Material Interactions - From the Sledgehammer to Nano-GPS. In Advances in Bio-Imaging: From Physics to Signal Understanding Issues. State-of-the-Art and Challenges; SpringlerLink, 2012; pp. 85–111.
  14. Free, P.; Paramelle, D.; Bosman, M.; Hobley, J.; Fernig, D. G. Synthesis of Silver Nanoparticles with Monovalently Functionalized Self-Assembled Monolayers. Aust. J. Chem. 2012, 65, 275.
  15. Paramelle, D.; Enjalbal, C.; Amblard, M.; Forest, E.; Heymann, M.; Cantel, S.; Geourjon, C.; Martinez, J.; Subra, G. Solid-Phase Cross-Linking (SPCL): A New Tool for Protein Structure Studies. Proteomics 2011, 11, 1277–1286.
  16. Vezenkov, L. L.; Andre, C.; Paramelle, D.; Maynadier, M.; Hernandez, J. F.; Garcia, M.; Calmes, M.; Subra, G.; Benedetti, E.; Martinez, J.; et al. Short Constrained Dipeptide Mimic Oligomers as Uncharged Cell Penetrating Compounds. In 11th Chinese International Peptide Symposium; 2011; pp. 157–160.
  17. Paramelle, D.; Subra, G.; Vezenkov, L. L.; Maynadier, M.; André, C.; Enjalbal, C.; Calmès, M.; Garcia, M.; Martinez, J.; Amblard, M. A Straightforward Approach for Cellular-Uptake Quantification. Angew. Chemie 2010, 49, 8240–8243.
  18. Paramelle, D.; Cantel, S.; Enjalbal, C.; Amblard, M.; Forest, E.; Heymann, M.; Geourjon, C.; Martinez, J.; Subra, G. A New Generation of Cross-Linkers for Selective Detection by MALDI MS. Proteomics 2009, 9, 5384–5388.
  19. Heymann, M.; Paramelle, D.; Subra, G.; Forest, E.; Martinez, J.; Geourjon, C.; Deléage, G. MSX-3D: A Tool to Validate 3D Protein Models Using Mass Spectrometry. Bioinformatics 2008, 24, 2782–2783.
  20. Lascoux, D.; Paramelle, D.; Subra, G.; Heymann, M.; Geourjon, C.; Martinez, J.; Forest, E. Discrimination and Selective Enhancement of Signals in the MALDI Mass Spectrum of a Protein by Combining a Matrix-Based Label for Lysine Residues with a Neutral Matrix. Angew. Chemie Int. Ed. 2007, 46, 5594–5597.       


"Coating for iron oxide nanoparticles", SG Patent Application 10201508038W

"Multifunctional Zinc Oxide Quantum Dots with Photoluminescence, Mesoporous and Anti-Cancer Properties", Singapore Patent Application No. 201304450-8

"Specific internalization of nanoparticles into protein cages", US Patent Application No: 14/651,626

"CROSS-LINKING AGENTS", 2010 European Patent n° EP 09305201.7, 2012 US Patent n°US20120070856A1

"Cross-linking agents on solid medium", 2010 European Patent n°EP2226637A1

Last updated on : 03 Apr 2019 04:36 PM