Equipment in SBIC 

Imaging Instruments

Siemens Magnetom Skyra 3T

Siemen’s top-of-the-line 70 cm 3T clinical R&D system with X-nuclei capability for imaging large animals (NHPs & Swine)

  • Co-located with GE Spin Lab for C13 metabolic imaging
  • Situated within an AAALAC-accredited animal holding facility
                              



 



 



 



 


Bruker BioSpec 11.7T (117/16 USR)

State-of-the-art ultrahigh-field pre-clinical R&D system with B-GA9S HP gradient capable of imaging small animals (mice to rats), actively shielded gradients, integrated shim sets and a comprehensive range of RF coils, including a 1H MRI CryoProbeTM 4 Element Array Kit for Mice.

                        




 



 




 


 Agilent (Varian) 9.4T/31cm MRI            

  • State-of-the-art high field animal MRI system equipped with high performance gradient, 4-channel receivers and broadband RF system.
  • Optimized for in vivo rodent imaging. Application includes: high-resolution anatomical imaging, functional MRI, perfusion imaging, diffusion tensor/spectrum imaging, X-nuclei (eg, 31P, 13C) spectroscopy and imaging.
 


Bruker 7T/20cm ClinScan MRI

  • High performance animal MRI system equips with high power gradient, multi-channel receivers, broadband RF system, and Siemens console and software.
  • Optimized imaging protocols for translational study. Application includes: high-resolution anatomical imaging, perfusion imaging, diffusion tensor imaging, angiography, susceptibility weighted imaging, cardiac imaging, spectroscopic imaging.


Bruker BioSpec 9.4T (94/30 USR)

  • State-of-the-art high field pre-clinical R&D system with B-GA 20S and B-GA 12S gradient inserts capable of imaging small and large animals (mice to rabbits), actively shielded gradients, integrated shim sets and a comprehensive range of RF coils.
                                     

 MEDISO SPECT CT

  • MEDISO SPECT /CT system provides fully quantitative rodent SPECT imaging at sub millimeter resolution.  For more information go to: http://www.mediso.hu/index.php
 

Siemens Inveon PET CT         


ImageXpressTM Micro with with Transmitted Light High Content Screening System

  • http://www.moleculardevices.com/Products/Instruments/High-Content-Screening/ImageXpress-Micro.html 
  • Fully automated X-Y sample stage and Z focus stage with > 100 nm resolution
  • Filter cubes configured for specific dye excitation and emission
 
Renishaw InVia Ramman microscope

  • http://www.renishaw.com/en/invia-raman-microscope--6260 
  • High-sensitivity systems with integrated research grade microscopes, enabling high resolution confocal measurements.
  • 633 nm (He-Ne laser) and 785 nm (near infrared diode laser)

‚ÄčiThera Medical Multispectral Optoacoustic Tomography

  • http://www.ithera-medical.com/technology/preclinical-systems.html
  • multispectral preclinical whole-body photoacoustic tomographic imaging (680-980 nm)
  • anatomical, functional and molecular imaging
             
Nikon BioStation IM

  • http://www.nikon.com/products/instruments/lineup/bioscience/time/imq/index.htm
  • The BioStation IM-Q incorporates a microscope, an incubator and a high-sensitivity cooled CCD camera in a compact body
  • long-term, time-lapse, live-cell imaging 
                                   
Bioptonics OPT Optical Projection Tomography 3001

  • http://www.bioptonics.com/OPT3001.pdf 
  • Optical Projection Tomography (OPT) is a novel, unique and fast wholemount imaging technology, which produces stunning 3D images and virtual sections of small biological specimens
 
BrukerUltraflexIII TOF-TOF MALDI mass spectrometry imaging system

  • UltraflexIII TOF/TOF MS and MSMS and ImagePrep
  • Application: MALDI Imaging, proteomics and metabolomics
 
Chemistry instruments 

HyperSense® -DNP for NMR the in-vitro DNP Polariser

  • http://www.oxford-instruments.com/products/dnp/hyperSense/Pages/hyperSense.aspx
  • Dynamic Nuclear Polarisation (DNP) is the method for obtaining strongly polarised nuclear spins in solution.
  • HyperSense allows the user to drive NMR sensitivity to levels never seen before.
 
Bruker 400MHz/54mm NMR

  • Bruker 400 MHz standard bore equipped Avance III console
  • Three broad-band liquid-state probes with a ~55 G cm-1z-gradient coil and a variable temperature unit (BCU-05)
 

BD LSRFortessaâ„¢ cell analyzer With BD high throughput screening sampler (HTS)           

  • http://www.bdbiosciences.com/instruments/lsr/index.jsp
  • The BD LSRFortessaâ„¢ cell analyzer has 4 lasers for 12 simultaneously color detection and can perform 4-color FCM analysis without compensation.
  • The system reads from 96 well or 384 well plates
 

Shimazu High Performance Liquid Chromatography with radiochromatography detector, tandem gamma/position detector and Mini-Scan TLC Radiochromatography System           

  • routine quality control of 18F FDG, 99mTc, 123I radiopharmaceuticals
  • TLC or HPLC of radiopharmaceuticals labeled with gamma, beta, and alpha emitters
 

Agilent 5975C GC-MS system
http://www.chem.agilent.com/en-us/products/instruments/ms/gc-ms/systems/5975cseriesgcmsd/pages/default.aspx           

  • Agilent 5975C inert XL EI/CI MSD with Triple-Axis HED-EMdetector
  • High performance Agilent 7890A Gas Chromatograph(GC) and 7693B series autosampler
 

GE Healthcare Typhoon 9400 Variable Mode Imager           

  • Highly sensitive confocal optics enables direct and highly quantitative imaging of fluorescence and chemiluminescence as well as storage phosphor
  • agarose and polyacrylamide gels, membranes, mounted or unmounted storage phosphor screens, microplates, microarrays, and in situslides
 

Preparative HPLC Systems for nanoparticle and preclininal contrasts agents s separation and purification        

  • kata purifier 10 FPLC from GE Healthcare with fraction collector
  • Shimadzu prominence UFPLC system with fraction collector
 

Malvern Zetasizer nano and MPT-2 Autotitrator            

  • Determination of molecular weight, hydrodynamic radius (particle size) and zeta-potential as well as a detector for size exclusion chromatography 

Dionex Ultimate 3000 2D –Biocompatible analytical HPLC            

  • Combination of two orthogonal chromatographic techniques, for example, IEX and RP-HPLC or high and low pH RP-HPLC separation of complex samples
 

Christ Freeze-drying system Alpha 2-4 LD plus and LABCONCO CentriVap Centrifugal Vacuum Concentrator    

  • Christ Freeze dryer: -85 oC, 24 pieces round bottom flasks.
  • LABCONCO Refrigerated CentriVap Centrifugal Concentrator (-4ºC to 100ºC ) coupled with CentriVap -84°C Cold Trap
 

Biology instruments
 

Oxymax/CLAMS 12-chamber Comprehensive Lab Animal Monitoring system

  • http://www.colinst.com/brief.php?id=61 
  • Incorporating sub-systems for open circuit calorimetry, activity, body mass, feeding, drinking, food access control, running wheel, urine collection, sleep detection, body core temperature and heart rate in an environmental chamber

EchoMRI Whole Body Composition Analyzer

  • http://www.echomri.com/echo_upto_mice.aspx 
  • Magnetic Resonance Analyzer for measuring mouse fat mass, lean tissue mass, free water, and total body water
 
Nikon Motorized laser TIRF (Total Internal Reflection Fluorescence) Microscope system

  • single molecule visualization, allowing dynamic observation and functional analyses (activity and interactions) of both in vitro and living cells at the molecular level
 
Computer controlled electrophysiology Microscope with HEKA EPC patch Clamp system

  • Nikon Electrophysiology Microscope, HEKA EPC Patch Clamp and Photometry Microscope System
 
Calcium Imaging System with Multi-manipulator system

  • Calcium Imaging System with Sutter Lambda DG-5 High Speed wavelength switcher with 300W xenon, MPC-325-2 Multi-manipulator System