The term "metabolist" is the perfect descriptor for Magkos, given his research and teaching interests revolve around human metabolism. His undergraduate and graduate study background at the Department of Nutrition and Dietetics at Harokopio University (Athens, Greece), the Washington University School of Medicine (St. Louis, Missouri, USA), and the Harvard Medical School (Boston, Massachusetts, USA), has been heavily weighted towards the understanding of human metabolism in health and disease, mainly through studying the effects of diet and exercise. He holds B.Sc. in human nutrition and clinical dietetics; M.Sc. in exercise physiology, nutrition and metabolism; and Ph.D. in human metabolism. Following his post-doctoral studies (endocrinology), Magkos served as Assistant Professor of Medicine at the Center for Human Nutrition, Division of Geriatrics & Nutritional Science at Washington University School of Medicine in St. Louis, Missouri, USA. Since September 2015, he holds a joint appointment as Principal Investigator at the Clinical Nutrition Research Centre (CNRC), Singapore Institute for Clinical Sciences (SICS), and Assistant Professor (tenure track) in the Department of Physiology, Yong Loo Lin School of Medicine at National University of Singapore (NUS).
Magkos' research has focused on evaluating the effects of diet and exercise on various physiological and metabolic functions in human subjects in vivo and has resulted in 115 peer-reviewed publications and more than 3,000 citations to date. He is particularly interested in performing transdisciplinary metabolic research in humans, at the interface between basic biochemistry and clinical physiology, in order to better understand the effects of nutrition on bodily functions and the mechanisms by which diet can promote health and prevent, delay, or treat disease. He is also interested in exercise, which – together with diet – are the two sides of the "lifestyle coin." Magkos' vision is to bring together and fuse different research expertise, and create a melting pot of different types of research – from clinical to basic research and anything in-between – to gain a deeper and better understanding of the mechanisms by which the human body works
We use a variety of tools to assess human metabolism in vivo. Among others, the oral and intravenous glucose tolerance tests in conjunction with mathematical modeling to evaluate glucose tolerance, insulin sensitivity and pancreatic beta cell function (insulin secretion); the hyperinsulinemic-euglycemic clamp technique in conjunction with stable isotope tracer infusions to evaluate multi-organ insulin action; dual X ray absorptiometry (DEXA), magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS) to evaluate body composition, fat distribution and ectopic fat deposition; tissue biopsies to evaluate relevant cellular factors; indirect and direct calorimetry to evaluate basal metabolic rate and diet- and exercise-induced thermogenesis.
We are not fixated on methods and tools per se, but rather on the physiological question(s) of interest. We use whichever method and tool can help us answer the question we are asking.
Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. ''Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity''. Nutr J. 01 Dec 2016. 15(1):100. doi: 10.1186/s12937-016-0219-0.
Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. ''Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility''. Nutr Metab (Lond). 27 Oct 2016. 13:74. doi: 10.1186/s12986-016-0135-5.
Sun L, Tan KW, Lim JZ, Magkos F, Henry CJ. ''Dietary fat and carbohydrate quality have independent effects on postprandial glucose and lipid responses''. Eur J Nutr. 21 Oct 2016. doi: 10.1007/s00394-016-1313-y.
Ding C, Chan Z, Magkos F. ''Lean, but not healthy: the 'metabolically obese, normal-weight' phenotype''. Curr Opin Clin Nutr Metab Care. 20 Aug 2016. 19(6):408-417. doi: 10.1097/MCO.0000000000000317.
Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, de Las Fuentes L, He S, Okunade AL, Patterson BW, Klein S. ''Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity''. Cell Metab. 22 Feb 2016. 23(4):591-601. doi: 10.1016/j.cmet.2016.02.005.
Magkos F, Bradley D, Eagon JC, Patterson BW, Klein S. ''Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on gastrointestinal metabolism of ingested glucose''. Am J Clin Nutr. 25 Nov 2015. 103(1):61-5. doi: 10.3945/ajcn.115.116111.
Fabbrini E, Yoshino J, Yoshino M, Magkos F, Tiemann Luecking C, Samovski D, Fraterrigo G, Okunade AL, Patterson BW, Klein S. "Metabolically normal obese people are protected from adverse effects following weight gain". Journal of Clinical Investigation. 02 Jan 2015. 125(2):787-795. doi: 10.1172/JCI78425.
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