Jan Paul BUSCHDORF
Research Scientist - Integrative Neurosciences
Jan Paul graduated from the Christian-Albrechts University of Kiel, Germany with an MSc in Biology, and received his PhD at the University of Hamburg, Germany. He joined SICS in 2010 to set up the Molecular Neuroscience Lab together with Michael Meaney as Principle Investigator.
The research in the Molecular Neuroscience lab focuses on the molecular mechanisms through which early development influences feeding behavior, the occurrence of obesity and other diseases as well as emotional/cognitive function. With special focus on the brain, their studies examine the developmental regulation of gene transcription using molecular and biochemical approaches, including methods to analyze epigenetic modifications of chromatin, protein/DNA as well as protein/protein interactions and gene expression.
In particular, they study the mechanisms and adaptations associated with low birth weight and intrauterine growth restriction in relevant brain structures like the hippocampus, amygdala and hypothalamus. Their aim is to characterize the gene expression program and signaling pathways that are induced by reduced nutrient supply and/or stress. Their research complements the GUSTO study by elucidating the role of the central nervous system in the development of mental diseases.
Buschdorf JP, Ong ML, Ong SX, MacIsaac JL, Chng K, Kobor MS, Meaney MJ, Holbrook JD. ''Low birth weight associates with Hippocampal Gene Expression''. Neuroscience. 11 Jan 2016. 318:190-205. doi: 10.1016/j.neuroscience.2016.01.013.
Buschdorf JP, Meaney MJ. ''Epigenetics/Programming in the HPA Axis''. Compr Physiol. 15 Dec 2015. 6(1):87-110. doi: 10.1002/cphy.c140027.
Chen L, Pan H, Tuan TA, Teh AL, MacIsaac JL, Mah SM, McEwen LM, Li Y, Chen H, Broekman BF, Buschdorf JP, Chong YS, Kwek K, Saw SM, Gluckman P, Fortier MV, Rifkin-Graboi A, Kobor MS, Qiu A, Meaney MJ, Holbrook JD. ''Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes''. Dev Psychopathol. 02 Feb 2015. 27(1):137-150. doi: 101017/S0954579414001357.
Ong ML, Tan PY, MacIsaac JL, Mah SM, Buschdorf JP, Cheong CY, Stunkel W, Chan L, Gluckman P, Chng K, Kobor MS, Meaney MJ, Holbrook JD. ''Infinium monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis)''. G3. 08 May 2014. 4(7):1227-34. doi: 101534/g3114010967.
Teh AL, Pan H, Chen L, Ong ML, Dogra S, Wong J, MacIsaac JL, Mah SM, McEwen LM, Saw SM, Godfrey KM, Chong YS, Kwek K, Kwoh CK, Soh SE, Chong MF, Barton S, Karnani N, Cheong CY, Buschdorf JP, Stünkel W, Kobor MS, Meaney MJ, Gluckman P, Holbrook JD. ''The effect of genotype and in utero environment on inter-individual variation in neonate DNA methylomes''. Genome Res. 07 Apr 2014. 24(7):1064-74. doi: 101101/gr171439113.
Ong SX, Chng K, Meaney MJ, Buschdorf JP. ''Decreased hippocampal mineralocorticoid:glucocorticoid receptor ratio is associated with low birth weight in female cynomolgus macaque neonates''. J Mol Endorcrinol. 16 Apr 2013. 51(1):59-67. doi: 101530/JME-12-0218.
Buschdorf JP, Lee PK, Lim VK, Kappeler L, Sng JC. ''Conference scene: Epigenetics goes translational''. Epigenomics. 01 Aug 2010. 2(4):509-12. doi: 102217/epi1034.
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