Please click on the individual institution's tab for full listing of PhD projects. To narrow your search, type in keywords here.
Degree by NTU / NUS / SUTD
Degree by NTU / NUS
*These projects will be jointly supervised by Dr Prakash Arumugam
and Prof. Chandra Varma
Degree by NUS
Multiscale Simulation, Modelling & Design in Biological Chemistry and Biophysics Group:
Multiscale modelling and simulation of biomolecular recognition and assembly.
Focus on immune receptor function, virus dynamics, and biomembranes.
Degree by NTU
Synthetic and Systems Biotechnology of Microbial Cells.
Engineering and Application of Phages.
Enzymes and Antibody Fragments.
Understanding and Overcoming Microbial Stress Response during Bioprocesses.
Degree by Nil
Recombinant protein expression and production in mammalian cells.
Cell culture media and bioreactor process development.
Development of anti-microbials.
Vector design, cell line development, cell engineering, and bioprocess development to enhance production of recombinant protein production in mammalian cells.
Computational Analysis and Engineering of Biological Systems.
Bioinformatics Analysis of Omics Data.
Bioinformatics Platform and Tool Development.
Development of novel mesenchymal stem cell bioprocessing for therapeutic applications.
Bioprocesses for integrated expansion and differentiation of human pluripotent stem cells.
Degree by NUS/NTU
Degree by NTU/ NUS
Statistical analysis for cancer biomarker discovery, Metabolic modelling of microbial communities, Algorithms for Precision Medicine.
Stem cells for cancer gene therapy and cancer immunotherapy.
Insect baculovirus to combat human cancer.
Codelivery of genes/proteins and small drug molecules for targeting cancer stem cells using biocompatible polymer nanocarriers.
Targeted delivery of multiple anticancer drugs using biodegradable functional polymer nanoparticles to prevent metastasis and relapse.
Development of cationic amphiphilic polymers/short synthetic peptides as antimicrobial agents to overcome multidrug resistance.
Stem cell differentiation and direct reprogramming for generating specific cell types.
Antibody engineering for targeted delivery of macromolecules.
Bioengineering for ophthalmological applications.
Cardiac tissue engineering for regenerative medicine.
Quantitative pathology with advanced microscopy technologies.
Development of in vitro toxicity testing platforms with micro-tissue constructs.
Micro-tissue fabrication factory to precisely engineer inter-cellular epithelial tissue structures.
Maturation of stem-cell differentiated cells for drug testing applications.
Macromolecular therapeutics/nanomedicine for treatment of multidrug-resistant tuberculosis mycobacterial infections.
Development of a bioartificial kidney.
Development of human tissue models for in vitro toxicology.
Development of xeno-free stem cell cultures.
Differentiation of pluripotent stem cells into human renal cells.
Circulating tumor cells as noninvasive evaluation of outcomes in cancer.
Genetic determinants of outcomes of cancer therapeutics.
Induced pluripotent stem cells as ex vivo toxicology models.
Miniaturized systems for drug screening and toxicology.
Development of novel heterogeneous catalysts for pharmaceuticals synthesis.
Nanocomposite materials for catalysis, fuel cells and batteries.
New catalysis in green chemistry and sustainable energy.
Development of novel heterogeneous catalysts and their application in organic synthesis.
MicroRNA- mediated translational regulation in Cancer stem cells.
Translational regulation in injury and wound healing.
Role of Non-coding RNAs in human embryonic stem cell differentiation.
Roles of cilia in the regulation of embryonic development and adult physiology.
Cilia and human diseases.
Comparative Genomics/evolution of cis-regulatory elements/evolution.
Regulation of Hox cluster genes.
Chromosomal Instability in Liver Cancers( funded by MOE Tier 1)
Aneuploidy-related signalling pathways upon treatment with antimitotics( funded by NRF).
Replication stress and Chromothripsis ( funded by NRF) .
Bioinformatic analysis of Genome wide Chip-seq and RNA-seq datasets.
Role of arginine methylation in transcriptional control.
Role of PRDM methyltransferases in mammalian development.
Cancer Genetics and Therapeutics.
Project: Bioinformatics analysis of chromatin interaction datasets in cancer (the Ph.D candidate should have been trained in computational biology or equivalent fields).
Define the precise role of a subset of genes, their relationship and their mechanism of action in the development of metabolic syndrome and cancer.
Skin wound repair focus on cell communication between different cell types.
Diabetic wound repair (translational).
Regulation of NFkB function .
Inflammation metabolism and Cancer.
Telomerase the central regulator of all the hallmarks of cancer.
Cancer epigenomics and genetics.
Dynamics of histone modification during adaptation to DNA damage.
Role of Sumoylation during chromosome segregation and DNA damage.
Regulation of spindle dynamics by ubiquitin-conjugating E2 enzyme Cdc34.
Mechanisms of obesity and food addiction.
Cognitive aspects of memory and learning.
Neurogenetics of anxiety and tranquillity.
Thermotolerant genomes for structural neurobiology.
Behavioral neuroscience research engineering.
Degree by Duke-NUS (Neuroscience) and NUS (Physiology)
Stem cell and cellular reprogramming for human disease modeling.
Genetic and epigenetic regulation of cell fate switches.
Role of long non-coding RNAs in Amyotrophic Lateral Sclerosis.
Disease epigenetics: Understanding and targeting chromatin dysfunction in neurological disorders and cancer.
Investigating the relationship between chromatin plasticity and cellular potency for regenerative medicine applications.
Degree by NUS (Medicine) NTU(SBS or LKCMedicine)
Role of tight junction proteins in stem cells, GI tract, skin, central and peripheral nervous system, blood-brain barrier, heart, pancreas, mammary gland, B- and T-cells, and dendritic cells using in vitro and mouse models.
Phyisiological role of BRAP, a novel regulator of voltage gated calcium channels in animal models. Characterization of BARP interacting proteins.
SNAREs in membrane traffic and physiology.
Sorting nexins in membrane traffic and physiology.
Hippo Pathway and TAZ/YAP in cancer cell migration, invasion and tumorigenesis.
Role ofTom1-L1 in mediating endocytosis of receptor tyrosine kinase.
Structure and Functional interactions of translational factors with ribosome
Structure and regulation of c-di-GMP signalling.
Protein-DNA/RNA interaction and regulatory function.
Antiviral and vaccines developments for human enteroviruses that causes HFMD.
Molecular mechanism of viral pathogenesis of human enteroviruses.
Reverse genetics assays and murine models of human enteroviruses.
Quorum sensing in regulation of bacterial virulence.
Cell-cell communication in host-pathogen interactions.
Molecular mechanisms of bacterial biofilm dispersion.
Understanding viral-host interplay in hepatitis virus infection.
Understanding viral-host interplay in RNA virus infection.
Cell polarity and morphogenesis control in the dimorphic fungus Candida albicans.
Signal sensing and integration in Candida albicans.
Candida albicans-host interaction.
Molecular mechanisms of nonsense-mediated mRNA decay and miRNA-mediated translational repression.
Structural studies on proteins involved the Hippo tumor suppressor pathway and anti-cancer drug design.
Humanization of mouse kidney and study of the interactions between human immune system and renal cancers in humanized mouse.
Modelling Enterovirus 71 infection, disease and human immune responses in humanized mouse.
Characterization of tissue residential human Natural Killer cells and their roles in organ specific diseases.
Breast cancer biomarker and possible drug target identification and characterization using discovery and targeted proteomics.
Mass Spectrometry-based quantitative proteomics technology development (biochemical and computational).
Mapping comprehensive interaction proteomes of key signaling pathways.
Mode of action of small molecule anti-cancer natural products using proteomics-based Systems Biology.
Translational Imaging of Fat Metabolism (WAT / BAT).
Translational Imaging of Skeletal Muscle Metabolism.
Fat-derived stem cells in metabolic diseases.
Imaging on fat metabolism in collaboration.
Degree by NTU LKC SoM (via SBS)
Innovative computational algorithms for analyzing single-cell RNA-sequencing data.
Single-cell RNA-sequencing allows for measurements of cellular heterogeneity with unprecedented dimensionality. However, data analysis pose a significant technical challenge. The project will focus on developing novel methods of normalization, dimension reduction, clustering, gene selection for clustering and differential expression analysis.
Molecular mechanism of innate immune activation by attenuated and wild type dengue virus.
Skin-associated dengue infection and immune cell activation.
Human anti-viral B cell responses
Defining protective immune mechanisms and correlates of protection.
Deciphering the immune mechanisms involved in malaria-induced pathologies.
Myeloid cell trafficking in health and disease.
Understanding inflammatory responses by intravital multiphoton microscopy.
1. Myeloid cell trafficking in health and disease.
2. Understanding inflammatory responses by intravital multiphoton microscopy
Brown fat activity measurement with infrared imaging thermography and thermogenesis.
Assessment of phosphocreatine recovery, proton handling, and muscle oxygenation in Thyroid Disorders using 31P Magnetic Resonance Spectroscopy and Near Infrared Spectroscopy.
Role of histone modification in fat cell differentiation.
Role of microRNA in fat cell differentiation.
Investigating the roles of natural killer cells in hematopoietic stem cell transplant and hematological malignancy.
Engineering new approaches for human NK cell response enhancement against cancer.
Investigation of NK cell biology in tissues.
We are interested in understanding neuroanatomical, cognitive, and socio-emotional development, and will consider a broad range of topics relevant to this theme including those focused upon:
Sources of individual variation in brain, cognition, and behavior/psychological functioning including parental mental health, parenting (mother-child attachment), genetics, epigenetics, and nutrition.
Predictive validity of early life screening tools and cognitive batteries in distinguishing neurocognitive and psychological trajectories in later childhood.
Determining normative developmental trajectories and/or relations between cognitive function and neuroanatomical variation.
Methodologies include electrophysiology (ERP), eye tracking, behavioral observation, computer based tests, heart rate/RSA/IBI, and interviews. We partner with a variety of researchers expert in areas such as MRI/DTI, genetics/epigenetics, and nutrition.
Genome based evaluation of epigenetic regulatory networks (DNA methylation, post-translational modification of histones, and non-coding RNAs) to identify biomarkers for early prevention /intervention of metabolic and neurocognitive disorders.
Role of micronutrient deficiency in genome instability.
Development of device characterisation and IC design integration strategies for non-volatile memories
Quantum - nano optical interfaces.
Biological interfaces with quantum light.
Spectral and temporal characterization of entangled states
Intelligent Data Management.
Adaptive and distributed resource provision for multi-tenanted data centers.
Nano Science and Technology.
Electronics / Solid State Devices.
Degree by NUS/NTU
Dr Khin Mi Mi Aung
Fabrication and characterization of nanophotonic devices based on resonant dielectric and metallic nanostructures.a
Spectral and temporal characterization of entangled states.
Integrated Photonics, Nanofabrication, Optical Material.
Degree by NUS/NTU/SUTD
Nanophotonics and plasmonics.
Flat optics with metasurfaces.
Resonant optical structures.
Integrated nano light source.
Nanophotonic chip optical coupling.
Laser integration and optical coupling.
Computational nanophotonics and design.
Persistent In-memory computing with Non-viotile memory.
Persistent In-memory File System/Database (SQL or No-SQL).
Distributed In-memory system for Big Data.
High Performance Android platform.
Storage reliability and availability for both local storage system and large scale storage system.
File system and data managament for both non-volatile memory and disk storage system.
Data compression/deduplication and management.
Large-scale distributed system for data-intensive computing.
High performance in-memory computing.
Distributed data analytics for big data.
Development of novel overcoat for heat assisted magnetic recording.
Plasmonics materials for heat assisted magnetic recording near field transducer .
Phase change materials and application in data storage.
Oxide materials and devices for information storage.
Magnetic materials and application in solid state memory.
Network security (DNS traffic analysis, SDN-based security, Covert channels and communications).
Brain–computer interface algorithms, systems, adaptation, and applications.
Neural and biomedical signal processing, machine learning and pattern recognition.
Neural and cognitive process and neural image processing.
Deep Learning for Spoken Language Processing.
Continuous Space Language Modelling in Speech and Language Processing.
Human Robot Interaction.
User modelling and recommendation.
Biological and social network mining.
Financial data analysis.
Biomedical data analysis and its applications in Healthcare.
Advanced condition monitoring systems and applications.
Cognitive and Cooperative Wireless Networks.
Green Wireless Networks.
Future Generations of Broadband Communications.
Video analytics, Computer Vision, Multimedia forensics.
Big Data management and processing for Smart Cities, Big Data Visualisation, and Urban Mobility Mining.
Degree by SUTD
Data collection, fusion, and application in network management and optimization .
Context-aware incentives, inteference, and resource management in 5G heterogeneous networks.
5G transmission technologies.
Cognitive C-RAN for 5G.
Green 5G communications and networking.
Deep packet inspection for wireless multimedia communications.
Information collection, fusion, and, application in internet of vehicles/robots/things.
Intelligent assistive humanoid robot system.
Novel robot system with active perception-action framework.
Visual Expressive Speech Synthesis.
Complex Source Separation Algorithms and Applications.
Paralinguistice Modeling and Synthesis.
Speech Therapy Monitoring and Personalized Voice for Patients with Speech Disorders.
Affective Social Multimedia Computing.
Voice Transformation and Conversion.
Emotion-Enable Dialogue System.
Deep Learning for Multi-Modal Processing.
Continuous Space Emotion Modelling and Synthesis in Speech/Video/Text Processing.
Human Machine Interaction.
Automatic Speech Recognition.
Deep Learning for Speech Recognition.
Spoken Document Retrieval.
Graph data mining and graph-based machine learning.
Social network analysis.
Online Learning to Scalable Data Stream Mining.
Stochastic Optimization for Big Data Analytics.
Personalized Ranking based Recommendation System.
Degree by NTU/NUS/SUTD
Real time physically based rendering effects on large GPU arrays for Immersive Virtual Environment.
Real time full body 3D capture in Immersive Virtual Environment.
Real-time 3D Human Pose Estimation.
Real-time Clothes Animation based on 3D User Pose.
Data driven expressive face modeling.
Data driven moving texture synthesis.
Parallel computational geometry algorithms.
Large scale document clustering and classification.
Social media analysis.
Opinion mining/Sentimental analysis.
Partially supervised document analysis.
Speaker and Spoken Language Recognition.
Cross-layer optimization for Quality-of-Experience (QoE)-consistent wireless multimedia communications.
Joint source-channel processing.
Cybercrime Detection & Analysis
Digital (Multimedia, Network, Mobile) Forensics.
Systems & Mobile Security.
Multimedia Search and Retrieval.
Spoken Dialogue Technology.
Knowledge Representation and Acquisition for Chatbot.
Clustering and Dimensionality Reduction.
Parallel and Distributed Big Data Analytics Using MapReduce and HADOOP.
Human-robot collaboration. Robotic manipulation. Adaptive human-robot interfaces. Intelligent control systems.
Audio Signal Processing.
Cognitive radios and dynamic spectrum allocation.
Spectrally efficient technologies for next generation radio systems.
Multicarrier modulation techniques. Radio Resource Management.
Use of game, auction and decision theories in telecommunications
5G Communication Systems.
Large distributed antenna system/network.
Energy-efficient cooperative communications.
Sustainable wireless communications for healthcare and medical care.
Privacy-preserving data mining.
Private record linkage.
Data stream processing.
Searchable encryption on outsourced data.
Modelling Speech Prosody with Deep Learning on Big Speech Data.
Billingual Speech Synthsis by Voice Adapation.
Cross Language Voice Conversion for Speech Translation.
Novel parallel hardware platform for big data analytic.
Low-power, high-efficiency hardware architecture for beyond von Neumann computing.
Deep learning for spoken language processing.
Continuous space language modelling in speech and language processing.
Big data analytics.
Data Stream Mining.
Positive Unlabelled Learning.
Multiple source learning.
Visual Search Algorithms Inspired by Human Attention and Memory Models.
Discriminative Methods for Object and Scene Recognition.
A Cognitive Architecture for Autonomous Visual Information Processing.
Visual Coding and Pooling.
Image/Video Compression, Processing and Analytics.
Multimedia Search, Retrieval & Delivery System.
Video Super-resolution and Enhancement.
Video Content Networking & Caching for High Throughput Performance.
Cybercrime Detection & Analysis.
Multi-modal multi-robot collaboration for active perception.
Robot learning from observation.
Automatic feature engineering and extraction for data analytics.
Web-scale social network mining for data analytics.
Algorithms and systems for Cloud-scale Machine Learning.
Degree by SMU
Speaker Recognition and Characterization.
Multilingual Recognition and Identification.
Rule/pattern based prediction and recommendation.
Exploratory data analysis.
1. Clustering and Dimensionality Reduction
2. Mobility Mining
3. Parallel and Distributed Big Data Analytics Using MapReduce and HADOOP
4. Topic Model
Data collection, fusion, and application in network management and optimization.
Incentives, Inteference and Resource Management in heterogeneous networks.
Physical layer security.
Big Data-enabled context-aware resource management in software-defined 5G heterogeneous networks.
Sound Event Detection.
Localization and Classification.
Distant Speech Recognition.
Side Channel Resistant Vehicular Hardware Components.
Security-aware Sensor Fusion for Vehicular Applications.
Embedded Security for Next-generation Vehicular Communications.
Nano Science and Technology
Pharmaceutical Science and Technology, and Environmental Life Cycle Assessment
Pharmaceutical Science and Technology, and Environmental Life Cycle Assessment.
Synthesis of functional molecules.
Development of green and sustainable methodologies.
Pharmaceutical design and particle technology.
(Chemical and Pharmaceutical Processing).
(Pharmaceutical Science and Technology).
Catalyst design for olefin hydroamination and hydration (Chemical and Pharmaceutical Processing, reactor design, formulation processes).
Catalyst design for polymer chain-end functionalization.
Green, clean & cost-effective pretreatment of lignocellulose (Chemical and Pharmaceutical Processing, reactor design, formulation processes).
Fermentation of hemicellulose sugars to optically pure L- and D-lactic acids (Material Sciences).
Engineering thermophilic Bacillus coagulans for lactic acid production from lignocelluloses (Material Sciences & Alternate Energy).
Electrical Drives and Control.
Power Systems Stability and Control.
Microgrids and their control.
Condition Monitoring and Diagnosis.
Development of Catalyst & Catalytic Processes
Development of Catalyst & Catalytic Processes.
Network-based analysis, modelling & simulation.
Infectious disease analytics.
Logistic and supply chain management.
Social computing, social analytics, cognitive computing.
Degree by NTU/NUS/SUTD/SMU
1. Accelerator Computing (GPU,FPGA or Many-core)
2. Machine Learning
3. Image Processing
4. Natural Language Processing
Intelligent nautical traffic analysis.
Multi-modal lane analysis for logistics planning.
Agent-based modelling and simulation.
Degree by NUS/NTU/SMU
Intuitive human machine interface.
Complex networks, Transportation systems
High performance computing.
Bioinformatics, social computing, social analytics, behavioural informatics.
Reasoning, learning, and planning under uncertainty; big data analytics.
Big data analytics, knowledge discovery and data mining.
Social computing and Social analytics.
Opinion mining and automatic sentiment categorization.
Multilingual sentiment analysis and Social sensing.
Geometrical and mesh modelling
Mechanical properties of load-bearing biological.
Structures and physical properties of two-dimensional.
Growth modelling of low-dimensional nanomaterials.
Healthcare and medical devices.
Computational algorithms for nanooptics and nanophotonics.
Aerospace and smart city applications.
Metasurface based optical phased array antenna.
Dielectric optical nanoantenna.
Optimal design for near field enhancement.
Nanoscale device and ultrafast device modelling and simulation.
High performance computing for computational science.
Energy efficient computing/Green computing.
High speed optoelectronic devices.
Wireless charging and networks.
Healthcare and medical technology.
Computational alogrithms for nano-optics and nanophotonics.
Degree by NUS/NTU/SUTD/SMU
Nano structure optical materials.
Metallic glass and nanoglass.
Mechanical properties of nanomaterials.
Metal and ceramics under extreme conditions.
Deformation, fracture, plasticity.
Metallic glass and nanoglass
Mechanical properties of nanomaterials
Metal and ceramics under extreme conditions
Deformation, fracture, plasticity