Mei Chin Lee

RESEARCH

Dr. Lee Mei Chin is a biochemist and molecular biologist by training. Her research focus on application of unbiased genome wide and transcriptomic approaches to dissect the regulatory signalling networks associated with liver diseases. It is of her interest to reveal novel insights into the mechanisms of liver diseases through curated in-vitro assay pipelines developed in the Laboratory of Precision Disease Therapeutics. Findings derived from her research efforts will be further translated into biochemical insights that could invoke opportunities for development of novel diagnostic or therapeutic tools to lessen the socio-economic burden of liver diseases.

As the Senior Programme Manager for EMULSION, Dr. Lee manages the research within the Laboratory of Precision Disease Therapeutics and monitors the progress of EMULSION programme across major institutions (GIS, IMCB, IBB, NUH, SGH, KTPH, CGH), academia (NUS, NTU) and industry partners.

COMPLETE PUBLICATION LIST

Li Z, Wang Z, Lee MC, Zenkel M, Peh E, Ozaki M, Topouzis F, Nakano S, Chan A, Chen S, Williams S, Orr A, Nakano M et al., Association of rare CYP39A1 variants with exfoliation syndrome involving the anterior chamber of the eye. Journal of the American Medical Association, 2021 23;325(8):753-764. Joint-first author. Abstract

Yonova-Doing E, Zhao W, Igo P, Wang C, Sundaresan P, Lee KE, Jun G, Alves AC, Chan AS, Lee MC, Fong A, Tan A, Khor CC, Chew E, Qiao F, Chua J, Chung J, Liao J, Colijn JM, Burdon K, Fritsche LG et al., Common variants in developmental eye genes such as SOX2-OT and congenital cataract genes contributes to age-related nuclear cataract. Communications Biology, 2020; 11;3(1):755-762. Co-Author. Abstract

Lee MC, Shei W, Chan AS, Chua BT, Goh SR, Chong YF, Hilmy MH, Nongpiur ME, Baskaran M, Khor CC, Aung T, Hunziker W, and Vithana EN. Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function. Human molecular genetics, 2017; 26(20):4011-4027. First-Author. Abstract

Aung T, Ozaki M, Lee MC, Schllötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, Igo P, Haripriya A, Williams SE, Astakhov YS, Orr AC, Burdon KP, Nakano S, Mori K, Abu-Amero K, Hauser M, Li Z, Prakadeeswari G, Cooke Bailey JN, Cherecheanu AP, Kang JH, Nelson S, Hayashi K, Manabe S, Kazama S, Zarnowski T, Inoue K, Irkec M et al., Worldwide genetic association study of exfoliation syndrome identifies highly protective rare variants at LOXL1 and five new common-variant susceptibility loci. Nature Genetics, 2017; 49(7):993-1004. Joint-first Author. Abstract

Khor CC, Do T, Jia H, Nakano M, George R, Abu-Amero K, Duvesh R, Chen LJ, Li Z, Nongpiur ME, Perera SA, Qiao C, Wong HT, Sakai H, Barbosa de Melo M, Lee MC, Chan AS, Azhany Y, Dao TL, Ikeda Y, Perez-Grossmann RA, Zarnowski T, Day AC, Jonas JB, Tam PO, Tran TA, Ayub H, Akhtar F, Micheal S, Chew PT, Aljasim LA, Dada T, Luu TT, et al., Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature Genetics, 2016; 48(5):556-62. Co-Author. Abstract

Li Z, Allingham RR, Nakano M, Jia L, Chen Y, Ikeda Y, Mani B, Chen LJ, Kee C, Garway-Heath DF, Sripriya S, Fuse N, Abu-Amero KK, Huang C, Namburi P, Burdon K, Perera SA, Gharahkhani P, Lin Y, Ueno M, Ozaki M, Mizoguchi T, Krishnadas SR, Osman EA, Lee MC, Chan AS, Tajudin LS, Do T, Goncalves A, Reynier P, Zhang H, Bourne R, Goh D, Broadway D, Husain R, Negi AK, Su DH, Ho CL, Blanco AA, Leung CK, Wong TT, Yakub A, Liu Y, et al., A common variant near TGFBR3 is associated with primary open angle glaucoma. Human molecular genetics, 2015; 24(13):3880-92. Co-Author. Abstract

Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS, Abu-Amero KK, Zenteno JC, Nilgun Y, Zarnowski T, Pakravan M, Safieh LA, Jia L, Wang YX, Williams S, Paoli D, Schlottmann PG, Huang L, Sim KS, Foo JN, Nakano M, Ikeda Y, et al., A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. Nature Genetics, 2015; 47(4):387-92. Co-Author. Abstract

Lee MC, Chan AS, Goh SR, Hilmy MH, Nongpiur ME, Hong W, Aung T, Hunziker W, Vithana EN. Expression of the primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 in endothelial and epithelial cell junctions in the eye. Investigative Ophthalmology & Visual Science, 2014; 55(6):3833-41. First-Author. Abstract

Zhang YH, Bhunia A, Wan KF, Lee MC, Chan SL, Yu VC, Mok YK. Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft. Journal of Molecular Biology 2006; 364(3):536-49. Co-Author. Abstract

Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD, Yu VC. Identification of chelerythrine as an inhibitor of BclXL function. The Journal of biological chemistry 2003; 278(23):20453-6. Co-Author. Abstract