Previous NATi Call for Proposals (Closed)

Call for Proposals N01

Call Opens: 19 December 2023
Submission Deadline: 24 January 2024, 1200 hrs (SGT)

Maximum Duration: 3 years
Maximum Quantum: S$3 million (excluding 30% indirect costs)

Call for Proposals N01 aims to address the following problem statements:
#Problem Statement Objectives Deliverables

1.

Lack of local production capacities and automation capabilities to accelerate the development of mRNA assets to clinical readiness

  • Develop mRNA manufacturing and quality control capabilities to be routinely operated in compliance with GLP, with ability to adopt GMP-like operations on demand
  • Develop automation strategies to improve consistency, reduce waste and increase turnaround time
  • Demonstrate GLP production at sufficient yield and quality for preclinical studies
  • Develop analytical workflows and control strategies to enable adoption of QbD framework
  • Integrate unit operations to support end-to-end manufacturing
  • Demonstrate quantified improvements over conventional processes

2.

Lack of local production capacities and automation capabilities to accelerate the development of siRNA/ ASO assets to clinical readiness

  • Develop siRNA/ ASO manufacturing and quality control capabilities to be routinely operated in compliance with GLP, with ability to adopt GMP-like operations on demand
  • Develop automation strategies to improve consistency, reduce waste and increase turnaround time
  • Demonstrate GLP production at sufficient yield and quality for preclinical studies
  • Develop analytical workflows and control strategies to enable adoption of QbD framework
  • Integrate unit operations to support end-to-end manufacturing
  • Demonstrate quantified improvements over conventional processes

RNA: ribonucleic acid; mRNA: messenger RNA; siRNA: small interfering RNA; ASO: antisense oligonucleotide; GLP: Good Laboratory Practice; GMP: Good Manufacturing Practice; QbD: Quality by Design

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