Bacteriophage DNA Modifications

A collaborative study with researchers from China and US led to the discovery of the mechanism for synthesis of DNA genomes containing the bases ZGTC, instead of AGTC in regular DNA.

A*STAR’s Singapore Institute of Food and Biotechnology Innovation (SIFBI), ShanghaiTech University and Tianjin University in China, and the University of Illinois at Urbana-Champaign in USA

A Widespread Pathway for Substitution of Adenine by Diaminopurine in Phage Genomesmore

B2ii(a) SIFBI DNA genomes_Ang Ee Lui TOC copy
Modified Z base forms a triple bond with a T base on the complementary DNA strand.