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Dermatotoxicology

DermatotoxicologyModels for Organ Specific, Developmental & Genetic ToxicityPBTK & Exposure ModellingAllergen PredictionToxicity Mode-of-Action Discovery (ToxMAD) Platform


Screening of Underlying Reactive Protein Adductome in chemical-induced Skin Sensitization (SURPASS)

Screening of Underlying Reactive Protein Adductome in chemical-induced Skin Sensitization (SURPASS)

SURPASS aims to develop animal-free, human-relevant and industry-ready safety assessment approaches for screening chemical-induced skin sensitization by leveraging on a mechanistic understanding of dermal chemical exposure and the adduction-immunogenicity paradigm.

By coupling the identification of chemical sensitization and potency (covalent skin protein adductome profiling) with the prediction of chemical dermal exposure (physiologically-based toxicokinetic modelling), our efforts culminate in a decision tree that integrates toxicodynamic and toxicokinetic data for hazard potency prediction and overall skin sensitization risk assessment.

A*STAR IFCS SURPASS

Key Team Members

Prof. Eric Chun Yong Chan
Prof. Zee Upton
Assoc. Prof. Ee Chee Ren
Dr. Hao Fan
Dr. Radoslaw Sobota
Dr. James Chun Yip Chan



Global Metabolomics Profiling of an In Vitro Skin Irritation Model to Predict Irritation Potency of Chemicals

Global Metabolomics Profiling of an In Vitro Skin Irritation Model to Predict Irritation Potency of Chemicals

Skin irritation can occur after use of beauty products, resulting in localized itching, swelling and redness due to tissue damage. To help companies reduce irritation risk caused by ingredients in their products, we monitor extensively the changes in metabolite levels within lab-based skin models using sensitive analytical tools. These changes can be correlated to the degree of tissue damage, allowing companies to exclude ingredients or redesign products to minimize risk.

Key Team Members

Dr. James Chun Yip Chan
Dr. John Common
Dr. Vincent Lim
Prof. Eric Chun Yong Chan
Prof. Zee Upton


High-throughput Screening Platform to Identify Compounds with Sensory Irritant Activity

Sensory Irritation

Evaluation of chemical sensory irritation is an essential component of safety testing of personal care products, cosmetics and topical medications. Current methods for sensory irritation testing include in vivo animal tests and in vitro skin cell viability-based assays which fail to detect weak irritants and offer no mechanistic information.

We aim to bridge this gap by developing a predictive ‘Mechanism-based Irritant Screening Platform’ that combines sophisticated molecular and cellular assays with carefully-performed human-level studies.

Key Team Members

Dr. Prakash Arumugam
Dr. John Common
Dr. Ann Koay
Dr. Wei Guang Seetoh
Dr. Benjamin Smith


 

Agency for Science, Technology and Research (A*STAR)

1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632

 

contact@a-star.edu.sg

 

(65) 6826 6111


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