• Dermatotoxicology • Models for Organ Specific, Developmental & Genetic Toxicity • PBTK & Exposure Modelling • Allergen Prediction • Toxicity Mode-of-Action Discovery (ToxMAD) Platform
SURPASS aims to develop animal-free, human-relevant and industry-ready safety assessment approaches for screening chemical-induced skin sensitization by leveraging on a mechanistic understanding of dermal chemical exposure and the adduction-immunogenicity paradigm.By coupling the identification of chemical sensitization and potency (covalent skin protein adductome profiling) with the prediction of chemical dermal exposure (physiologically-based toxicokinetic modelling), our efforts culminate in a decision tree that integrates toxicodynamic and toxicokinetic data for hazard potency prediction and overall skin sensitization risk assessment.
Prof. Eric Chun Yong ChanProf. Zee Upton
Assoc. Prof. Ee Chee RenDr. Hao FanDr. Radoslaw SobotaDr. James Chun Yip Chan
Skin irritation can occur after use of beauty products, resulting in localized itching, swelling and redness due to tissue damage. To help companies reduce irritation risk caused by ingredients in their products, we monitor extensively the changes in metabolite levels within lab-based skin models using sensitive analytical tools. These changes can be correlated to the degree of tissue damage, allowing companies to exclude ingredients or redesign products to minimize risk.
Dr. James Chun Yip Chan Dr. John Common
Dr. Vincent Lim Prof. Eric Chun Yong ChanProf. Zee Upton
Evaluation of chemical sensory irritation is an essential component of safety testing of personal care products, cosmetics and topical medications. Current methods for sensory irritation testing include in vivo animal tests and in vitro skin cell viability-based assays which fail to detect weak irritants and offer no mechanistic information.We aim to bridge this gap by developing a predictive ‘Mechanism-based Irritant Screening Platform’ that combines sophisticated molecular and cellular assays with carefully-performed human-level studies.
Dr. Prakash ArumugamDr. John CommonDr. Ann KoayDr. Wei Guang SeetohDr. Benjamin Smith