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Models For Organ Specific, Developmental & Genetic Toxicity

DermatotoxicologyModels for Organ Specific, Developmental & Genetic ToxicityPBTK & Exposure ModellingAllergen PredictionToxicity Mode-of-Action Discovery (ToxMAD) Platform


Advanced Donor-Matched Human In Vitro Liver Co-Culture Model for Hepatotoxicity Prediction

Advanced Donor-Matched Human In Vitro Liver Co-Culture Model for Hepatotoxicity Prediction

This project deploys co culture of donor-matched, human iPSC-derived liver-resident macrophages - Kupffer cells (iKCs) and iPSC-derived hepatocytes (iHep) for development of inflammation-sensitive in vitro liver model for testing hepatotoxicity of a wide range of compounds drugs, food and consumer care products, cosmetics and environmental toxins.

Advanced Donor-Matched Human In Vitro Liver Co-Culture Model for Hepatotoxicity Prediction infographics

Team

Prof. Hanry Yu
Dr. Florent Ginhoux
Dr. Farah TASNIM
Christopher Lee
Xiaozhong Huang
Camille Blériot



A Predictive Kidney-Specific High-Throughput Screening (HTS) Platform Based on Human Induced Pluripotent Stem Cells

Predictive Kidney-Specific HTS Platform based on Human iPSCs

This project aims to combine our method for generating induced pluripotent stem cell (iPSC)-derived human renal cells with our award-winning high-content screening (HCS) platform for predicting nephrotoxicity in humans with high accuracy. The resulting iPSC-based HCS platform for nephrotoxicity prediction will be validated with a robust number of compounds, and the predictive performance metrics will be determined. In-depth characterization of the modes-of-action of selected compounds will be performed in collaboration with other IFCS groups. 

D_Zink


TEAM

Dr. Daniele Zink
Dr. Lit-Hsin Loo
Dr. Sreetama Basu
Dr. Riga Tawo


Physiologically Relevant GI-tract Models For (Nano)-Genotoxicity

GI-tract Nanogenotoxicity

Although significant understanding about the mechanisms of nanotoxicity has been made over the last decade, limited attention has been given to making nanotoxicology testing fit for regulatory purposes. Collaborating with the Singapore Food Agency (SFA), we aim to develop reliable and robust methods for genotoxicity testing using commercially available 3D-Reconstituted Human Intestinal Epithelia and in-house co-culture models, and to validate these for regulatory use.

Team

Dr. Benjamin Smith
Assoc. Prof. David Ian Leavesley
Dr. Hui Kheng Lim
Dr. Zheng Ming Wang
Dr. Jasmine Li
Dr. Calvin Yeo
Dr. Man Ling Chau
Assoc. Prof. Kee Woei Ng
Dr. Mustafa Hussain Kathawal


In Vitro Micropatterned Human Pluripotent Stem Cell Test (μP- hPST) for Morphometric-Based Teratogen Screening

In Vitro Micropatterned Human Pluripotent Stem Cell Test (μP- hPST) for Morphometric-Based Teratogen Screening

μP-hPST can recapitulate morphological disruption of spatiotemporally controlled mesoendoderm development upon treatment with known teratogens. The model has been validated using 34 pharmaceutical compounds and classified compounds with 97% accuracy, 100% specificity and 93% sensitivity and successfully identified misclassified drugs. This project focuses on testing the teratogenicity of environmental, industrial and agro chemicals using this model with the bigger aim of improving the overall predictivity of developmental toxicity models.

Team

Prof. Hanry Yu
Dr. Samuel Wong
Dr. Farah Tasnim



 

Agency for Science, Technology and Research (A*STAR)

1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632

 

contact@a-star.edu.sg

 

(65) 6826 6111


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