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September 2019


Rare Human Missense Variants can affect the Function of Disease-Relevant Proteins by Loss and Gain of Peroxisomal Targeting Motifs

Researchers from A*STAR’s Bioinformatics Institute (BII) show how a complementary approach incorporating bioinformatics methods and experimental testing can successfully identify SNVs capable of altering peroxisome protein import, which may have implications in human disease.
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June 2019


Predicting Protein Allergens Accurately

Predicting Protein Allergens Accurately

The AllerCatPro analysis workflow helps researchers predict the likelihood of a protein producing an allergic response in people.
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May 2019


Delivering a Renewable Source of Kupffer Cells

Delivering a Renewable Source of Kupffer Cells

Researchers from A*STAR’s Institute of Bioengineering and Nanotechnology (IBN) led by Dr Hanry Yu have devised a method to generate mature human Kupffer cells from iPSC cells, replacing the current reliance on primary Kupffer cells (pKCs) obtained from adult human livers. The researchers first generated immature immune cells known as macrophage precursors from iPSCs. They then differentiated these precursors into induced Kupffer cells (iKCs) using primary human hepatocyte conditioned media.
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