Project 2: Epigenetic studies
Modifiable Disease Mechanisms
- Chromatin organization: histone modifications, DNA methylation, lamina-domains
- Do different sub-populations of cardiomyocytes exist?
- What are the novel histone modifications in cardiomyocytes
- Map of the cardiac epigenome of 100 human hearts
- Experimental models of diseases
- Pig model: track progression of disease and its reversibility
Aim: Novel therapeutic targets in cardiac epigenome/chromatin