Waters Collaborate with BTI on Glycosphingolipid Project, Chromatography Online
Waters Corporation (Massachusetts, USA) has announced a collaboration with the Bioprocessing Technology Institute (BTI), a research institute within Singapore’s Agency for Science, Technology, and Research (A*STAR). The joint effort will develop a glycosphingolipid (GSL) head group database containing Glucose Unit (GU) retention times1 and collision cross-section (CCS) values, forming an experimental library for disease related GSL glycans together with a glycan/MS spectral library. GSLs constitute a glycan head group attached to fatty acyl moieties, and are critical for cell growth interaction, and signalling. Alterations to their structure can cause disease or promote cancer development, however, analysis of glycan head groups has proved difficult because their isomeric structures are not easily differentiated by either liquid chromatography (LC) or mass spectrometry (MS) when used alone.