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16
Dec 2015

Researchers mass-producing stem cells to satisfy the demands of regenerative medicine, Biotech In Asia

Growing demand of stem cells in regenerative medicine has led scientists to expedite the production of these cells. Researchers at the A*STAR Bioprocessing Technology Institute (BTI) in Singapore have designed a process for mass-production of stem cells. Dr Steve Oh’s group has been growing stem cells by conventional means at BTI for seven long years, when in 2008 his colleague Shaul Reuveny proposed an idea for mass-production.

08
Dec 2015

To have and to hold, in sickness and in health, Asia One Online

Every morning for four years, retired lecturer Yap Kian Tiong dutifully cleared phlegm from his bed-ridden wife's throat with a suction machine, checked to see if her eyes were watery and massaged her.He literally provided her support as she went about her daily 90-minute physiotherapy. "She was heavy and it was a rigorous process," said Professor Yap.

07
Dec 2015

Yap Kian Tiong recalls life with top scientist Miranda Yap: To have and to hold, in sickness and in health, The Straits Times Online

Every morning for four years, retired lecturer Yap Kian Tiong dutifully cleared phlegm from his bed-ridden wife's throat with a suction machine, checked to see if her eyes were watery and massaged her. He literally provided her support as she went about her daily 90-minute physiotherapy. "She was heavy and it was a rigorous process," said Professor Yap.

07
Nov 2015

Cell therapy for heart repair, Biotech In Asia

An innovative study on repairing damaged heart tissue through stem cell therapy has given a hope to patients suffering from heart disease. Heart attacks damage cardiac muscle cells or ‘cardiomyocytes’, often leading to irreversible functional damage. Researchers from the A*STAR Bioprocessing Technology Institute (BTI) have developed a method to isolate and expand human heart stem cells, also known as cardiac progenitor cells, which lead to a potential treatment option by replacing the damaged cells with new functional cardiomyocytes through stem cell therapy.

17
Oct 2015

Biomedical sciences pioneer dies, The Straits Times

One of Singapore's top scientists, Professor Miranda Yap, died on Wednesday, more than four years after she suffered an aneurysm. Prof Yap was most noted for setting up the Bioprocessing Technology Unit in 1990 with a $6 million grant from the Economic Development Board. It was renamed Bioprocessing Technology Institute (BTI) in 2003, as part of the Agency for Science, Technology and Research (A*STAR). She was also awarded the country's highest science and technology honour in 2009, the President's Science and Technology Medal, (formerly known as the National Science and Technology Medal).

16
Oct 2015

Leading scientist Miranda Yap dies, 4 years after suffering aneurysm, The Straits Times Online

One of Singapore's top scientists, Dr Miranda Yap, died on Wednesday, more than four years after she suffered an aneurysm on the golf course. Dr Yap, who was awarded the country's highest science and technology honour in 2009, had since remained bedridden and was largely unresponsive. The award, called President's Science and Technology Medal (PSTM), was formerly known as the National Science and Technology Medal. It was first given out in 1992, and there had been no female winners before Dr Yap.

16
Oct 2015

Female professor died after 4 years of coma despite care from husband, Lianhe WanBao

 

16
Oct 2015

Female Professor died after 4 years of coma, Shin Min Daily

 

21
Jul 2015

Agilent & BTI collaborate on glycoprotein analysism, Asian Scientist

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore’s Agency for Science, Technology and Research (A*STAR) will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

17
Jul 2015

Agilent and A*STAR to develop glycan analysis methods more suited to commercial setting, Biopharma

Agilent and A*STAR have partnered to create quicker, more accurate ways of testing the sugar content of therapeutic proteins and monoclonal antibodies (mAbs) that are tailored for commercial producers.

15
Jul 2015

Agilent Technologies and A*STAR's Bioprocessing Technology Institute Collaborate on New Bioanalytical, Nanotech Now

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

15
Jul 2015

Agilent, A*STAR to develop new analytical tools for glycoprotein testing, BioSpectrum

Through the partnership the two organizations aim to address gaps in analytical testing applied for drugs based on glycoproteins,that form the majority of approved biopharmaceutical drugs.

14
Jul 2015

Agilent Technologies and A*STAR's Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, Life Sciences Industry News

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Agilent, Singapore Institute to Collaborate on Protein Analytical Methods, PharmaAsia

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) will collaborate on new analytical approaches to analysing specific protein-linked sugar compounds.

14
Jul 2015

Agilent Technologies and A*STAR's Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, ACN Newswire

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) today announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Agilent Technologies and A*STAR’s Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, Benzinga

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) today announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Agilent Technologies and A*STAR's Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, News Sys Con

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) today announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Agilent Technologies and A*STAR's Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, Market Watch

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) today announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Agilent Technologies and A*STAR’s Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, StockHouse

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) today announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Singapore to trial new bioanalytical methodologies, Enterprise Innovation

The Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR), is partnering with Agilent Technologies Inc. on a project that will explore new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Agilent Technologies and A*STAR’s Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, News Maker

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) today announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Agilent Technologies and A*STAR's Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, Select Science

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore's Agency for Science, Technology and Research (A*STAR) today announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds.

14
Jul 2015

Agilent Technologies and A*STAR’s Bioprocessing Technology Institute Collaborate on New Bioanalytical Methodologies, Biotech In Asia

Agilent Technologies Inc. and the Bioprocessing Technology Institute (BTI), a research institute of Singapore’s Agency for Science, Technology and Research (A*STAR) today announced that they will collaborate on new analytical approaches to analyzing specific protein-linked sugar compounds. The collaboration will address a gap in analytical tests and standards applied for drugs based on glycoproteins, which now form the majority of approved biopharmaceutical drugs.

07
Jun 2015

BTI Executive Director, Professor Lam Kong Peng featured in “I am a Scientist” column in The Sunday Times

Agency for Science, Technology and Research's (A*Star's) Bioprocessing Technology Institute (BTI) is celebrating its 25th anniversary this year. BTI does research into the discovery and production of biologics, and develops the processes and technologies involved in the production process. Biologics are therapeutics produced by living cells and they are used to treat human ailments like cancer and other acute and chronic diseases. Examples of biologics include proteins, vaccines and monoclonal antibodies - a class of agents that targets specific proteins on the surface of cancer cells and stimulates the body's immune system to destroy these cells.

20
May 2015

A non-invasive tool for diagnosing cancer, Medical Xpress

Researchers in Singapore have developed an ultrasensitive method to detect micro-RNAs: tiny molecules that can indicate the presence of tumours. They are applying the technology toward a non-invasive screening test for gastric cancer.

30
Apr 2015

Learning how a key protein affects programmed cell death could help to develop vaccines and drugs, Medical Xpress

A*STAR researchers have clarified the role of one particular regulatory protein in controlling the development of plasma cells, opening up several new avenues toward clinical applications. Plasma cells produce large amounts of antibodies, which are the best-known weapons of the immune system against pathogens. "We are interested in understanding how plasma cells are generated with the aim of identifying new targets to modulate the antibody response, in particular during vaccination," explains Kong-Peng Lam of the A*STAR Bioprocessing Technology Institute in Singapore.

29
Mar 2015

Singapore scientists learn the art by which the body fights, Biotech in Asia

Scientists from A*STAR’s Bioprocess Technology Institute (BTI) have uncovered two crucial signaling molecules, DOK3 and SHP1, involved in the development and production of plasma cells which help the human body fight against pathogens. The antibodies secreted by plasma cells are key to the body’s immune system and its ability to defend itself against pathogens, such as bacteria and viruses. Proper maintenance of a pool of plasma cells is critical for the establishment of lifelong immunity elicited by vaccination.

29
Jan 2015

S'pore team develops blood test for cancers, AsiaOne

Scientists in Singapore have developed a blood test which takes just three hours and can detect even the early stages of the cancers, before symptoms start to appear. They achieved more than 90 per cent accuracy in laboratory tests, and plan to work with hospitals here to introduce the blood test as a screening tool by 2017. The blood test became possible when a team of scientists from the Agency for Science, Technology and Research (A*Star) developed a method to measure tiny changes in the levels of genes called micro-RNA in blood.

15
Oct 2014

Delivering DNA into B cells, Lab Online AU

The process of transfection - introducing foreign DNA into human cells - allows scientists to study gene expression in the laboratory and enables clinicians to treat genetic diseases. The research team, led by scientists at the A*STAR Bioprocessing Technology Institute and the A*STAR Institute of High Performance Computing, successfully introduced genes into B cells by optimising a technique called sonoporation.

02
Oct 2014

Singapore scientists find new pattern in immune cell mechanism, Biospectrum Asia

Scientists from A*STAR's Bioprocessing Technology Institute (BTI) have identified relationship between two cells which serve human body's natural defence mechanisms against diseases and infections. Natural killer T (NKT) cells and B cells are two of many immune cell types that work in tandem to help the body fight against foreign infectious agents. NKT cells have very potent functions and are crucial to the immune system despite making up only a small percentage of white blood cells. While scientists have established that NKT cells can promote the production of antibodies by B cells to combat infection, little is known about the effect of B cells on NKT cells until now.

02
Oct 2014

Autoimmunity’s Perfect Storm: B Cells, NKT Cells & Lipids, Asian Scientist

Scientists have identified a new role for B cells in autoimmunity: hyper-activating another class of cells known as natural killer T (NKT cells). Their research, published in the journal Cell Reports, could lead to novel lipid-based approaches to treating autoimmunity. NKT cells are a special population of immune cells which play an important role in the body’s response to lipid antigens. In particular, they respond to antibody-producing cells (B cells) which display lipid antigens on their surface, held in place by a molecule known as CD1d.

05
Sep 2014

Deciphering Signals Needed to Maintain Plasma Cell Pool, Genetic Engineering & Biotechnology News

Though few, plasma cells secrete large amounts of antibodies, and are thus crucial to the body’s fight against pathogens. To maintain its small but potent plasma cell cadres, the body relies on signaling molecules to sustain plasma cell production. Signaling molecules also influence the long-term survival of plasma cells. By identifying these signaling molecules, scientists hope to improve the design of vaccines. Tapping into the body’s signaling pathways could also point to therapies for autoimmune diseases.

02
Sep 2014

Understanding The Body’s Antibody Factories, Asian Scientist

Scientists have uncovered the crucial role of two signalling molecules involved in the development and production of plasma cells. These discoveries, published in the Proceedings of the National Academy of Sciences of the United States of America and Nature Communications, advance the understanding of plasma cells and antibody response, and may lead to optimised vaccine development and autoimmune disease treatments.

16
Jul 2014

Roche And A*STAR Ink Drug Discovery Deal, BioProcess Online

A*STAR's Bioprocessing Technology Institute (BTI) announced that it has signed into agreement with pharma giant Roche to identify new drug candidates for the treatment and early detection of cancer. The partnership will tap BTI’s capabilities in novel antibody discovery as well as Roche’s technology in developing monoclonal antibody (mAbs) therapeutics.

14
Jul 2014

A*STAR Partners Roche to Develop New Cancer Therapeutics, Biz Daily

BTI’s mAbs have a novel mechanism of action; causing membrane damage to cancer cells that result in cell death. The image on the left shows untreated cancer cells, while the image on the right depicts antibody-treated cancer cells with lesions and pores on the cell surface.

14
Jul 2014

A*STAR Partners Roche to Develop New Cancer Therapeutics, ACN Newswire

Partnership with Roche Pharma Research and Early Development leverages a unique discovery by A*STAR's Bioprocessing Technology Institute to develop new approaches for cancer detection and treatment.

15
May 2014

Void Exclusive Biomanufacturing Method, Genetic Engineering and Biotechnology News

Anion exchange chromatography (AEC) is one of the pillars of downstream processing, especially for IgG purification. Its ability to simultaneously reduce DNA, virus, and host protein contamination has made it an essential polishing tool, and it is the only fractionation method used in more processes than affinity chromatography.

05
May 2014

Synthetic Biology in Singapore, Asia Pacific Biotech News

Have you ever imaged that artificial living cells or organisms can be created just like the way you build toy castle using your Lego bricks? Although this sounds very much like a crazy idea from some science fiction movie that will not happen in the near future, this ambitious goal is what synthetic biology desires to achieve and enormous efforts are being put into this field to reshape the world we live in.

13
Feb 2014

A*STAR institute, Korea institutions team up, Business Times

An A*Star institute here has teamed up with two Korean institutions to undertake research projects, run conferences and manpower training programmes in the field of glycomics. Glycomics is the study of sugars in biological systems, and has implications for biopharmaceutical drug-testing and treatments for a variety of diseases. The two Korean institutions which A*Star's Bioprocessing Technology Institute will partner with are the Korea Basic Science Institute and the Chungnam National University's Graduate School of Analytics Science & Technology.

12
Feb 2014

A*STAR signs pact with South Korean institutes to advance glycomics research, Channel NewsAsia

A*STAR's Bioprocessing Technology Institute on Wednesday signed MOUs with two South Korean institutes to advance collaboration in the field of glycomics in Asia.

12
Feb 2014

A*STAR's Bioprocessing Technology Institute (BTI) partners South Korean Institutes to advance glycomics research in Asia, Warna FM, Radio Broadcast

 

12
Feb 2014

A*STAR signs pact with South Korean institutes to advance glycomics research, XinMSN

A*STAR's Bioprocessing Technology Institute (BTI) on Wednesday signed Memorandums of Understanding (MOUs) with two South Korean institutes to advance collaboration in the field of glycomics in Asia. BTI, Korea Basic Science Institute (KBSI) and Chungnam National University's Graduate School of Analytics Science and Technology (GRAST) signed the agreements at a two-day symposium on glycomics, which ends on Thursday.

12
Nov 2013

Growth in Biologics, Good Morning Singapore, Channel 8

 

11
Nov 2013

BTI Executive Director, Professor Lam Kong Peng, interviewed by Business Singapore, Channel NewsAsia

Prof Lam Kong Peng was interviewed by Channel NewsAsia on his views of the key demand factors that drives the growth in the biologics sector in Singapore. Prof Lam shared on the difference between biologics and traditional drugs/pharmaceuticals, as well as BTI’s research and training capabilities. Kevin Lai (Director, Biomedical Sciences & Consumer Businesses, EDB) and Aart Buiter (VP & GM, Roche Singapore Technical Operations) were also interviewed in the same segment.

11
Nov 2013

Jobs in Singapore biologic sector to increase, Channel NewsAsia

Pharmaceutical giants have invested S$2.4 billion in Singapore, setting up eight biologics manufacturing plants within the last five years. EDB estimates that new jobs in the sector will increase by 60 per cent, or 1,000 jobs, over the next three to four years.

17
Oct 2013

Electrical Stimulation Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells, ESC & iPSC News

Scientists sought to determine whether electrical stimulation could enhance the differentiation and maturation of human embryonic stem cell-derived cardiomyocytes.

31
Aug 2013

Microcarrier culture in stem cell bioprocessing, News & Analysis Interview, Pharmaceutical Bioprocessing

Dr Steve Oh was interviewed by Ms Alice O’Hare, Commissioning Editor, Pharmaceutical Bioprocesing on the field of stem cell bioprocessing.

27
May 2013

Agilent, University Of Rouen, A*STAR To Collaborate In Glycomics, Asian Scientist

Agilent, the University of Rouen, and A*STAR have signed an MOU to develop tools to effectively analyze biologics and vaccines.

27
May 2013

Agilent, A*Star, French univ sign biologics MoU, BioSpectrum

Agilent Technologies, Glyco-MEV laboratory at the University of Rouen, France, and Bioprocessing Technology Institute (BTI) at A*STAR, Singapore, signed a MoU to develop tools to effectively analyze biologics and vaccines.

16
May 2013

BTI Research Scientist, Dr Marvin Lee, interviewed by Good Morning Singapore, Channel 8

 

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