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Engineering CELLS,
   Engineering RESPONSES

IMMUNOLOGY

Experiment, Discover and Innovate

The immunology group is positioned upstream of BTI's spectrum of R&D activities and complements existing capabilities by providing expertise in molecular and cellular immunological techniques and assays, developing mouse models of autoimmune and inflammatory diseases and identifying targets for downstream development with the aim of discovering biomolecules that have potential applications in human healthcare.

The group has three major research directions. The first is studying the terminal differentiation of B cell with special emphasis on memory B cells and long-lived plasma cells. We focus on deciphering the regulatory functions of microRNAs and signalling molecules in B cell differentiation, and aim to identify new targets for modulating the antibody response. This has a direct impact on the development of novel therapeutic strategies for the modulation of autoantibody production in autoimmune diseases and in the treatment of B cell-derived cancers.

The second area of research is to investigate the immunoregulatory function of natural killer T (NKT) cells in normal immune and autoimmune settings. As these cells uniquely respond to lipid antigens, we aim to discover lipid candidates which could modulate their responses to infection or autoimmunity with the view to develop these lipids as potential vaccine adjuvants.

Last but not least, our third area of research is to understand signal transduction mechanisms in innate immunity focussing on the sensing of pathogenic nucleic acids. In particular, we are interested in studying how molecules such as kinases, helicases and adaptor proteins function in innate immunity against infectious diseases. This could yield novel molecular targets that are amenable for the development of therapeutic drugs such as those that could either enhance the host antimicrobial response or prevent exaggerated host inflammatory response.

immunology pic

People

Prof Lam Kong Peng

PhD in Microbiology (1994), Columbia University, USA

Research Focus/Interests
  • Immunology
  • Infectious Diseases and Autoimmunity

Dr. Xu Shengli

PhD in Immunology (2003) National University of Singapore, Singapore

Research Focus/Interests
  • Regulation of immune response
  • Differentiation of plasma cells

Dr. Huo Jianxin

PhD in Biochemistry (2003), National University of Singapore, Singapore

Research Focus/Interests
  • Chronic Inflammation and Obesity/ Hepatocellular Carcinoma (HCC)
  • Molecular Aetiology of Multiple Myeloma (MM)
  • Islet Biology/Transplantation
  • T cell Development
  • Cell Cycle and Apoptosis Signalling

Dr. Ivan Tan

PhD in Molecular and Cell Biology (2003) National University of Singapore

Research Focus/Interests
  • Post-translational regulation in immune cell proliferation and differentiation
  • Immune cell metabolism regulation

Susana Kim

Dr. Susana Kim

PhD In Immunology (2013), National University of Singapore, Singapore

Research Focus/Interests
  • Biology of autoreactive B cells

Dr. Leoh Lai Sum

PhD in Microbiology and Molecular Genetics (2011), Loma Linda University, California, USA

Research Focus/Interests
  • Cancer immunotherapy

Dr. Loh Jia Tong

PhD in Biological Sciences (2016), Nanyang Technological University, Singapore

Research Focus/Interests
  • Innate immunity

Dr. Choy Fong Chan

PhD in Genetics (2015), The University of Adelaide, Australia

Research Focus/Interests
  • Biotherapeutics and Immunology

Dr. Lucas Goh

PhD in Infectious Diseases, Microbiology & Biotechnology (2015), The University of Queensland, Australia

Research Focus/Interests
  • Infectious Diseases & Immunotherapy

Year 2018

    Andy Hee-Meng Tan, Arleen Sanny, Sze-Wai Ng, Ying-Swan Ho, Nurhidayah Basri, Alison Ping Lee & Kong-Peng Lam (2018) Excessive interferon-a signaling in autoimmunity alters glycosphingolipid processing in B cells. Journal of Autoimmunity S0896-8411(17)30603-0

Year 2017

    Miran Rada, Mohammad Althubiti, Akang E. Ekpenyong-Akiba, Koon-Guan Lee, Kong Peng Lam, Olga Fedorova, Nickolai A. Barlev and Salvador Macip (2017) BTK blocks the inhibitory effects of MDM2 on p53 activity. Oncotarget 8(63): 106639-106647

    Jianxin Huo, Yuhan Huang, Shengli Xu and Kong-Peng Lam (2017) Analysis of signaling events in B-1a cells. Methods in Molecular Biology 1643: 75-83

    Janice H.C. Plani-Lam, Neli S. Slavova-Azmanova, Nicole Kucera, Alison Louw, Jiulia Satiaputraa, Peter Singer, Kong-Peng Lam, Margaret L. Hibbs, and Evan Ingley (2017) Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity. Experimental Hematology 46: 70-82.e10

    Yan-Feng Li, Shengli Xu, Yuhan Huang, Xijun Ou & Kong-Peng Lam (2016) Tyrosine kinase c-Abl regulates the survival of plasma cells. Scientific Reports 7: 40133

Year 2016

    Mohammad Althubiti, Miran Rada, Jesvin Samuel, Josep M. Escorsa, Hishyar Najeeb, Koon-Guan Lee, Kong-Peng Lam, George D.D. Jones, Nickolai A. Barlev, and Salvador Macip (2016) BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses. Cancer Research 76(18): 5405-5414

    Chang-Yien Chan, Isaac Desheng Liu, Lourdes Paula Resontoc, Kar-Hui Ng, Yiong-Huak Chan, Perry Yew-Weng Lau, Mya Than, Stanley C. Jordan, Kong-Peng Lam, Wee-Song Yeo, and Hui-Kim Yap (2016) T-lymphocyte activation markers as predictors of responsiveness to Rituximab among patients with FSGS. Clinical Journal of the American Society of Nephrology 11(8): 1360-1368

    Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani, Wei Hseun Yeap, Peter See Chi Ee, Boris San Luis, Bernett Lee, Terence Lee, Shi Ya Mak, Ying Swan Ho, Kong Peng Lam, Choon Kiat Ong, Ruby Y. J. Huang, Florent Ginhoux, Olaf Rotzschke, Roger D. Kamm, and Siew Cheng Wong (2016) Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology 5(8): e1191731

    Yan-Feng Li, Xijun Ou, Shengli Xu, Zi-Bing Jin, Naoharu Iwai, and Kong-Peng Lam (2016) Loss of miR-182 affects B-cell extrafollicular antibody response. Immunology 148(2): 140-149

    Jianxin Huo, Yi Ma, Jian-Jun Liu, Ying Swan Ho, Sylvia Liu, Li Ying Soh, Shuwen Chen, Shengli Xu, Weiping Han, An Hong, Su Chi Lim, Kong-Peng Lam (2016) Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis. Cell Death and Disease 7: e2091

Year 2015

    Lee Koon Guan and Lam Kong Peng (2015) BTK: sensing pathogenic nucleic acids. Oncotarget 6(24):19948-19949

    Shengli Xu, Xijun Ou, Jianxin Huo, Kristen Lim, Yuhan Huang, Sheena Chee & Kong-Peng Lam (2015) Mir-17~92 regulates bone marrow homing of plasma cells and production of immunoglobulin G 2c. Nature Communications 6: 6764

    Koon-Guan Lee, Susana Soo-Yeon Kim, Lin Kui, Dominic Chih-Cheng Voon, Marjorie Mauduit, Pradeep Bist, Xuezhi Bi, Natasha Ann Pereira, Chengcheng Liu, Bindu Sukumaran, Laurent Rénia, Yoshiaki Ito and Kong-Peng Lam (2015) Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response. Cell Reports 10(7):1055-1065

Year 2014

    Wan Ping Loh, Bernard Loo, Lihan Zhou, Peiqing Zhang, Dong-Yup Lee, Yuansheng Yang and Kong Peng Lam (2014) Overexpression of microRNAs enhances recombinant protein production in Chinese hamster ovary cells. Biotechnology Journal 9(9): 1140-1151

    Xijun Ou, Shengli Xu, Yan-Feng Li and Kong-Peng Lam (2014) Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands. Proceedings of the National Academy of Sciences (PNAS) 111(31): 11431-11436

    Andy Hee-Meng Tan, William Pooi-Kat Chong, Sze-Wai Ng, Nurhidayah Basri, Shengli Xu, and Kong-Peng Lam (2014) Aberrant presentation of self-lipids by autoimmune B cells depletes peripheral iNKT cells. Cell Reports 9(1): 24-31

    Yan-Feng Li, Koon-Guan Lee, Xijun Ou, and Kong-Peng Lam (2014) Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells. Public Library of Science (PLOS) 9(8): e105420

    Susana Soo-Yeon Kim, Koon-Guan Lee, Ching-Siang Chin, Say-Kong Ng, Natasha Ann Pereira, Shengli Xu, and Kong-Peng Lam (2014) DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation. Journal of Immunology 193(2): 840-848

    Yan-Feng Li, Shengli Xu, Xijun Ou and Kong-Peng Lam (2014) Shp1 signaling is required to establish the long-lived bone marrow plasma cell pool. Nature Communications 5: 4273

Year 2013

    Yacine Bounab, Anne-Marie-Hesse, Bruno Iannascoli, Luca Grieco, Yohann Coute, Anna Niarakis, Romain Roncagalli, Eunkyung Lie, Kong-Peng Lam, Caroline Demangel, Denis Thieffry, Jerome Garin, Bernard Malissen and Mark Daeron (2013) Proteomic analysis of the SLP76 interactome in resting and activated primary mast cells. Molecular & Cellular Proteomics 12(10): 2874-2889

Year 2012

    Jianxin Huo, Shengli Xu, Baohong Lin, Wee-Joo Chng and Kong-Peng Lam (2012) Fas Apoptosis Inhibitory Molecule (FAIM) is up-regulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in Multiple Myeloma. Leukemia 27: 1165-1171

    Timo Lischke, Anika Hegemann, Stephanie Gurka, Dana Vu Van, Yvonne Burmeister, Kong-Peng Lam, Olivia Kershaw, Hans-Joachim Mollenkopf, Hans Werner Mages, Andreas Hutloff, and Richard A. Kroczek (2012) Comprehensive Analysis of CD4+ T Cells in the Decision between Tolerance and Immunity In Vivo Reveals a Pivotal Role for ICOS. The Journal of Immunology 189(1): 234-244

    Qiao Jing Lew, Yi Ling Chia, Kai Ling Chu, Yuen Ting Lam, Meera Gurumurthy, Shengli Xu, Kong Peng Lam, Nge Cheong, and Sheng-Hao Chao (2012) Identification of HEXIM1 as a positive regulator of p53. Journal of Biological Chemistry 287 (43): 36443–36454

    Xijun Ou, Shengli, and Kong-Peng Lam (2012) Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival. Proceedings of the National Academy of Sciences 109 (38): 15401 - 15406

    Koon-Guan Lee, Shengli Xu, Zi-Han Kang, Jianxin Huo, Mei Huang, Dingxiang Liu, Osamu Takeuchi, Shizuo Akira, and Kong-Peng Lam (2012) Bruton’s tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response, Proceedings of the National Academy of Sciences 109 (15): 5791 - 5796

    Say Kong Ng, Tessa Rui Min Tan, Yang Wang , Daniel Ng, Lin-Tang Goh, Muriel Bardor, Victor Vai Tak Wong, Kong Peng Lam (2012) Production of functional soluable dectin-1 glycoproteiin using an IRES-linked destabilized-dihydrofolate reductase expression vector. PlosOne 7(12): e52785

Year 2011

    Xu S, Guo K, Zeng Q, Huo J, Lam KP (2011) The RNase III enzyme Dicer is essential for germinal center B cell formation. BLOOD 119: 767-776

    Silva DG, Daley SR, Hogan J, Lee SK, Teh CE, Hu DY, Lam KP, Goodnow CC, Vinuesa CG (2011) Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells. Diabetes 60(8):2102-11

    Nasirudeen AMA, Wong HH, Thien P, Xu S, Lam KP, Liu DX (2011) RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection. PloS Neglected Tropical Diseases 4;5(1):e92

    Geoffrey Koh, Ariana Low, Daren Poh, Yujian Yao, Say Kong Ng, Victor Vai Tak Wong, Vincent Vagenende, Kong-Peng Lam and Dong-Yup Lee (2011) Integrative analysis workflow for the structural and functional classification of C-type lectins. BMC Bioinformatics 12(14):S5

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