The Centre for Big Data and Integrative Genomics (c-BIG) is a multi-institutional effort to enable big data analytics and integrative genomics in Singapore.

Mission

Our mission is to enable big data analytics and integrative genomics in Singapore.

Genomics Data Hub

Leverage genomics technology, big data sciences and high-performance computing to advance applied R&D in Singapore

Genomics Big Data Analytics

Enable big data analytics and integrative genomics to support precision medicine, health and wellness in Singapore.

World-class training environment

Provide leadership for future broad health information infrastructure ranging from genomics and clinical outcomes to prevention, nutrition and behavioural profiles.

Resources and Projects

Genomics big data research projects and infrastructure currently developed in c-BIG.

CellHuB

Cellular Human Bodymap of one million single cell transcriptomes

Platinum Asian Genomes

Platinum Asian genomes as a reference for Clinical Genomics in Singapore

SG10K

Singapore 10,000 Genomes Project

ROUTES

Resistance and Outbreak Tracking in Singapore

Clinical-Grade Genomics

We develop clinical grade genomics software

Cancer Genomics

Singapore Oncology Data Portal

ToxPreCIS

TOXicity PREdiction for Clinical Innovations in Singapore

Augmented Pathology

Intelligent software for histology image analysis and biophysical modelling

A*STAR Data Analytics Exchange Platform

A*STAR Data Analytics Exchange Platform for federated data

Big Data Analytics in Precision Medicine

Powering data-driven personalized healthcare for everyone

Members

The founding member institutions of c-BIG are all inter-connected in the Biopolis and Fusionopolis research cluster.

Advisory Group

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Teri MANOLIO

Director, National Human Genome Research Institute (NHGRI)
Division of Genomic Medicine,
USA

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Paul FLICEK

Team Leader and Senior Scientist Vertebrate Genomics Team,
Head of Genes, Genomes and Variation Resources,
European Bioinformatics Institute (EBI-EMBL),
UK

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Chris SANDER

Director, cBio Centre,
Dana-Farber Cancer Institute,
USA

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Rebecca DENT

Head of Medical Oncology, National Cancer Center Singapore (NCCS),
Associate Professor, Duke-NUS,
Singapore

Jobs



We have multiple positions available in various Bioinformatics, Computational Biology, Statistical Genetics and Data Analytics.



Statistical Genetics and Computational Genomics

Faculty Positions
We seek outstanding researchers with the potential to establish impactful, independent and creative Precision Medicine research programs at the GIS, and play a leadership role in Singapore’s National Precision Medicine (NPM) Program.

The Statistical Genetics faculty position requires expertise in population genetics and next-gen sequencing (NGS), as well as the ability to develop new statistical and computational methods relevant to human genetics. The candidate will be expected to lead the c-BIG team analyzing whole-genome sequencing data from over 10,000 Singaporeans, as part of the NPM program. The candidate will also be expected to work closely with clinicians to examine the genetic basis of various human diseases. Experience in integrating data from electronic health records (EHR) or electronic medical records (EMR) is a plus.

The Computational Genomics faculty positions require expertise in areas such as machine learning, algorithm development, NGS data analysis, disease omics (cancer, metabolic diseases including diabetes, heart disease, infectious disease, neurological disease), whole genome sequencing, transcriptomics, aging and image analysis. Candidates will be expected to build a strong, interdisciplinary research program and work closely with the clinical community and industry to lead projects that have a positive social impact.

All faculty candidates are expected to have demonstrated exceptional originality and excellence in their previous work. We have immediate openings and expect to fill several positions in the next two years. Applicants* should submit a CV, a statement of research interests and the names of three references by email (with job code “cBIG-Faculty” in the subject line) to: gisrecruit@gis.a-star.edu.sg.



Spatial Transcriptomics And Single Cell Oncology Program

PhD Students / Postdoctoral Fellows (Wet Lab and Computational Tracks) We are a large, well-supported multidisciplinary program that aims to introduce new paradigms for cancer biology and diagnostics using spatial and non-spatial omics technologies.

Our team comprises oncologists (lead: Iain Tan), computational biologists (lead: Shyam Prabhakar), biotechnologists (lead: Kok Hao Chen), and pathologists (lead: Tony Lim) with a track record of combining cutting-edge computational and experimental approaches to infer disease mechanisms and develop clinical applications (Chen et al., Science 2015; Li et al., Nat Genet 2017; Sun et al., Cell 2016; Fukawa et al., Nat Med 2016; del Rosario et al., Nat Methods 2015; Kumar et al., Nat Biotechnol 2013; Lancet Oncol 2012).

Wet Lab Track
Assay Development, Cancer Markers and Mechanisms

Successful candidates will have the opportunity to lead experimental design and execution for a spatial transcriptomics study looking at DNA and RNA changes in a variety of human cancers at subcellular resolution.

Qualifications:
  • Expertise in cancer biology, immunology, genomics or related fields.
  • Skilled in molecular and cellular assays.
  • Strong publication record (postdoctoral candidates).
  • Team player and strong communication skills (oral and written).
  • The ability to work closely with clinicians and computational biologists.


Computational Track
Machine Learning and Mathematical Analysis of Spatial Transcriptomics Data

Successful candidates will develop and apply algorithms for the analysis of large-scale cancer data. This will be a unique opportunity to lead computational analysis of new types of data in the nascent field of spatial transcriptomics.

Qualifications:
  • Strong programming skills.
  • Expertise in mathematics, computer science, statistics, engineering, machine learning, signal processing, computational genomics, or a related field.
  • General quantitative intuition.
  • Strong publication record (postdoctoral candidates).
  • Strong communication skills.
  • The ability to work closely with clinicians and experimental biologists


To apply, please email your CV and names of references to: prabhakars@gis.a-star.edu.sg



Group of Shyam Prabhakar (Single-cell Data Analytics and Epigenomics)

The Prabhakar lab at the Genome Institute of Singapore (GIS) is looking for creative and highly motivated PhD students and Postdoctoral Fellows to drive epigenomics and single-cell analysis projects in the areas of autism, depression and autoimmune diseases such as Type 1 diabetes. We have strong links to clinicians and a track record of combining cutting-edge experimental and computational approaches to infer gene regulatory mechanisms in development and disease (Kumar et al., Nat Biotechnol 2013; del Rosario et al., Nat Methods 2015; Sengupta et al., biorXiv 2016; Cima et al., Sci Transl Med 2016, Sun et al., Cell 2016). The focus of this call for applications is on cohort-scale epigenomic profiling and single cell omics to understand mechanisms of psychiatric and autoimmune diseases, working in close collaboration with wet-lab counterparts.

Qualifications: Candidates for all levels should have a bachelor’s degree in a quantitative field, strong mathematical intuition, a strong publication record (postdoctoral candidates), strong communication skills and programming skills, the ability to design new algorithms and the ability to work closely with clinicians and experimental biologists. Expertise is required in at least some of the following areas: mathematics, statistics, machine learning, signal processing, computational genomics.

GIS website: Shyam Prabhakar

To apply, please email your CV and names of references to: prabhakars@gis.a-star.edu.sg



GROUP OF PAVITRA KRISHNASWAMY (I2R – PRECISION MEDECINE)

Research Scientist
A research scientist position is available immediately at the Institute for Infocomm Research (I2R), A*STAR, Singapore. The project focuses on development of machine learning, deep learning and artificial intelligence algorithms for applications in precision medicine.

Specific research themes include:
  • Multimodal data analytics on heterogeneous healthcare datasets (genomics, EMR, imaging, lifestyle) to predict treatment response and/or patient outcomes
  • Methods to incorporate domain knowledge with machine learning and deep learning approaches for biomedical data analysis
  • Interpretable machine learning and deep learning approaches for biomarker identification, knowledge discovery and clinical applications
The position entails working in a multi-disciplinary machine learning and deep learning team in close collaboration with bioinformatics experts, biologists, clinicians, as well as other leading academic and industry partners on impactful projects that have the potential to transform patient-care and deliver improved health outcomes. Appointments will be based in Singapore for 3 years duration.

Research Engineer
A research engineer position is available immediately at the Institute for Infocomm Research (I2R), A*STAR, Singapore. The project focuses on development of machine learning, deep learning and artificial intelligence algorithms for applications in precision medicine.

Candidates should have demonstrated interests or experience in one or more of the following:
  1. Analysis of large scale heterogeneous biomedical datastreams (genomics, EMR, imaging, lifestyle)
  2. Projects involving biomarker identification, knowledge discovery, predictive analytics for patient outcomes, and/or clinical application
  3. R&D for advanced algorithms
Core responsibilities include preprocessing of raw disparate biomedical datasets, development of automated knowledge extraction and feature engineering pipelines, and design of pilot studies/demos. The position entails working in a multi-disciplinary machine learning and deep learning team in close collaboration with bioinformatics experts, biologists, clinicians, as well as other leading academic and industry partners on impactful projects that have the potential to transform patient-care and deliver improved health outcomes. Appointments will be based in Singapore for 2 years duration.


Click here to get details on both positions.

To apply, please email your CV and names of references to: Pavitra Krishnaswamy



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