NICOLAS BERTIN

Research

By explicitly recognizing the importance of individual and population-level genetic variations and other molecular factors in determining or predicting clinical outcomes, Precision Medicine (PM) promises to transform how we assess disease risk, deliver more accurate diagnoses, and tailor appropriate therapies while minimizing treatment-related side effects. To address the challenge of big data analytics and integrative omics for PM, four institutions have come together to form the Centre for Big Data and Integrative Genomics (c-BIG).

As the Programme Manager for c-BIG, Dr. Bertin coordinates efforts and tracks progress across the centre's four partner institutions (GIS, BII, IHPC, I2R), oversees the deployment of the multi-institutional centre’s data acquisition, storage, and analytic capacities for large-scale clinical and research omics, and drives industry collaborations related to c-BIG infrastructure.

Links

NPM (A*STAR) :  https://www.a-star.edu.sg/gis/our-science/precision-medicine-and-population-genomics/npm
NPM (PRECISE) : https://www.npm.sg/research/research-highlights/
Genome Research Informatics and Data Science (GRIDS) Platform : https://www.a-star.edu.sg/gis/our-science/genome-informatics-and-ai/grids

Selected Publications

• Tan JHJ, Li Z, Porta MG, Rajaby R, …, Prabhakar S, Tan P^#, Bertin N^#. A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes. Nature Communications, 2024
• Maulana Y, Toro Jimenez R, Twesigomwe D, …, Bertin N, Gonzalez-Porta M. The variation landscape of CYP2D6 in a multi-ethnic Asian population. Nature Scientific Reports, 2024
• Wong E, Bertin N*, Hebrard M, Tirado-Magallanes R, … Chambers JC, Tai ES, Tan P. The Singapore National Precision Medicine Strategy. Nature Genetics, 2023
• Shih CC, Chen J, Lee AS, Bertin N, …Tan P, Dorajoo R. A five-safes approach to a secure and scalable genomics data repository. iScience. 2023
• Chan SH, Bylstra Y, …, Bertin N, …, Ngeow J, Lim WK. Analysis of clinically relevant variants from ancestrally diverse Asian genomes. Nature Communications, 2022
• Bylstra Y, Lim WK, …, Bertin N, …, Orlando LA, Tan P. Family History Assessment Significantly Enhances Delivery of Precision Medicine in the Genomics Era. Genome Medicine, 2021
• Wu D, Dou J, …, Bertin N, …, SG10K Consortium, Liu J, Wang C. Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore. Cell, 2019
• Hon CC*, Ramilowski JA*, Harshbarger J*, Bertin N*, …, Carninci P, Forrest ARR. An atlas of human long non-coding RNAs with accurate 5' ends. Nature, 2017
• Arner E, Daub CO, …, Bertin N, …, FANTOM Consortium, Hume DA, Forrest ARR, Sandelin A, Carninci P, Hayashizaki Y. Gene Regulation: Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 2015
• Severin J, …, Hayashizaki Y, Bertin N^#, Forrest ARR^#. ZENBU: secured scientific collaborations, data integration and omics visualization. Nature Biotechnology, 2014