Application of high throughput technologies in the development of acute myeloid leukemia therapy: Challenges and progress 
Int J Mol Sci. 2022 Mar 5;23(5):2863. doi: 10.3390/ijms23052863.

Structures and dynamics of dengue virus nonstructural membrane proteins 
Membranes (Basel). 2022 Feb 17;12(2):231. doi: 10.3390/membranes12020231.

More than meets the Kappa for antibody superantigen protein L 
Antibodies (Basel). 2022 Feb 11;11(1):14. doi: 10.3390/antib11010014.

Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase 
Protein Sci. 2022 Feb;31(2):422-431. doi: 10.1002/pro.4234. Epub 2021 Nov 18.

Update on the development of M&K inhibitors as therapeutic agents 
J Med Chem. 2022 Jan 27;65(2):983-1007. doi: 10.1021/acs.jmedchem.1c00368. Epub 2021 Sep 17.

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
Nucleic Acids Res. 2022 Jan 25;50(2):1000-1016. doi: 10.1093/nar/gkab1302.

Secondary structures of the transmembrane domain of SARS-CoV-2 spike protein in detergent micelles 
Int J Mol Sci. 2022 Jan 18;23(3):1040. doi: 10.3390/ijms23031040.

A patent review on SARS coronavirus main protease ( 3CLpro) inhibiters 
ChemMedChem. 2022 Jan 5;17(1):e202100576. doi: 10.1002/cmdc.202100576. Epub 2021 Oct 28.
Structural model of human PORCN illuminates disease-associated variants and drug-binding sites 
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Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe 
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Fragment-based lead discovery of indazole- based compounds AXL kinase inhibitors 
Bioorg Med Chem. 2021 Nov 1;49:116437. doi: 10.1016/j.bmc.2021.116437. Epub 2021 Sep 25.

Superantigen recognition and interactions: Functions, mechanisms and applications
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A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors
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Structure and dynamics of Zika virus protease and its insights into inhibitor design
Biomedicines. 2021 Aug 19;9(8):1044. doi: 10.3390/biomedicines9081044.

To plate or simply unfreeze, that is the question for optimal plasmid extraction
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Strategic design of catalytic Lysine-targeting reversible covalent BCR-ABL inhibitors*
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Molecular insights of nickel binding to therapeutic antibodies as a possible new antibody superantigen
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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
Biomedicines. 2021 Aug 19;9(8):1044. doi: 10.3390/biomedicines9081044.

Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy
Cell Rep. 2021 May 4;35(5):109071. doi: 10.1016/j.celrep.2021.109071.

Topography of transcriptionally active chromatin in glioblastoma
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Designing a leucine-rich antibacterial nonpeptide with potent activity against mupirocin-resistant MRSA via a structure-activity relationship study
Chem Biol Drug Des. 2021 Jun;97(6):1185-1193. doi: 10.1111/cbdd.13840. Epub 2021 Apr 5.

WNT inhibition creates a BRCA-like state in Wnt-addicted cancer
EMBO Mol Med. 2021 Apr 9;13(4):e13349. doi: 10.15252/emmm.202013349. Epub 2021 Mar 4.

Identification of pathways modulating vemurafenib resistance in melanoma cells via a genome-wide CRISPR/Cas9 screen
G3 (Bethesda). 2021 Feb 9;11(2):jkaa069. doi: 10.1093/g3journal/jkaa069.

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissure sarcoma
Oncogene. 2021 Mar;40(10):1851-1867. doi: 10.1038/s41388-021-01661-4. Epub 2021 Feb 9.


Spontaneous mutation in HIV-1 gag, protease, RTp66 in the first replication cycle and how they appear: insights from an in-vitro assay on mutation rates and types
Int J Mol Sci. 2020 Dec 31;22(1):370. doi: 10.3390/ijms22010370.

The impact of Gag non-cleavage site mutations on HIV-1 viral fitness from integrative modelling and simulations
Comput Struct Biotechnol J. 2020 Dec 23;19:330-342. doi: 10.1016/j.csbj.2020.12.022. eCollection 2021.

An alternative to HIV-1 non-nucleoside reverse transcriptase inhibition mechanism: Targeting the p51 subunit
Molecules. 2020 Dec 13;25(24):5902. doi: 10.3390/molecules25245902.

Essentially leading antibody production: An investigation of amino acids, myeloma, and natural V-region signal peptides in producing Pertuzumab and Trastuzumab variants
Front Immunol. 2020 Dec 7;11:604318. doi: 10.3389/fimmu.2020.604318. eCollection 2020.

Metabolic alterations and vulnerabilities in hepatocellular carcinoma
Gastroenterol Rep (Oxf). 2020 Nov 18;9(1):1-13. doi: 10.1093/gastro/goaa066. eCollection 2021 Jan.

Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket
J Med Chem. 2020 Oct 22;63(20):11972-11989. doi: 10.1021/acs.jmedchem.0c01275. Epub 2020 Oct 1.

High glucose alters the DNA methylation pattern of neurodevelopment associated genes in human neural progenitor cells in vitro
Sci Rep. 2020 Sep 24;10(1):15676. doi: 10.1038/s41598-020-72485-7.

Progress in developing inhibitors of SARS-CoV-2 3C-like protease
Microorganisms. 2020 Aug 18;8(8):1250. doi: 10.3390/microorganisms8081250.

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
Nat Chem Biol. 2020 Aug;16(8):876-886. doi: 10.1038/s41589-020-0553-6. Epub 2020 May 25.

Discovery of a novel mycobacterial F-ATP synthase inhibitor and its potency in combination with diarylquinolines
Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13295-13304. doi: 10.1002/anie.202002546. Epub 2020 May 26.

Rescue of oxytocin response and social behaviour in a mouse model of autism
Nature. 2020 Aug;584(7820):252-256. doi: 10.1038/s41586-020-2563-7. Epub 2020 Aug 5.

Mechanisms of action for small molecules revealed by structural biology in drug discovery
Int J Mol Sci. 2020 Jul 24;21(15):5262. doi: 10.3390/ijms21155262.

Loss of PYCR2 causes neurodegeneration by increasing cerebral glycine levels via SHMT2
Neuron. 2020 Jul 8;107(1):82-94.e6. doi: 10.1016/j.neuron.2020.03.028. Epub 2020 Apr 23.

A practical perspective on the roles of solution NMR spectroscopy in drug discovery
Molecules. 2020 Jun 28;25(13):2974. doi: 10.3390/molecules25132974.

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7
Molecules. 2020 Jun 28;25(13):2968. doi: 10.3390/molecules25132968.

Probability of change in life: amino acid changes in single nucleotide substitutions
Biosystems. 2020 Jun;193-194:104135. doi: 10.1016/j.biosystems.2020.104135. Epub 2020 Apr 4.

Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with clinical application
Sci Rep. 2020 May 18;10(1):8159. doi: 10.1038/s41598-020-65152-4.

Insights into structures and dynamics of Flavivirus proteases from NMR studies
Int J Mol Sci. 2020 Apr 5;21(7):2527. doi: 10.3390/ijms21072527

Tethered primary hepatocyte spheroids on polystyrene multi-well plated for high-throughput drug safety testing
Sci Rep. 2020 Mar 16;10(1):4768. doi: 10.1038/s41598-020-61699-4.

The determination of HIV-1 RT mutation rate, its possible allosteric effects, and its implications on drug resistance
Viruses. 2020 Mar 9;12(3):297. doi: 10.3390/v12030297.

Probing biological mechanisms with chemical tools
Pharmacol Res. 2020 Mar;153:104656. doi: 10.1016/j.phrs.2020.104656. Epub 2020 Jan 18.

Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease
Antiviral Res. 2020 Mar;175:104707. doi: 10.1016/j.antiviral.2020.104707. Epub 2020 Jan 15.

Stepwise evolution of fragment hits against MAPK interacting kinases 1 nd 2
J Med Chem. 2020 Jan 23;63(2):621-637. doi: 10.1021/acs.jmedchem.9b01582. Epub 2020 Jan 7.

First-in-Human, healthy volunteers integrated protocol of ETC-206, an oral Mnk 1/2 kinase inhibitor oncology drug
Clin Transl Sci. 2020 Jan;13(1):57-66. doi: 10.1111/cts.12678. Epub 2019 Sep 9.


Dengue NS2A protein orchestrates virus assembly
Cell Host microbe. 2019 Nov 13;26(5):606-622.e8. doi: 10.1016/j.chom.2019.09.015. Epub 2019 Oct 17.

PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers
Oncogene. 2019 Oct;38(40):6662-6677. doi: 10.1038/s41388-019-0908-1. Epub 2019 Aug 7.

Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats
Br J Pharmacol. 2019 Oct;176(20):3899-3923. doi: 10.1111/bph.14774. Epub 2019 Sep 11.

Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa
Biomol NMR Assign. 2019 Oct;13(2):327-332. doi: 10.1007/s12104-019-09900-2. Epub 2019 Jun 7.

Structural and functional analyses of an allosteric EYA2 phosphatase inhibitor that has on-target effects in human lung cancer cells
Mol Cancer Ther. 2019 Sep;18(9):1484-1496. doi: 10.1158/1535-7163.MCT-18-1239. Epub 2019 Jul 8.

Discovery of irreversible inhibitors targeting histone methyltransferase, SMYD3
ACS Med Chem Lett. 2019 May 23;10(6):978-984. doi: 10.1021/acsmedchemlett.9b00170. eCollection 2019 Jun 13.

19F-NMR in target-based drug discovery
Curr Med Chem. 2019 Jun 10. doi: 10.2174/0929867326666190610160534. Online ahead of print.

Changes in Stemness properties, differentiation potential, oxidative stress, senescence and mitochondrial function in Wharton’s jelly stem cells of umbilical cords of mothers with gestational diabetes mellitus
Stem Cell Rev Rep. 2019 Jun;15(3):415-426. doi: 10.1007/s12015-019-9872-y

Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase
Biomol NMR Assign. 2019 Apr;13(1):49-53. doi: 10.1007/s12104-018-9849-9. Epub 2018 Oct 8. 

Targeting the bacterial epitranscriptome for antibiotic development: discovery of novel tRNA-(N1G37) methyltransferase (TrmD) inhibitors
ACS Infect Dis. 2019 Mar 8;5(3):326-335. doi: 10.1021/acsinfecdis.8b00275. Epub 2019 Feb 4.

Secondary structure and topology of the transmembrane domain of Syndecan-2 in detergent micelles
FEBS Lett. 2019 Mar;593(5):554-561. doi: 10.1002/1873-3468.13335. Epub 2019 Feb 22.

Fragment-based discovery of a small-molecule protein kinase C-iota inhibitor binding post-kinase domain residues
ACS Med Chem Lett. 2019 Feb 15;10(3):318-323. doi: 10.1021/acsmedchemlett.8b00546. eCollection 2019 Mar 14.

Ethnicity-specific skeletal muscle transcriptional signatures and their relevance to insulin resistance in Singapore
J Clin Endocrinol Metab. 2019 Feb 1;104(2):465-486. doi: 10.1210/jc.2018-00309.\

Expression, purification of Zika virus membrane protein-NS2B in detergent micelles for NMR studies
Protein Expr Purif. 2019 Feb;154:1-6. doi: 10.1016/j.pep.2018.09.013. Epub 2018 Sep 21.

Applications of in-cell NMR in structural biology and drug discovery
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Designing an ultra-short antibacterial peptide with potent activity against Mupirocin-resistant MRSA
Chem Biol Drug Des. 2019 Jan;93(1):4-11. doi: 10.1111/cbdd.13377. Epub 2018 Sep 12.


Introduction of human T-cell and cytokine responses following vaccination with a novel influenza vaccine
Sci Rep. 2018 Dec 20;8(1):18007. doi: 10.1038/s41598-018-36703-7.

Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on the pharmacophores of XL019 and vorinostat
Eur J Med Chem. 2018 Oct 5;158:593-619. doi: 10.1016/j.ejmech.2018.09.024. Epub 2018 Sep 11.

Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria
Eur J Med Chem. 2018 Sep 5;157:610-621. doi: 10.1016/j.ejmech.2018.08.025. Epub 2018 Aug 11.

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers
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Drugs’ development in acute heart failure: what went wrong?
Heart Fail Rev. 2018 Sep;23(5):667-691. doi: 10.1007/s10741-018-9707-y.

Characterization of molecular interactions between Zika virus protease and peptides derived from the C-terminus of NS2B
Biochem Biophys Res Commun. 2018 Sep 5;503(2):691-696. doi: 10.1016/j.bbrc.2018.06.062. Epub 2018 Jun 21.

Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6)
Bioorg Med Chem Lett. 2018 Aug 15;28(15):2636-2640. doi: 10.1016/j.bmcl.2018.06.037. Epub 2018 Jun 19.

Elucidating the bacterial mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2
Biochim Biophys Acta Biomembr. 2018 Aug;1860(8):1517-1527. doi: 10.1016/j.bbamem.2018.05.004. Epub 2018 May 11.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.

Phenotypic screening for inhibitors of a mutant thrombopoietin receptor
Methods Mol Biol. 2018;1787:53-66. doi: 10.1007/978-1-4939-7847-2_4.

Structural and ligand-binding analysis of the YAP-binding domain of the transcription factor TEAD4
Biochem J. 2018 Jun 26;475(12):2043-2055. doi: 10.1042/BCJ20180225.

Pyrosequencing method for sensitive detection of HBV drug resistance mutations
J Med Virol. 2018 Jun;90(6):1071-1079. doi: 10.1002/jmv.25066. Epub 2018 Mar 14.

Fragment-based drug discovery of potent protein kinase C iota inhibitors
J Med Chem. 2018 May 24;61(10):4386-4396. doi: 10.1021/acs.jmedchem.8b00060. Epub 2018 May 4.

Optimization of selective mitogen-activated protein kinase interacting kinases 1 and 2 inhibitors for the treatment of blast crisis leukemia
J Med Chem. 2018 May 24;61(10):4348-4369. doi: 10.1021/acs.jmedchem.7b01714. Epub 2018 May 7.

Structure-activity relationship studies of ultra-short peptides with potent activity against fluconazole-resistant Candida albicans
Eur J Med Chem. 2018 Apr 25;150:479-490. doi: 10.1016/j.ejmech.2018.03.027. Epub 2018 Mar 9.

Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a Small Molecule innhibitor
Structure. 2018 Apr 3;26(4):555-564.e3. doi: 10.1016/j.str.2018.02.005. Epub 2018 Mar 8.

Applications of NMR and ITC for the study of the kinetics of carbohydrate binding by AMPK β-subunit carbohydrate-binding molecules
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Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein
PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006209. doi: 10.1371/journal.pntd.0006209. eCollection 2018 Feb.

Editorial: Antimicrobial and anti-cancer peptides
Front Chem. 2018 Feb 6;6:13. doi: 10.3389/fchem.2018.00013. eCollection 2018.

Secondary structure and membrane topology of dengue virus NS4A protein in micelles
Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):442-450. doi: 10.1016/j.bbamem.2017.10.016. Epub 2017 Oct 18.

Repurposing Zidovudine in combination with Tigecycline for treating carbapenem-resistent Enterobacteriaceae infections
Eur J Clin Microbiol Infect Dis. 2018 Jan;37(1):141-148. doi: 10.1007/s10096-017-3114-5. Epub 2017 Oct 10.


Preliminary investigations into developing all-D Omiganan for treating Mupirocin-resistant MRSA skin infections
Chem Biol Drug Des. 2017 Dec;90(6):1155-1160. doi: 10.1111/cbdd.13035. Epub 2017 Jul 11.

Small molecules targeting the inactive form of the MNK1/2 kinases
ACS Omega. 2017 Nov 30;2(11):7881-7891. doi: 10.1021/acsomega.7b01403. Epub 2017 Nov 14.

Design and synthesis of ligand efficient dual inhibitors of Janus Kinase (JAK) and histone deacetylase (HDAC) based on Ruxolitinib and Vorinostat
J Med Chem. 2017 Oct 26;60(20):8336-8357. doi: 10.1021/acs.jmedchem.7b00678. Epub 2017 Oct 10.

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor
Biomol NMR Assign. 2017 Oct;11(2):225-229. doi: 10.1007/s12104-017-9753-8. Epub 2017 Aug 14.

Zika virus protease: An antiviral drug target
Trends Microbiol. 2017 Oct;25(10):797-808. doi: 10.1016/j.tim.2017.07.001. Epub 2017 Aug 5.

Solution NMR spectroscopy in target-based drug discovery
Molecules. 2017 Aug 23;22(9):1399. doi: 10.3390/molecules22091399.

Investigating structural requirements for the antiproliferative activity of biphenyl nicotinamides
ChemMedChem. 2017 Aug 22;12(16):1380-1389. doi: 10.1002/cmdc.201700365. Epub 2017 Aug 3.

Scaffold hopping and optimization of Maleimide based porcupine inhibitors
J Med Chem. 2017 Aug 10;60(15):6678-6692. doi: 10.1021/acs.jmedchem.7b00662. Epub 2017 Jul 20.

Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors
Structure. 2017 Aug 1;25(8):1242-1250.e3. doi: 10.1016/j.str.2017.06.006. Epub 2017 Jul 6.

Structural characterization of the linked NS2B-NS3 protease of Zika virus
FEBS Lett. 2017 Aug;591(15):2338-2347. doi: 10.1002/1873-3468.12741. Epub 2017 Jul 20.

Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates
Antiviral Res. 2017 Aug;144:44-47. doi: 10.1016/j.antiviral.2017.05.007. Epub 2017 May 18.

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease
Sci Signal. 2017 Jul 18;10(488):eaam6790. doi: 10.1126/scisignal.aam6790.

Erythropoietin receptor structural domains
Vitam Horm. 2017;105:1-17. doi: 10.1016/bs.vh.2017.02.005. Epub 2017 Mar 24.

Discovery and characterization of the automethylation properties of PRDM9
Biochem J. 2017 Mar 7;474(6):971-982. doi: 10.1042/BCJ20161067.

Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistant Candida albicans
J Pept Sci. 2017 Mar;23(3):215-221. doi: 10.1002/psc.2970. Epub 2017 Jan 19.

Pseudomonas aeruginosa develops Ciprofloxacin resistance from low to high level with distinctive proteome changes
J Proteomics. 2017 Jan 30;152:75-87. doi: 10.1016/j.jprot.2016.10.005. Epub 2016 Oct 19.

Dengue virus compartmentalization during antibody-enhanced infection
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Crystal structure of unlinked NS2B-NS3 protease from Zika virus
Science. 2016 Dec 23;354(6319):1597-1600. doi: 10.1126/science.aai9309. Epub 2016 Dec 8.

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
Nat Commun. 2016 Nov 15;7:13410. doi: 10.1038/ncomms13410.

Pseudomonas aeruginosa develops Ciprofloxacin resistance from low to high level with distinctive proteome changes
J Proteomics. 2017 Jan 30;152:75-87. doi: 10.1016/j.jprot.2016.10.005. Epub 2016 Oct 19.

Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease
Sci Rep. 2016 Sep 20;6:33663. doi: 10.1038/srep33663.

Structural basis for KCNE3 modulation of potassium recycling in epithelia
Sci Adv. 2016 Sep 9;2(9):e1501228. doi: 10.1126/sciadv.1501228. eCollection 2016 Sep.

Design and synthesis of janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) bispecific inhibitors based on pancritinib and evidence of dual pathway inhibition in haematological cell lines
J Med Chem. 2016 Sep 22;59(18):8233-62. doi: 10.1021/acs.jmedchem.6b00157. Epub 2016 Sep 8.

Viral manipulation of host inhibitory receptor signalling for immune evasion
PLoS Pathog. 2016 Sep 1;12(9):e1005776. doi: 10.1371/journal.ppat.1005776. eCollection 2016 Sep.

Secondary structure and membrane topology of the full-length dengue virus NS4B in micelles
Angew Chem Int Ed Engl. 2016 Sep 19;55(39):12068-72. doi: 10.1002/anie.201606609. Epub 2016 Aug 24.

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity
Peptides. 2016 Oct;84:44-57. doi: 10.1016/j.peptides.2016.08.001. Epub 2016 Aug 3.

Escherichia coli topoisomerase IV E subunit and inhibitor binding mode revealed by NMR spectroscopy
J Biol Chem. 2016 Aug 19;291(34):17743-53. doi: 10.1074/jbc.M116.737429. Epub 2016 Jun 30.

Structure-activity relationship studies of mitogen activated protein kinase interacting kinase (MNK) 1 and 2 are BCR-ABL1 inhibitors targeting chronic myeloid leukemic cells
J Med Chem. 2016 Apr 14;59(7):3063-78. doi: 10.1021/acs.jmedchem.5b01712. Epub 2016 Apr 5.

Structure of the cyclic nucleotide-binding homology domain of the hERG channel and its insight into type 2 long QT syndrome
Sci Rep. 2016 Mar 30;6:23712. doi: 10.1038/srep23712.

NOTUM is a potential pharmacodynamics biomarker of Wnt pathway inhibition
Oncotarget. 2016 Mar 15;7(11):12386-92. doi: 10.18632/oncotarget.7157.

Isolation of recombinant antibody specific for a surface marker of the corneal endothelium by phage display
Sci Rep. 2016 Feb 23;6:21661. doi: 10.1038/srep21661.

Selection of suitable detergents for obtaining an active dengue protease in its natural form from E.Coli
Protein Expr Purif. 2016 May;121:141-8. doi: 10.1016/j.pep.2016.02.001. Epub 2016 Feb 3.

Structure of the transmembrane domain of human nicastrin-a component of γ-secretase
Sci Rep. 2016 Jan 18;6:19522. doi: 10.1038/srep19522.

A phenotypic screen for small-molecule inhibitors of constitutively active mutant thrombopoietin receptor implicated in myeloproliferative neoplasms
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Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease
J Enzyme Inhib Med Chem. 2016;31(sup2):194-200. doi: 10.1080/14756366.2016.1190713. Epub 2016 May 31.

Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit
Biomol NMR Assign. 2016 Apr;10(1):135-8. doi: 10.1007/s12104-015-9652-9. Epub 2015 Oct 19.

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study
J Enzyme Inhib Med Chem. 2016;31(2):332-9. doi: 10.3109/14756366.2015.1018245. Epub 2015 Sep 4.

Wnt addiction of genetically define cancers reversed by PORCN inhibition
Oncogene. 2016 Apr 28;35(17):2197-207. doi: 10.1038/onc.2015.280. Epub 2015 Aug 10.


Identification of covalent active site inhibitors of dengue virus protease
Drug Des Devel Ther. 2015 Dec 10;9:6389-99. doi: 10.2147/DDDT.S94207. eCollection 2015.

Biophysical studies of bacterial topoisomerases substantiate their binding modes to an inhibitor
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The use of porcupine inhibitors to target Wnt-driven cancers
Bioorg Med Chem Lett. 2015 Dec 1;25(23):5472-6. doi: 10.1016/j.bmcl.2015.10.032. Epub 2015 Oct 23.

Targeting the central pocket in human transcription factor TEAD as a potential cancer therapeutic strategy
Structure. 2015 Nov 3;23(11):2076-86. doi: 10.1016/j.str.2015.09.009. Epub 2015 Oct 22.

Discovery of an ultra-short linear antibacterial tetrapeptide with anti-MRSA activity from a structure-activity relationship study
Eur J Med Chem. 2015 Nov 13;105:138-44. doi: 10.1016/j.ejmech.2015.10.015. Epub 2015 Oct 22.

Characterization of the interaction between Escherichia coli topoisomerase IV E subunit and an ATP competitive inhibitor
Biochem Biophys Res Commun. 2015 Nov 27;467(4):961-6. doi: 10.1016/j.bbrc.2015.10.036. Epub 2015 Oct 17.

An FDA-drug library screen for compounds with bioactives against Meticillin-Resistant Staphylococcus aureus (MRSA)
Antibiotics (Basel). 2015 Oct 9;4(4):424-34. doi: 10.3390/antibiotics4040424.

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids
Biochim Biophys Acta. 2015 Dec;1848(12):3150-7. doi: 10.1016/j.bbamem.2015.09.016. Epub 2015 Sep 25.

Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles
Sci Rep. 2015 Aug 28;5:13586. doi: 10.1038/srep13586.

NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudonomas aeruginosa and its complex with an inhibitor
FEBS Lett. 2015 Sep 14;589(19 Pt B):2683-9. doi: 10.1016/j.febslet.2015.07.044. Epub 2015 Aug 10.

Discovery and optimization of a porcupine inhibitor
J Med Chem. 2015 Aug 13;58(15):5889-99. doi: 10.1021/acs.jmedchem.5b00507. Epub 2015 Jul 16.

Corrigendum to “Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an a typical and versatile PDZ-domain motif interaction and identification of putative functional modules” [FEBS Open Bio 4 (2014) 571-583]
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Application of fragment-based drug discovery against DNA gyrase B
Chempluschem. 2015 Aug;80(8):1250-1254. doi: 10.1002/cplu.201500197. Epub 2015 Jun 24.

Pharmacophore model for Wnt/porcupine inhibitors and its use in drug design
J Chem Inf Model. 2015 Jul 27;55(7):1435-48. doi: 10.1021/acs.jcim.5b00159. Epub 2015 Jun 15.

Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy
Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2244-52. doi: 10.1016/j.bbamem.2015.06.010. Epub 2015 Jun 11.

Structural transitions in Bcl-cL and its potential association with mitochondrial calcium ion transport
Sci Rep. 2015 May 29;5:10609. doi: 10.1038/srep10609.

Determinants of dengue virus NS4A protein oligomerization
J Virol. 2015 Jun;89(12):6171-83. doi: 10.1128/JVI.00546-15. Epub 2015 Apr 1.

Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay
Antiviral Res. 2015 Jun;118:68-74. doi: 10.1016/j.antiviral.2015.03.010. Epub 2015 Mar 27.

An integrative approach identified genes associated with drug response in gastric cancer
Carcinogenesis. 2015 Apr;36(4):441-51. doi: 10.1093/carcin/bgv014. Epub 2015 Mar 5.

Mapping the interactions between the NS4A and NS4B proteins of dengue virus
J Virol. 2015 Apr;89(7):3471-83. doi: 10.1128/JVI.03454-14. Epub 2015 Jan 14.

Characterization of dengue virus NS4A and NS4B protein interaction
J Virol. 2015 Apr;89(7):3471-83. doi: 10.1128/JVI.03454-14. Epub 2015 Jan 14.

Fc receptors and their influence on efficacy of therapeutic antibodies for treatment of viral diseases
Expert Rev Anti Infect Ther. 2015;13(11):1351-60. doi: 10.1586/14787210.2015.1079127. Epub 2015 Aug 24.

Structural analysis of the S4-S5 linker of the human KCNQ1 potassium channel
Biochem Biophys Res Commun. 2015 Jan 2;456(1):410-4. doi: 10.1016/j.bbrc.2014.11.097. Epub 2014 Dec 2.


Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers
Vaccine. 2014 Sep 3;32(39):5041-8. doi: 10.1016/j.vaccine.2014.07.011. Epub 2014 Jul 18.

Structural insight into the transmembrane domain and the juxtamembrane region of the enthropoietin receptor in micelles
Biophys J. 2014 Nov 18;107(10):2325-36. doi: 10.1016/j.bpj.2014.10.013.

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters
PLoS One. 2014 Oct 24;9(10):e111146. doi: 10.1371/journal.pone.0111146. eCollection 2014.

Characterization of ductal carcinoma in situ cell lines established from breast tumor of Singapore Chinese patient
Cancer Cell Int. 2014 Sep 20;14(1):94. doi: 10.1186/s12935-014-0094-8. eCollection 2014.

Establishment and characterization of a Singapore Chinese lung adenocarcinoma cell line with four copies of the epidermal growth factor receptor gene
Biores Open Access. 2014 Aug 1;3(4):176-82. doi: 10.1089/biores.2014.0011.

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques
Biochem J. 2014 Jul 15;461(2):323-34. doi: 10.1042/BJ20140374.

Insight into the molecular interaction between the cyclic nucleotide-binding hoimology domain and the eag domain of the hERG channel
FEBS Lett. 2014 Aug 25;588(17):2782-8. doi: 10.1016/j.febslet.2014.05.056. Epub 2014 Jun 12.

Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an a typical and versatile PDZ-domain motif interaction and identification of putative functional modules
FEBS Open Bio. 2014 Jun 6;4:571-83. doi: 10.1016/j.fob.2014.05.005. eCollection 2014.

Solution structure of cyclic-nucleotide binding homology domain of a KCNH channel
J Struct Biol. 2014 Apr;186(1):68-74. doi: 10.1016/j.jsb.2014.03.008. Epub 2014 Mar 14.

Clinical evaluation of a low cost, in-house developed real-time RT-PCR human immunodeficiency virus type 1 (HIV-1) quantitation assay for HIV-1 infected patients
PLoS One. 2014 Mar 6;9(3):e89826. doi: 10.1371/journal.pone.0089826. eCollection 2014.

Prospective surveillance and molecular characterization of season influenza in a university cohort in Singapore
PLoS One. 2014 Feb 10;9(2):e88345. doi: 10.1371/journal.pone.0088345. eCollection 2014.

Role of tryptophan side chain dynamics on the Trp-cage mini-protein folding studied by molecular dynamics simulations
PLoS One. 2014 Feb 7;9(2):e88383. doi: 10.1371/journal.pone.0088383. eCollection 2014.

Solution structure of the transmembrane domain of the insulin receptor in detergent micelles
Biochim Biophys Acta. 2014 May;1838(5):1313-21. doi: 10.1016/j.bbamem.2014.01.005. Epub 2014 Jan 16.

Establishment of a novel whole animal HTS technology platform for meliodosis drug discovery
Comb Chem High Throughput Screen. 2014;17(9):790-803. doi: 10.2174/1386207317666141019195031.

A P2 and P3 substrate specificity comparison between Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides
Peptides. 2014 Feb;52:49-52. doi: 10.1016/j.peptides.2013.12.002. Epub 2013 Dec 9.

1H, 13C and 13N chemical shift assignments for the N-terminal PAS domain of the KCNH channel from zebrafish
Biomol NMR Assign. 2014 Apr;8(1):165-8. doi: 10.1007/s12104-013-9475-5. Epub 2013 Apr 18.


Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitoxicity
Brain Behav. 2013 Mar;3(2):67-74. doi: 10.1002/brb3.118. Epub 2013 Jan 11.

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors
J Cell Mol Med. 2013 Nov;17(11):1397-409. doi: 10.1111/jcmm.12156. Epub 2013 Nov 19.

Lyso-myristoyl phosphatidylcholine micelles sustain the activity of dengue non-structural (NS) protein 3 protease domain fused with the full-length NS2B
Protein Expr Purif. 2013 Dec;92(2):156-62. doi: 10.1016/j.pep.2013.09.015. Epub 2013 Sep 29.

Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study
Eur J Med Chem. 2013 Oct;68:72-80. doi: 10.1016/j.ejmech.2013.07.028. Epub 2013 Aug 9.

Identification of cell surface markers glypican-4 and CD200 that differentiate human corneal endothelium from stromal fibroblasts
Invest Ophthalmol Vis Sci. 2013 Jul 8;54(7):4538-47. doi: 10.1167/iovs.13-11754.

The quest for a H1N1 flu vaccine
Ann Acad Med Singap. 2013 Jul;42(7):354-5.

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex
J Biol Chem. 2013 May 3;288(18):12891-900. doi: 10.1074/jbc.M112.442723. Epub 2013 Mar 19.

Novel agmatine dipeptide inhibitors against the West Nile virus NS2B-NS3 protease: a P3 and N-cap optimization study
Eur J Med Chem. 2013 Apr;62:199-205. doi: 10.1016/j.ejmech.2012.12.043. Epub 2013 Jan 3.

West Nile virus protease activity in detergent solutions and application for affinity tag removal
Anal Biochem. 2013 Apr 1;435(1):44-6. doi: 10.1016/j.ab.2012.12.015. Epub 2013 Jan 3.


Purification and structural characterization of the voltage-sensor domain of the hERG potassium channel
Protein Expr Purif. 2012 Dec;86(2):98-104. doi: 10.1016/j.pep.2012.09.003. Epub 2012 Oct 3.

Solution NMR study of the transmembrane domain of single-span membrane proteins: Opportunities and strategies
Curr Protein Pept Sci. 2012 Sep;13(6):585-600. doi: 10.2174/138920312803582979.

West Nile Virus (WNV) protease and membrane interactions revealed by NMR spectroscopy
Biochem Biophys Res Commun. 2012 Jul 13;423(4):799-804. doi: 10.1016/j.bbrc.2012.06.043. Epub 2012 Jun 16.

Analysis of p53 binding to DNA by fluorescence imaging microscopy
Micron. 2012 Sep;43(9):996-1000. doi: 10.1016/j.micron.2012.03.024. Epub 2012 Apr 6.

The solution structure of the S4-S5 linker of the hERG potassium channel
J Pept Sci. 2012 Feb;18(2):140-5. doi: 10.1002/psc.1427. Epub 2011 Nov 3.



Expression, purification, and initial structural characterization of non-structural protein 2B, an integral membrane protein of Dengue-2 virus, in detergent micelles
Protein Expr Purif. 2011 Dec;80(2):169-75. doi: 10.1016/j.pep.2011.08.008. Epub 2011 Aug 22.

Natural products from synthetic biology
Curr Opin Chem Biol. 2011 Aug;15(4):505-15. doi: 10.1016/j.cbpa.2011.05.017.

Solution NMR study of integral membrane proteins
Curr Opin Chem Biol. 2011 Aug;15(4):560-9. doi: 10.1016/j.cbpa.2011.05.025.

Drug target deconvolution by chemical proteomics
Curr Opin Chem Biol. 2011 Aug;15(4):570-5. doi: 10.1016/j.cbpa.2011.06.016. Epub 2011 Jul 18.

Large-scale integrated super-computing platform for next generation virtual drug discovery
Curr Opin Chem Biol. 2011 Aug;15(4):553-9. doi: 10.1016/j.cbpa.2011.06.005. Epub 2011 Jun 30.

An NMR study of the N-terminal domain of wild-type hERG and a T65P trafficking deficient hERG mutant
Proteins. 2011 Aug;79(8):2557-65. doi: 10.1002/prot.23089. Epub 2011 Jun 9.

NMR structural study of intracellular loop 3 of the serotonin 5-HT(1A) receptor and its interaction with calmodulin
Biochim Biophys Acta. 2011 Sep;1808(9):2224-32. doi: 10.1016/j.bbamem.2011.05.014. Epub 2011 May 24.

Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease
Eur J Med Chem. 2011 Jul;46(7):3130-4. doi: 10.1016/j.ejmech.2011.04.055. Epub 2011 Apr 28.

Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin
Biopolymers. 2011;96(2):147-57. doi: 10.1002/bip.21438.


Casein Kinase II: An attractive target for anti-cancer drug design
Int J Biochem Cell Biol. 2010 Oct;42(10):1602-5. doi: 10.1016/j.biocel.2010.06.010. Epub 2010 Jun 15.

Biochemical characterization of Murray Valley encephalitis virus proteinase
FEBS Lett. 2010 Jul 16;584(14):3149-52. doi: 10.1016/j.febslet.2010.05.062. Epub 2010 Jun 1.


Metastasis: Alone or together?
Curr Biol. 2009 Dec 29;19(24):R1121-3. doi: 10.1016/j.cub.2009.11.001.

Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy
Cell Cycle. 2009 Sep 1;8(17):2810-8. doi: 10.4161/cc.8.17.9503. Epub 2009 Sep 13.

Overview of high-throughput screening
Curr Protoc Pharmacol. 2009 Mar;Chapter 9:Unit 9.4. doi: 10.1002/0471141755.ph0904s44.