PAST EVENTS

Nov 10, 2019 - Nov 11, 2019

Human Cell Atlas (HCA) Asia Meeting 2019

Venue: Biopolis, Singapore

Event URL: https://www.gisevents.org/hcam2019

Events

Human Cell Atlas (HCA) Asia Meeting 2019

Date : Nov 10, 2019 - Nov 11, 2019

Venue: Biopolis, Singapore

Event URL: https://www.gisevents.org/hcam2019

Oct 14, 2019 - Oct 15, 2019

1st Annual Human Genomics Symposium 2019

Venue: National University of Singapore, Singapore

National University Health System (NUHS), Genome Institute of Singapore (GIS) and NovogeneAIT Genomics Singapore will be jointly hosting the 1st Annual Human Genomics Symposium. The theme of the symposium is “Advancing Genomics Research”. This symposium will focus on emerging, or next generation research areas in the field of human genomics and technologies for research and diagnostics. This symposium aims to provide a platform for clinicians and scientists to present their work, exchange ideas and learn about the latest advancements in this rapidly evolving field. We expect around 200 scientists and clinicians who are working in the field of human genomics to participate in the symposium. The symposium topics have been selected to capture a snapshot of the state of the art in these rapidly evolving research areas. The topics include Cancer, Population Genomics, and Chronic Diseases.

Event URL: https://event.novogeneait.sg/

Events

1st Annual Human Genomics Symposium 2019

Date : Oct 14, 2019 - Oct 15, 2019

Venue: National University of Singapore, Singapore

National University Health System (NUHS), Genome Institute of Singapore (GIS) and NovogeneAIT Genomics Singapore will be jointly hosting the 1st Annual Human Genomics Symposium. The theme of the symposium is “Advancing Genomics Research”. This symposium will focus on emerging, or next generation research areas in the field of human genomics and technologies for research and diagnostics. This symposium aims to provide a platform for clinicians and scientists to present their work, exchange ideas and learn about the latest advancements in this rapidly evolving field. We expect around 200 scientists and clinicians who are working in the field of human genomics to participate in the symposium. The symposium topics have been selected to capture a snapshot of the state of the art in these rapidly evolving research areas. The topics include Cancer, Population Genomics, and Chronic Diseases.

Event URL: https://event.novogeneait.sg/

Mar 11, 2019 - Mar 11, 2019

c-BIG Symposium 2019

Biopolis, Singapore

Event URL: https://www.a-star.edu.sg/c-big/events/cBIGSymposium2019

Click here for the flyer.

Events

c-BIG Symposium 2019

Date : Mar 11, 2019 - Mar 11, 2019

Biopolis, Singapore

Event URL: https://www.a-star.edu.sg/c-big/events/cBIGSymposium2019

Click here for the flyer.

Feb 24, 2019 - Feb 26, 2019

Cell Symposium 2019 - Single Cell: Technology to Biology

Biopolis, Singapore Event URL: http://www.cell-symposia.com/single-cells/default.asp

Events

Cell Symposium 2019 - Single Cell: Technology to Biology

Date : Feb 24, 2019 - Feb 26, 2019

Biopolis, Singapore Event URL: http://www.cell-symposia.com/single-cells/default.asp

Sep 18, 2018 - Sep 22, 2018

Sing-a-Pore Camp 2018

Biopolis, Singapore Event URL: http://porecamp.github.io/singapore

Events

Sing-a-Pore Camp 2018

Date : Sep 18, 2018 - Sep 22, 2018

Biopolis, Singapore Event URL: http://porecamp.github.io/singapore

Nov 16, 2017 - Nov 17, 2017

Stem Cell Society Singapore Symposium 2017

Academia, Singapore General Hospital Event URL: http://stemcell.org.sg/symposia/symposia2017.php

Events

Stem Cell Society Singapore Symposium 2017

Date : Nov 16, 2017 - Nov 17, 2017

Academia, Singapore General Hospital Event URL: http://stemcell.org.sg/symposia/symposia2017.php

Nov 13, 2017 - Nov 14, 2017

Joint Singapore-EMBL Symposium on Precision Medicine 2017

13th November (public), Breakthrough and Discovery theatrettes, Biopolis, Singapore
14th November (closed-door), Genome Institute of Singapore, Biopolis, Singapore

Events

Joint Singapore-EMBL Symposium on Precision Medicine 2017

Date : Nov 13, 2017 - Nov 14, 2017

13th November (public), Breakthrough and Discovery theatrettes, Biopolis, Singapore
14th November (closed-door), Genome Institute of Singapore, Biopolis, Singapore

Nov 06, 2017 - Nov 08, 2017

Frontiers in Cancer Science 2017

Venue: Matrix, Biopolis, Singapore

For more information, please visit
https://www.csi.nus.edu.sg/FCS2017/

Events

Frontiers in Cancer Science 2017

Date : Nov 06, 2017 - Nov 08, 2017

Venue: Matrix, Biopolis, Singapore

For more information, please visit
https://www.csi.nus.edu.sg/FCS2017/

Jul 24, 2017 - Jul 24, 2017

Launch of GIS-IVQ Joint Innovation Laboratory for Precision Oncology

Venue: Tudor Ballroom, Goodwood Park Hotel

Events

Launch of GIS-IVQ Joint Innovation Laboratory for Precision Oncology

Date : Jul 24, 2017 - Jul 24, 2017

Venue: Tudor Ballroom, Goodwood Park Hotel

Dec 15, 2016 - Dec 15, 2016

GIS-NCIS Faculty Exchange Programme MOU Signing Ceremony

Venue: National Cancer Centre, Singapore

Events

GIS-NCIS Faculty Exchange Programme MOU Signing Ceremony

Date : Dec 15, 2016 - Dec 15, 2016

Venue: National Cancer Centre, Singapore

Dec 13, 2016 - Dec 13, 2016

Atreca-GIS Joint Lab for Immuno-Oncology Opening Ceremony

Venue: Genome, Biopolis, Singapore

Events

Atreca-GIS Joint Lab for Immuno-Oncology Opening Ceremony

Date : Dec 13, 2016 - Dec 13, 2016

Venue: Genome, Biopolis, Singapore

Nov 10, 2016 - Nov 11, 2016

c-BIG Symposium 2016

Venue: Matrix, Biopolis, Singapore

Events

c-BIG Symposium 2016

Date : Nov 10, 2016 - Nov 11, 2016

Venue: Matrix, Biopolis, Singapore

Nov 07, 2016 - Nov 08, 2016

SCSS Symposium 2016

Venue: Matrix, Biopolis, Singapore

Events

SCSS Symposium 2016

Date : Nov 07, 2016 - Nov 08, 2016

Venue: Matrix, Biopolis, Singapore

Apr 26, 2016 - Apr 26, 2016

PerkinElmer-GIS Centre for Precision Oncology Opening Ceremony

Venue: Genome, Biopolis, Singapore

Events

PerkinElmer-GIS Centre for Precision Oncology Opening Ceremony

Date : Apr 26, 2016 - Apr 26, 2016

Venue: Genome, Biopolis, Singapore

Dec 04, 2015 - Dec 04, 2015

GIS 15th Anniversary Gala Dinner

Venue: Shangri-La Hotel, Tower Ballroom, Singapore 258350

Events

GIS 15th Anniversary Gala Dinner

Date : Dec 04, 2015 - Dec 04, 2015

Venue: Shangri-La Hotel, Tower Ballroom, Singapore 258350

Nov 23, 2015 - Nov 26, 2015

ICSB 2015

Venue: Biopolis, Singapore

For more information, please visit
http://icsb15.apbionet.org/

Events

ICSB 2015

Date : Nov 23, 2015 - Nov 26, 2015

Venue: Biopolis, Singapore

For more information, please visit
http://icsb15.apbionet.org/

Nov 17, 2015 - Nov 18, 2015

Stem Cell Society Singapore Symposium 2015
"Opportunities & Challenges in Stem Cell Based Medicine"

Venue: Biopolis, Singapore

For more information, please visit
http://stemcell.org.sg/symposia/symposia2015.php

Events

Stem Cell Society Singapore Symposium 2015
"Opportunities & Challenges in Stem Cell Based Medicine"

Date : Nov 17, 2015 - Nov 18, 2015

Venue: Biopolis, Singapore

For more information, please visit
http://stemcell.org.sg/symposia/symposia2015.php

Nov 08, 2015 - Nov 10, 2015

Cell Symposium: Human Genomics

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.cell-symposia-humangenomics.com/

Events

Cell Symposium: Human Genomics

Date : Nov 08, 2015 - Nov 10, 2015

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.cell-symposia-humangenomics.com/

Aug 31, 2015 - Aug 31, 2015

6th Next-Generation Sequencing Conference

Venue: Biopolis, Matrix
Breakthrough/ Discovery Theatre

For more information, please visit
http://www.aitbiotech.com/6th-ngs-conference-2015/

Events

6th Next-Generation Sequencing Conference

Date : Aug 31, 2015 - Aug 31, 2015

Venue: Biopolis, Matrix
Breakthrough/ Discovery Theatre

For more information, please visit
http://www.aitbiotech.com/6th-ngs-conference-2015/

Jan 15, 2015 - Jan 15, 2015

Functions of Non-Coding RNAs in Evolution, Epigenetics and Therapeutic Applications

Venue: Genome Institute of Singapore

For more information, please visit
http://www.abcam.com/index.html?pageconfig=resource&rid=16325

Events

Functions of Non-Coding RNAs in Evolution, Epigenetics and Therapeutic Applications

Date : Jan 15, 2015 - Jan 15, 2015

Venue: Genome Institute of Singapore

For more information, please visit
http://www.abcam.com/index.html?pageconfig=resource&rid=16325

Nov 05, 2014 - Nov 07, 2014

Regional Forum Series 2014: Global Controls in Stem Cells

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.isscr.org/home/regionalforums/singapore-2014?utm_source=scssoutreach&utm_medium=email&utm_campaign=singapore2014

Events

Regional Forum Series 2014: Global Controls in Stem Cells

Date : Nov 05, 2014 - Nov 07, 2014

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.isscr.org/home/regionalforums/singapore-2014?utm_source=scssoutreach&utm_medium=email&utm_campaign=singapore2014

Aug 25, 2014 - Aug 26, 2014

Epigenetics in Development and Diseases: 9th Asian Epigenomics Meeting

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.gis.a-star.edu.sg/epigenomics2014

Events

Epigenetics in Development and Diseases: 9th Asian Epigenomics Meeting

Date : Aug 25, 2014 - Aug 26, 2014

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.gis.a-star.edu.sg/epigenomics2014

Jun 06, 2014 - Jun 06, 2014

Stem cells for modeling development and disease

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.abcam.com/index.html?pageconfig=resource&rid=16340

Events

Stem cells for modeling development and disease

Date : Jun 06, 2014 - Jun 06, 2014

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.abcam.com/index.html?pageconfig=resource&rid=16340

Oct 17, 2013 - Oct 17, 2013

BD BIOSCIENCES and GIS collaborate on 'Isolation and characterization of human tissue samples using Flow Cytometry and RNAFlow Technology'

For more info, click here

Events

BD BIOSCIENCES and GIS collaborate on 'Isolation and characterization of human tissue samples using Flow Cytometry and RNAFlow Technology'

Date : Oct 17, 2013 - Oct 17, 2013

For more info, click here

Sep 06, 2012 - Sep 07, 2012

SCSS SYMPOSIUM 2012

Stem Cell Based Therapy
For more info, click here

Events

SCSS SYMPOSIUM 2012

Date : Sep 06, 2012 - Sep 07, 2012

Stem Cell Based Therapy
For more info, click here

Mar 20, 2012 - Mar 21, 2012

Partner of 5th Annual BioPharma Asia Convention 2012

For more info, click here

Events

Partner of 5th Annual BioPharma Asia Convention 2012

Date : Mar 20, 2012 - Mar 21, 2012

For more info, click here

Mar 11, 2012 - Mar 14, 2012

Human Genome Meeting 2012

Genetics and Genomics in Personalized Medicine
Sydney, Australia


Though the practice of medicine has always sought to "personalise" the care and treatment of patients, the genetics-to-genomics revolution has taken this to the next level with comprehensive, precise, and quantitative genomic technologies. Next generation DNA sequencing, SNP arrays, novel amplification technologies, and microfluidic devices with the accompanying computational advances now speed discovery and the resolution of diagnosis by orders of magnitude. The promise of precise diagnosis, of accurate patient stratification for risk assessment and treatment, and sensitive monitoring is likely to be fulfilled in the next decade. Underpinning all this are the advances in computational biology and eHealth that are necessary to deal with the impending information overload. HGM 2012 will explore the fundamental, translational, and clinical sciences driving the progress of this personalised medicine movement. With the Royal College of Pathologists of Australasia, we will also host a special session on Genomic Pathology to highlight the importance of this discipline to personalised genomic-based medicine...

Visit www.hgm2012.org to find out more!

Events

Human Genome Meeting 2012

Date : Mar 11, 2012 - Mar 14, 2012

Genetics and Genomics in Personalized Medicine
Sydney, Australia


Though the practice of medicine has always sought to "personalise" the care and treatment of patients, the genetics-to-genomics revolution has taken this to the next level with comprehensive, precise, and quantitative genomic technologies. Next generation DNA sequencing, SNP arrays, novel amplification technologies, and microfluidic devices with the accompanying computational advances now speed discovery and the resolution of diagnosis by orders of magnitude. The promise of precise diagnosis, of accurate patient stratification for risk assessment and treatment, and sensitive monitoring is likely to be fulfilled in the next decade. Underpinning all this are the advances in computational biology and eHealth that are necessary to deal with the impending information overload. HGM 2012 will explore the fundamental, translational, and clinical sciences driving the progress of this personalised medicine movement. With the Royal College of Pathologists of Australasia, we will also host a special session on Genomic Pathology to highlight the importance of this discipline to personalised genomic-based medicine...

Visit www.hgm2012.org to find out more!

Nov 22, 2011 - Nov 23, 2011

3rd Annual RNAi Asia, 22 – 23Nov 2011

More details can be found at the following website: http://www.selectbiosciences.com/conferences/RNAiA2011/

Events

3rd Annual RNAi Asia, 22 – 23Nov 2011

Date : Nov 22, 2011 - Nov 23, 2011

More details can be found at the following website: http://www.selectbiosciences.com/conferences/RNAiA2011/

Oct 31, 2011 - Nov 03, 2011

Frontiers in Cancer Science 2011, 31 Oct – 3 Nov 2011

More details can be found at the following website: http://www.csi.nus.edu.sg/conference2011/



Click here for the poster

Events

Frontiers in Cancer Science 2011, 31 Oct – 3 Nov 2011

Date : Oct 31, 2011 - Nov 03, 2011

More details can be found at the following website: http://www.csi.nus.edu.sg/conference2011/



Click here for the poster

Apr 04, 2011 - Apr 08, 2011

ChIA-PET Analysis Workshop: Methods for a Chromatin Interaction Analysis

Venue: Genome, Biopolis, Singapore

For more information, please visit
http://www.gis.a-star.edu.sg/chiapet2011/

Events

ChIA-PET Analysis Workshop: Methods for a Chromatin Interaction Analysis

Date : Apr 04, 2011 - Apr 08, 2011

Venue: Genome, Biopolis, Singapore

For more information, please visit
http://www.gis.a-star.edu.sg/chiapet2011/

Feb 21, 2011 - Feb 23, 2011

Personalized Cancer Medicine 2011: Towards individualized cancer treatments

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.gis.a-star.edu.sg/cancermedicine2011/

Events

Personalized Cancer Medicine 2011: Towards individualized cancer treatments

Date : Feb 21, 2011 - Feb 23, 2011

Venue: Matrix, Biopolis, Singapore

For more information, please visit
http://www.gis.a-star.edu.sg/cancermedicine2011/

Nov 15, 2010 - Nov 16, 2010

RNAi Asia/Screening Asia

Venue: Matrix, Biopolis, Singapore

For more information, please visit http://www.selectbiosciences.com/conferences/RNAiA2010/index.aspx

Events

RNAi Asia/Screening Asia

Date : Nov 15, 2010 - Nov 16, 2010

Venue: Matrix, Biopolis, Singapore

For more information, please visit http://www.selectbiosciences.com/conferences/RNAiA2010/index.aspx

Nov 02, 2010 - Nov 03, 2010

Stem Cell Society Singapore Symposium 2010 Translating Science to Therapy

Venue: Matrix, Biopolis, Singapore

For more information, please visit http://www.stemcell.org.sg/

Events

Stem Cell Society Singapore Symposium 2010 Translating Science to Therapy

Date : Nov 02, 2010 - Nov 03, 2010

Venue: Matrix, Biopolis, Singapore

For more information, please visit http://www.stemcell.org.sg/

Oct 05, 2010 - Oct 07, 2010

27th HUGO-IABCR Congress 2010

Click on link for program information
http://www.hugo-iabcr2010.org

Venue: Biopolis, Singapore

Events

27th HUGO-IABCR Congress 2010

Date : Oct 05, 2010 - Oct 07, 2010

Click on link for program information
http://www.hugo-iabcr2010.org

Venue: Biopolis, Singapore

Aug 11, 2010 - Aug 11, 2010

National Science Challenge

Venue: Genome, Biopolis, Singapore

Events

National Science Challenge

Date : Aug 11, 2010 - Aug 11, 2010

Venue: Genome, Biopolis, Singapore

Jul 29, 2010 - Jul 29, 2010

GIS-AH MOU Signing Ceremony

Venue: Khoo Teck Puat Hospital, Singapore

Events

GIS-AH MOU Signing Ceremony

Date : Jul 29, 2010 - Jul 29, 2010

Venue: Khoo Teck Puat Hospital, Singapore

May 13, 2010 - May 14, 2010

Seminars by GIS Distinguished Speaker, Dr. Kevin Struhl

Venue: Matrix, Biopolis, Singapore

Events

Seminars by GIS Distinguished Speaker, Dr. Kevin Struhl

Date : May 13, 2010 - May 14, 2010

Venue: Matrix, Biopolis, Singapore

Aug 24, 2009 - Aug 24, 2009

Epigenetics in Development and Diseases Conference: 4th Asian Epigenomics Meeting

Click on link for program information http://www.gis.a-star.edu.sg/epigenomics09/ Venue: Biopolis, Singapore

Events

Epigenetics in Development and Diseases Conference: 4th Asian Epigenomics Meeting

Date : Aug 24, 2009 - Aug 24, 2009

Click on link for program information http://www.gis.a-star.edu.sg/epigenomics09/ Venue: Biopolis, Singapore

Jun 01, 2009 - Jun 01, 2009

Statistical Genomics Program

Click on link for program information http://www.ims.nus.edu.sg/Programs/genomics09/index.htm Venue: Singapore

Events

Statistical Genomics Program

Date : Jun 01, 2009 - Jun 01, 2009

Click on link for program information http://www.ims.nus.edu.sg/Programs/genomics09/index.htm Venue: Singapore

Apr 13, 2009 - Apr 13, 2009

FRET, FLIM, FCS, FRAP and 3-D Imaging : Application to Cell and Developmental Biology

Click on link for program information http://cwp.embo.org/wpc09-01/ Venue: Biopolis, Singapore

Events

FRET, FLIM, FCS, FRAP and 3-D Imaging : Application to Cell and Developmental Biology

Date : Apr 13, 2009 - Apr 13, 2009

Click on link for program information http://cwp.embo.org/wpc09-01/ Venue: Biopolis, Singapore

Mar 21, 2009 - Mar 21, 2009

Genetics and Genomics of Infectious Diseases Conference

Click on link for program information http://www.nature.com Venue: The Ritz Carlton Millenia Hotel, Singapore

Events

Genetics and Genomics of Infectious Diseases Conference

Date : Mar 21, 2009 - Mar 21, 2009

Click on link for program information http://www.nature.com Venue: The Ritz Carlton Millenia Hotel, Singapore

Feb 11, 2009 - Feb 11, 2009

Regulatory networks in Stems Cells Conference

Click on link for program information http://www.abcam.com Venue: Pan Pacific, Singapore

Events

Regulatory networks in Stems Cells Conference

Date : Feb 11, 2009 - Feb 11, 2009

Click on link for program information http://www.abcam.com Venue: Pan Pacific, Singapore

Feb 09, 2009 - Feb 09, 2009

Chromatin conference: Histones, Nucleosomes, Chromosomes and Genomes

Click on link for program information http://www.abcam.com Venue: Pan Pacific, Singapore

Events

Chromatin conference: Histones, Nucleosomes, Chromosomes and Genomes

Date : Feb 09, 2009 - Feb 09, 2009

Click on link for program information http://www.abcam.com Venue: Pan Pacific, Singapore

Jan 13, 2009 - Jan 13, 2009

A*STAR-Karolinska-Dundee Research Symposium

Click on link for program information Symposium Poster Venue: The Biopolis, Matrix, Singapore

Events

A*STAR-Karolinska-Dundee Research Symposium

Date : Jan 13, 2009 - Jan 13, 2009

Click on link for program information Symposium Poster Venue: The Biopolis, Matrix, Singapore

Sep 27, 2008 - Sep 30, 2008

Human Genome Organisation (HUGO) 13th Human Genome Meeting

Click on link for program information http://hgm2008.hugo-international.org Venue: Hyderabad, India

Events

Human Genome Organisation (HUGO) 13th Human Genome Meeting

Date : Sep 27, 2008 - Sep 30, 2008

Click on link for program information http://hgm2008.hugo-international.org Venue: Hyderabad, India

Jul 25, 2008 - Jul 27, 2008

Asia-Pacific Regional S.pombe Meeting 2008, Singapore 25 - 27 July 2008

Click on link for program information http://pombe.gis.a-star.edu.sg Venue: Biopolis and Temasek Life Sciences Laboratory (TLL)

Events

Asia-Pacific Regional S.pombe Meeting 2008, Singapore 25 - 27 July 2008

Date : Jul 25, 2008 - Jul 27, 2008

Click on link for program information http://pombe.gis.a-star.edu.sg Venue: Biopolis and Temasek Life Sciences Laboratory (TLL)

Apr 02, 2008 - Apr 05, 2008

Joint 7th Human Genome Organisation (HUGO) - Pacific Meeting and the 8th Asia-Pacific Conference on Human Genetics

Click on link for program information http://www.hugo-ap2008.ph Venue: Cebu, Philippines

Events

Joint 7th Human Genome Organisation (HUGO) - Pacific Meeting and the 8th Asia-Pacific Conference on Human Genetics

Date : Apr 02, 2008 - Apr 05, 2008

Click on link for program information http://www.hugo-ap2008.ph Venue: Cebu, Philippines

May 21, 2007 - Jan 08, 0007

AACR Centennial Conference

AACR Centennial Conference November 4 - 8, 2007 Suntec Singapore

Events

AACR Centennial Conference

Date : May 21, 2007 - Jan 08, 0007

AACR Centennial Conference November 4 - 8, 2007 Suntec Singapore

Feb 12, 2007 - Feb 16, 2007

GIS Invited Speakers Series 2007

Invited Speaker: Prof. Jack D. Keene Duke University Medical Center, Molecular Genetics & Microbiology, James B. Duke Professor) Hosted by: Dr. Andrew Thomson Seminar Date: To be confirmed Title of seminar: Coordination of Genetic Information by Post-transcriptional RNA Operons Venue: To be confirmed

Events

GIS Invited Speakers Series 2007

Date : Feb 12, 2007 - Feb 16, 2007

Invited Speaker: Prof. Jack D. Keene Duke University Medical Center, Molecular Genetics & Microbiology, James B. Duke Professor) Hosted by: Dr. Andrew Thomson Seminar Date: To be confirmed Title of seminar: Coordination of Genetic Information by Post-transcriptional RNA Operons Venue: To be confirmed

May 10, 2006 - May 17, 2006

Genome Institute of Singapore Open House

Explore opportunities for graduate study within a fast-paced and exciting genomics research institute Date: 16th May 2006, Tuesday Time: 9.30am to 2.00pm Programme for the day

9.00am An Introduction to GIS
Dr. Neil Clarke
Deputy Director
 
9.30am Talks by GIS Researchers

Exploring Transcriptome
Dr. Patrick Ng
Research Scientist

Stem Cells and Development
Dr. Thomas Lufkin
Senior Group Leader

Molecular Cytogenetics in Cancer Research
Dr. Nallasivam Palanisamy
Group Leader

Functional Genomics and Biomarker Discovery
Dr. Lance Miller
Senior Group Leader
 
11.30am Tour of GIS
12:30pm Lunch with GIS Researchers
Please register attendance, using the attached RSVP Form, via email to gisv23@a-star.edu.sg, by 11th May 2006. For more information on GIS, please refer to our website www.gis.a-star.edu.sg

Events

Genome Institute of Singapore Open House

Date : May 10, 2006 - May 17, 2006

Explore opportunities for graduate study within a fast-paced and exciting genomics research institute Date: 16th May 2006, Tuesday Time: 9.30am to 2.00pm Programme for the day

9.00am An Introduction to GIS
Dr. Neil Clarke
Deputy Director
 
9.30am Talks by GIS Researchers

Exploring Transcriptome
Dr. Patrick Ng
Research Scientist

Stem Cells and Development
Dr. Thomas Lufkin
Senior Group Leader

Molecular Cytogenetics in Cancer Research
Dr. Nallasivam Palanisamy
Group Leader

Functional Genomics and Biomarker Discovery
Dr. Lance Miller
Senior Group Leader
 
11.30am Tour of GIS
12:30pm Lunch with GIS Researchers
Please register attendance, using the attached RSVP Form, via email to gisv23@a-star.edu.sg, by 11th May 2006. For more information on GIS, please refer to our website www.gis.a-star.edu.sg

Mar 17, 2006 - Mar 24, 2006

Genetic variation and Individul landscape of gene expression

Guest Speaker: Professor Peter Little School of Biotechnology & Biomolecular Sciences, University of New South Wales, Sydney, Australia Date: 23 March 2006, Thursday Time: 4:00 – 5:00 pm Venue: Aspiration Theatrette – Level 2M, Matrix Building, Biopolis Host: Dr Larry Stanton Abstract: We wish to understand how genetic variation influences the tissue specific control of gene expression in mice. We use microarrays and networks to analyse and display genetic correlations and linkage, and to describe the landscape of genetic influence within and between tissues of individuals. These show that genetic variation can cause a gene's mRNA level to vary between individuals by an average factor of ~12. These large influences alter tissue specificity of gene expression and in many cases affect regulons (groups of co-ordinately influenced genes) and this further increases inter-tissue differences. The fact that individuals have very different tissue landscapes of gene expression highlights the potential role of this type of genetic variation in the evolution of morphology. We believe there is very limited prospect of using model tissues to predict outcome in target tissues; this has substantial implications for the design of human studies, where access to phenotypically relevant tissues is necessarily limited.

~ All are welcome ~

Events

Genetic variation and Individul landscape of gene expression

Date : Mar 17, 2006 - Mar 24, 2006

Guest Speaker: Professor Peter Little School of Biotechnology & Biomolecular Sciences, University of New South Wales, Sydney, Australia Date: 23 March 2006, Thursday Time: 4:00 – 5:00 pm Venue: Aspiration Theatrette – Level 2M, Matrix Building, Biopolis Host: Dr Larry Stanton Abstract: We wish to understand how genetic variation influences the tissue specific control of gene expression in mice. We use microarrays and networks to analyse and display genetic correlations and linkage, and to describe the landscape of genetic influence within and between tissues of individuals. These show that genetic variation can cause a gene's mRNA level to vary between individuals by an average factor of ~12. These large influences alter tissue specificity of gene expression and in many cases affect regulons (groups of co-ordinately influenced genes) and this further increases inter-tissue differences. The fact that individuals have very different tissue landscapes of gene expression highlights the potential role of this type of genetic variation in the evolution of morphology. We believe there is very limited prospect of using model tissues to predict outcome in target tissues; this has substantial implications for the design of human studies, where access to phenotypically relevant tissues is necessarily limited.

~ All are welcome ~

Feb 03, 2006 - Feb 20, 2006

Seminar: How the Epigenome Changes in Cancer

Guest Speaker: Prof. Peter A. Jones Distinguished Professor, Urology, Biochemistry & Molecular Biology University of Southern California, Keck School of Medicine, Los Angeles, CA President, American Association for Cancer Research Date: 15th February 2006, Wednesday Time: 9:00am – 10:00am Venue: Aspiration Theatrette, Level 2M Matrix Building, Biopolis Host: Prof. Edison Liu Abstract: The covalent modification of DNA cytosine residues and associated histone proteins play a major role in the stability and heritability of epigenetic states. These covalent modifications of DNA and proteins interact with the chromatin remodeling apparatus to regulate the interaction of transcription factors with DNA thus contributing to stable patterns of gene expression. CpG islands are usually unmethylated in normal tissues except for genes located on the inactive X-chromosome, imprinted genes and some tissue specific genes. Histones are marked by covalent modifications and we have found that active marks are highly localized to the start sites of human genes. These patterns of modification are altered during the formation of human cancer so that CpG islands become abnormally methylated, histones become modified with repressive marks and we have recently discovered that nucleosomal remodeling occurs, resulting in the silencing of genes. Focal changes such as these often occur in the presence of genomic cytosine hypomethylation and histone hyperacetylation showing a major imbalance in epigenetic programming. Epigenetic silencing can serve as a therapeutic target for epigenetic therapies which seek to reverse silencing and restore more normal gene expression patterns to cancer cells. To date, the focus has mainly been on the reactivation of protein coding genes yet we have found that micro RNAs can also become abnormally silenced in human cancer cells by such chromatin modifications. Reactivating micro RNAs could potentially yield a novel therapeutic strategy in the treatment of cancer.

Events

Seminar: How the Epigenome Changes in Cancer

Date : Feb 03, 2006 - Feb 20, 2006

Guest Speaker: Prof. Peter A. Jones Distinguished Professor, Urology, Biochemistry & Molecular Biology University of Southern California, Keck School of Medicine, Los Angeles, CA President, American Association for Cancer Research Date: 15th February 2006, Wednesday Time: 9:00am – 10:00am Venue: Aspiration Theatrette, Level 2M Matrix Building, Biopolis Host: Prof. Edison Liu Abstract: The covalent modification of DNA cytosine residues and associated histone proteins play a major role in the stability and heritability of epigenetic states. These covalent modifications of DNA and proteins interact with the chromatin remodeling apparatus to regulate the interaction of transcription factors with DNA thus contributing to stable patterns of gene expression. CpG islands are usually unmethylated in normal tissues except for genes located on the inactive X-chromosome, imprinted genes and some tissue specific genes. Histones are marked by covalent modifications and we have found that active marks are highly localized to the start sites of human genes. These patterns of modification are altered during the formation of human cancer so that CpG islands become abnormally methylated, histones become modified with repressive marks and we have recently discovered that nucleosomal remodeling occurs, resulting in the silencing of genes. Focal changes such as these often occur in the presence of genomic cytosine hypomethylation and histone hyperacetylation showing a major imbalance in epigenetic programming. Epigenetic silencing can serve as a therapeutic target for epigenetic therapies which seek to reverse silencing and restore more normal gene expression patterns to cancer cells. To date, the focus has mainly been on the reactivation of protein coding genes yet we have found that micro RNAs can also become abnormally silenced in human cancer cells by such chromatin modifications. Reactivating micro RNAs could potentially yield a novel therapeutic strategy in the treatment of cancer.

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