PUBLICATIONS

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"Methionine is a metabolic dependency of tumor-initiating cells." Wang Z, Yip LY, Lee JHJ, Wu Z, Chew HY, Chong PKW, Teo CC, Ang HY, Peh KLE, Yuan J, Ma S, Choo LSK, Basri N, Jiang X, Yu Q, Hillmer AM, Lim WT, Lim TKH, Takano A, Tan EH, Tan DSW, Ho YS, Lim B, Tam WL - Nat Med 2019 05 ; 25(5) : 825-837

2019

Abstract

"HER2-L755S mutation induces hyperactive MAPK and PI3K-mTOR signaling, leading to resistance to HER2 tyrosine kinase inhibitor treatment." Li J, Xiao Q, Bao Y, Wang W, Goh J, Wang P, Yu Q - Cell Cycle 2019 Jul ; 18(13) : 1513-1522

2019

Abstract

"Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue." Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, Prabhakar S, Geschwind DH, Mill J - Hum Mol Genet 2019 Jul 01 ; 28(13) : 2201-2211

2019

Abstract

"Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease." Ferrari Bardile C, Garcia-Miralles M, Caron NS, Rayan NA, Langley SR, Harmston N, Rondelli AM, Teo RTY, Waltl S, Anderson LM, Bae HG, Jung S, Williams A, Prabhakar S, Petretto E, Hayden MR, Pouladi MA - Proc Natl Acad Sci U S A 2019 May 07 ; 116(19) : 9622-9627

2019

Abstract

"A Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress-Gene Response." Lee DP, Tan WLW, Anene-Nzelu CG, Lee CJM, Li PY, Anh TD, Chan CX, Tiang Z, Ng SL, Huang X, Efthymios M, Autio MI, Jiang J, Fullwood MJ, Prabhakar S, Lieberman Aiden E, Foo RS - Circulation 2019 Feb 05

2019

Abstract

"Concurrent Single-Cell RNA and Targeted DNA Sequencing on an Automated Platform for Comeasurement of Genomic and Transcriptomic Signatures." Kong SL, Li H, Tai JA, Courtois ET, Poh HM, Lau DP, Haw YX, Iyer NG, Tan DSW, Prabhakar S, Ruff D, Hillmer AM - Clin Chem 2019 Feb ; 65(2) : 272-281

2019

Abstract

"Phenotypic and molecular features underlying neurodegeneration of motor neurons derived from spinal and bulbar muscular atrophy patients." Sheila M, Narayanan G, Ma S, Tam WL, Chai J, Stanton LW - Neurobiol Dis 2019 Apr ; 124 : 1-13

2019

Abstract

"Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer." Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH, Tan DSW - J Clin Oncol 2019 Jan 24

2019

Abstract

"Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort." Li J, Wen WX, Eklund M, Kvist A, Eriksson M, Christensen HN, Torstensson A, Bajalica-Lagercrantz S, Dunning AM, Decker B, Allen J, Luccarini C, Pooley K, Simard J, Dorling L, Easton DF, Teo SH, Hall P, Borg Å, Grönberg H, Czene K - Int J Cancer 2019 Mar 01 ; 144(5) : 1195-1204

2019

Abstract

"An AR-ERG transcriptional signature defined by long range chromatin interactomes in prostate cancer cells." Zhang Z, Chng K, Lingadahalli S, Chen Z, Liu MH, Do HH, Cai S, Rinaldi N, Poh HM, Li G, Sung Y, Heng CL, Core LJ, Tan SK, Ruan XA, Lis JT, Kellis M, Ruan Y, Sung WK, Cheung E - Genome Res 2019 Jan 03

2019

Abstract

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