PUBLICATIONS

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"Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders." Bylstra Y, Kuan JL, Lim WK, Bhalshankar JD, Teo JX, Davila S, Teh BT, Rozen S, Tan EC, Liew WKM, Yeo KK, Tan P, Saw SM, Cheng CY, Cook S, Foo R, Jamuar SS - Genet Med 2018 Jul 02

2018

Abstract

"Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats." Stenzig J, Schneeberger Y, Löser A, Peters BS, Schaefer A, Zhao RR, Ng SL, Höppner G, Geertz B, Hirt MN, Tan W, Wong E, Reichenspurner H, Foo RS, Eschenhagen T - J Mol Cell Cardiol 2018 Jul ; 120 : 53-63

2018

Abstract

"Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling." Zhao RR, Ackers-Johnson M, Stenzig J, Chen C, Ding T, Zhou Y, Wang P, Ng SL, Li PY, Teo G, Rudd PM, Fawcett JW, Foo RSY - Circulation 2018 Jun 05 ; 137(23) : 2497-2513

2018

Abstract

"Experience of Asian males communicating cardiac genetic risk within the family." Kam S, Bylstra Y, Forrest L, Macciocca I, Foo R - J Community Genet 2018 Jul ; 9(3) : 293-303

2018

Abstract

"PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature." Reijnders MRF, Janowski R, Alvi M, Self JE, van Essen TJ, Vreeburg M, Rouhl RPW, Stevens SJC, Stegmann APA, Schieving J, Pfundt R, van Dijk K, Smeets E, Stumpel CTRM, Bok LA, Cobben JM, Engelen M, Mansour S, Whiteford M, Chandler KE, Douzgou S, Cooper NS, Tan EC, Foo R, Lai AHM, Rankin J, Green A, Lönnqvist T, Isohanni P, Williams S, Ruhoy I, Carvalho KS, Dowling JJ, Lev DL, Sterbova K, Lassuthova P, Neupauerová J, Waugh JL, Keros S, Clayton-Smith J, Smithson SF, Brunner HG, van Hoeckel C, Anderson M, Clowes VE, Siu VM, Ddd Study T, Selber P, Leventer RJ, Nellaker C, Niessing D, Hunt D, Baralle D - J Med Genet 2018 Feb ; 55(2) : 104-113

2018

Abstract

"Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers." Guo YA, Chang MM, Huang W, Ooi WF, Xing M, Tan P, Skanderup AJ - Nat Commun 2018 Apr 18 ; 9(1) : 1520

2018

Abstract

"Identification of Tumor Initiating Cells with a Small-Molecule Fluorescent Probe by Using Vimentin as a Biomarker." Lee YA, Kim JJ, Lee J, Lee JHJ, Sahu S, Kwon HY, Park SJ, Jang SY, Lee JS, Wang Z, Tam WL, Lim B, Kang NY, Chang YT - Angew Chem Int Ed Engl 2018 Mar 05 ; 57(11) : 2851-2854

2018

Abstract

"Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates." Simoni Y, Becht E, Fehlings M, Loh CY, Koo SL, Teng KWW, Yeong JPS, Nahar R, Zhang T, Kared H, Duan K, Ang N, Poidinger M, Lee YY, Larbi A, Khng AJ, Tan E, Fu C, Mathew R, Teo M, Lim WT, Toh CK, Ong BH, Koh T, Hillmer AM, Takano A, Lim TKH, Tan EH, Zhai W, Tan DSW, Tan IB, Newell EW - Nature 2018 May 16

2018

Abstract

"Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy." Zhao Y, Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y, Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE, Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q - Gut 2018 Mar 30

2018

Abstract

"DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1." Wang X, Srivastava Y, Jankowski A, Malik V, Wei Y, Del Rosario RCH, Cojocaru V, Prabhakar S, Jauch R - Nucleic Acids Res 2018 Apr 14

2018

Abstract

"ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients." Bertrand D, Dris sler S, Chia BK, Koh JY, Li C, Suphavilai C, Tan IB, Nagarajan N - Cancer Res 2018 Jan 01 ; 78(1) : 290-301

2018

Abstract

"The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat." Yip LY, Aw CC, Lee SH, Hong YS, Ku HC, Xu WH, Chan JMX, Cheong EJY, Chng KR, Ng AHQ, Nagarajan N, Mahendran R, Lee YK, Browne ER, Chan ECY - Hepatology 2018 01 ; 67(1) : 282-295

2018

Abstract

"Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing." Nahar R, Zhai W, Zhang T, Takano A, Khng AJ, Lee YY, Liu X, Lim CH, Koh TPT, Aung ZW, Lim TKH, Veer avalli L, Yuan J, Teo ASM, Chan CX, Poh HM, Chua IML, Liew AA, Lau DPX, Kwang XL, Toh CK, Lim WT, Lim B, Tam WL, Tan EH, Hillmer AM, Tan DSW - Nat Commun 2018 Jan 15 ; 9(1) : 216

2018

Abstract

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