The most commonly studied DNA modification in human epigenetics is 5-methyl-cytosine, where its role in regulating gene expression and cellular function is already well-documented. However, recent advances propose that there also exist other less common DNA modifications, each opening up a new frontier in human epigenetics.
Our lab focuses on characterizing these rare and uncanonical human DNA modifications. We achieve this by developing novel high-throughput sequencing techniques to seek out atypical DNA modifications that are differentially regulated at various developmental stages or misregulated in diseased tissues. Our overall goal is to elucidate how these DNA modifications regulate cellular functions and in turn, contribute to human diseases.
**We are looking to hire motivated post-doctoral candidates with experiences in the fields of molecular biology and/or next-generation sequencing.**