Giridharan Periyasamy, Ph.D.
Manager, High Throughput / Content Screening Platform
periyasamyg@gis.a-star.edu.sg
RESEARCH FOCUS
 

To enable automated image-based screening at sub-cellular resolution
To probe kinetic parameters of biological processes in throughput mode with live cell automated microscopy
Discovery of new gene functions and phenotypes after depletion or knock-down / enhancer or over expression
Identification of new chemical or biological entities that induce equivalent phenotypes
Using chemico-genomic approaches to discover mode of action of compounds (comparison RNAi and chemical screens)
To build a tiered approach for Predictive Toxicity Screening using relevant 3D / Organotypic cell culture models

 

EDUCATION

1995 Bachelors in chemistry Bharathidasan University India

1997 Masters in Biochemistry Annamalai University India

2003 PhD in Biotechnology Centre for Biotech, Anna University India

 

PROFESSIONAL APPOINTMENTS

Nov 2012 - Sep 2013 Scientific Director -HTS/HCS Screening Core Facility, C-CAMP, NCBS-TIFR, Bangalore, India

Aug 2009 – Oct 2012 Group Leader, Screening and Lead Evaluation, Department of HTS, Piramal Healthcare Ltd, Mumbai, India

Aug 2005– Aug 2009 Senior Research Scientist, Department of HTS, Piramal Life Sciences Ltd, Mumbai, India

Jun 2003 - Aug 2005 Lecturer Biotechnology, Center for Biotechnology, Anna University, Chennai, India

 

HONORS AND AWARDS

1999 - 2000 Junior Research Fellow, Department of Biotechnology, Government of India

2000 - 2003 Senior Research Fellow, Department of Biotechnology, Government of India

2003 -2005 Principal Research Consultant in the area of cancer drug discovery for Nicholas Piramal India Limited, Mumbai

2006 & 2008 “Excel” achievement award for the best performance in the ongoing oncology drug discovery programme.

2011 Team award for effective co-ordination and completion of 2,57,000 microbial extracts screening for four therapeutic areas in DBT-Multi Institutional programme

 

PATENTS

2012 US Patent application No.: 61/617927 "Nucleoside analogue as an anticancer compound" US Patent application No.: 61/617927, Date of filing: March 30, 2012 Co-Inventor
2011 US Patent application no. : 61/491,569 A synergistic pharmaceutical combination for the treatment of squamous cell carcinoma of head and neck, US Patent application no. : 61/491,569, Date of filing: 31 May 2011. Primary Inventor
2011 US Patent application No.: 61/452,197 Synergistic pharmaceutical combination for the treatment of pancreatic cancer, US Patent application No.: 61/452,197, Date of filing: 15 March 2011. Primary Inventor
2010 USPTO # 20100152129 Novel synergistic combination of Gemcitabine with P276-00 orP1446a in treatment of cancer, Publication date: 06/17/2010. Primary Inventor
2008 WO/2008/090517 Enriched plant extract, compound, and methods for the treatment of proliferative disorders Pub. No.: (PCT/IB2008/050227) Publication date:31.07.2008 International Filing date: 23.01.2008. Primary Inventor
2003 WO/2003/022854 a substituted furochromenone derivative exhibiting anti-cancer and anti-proliferative properties. Pub. No.: PCT/IN2001/000156 Publication date: 20.03.2003 International Filing date: 11.09.2001. Primary Inventor

 

COMPLETE PUBLICATION LIST

Ragavan RV, Kumar KM, Vijayakumar V, Sarveswari S, Ramaiah S, Anbarasu A, Karthikeyan S, Giridharan P, Kumari NS "β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies." Org Med Chem Lett 2013 ; 3(1) : 6 Epub 2013 Jul 19
Abstract
 
Subramaniam D, Periyasamy G, Ponnurangam S, Chakrabarti D, Sugumar A, Padigaru M, Weir SJ, Balakrishnan A, Sharma S, Anant S "CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis." Mol Cancer Ther 2012 Jul ; 11(7) : 1598-608 Epub 2012 Apr 24
Abstract
 
Giridharan P, Verekar SA, Khanna A, Mishra PD, Deshmukh SK "Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim. & Udagawa." Indian J Exp Biol 2012 Jul ; 50(7) : 464-8
Abstract
 
Ramachandran G, Karthikeyan NS, Giridharan P, Sathiyanarayanan KI "Efficient iodine catalyzed three components domino reaction for the synthesis of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives possessing anticancer activities." Org Biomol Chem 2012 Jul 28 ; 10(28) : 5343-6 Epub 2012 Jun 14
Abstract
 
Chakor N, Patil G, Writer D, Periyasamy G, Sharma R, Roychowdhury A, Mishra PD "First total synthesis of prasinic acid and its anticancer activity." Bioorg Med Chem Lett 2012 Nov 1 ; 22(21) : 6608-10 Epub 2012 Sep 13
Abstract
 
Chauthe SK, Bharate SB, Periyasamy G, Khanna A, Bhutani KK, Mishra PD, Singh IP "One pot synthesis and anticancer activity of dimeric phloroglucinols." Bioorg Med Chem Lett 2012 Mar 15 ; 22(6) : 2251-6 Epub 2012 Jan 31
Abstract
 
Khanna A, Mahalingam K, Chakrabarti D, Periyasamy G "Ets-1 expression and gemcitabine chemoresistance in pancreatic cancer cells." Cell Mol Biol Lett 2011 Mar ; 16(1) : 101-13 Epub 2010 Dec 27
Abstract
 
Deshmukh SK, Mishra PD, Kulkarni-Almeida A, Verekar S, Sahoo MR, Periyasamy G, Goswami H, Khanna A, Balakrishnan A, Vishwakarma R "Anti-inflammatory and anticancer activity of ergoflavin isolated from an endophytic fungus." Chem Biodivers 2009 May ; 6(5) : 784-9
Abstract
 
Subramaniam D, Giridharan P, Murmu N, Shankaranarayanan NP, May R, Houchen CW, Ramanujam RP, Balakrishnan A, Vishwakarma RA, Anant S "Activation of apoptosis by 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos." Cancer Res 2008 Oct 15 ; 68(20) : 8573-81
Abstract
 
Senthil V, Ramadevi S, Venkatakrishnan V, Giridharan P, Lakshmi BS, Vishwakarma RA, Balakrishnan A "Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation." Chem Biol Interact 2007 Apr 5 ; 167(1) : 19-30 Epub 2007 Jan 12
Abstract
 
Giridharan P, Somasundaram ST, Perumal K, Vishwakarma RA, Karthikeyan NP, Velmurugan R, Balakrishnan A "Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis." Br J Cancer 2002 Jul 1 ; 87(1) : 98-105
Abstract