Institute of Bioengineering and Bioimaging (IBB)

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About us

The Institute of Bioengineering and Bioimaging (IBB) is located in Singapore's research and development hub for biomedical sciences, at the heart of Biopolis. The institute is located at Helios and Nanos and is staffed by imaging experts, bioengineers, chemists, physicists, biologists and clinicians. IBB integrates the capabilities and technologies built up by the Institute of Bioengineering and Nanotechnology (IBN) and Singapore Bioimaging Consortium (SBIC), which were established in 2003 and 2004 respectively. IBB's work includes the following scientific breakthroughs and innovations:

  • High-impact papers in leading scientific journals
  • Active patents under the Biomedical Research Council’s portfolio
  • 10 spin-off companies (such as Lucence, InvitroCue and Respiree)
IBB's Vision
To be a world-leading Bioengineering and Bioimaging Institute focused on the translation of technologies for the benefit of human and society.

IBB's Mission
The Institute of Bioengineering & Bioimaging strives to develop new technologies and engineering solutions addressing health, medical and sustainability challenges and to promote the advancement of disease prevention, diagnosis and therapy. With our comprehensive research capabilities at the interface of physical sciences, engineering and bioimaging, the institute brings together multi-disciplinary teams of leading scientists and engineers to tackle national and international health and technological priorities through partnership with both clinical and industry communities.

Our Focus Areas

Biomedical Devices & Diagnostics

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Bioengineering Systems

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Biophotonics & Bioimaging

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IBB spearheads multi-disciplinary, application-driven research at the interface of biology, chemistry, engineering and medicine, and work closely with stakeholders across the ecosystem to deliver innovative solutions in strategic areas such as cancer, infectious diseases, and food and nutrition.

Highlights

Local Study Demonstrates Synergies of Using Blood-based Liquid Biopsies to Complement Tissue Biopsies for Lung Cancer Diagnosis

SINGAPORE – Researchers from A*STAR’s Institute of Bioengineering and Bioimaging (IBB), in collaboration with Changi General Hospital (CGH) and Lucence, a local biomedical start-up, conducted the first local prospective study which demonstrated that a blood-based liquid biopsy can be used to complement the conventional tissue biopsy for lung cancer diagnosis.  

The study focuses on non-small cell lung cancer (NSCLC) and has shown that a liquid biopsy test could be used to extract relevant information for a preliminary diagnosis. This would benefit some patients who have had their cancer diagnosed, allowing them to track their response to treatment, or learn whether cancer has returned, and better assess and select the most suitable treatment earlier, using evidence-based methods. 

NSCLC accounts for 85 per cent of all lung cancers, making it one of the most common causes of cancer death worldwide . The median age of NSCLC diagnosis is 70 years of age and approximately 40 per cent of patients are diagnosed at a late stage. Such patients would benefit from the added option of liquid biopsies, which can provide additional information about the cancer that would complement tissue testing. 

Tissue biopsies are a vital part of cancer care as they provide representative tissue of the actual tumour that can be assessed by pathologists in a highly accurate manner, and are used to confirm a cancer diagnosis, identify the cell type of the tumour and provide predictive biomarkers of response to targeted treatments. While tissue biopsies remain the gold standard for cancer diagnosis, liquid biopsies, which are performed on blood samples, are able to complement this process and provide early detection of cancer recurrence. 

The liquid biopsy works by detecting mutant DNA from mutated cancer cells, which cannot be found in normal DNA. While the type of cancer cannot be confirmed, the information from the liquid biopsy helps to detect cancer, determine the appropriate course of treatment and potentially improve time to report and time to treatment. In this study, the process from blood-based liquid biopsy to diagnosis took an average of 10 days. Turnaround time for tissue results may take longer, depending on the quantity and quality of the specimen being biopsied.

Working with a local biomedical start-up, Lucence, the team tapped on IBB’s capabilities in ultrasensitive diagnostic assays and technologies and Lucence’s liquid biopsy test to process the samples in a clinically accredited laboratory. IBB researchers validated the results in tumour samples and clinical data provided by CGH. The results are applicable for local hospitals and clinics. It would also be clinically impactful for local patients.

Dr Jamie Mong, Senior Scientist at A*STAR’s IBB, said, “The aim of IBB’s research is to design and develop studies to help improve diagnostics tools for patients. The findings from this collaboration with Changi General Hospital and Lucence have shown that blood-based biopsies are very useful in preliminary diagnosis of non-small cell lung cancer, and this could help to improve health outcomes for patients.”  

“This collaborative study shows that liquid biopsy yields additional 26.8% actionable treatment options for patients, because of the limitations of conventional tissue testing,” said Dr Min-Han Tan, Founding CEO and Medical Director at Lucence. “Together with a ten day turnaround time, this means earlier and more guideline-concordant cancer treatments.”

“The research study findings showed the feasibility of liquid biopsy as an additional diagnostic option for non-small cell lung cancer when tissue biopsy for lung cancer mutation testing is not viable, particularly for medically unfit patients with progression of the cancer disease. In innovating healthcare for tomorrow, CGH collaborates widely with research partners to create new value and enhance care for patients,” said Clinical Associate Professor Augustine Tee, Deputy Chairman, Medical Board (Medical Disciplines) and Senior Consultant, Respiratory and Critical Care Medicine, Changi General Hospital.

Beyond diagnosis, the blood tests can be also used to monitor a patient’s condition and how receptive they are to treatment. 

For media queries and clarifications, please contact:

Viess Lian
Senior Officer, Corporate Communications
Agency for Science, Technology and Research
Tel: +65 6826 6309

Teo Yin Yin
Deputy Director, Corporate Communications
Changi General Hospital

Anastasia Lim
Sales & Marketing Executive
Lucence

 

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