Biophotonics & Bioimaging

Model Learning Analysis of 3D Optoacoustic Mesoscopic Images for the Classification of Atopic Dermatitis

Park, S., Saw, S.N., Li, X., Paknezhad, M., Coppola, D., Dinish, U.S., Attia, A.B.E., Yew, Y.W., Thng, S.T.G., Lee, H.K. and Olivo, M., 2021.
Biomedical Optics Express, 12(6), 3671-3683

Trajectories of Systolic Blood Pressure in Children: Risk Factors and Cardiometabolic Correlates

Yuan, W.L., Kramer, M.S., Michael, N., Sadananthan, S.A., Tint, M.T., Chen, L.W., Pang, W.W., Velan, S.S., Godfrey, K.M., Chong, Y.S. and Chong, M.F. (2021).
The Journal of Pediatrics.

Diffusely Increased 18F-FDG Thyroid Radionuclide Uptake is Not Always Hyperthyroidism

Sun, L., Goh, H. J., Wang, N. X., Verma, S. K., Velan, S. S., & Leow, M. K. S. (2021).
Postgraduate Medical Journal.

Early postnatal irradiation‐induced age‐dependent changes in adult mouse brain: MRI based characterization.

Ren, B.X., Huen, I., Wu, Z.J., Wang, H., Duan, M.Y., Guenther, I., Prakash, K.B. and Tang, F.R. (2021).
BMC neuroscience, 22(1), 1-14.

Model learning analysis of 3D optoacoustic mesoscopic images for the classification of atopic dermatitis

Sojeong Park, Shier Nee Saw, Xiuting Li, Mahsa Paknezhad, Davide Coppola, Dinish U.S., Amalina Binte Ebrahim Attia, Yik Weng Yew, Steven Tieng Guan Thng, Hwee Kuan Lee*, Malini Olivo*. Biomedical Optics Express. DOI: 10.1364/BOE.415105. (2021).

An Improved Synthesis of N-(4-[18F]Fluorobenzoyl)-Interleukin-2 for the Preclinical PET Imaging of Tumour-Infiltrating T-cells in CT26 and MC38 Colon Cancer Models.

Shivashankar Khanapur, Fui Fong Yong ,Siddesh V. Hartimath, Lingfan Jiang, Boominathan Ramasamy, Peter Cheng, Pradeep Narayanaswamy, Julian L. Goggi and Edward George Robins.
Molecules. 2021, 26(6), 1728;

Towards point-of-care SERS sensor for biomedical and food analysis applications: a review of recent advancements

Jayakumar Perumal, Yusong Wang, Amalina Binte Ebrahim Attia, Dinish U. S.*, Malini Olivo*,
Invited Review in Nanoscale. 2021; 13(2): 553-580. DOI: 10.1039/D0NR06832B.

Biophotonic technologies for intraoperative assessment of breast tumor surgical margins – a review

Ghayathri Balasundaram1, Christoph Krafft1, Ruochong Zhang, Bi Renzhe, Mohesh Moothanchery, Jürgen Popp, Malini Olivo*.
Invited Review in Journal of Biophotonics. 2021; 14(1): e202000280. DOI: 10.1002/jbio.202000280. Published on 20 Sep 2020.

Metasurfaces for Biomedical Applications: Imaging and Sensing from a Nanophotonics Perspective

Shuyan Zhang, Chi Lok Wong, Shuwen Zeng, Renzhe Bi, Kolvyn Tai, Kishan Dholakia, and Malini Olivo*,
Invited Review in Nanophotonics (Special Issue: Frontiers in Optics & Photonics). 2021; 10(1): 259-293. DOI: 10.1515/nanoph-2020-0373.

Raster-scanning optoacoustic mesoscopy (RSOM) imaging as an objective disease severity tool in atopic dermatitis patients

Yik Weng Yew, Dinish U.S., Amanda Hui Yu Kuan, Xiuting Li, Kapil Dev, Amalina Binte Ebrahim Attia, Renzhe Bi, Mohesh Moothanchery, Ghayathri Balasundaram, Juan Aguirre, Vasilis Ntziachristos*, Malini Olivo*, Steven Tien Guan Thng*,
Journal of American Academy of Dermatology. 2021; 84(4): 1121-1123. DOI: 10.1016/j.jaad.2020.06.045.

Granzyme B PET Imaging of Combined Chemotherapy and Immune Checkpoint Inhibitor Therapy in Colon Cancer.

Goggi, Julian L.; Hartimath, SV; Xuan, TY; Khanapur S; Jieu, B; Chin, HX (; Ramasamy, B; Cheng, P; Rong, TJ; Fong, YF ; Yuen, TY; Msallam, R; Chacko, AM; Renia, L; Johannes, C ; Hwang, YY; Robins, EG.
Molecular Imaging & Biology. 2020 Oct;22(5):1392-1402.

Role of a modified ultrafast MRI brain protocol in clinical paediatric neuroimaging.

S H Ahamed, Lee Kuan Jin, P H Tang.
Clinical Radiology. Volume 75, Issue 12, December 2020, Pages 914-920

Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia.

Colin Harper, Venkatesh Gopalan, Jorming Goh.
Translational Medicine. 19, Article number: 71 (2021).

COVID-19 endocrinopathy with hindsight from SARS.

Kothandaraman N, Rengaraj A, Xue B, Yew WS, Velan SS, Karnani N, Leow MKS.
American Journal of Physiology Endocrinology and Metabolism. 2021 Jan 1;320(1):E139-E150.

A 12-week aerobic exercise intervention results in improved metabolic function and lower adipose tissue and ectopic fat in high-fat diet fed rats.

Gopalan V, Yaligar J, Michael N, Kaur K, Anantharaj R, Verma SK, Sadananthan SA, Le GTT, Goh J, Velan SS.
Bioscience Reports. (2021) 41 (1): BSR20201707.

Cardiometabolic profile of different body composition phenotypes in children.

Ong YY, Huang JY, Michael N, Sadananthan SA, Yuan WL, Chen LW, Karnani N, Velan SS, Fortier MV, Tan KH, Gluckman PD, Yap F, Chong YS, Godfrey KM, Chong MF, Chan SY, Lee YS, Tint MT, Eriksson JG.
Journal of Clinical Endocrinology and Metabolism.

Branched-Chain Amino Acid Supplementation Does Not Preserve Lean Mass or Affect Metabolic Profile in Adults with Overweight or Obesity in a Randomized Controlled Weight Loss Intervention.

Ooi DSQ, Ling JQR, Sadananthan SA, Velan SS, Ong FY, Khoo CM, Tai ES, Henry CJ, Leow MKS, Khoo EYH, Tan CS, Lee YS, Chong MFF.
Journal of Nutrition.

ACohort profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO).

Loo EXL, Soh SE, Loy SL, Ng S, Tint MT, Chan SY, Huang JY, Yap F, Tan KH, Chern BSM, Tan HH, Meaney MJ, Karnani N, Godfrey KM, Lee YS, Chan JKY, Gluckman PD, Chong YS, Shek LP, Eriksson JG; S-PRESTO Study Group, Chia A, Fogel AM, Goh AEN, Chu AHY, Rifkin-Graboi A, Qiu A, Lee BW, Cheon BK, Vaz C, Henry CJ, Forde CG, Chi C, Koh DXP, Phua DY, Loh DNL, Quah EPL, Tham EH, Law ECN, Magkos F, Mueller-Riemenschneider F, Yeo GSH, Yong HEJ, Chen HY, Tan HH, Pan H, Bever HPSV, Tan HM, Aris IBM, Tay J, Chan JKY, Xu J, Yoong JS, Eriksson JG, Choo JTL, Bernard JY, Huang JY, Lai JS, Tan KML, Godfrey KM, Kwek KYC, McCrickerd K, Narasimhan K, Chong KW, Lee KJ, Chen L, Ling LH, Chen LW, Daniel LM, Shek LP, Fortier MV, Chong MF, Chua MC, Leow MK, Kee MZL, Gong M, Tint MT, Michael N, Lek N, Teoh OH, Mishra P, Li QLJ, Velan SS, Ang SB, Cai S, Goh SH, Lim SB, Tsotsi S, Hsu SC, Toh SES, Sadananthan SA, Tan TH, Yew TW, Gupta V, Rajadurai VS, Han WM, Pang WW, Yuan WL, Zhu Y, Cheung YB, Chan YH, Cheng ZR.
European Journal of Epidemiology. 36, pages129–142(2021)

Physical and Physiological Properties of Fat.

Sugii, S.; and Velan, S.S.
Chapter 26, Quantitative Magnetic Resonance Imaging. Elsevier.

Clinical noninvasive imaging and spectroscopic tools for dermatological applications: Review of recent progress.

Attia, A. B. E., Bi, R., Dev, K., Du, Y., & Olivo, M. (2020).
Translational Biophotonics.

Local and global dichotomic dysfunction in resting and evoked functional connectivity precedes tauopathy

Mandino, F., Yeow, L. Y., Bi, R., Lee, S., Bae, H. G., Baek, S. H., Lee, C. Y., Mohammad, H., Teoh, C. L.,  Lee, J., Lai, M. K. L., Jung, S., Yu, F., Olivo, M., Gigg, J., Grandjean, J. 
bioRxiv. DOI: 10.1101/2020.04.03.022590 (preprint), 2020.

Skin surface detection in 3D optoacoustic mesoscopy based on dynamic programming

Nitkunanantharajah, S., Zahnd, G., Olivo, M., Navab, N., Mohajerani, P., Ntziachristos, V.
IEEE Transactions on Medical Imaging. 2020; 39(2): 458-467. DOI: 10.1109/TMI.2019.2928393.

Method of respiratory rate measurement using a unique wearable platform and an adaptive optical-based approach.

Singh, G., Tee, A., Trakoolwilaiwan, T., Taha, A., & Olivo, M. (2020).
Intensive Care Medicine Experimental, 8(1), 15.

Metasurfaces for biomedical applications: imaging and sensing from a nanophotonics perspective.

Zhang, S., Wong, C. L., Zeng, S., Bi, R., Tai, K., Dholakia, K., & Olivo, M. (2020).
Nanophotonics.

Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study.

Tint, M.-T., Sadananthan, S. A., Soh, S.-E., Aris, I. M., Michael, N., Tan, K. H., … Lee, Y. S. (2020).
The American Journal of Clinical Nutrition, 112(1), 39–47.

Mismatch between poor fetal growth and rapid postnatal weight gain in the first 2 years of life is associated with higher blood pressure and insulin resistance without increased adiposity in childhood: the GUSTO cohort study.

Ong, Y. Y., Sadananthan, S. A., Aris, I. M., Tint, M. T., Yuan, W. L., Huang, J. Y., … Michael, N. (2020).
International Journal of Epidemiology.

Give and take: competition for BCAAs in the tumour microenvironment.

Ericksen, R. E., & Han, W. (2020).
Nature Metabolism, 2(8), 657–658.

The pancreatic beta cells: Still much to be learned.

Han, W., & Eizirik, D. L. (2020).
Seminars in Cell & Developmental Biology, 103, 1–2.

ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization.

Lam, H. Y., Arumugam, S., Bae, H. G., Wang, C. C., Jung, S., St. John, A. L., … Tergaonkar, V. (2020).
Science Advances, 6(31), eabb2497.

Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson ’ s disease. 11, 347.

Goggi, J. L., Qiu, L., Liao, M. C., Khanapur, S., Jiang, L., Boominathan, R., … Robins, E. G. (2020).
Molecular Imaging and Biology.

Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes.

Goggi, J. L., Tan, Y. X., Hartimath, S. V, Jieu, B., Hwang, Y. Y., Jiang, L., … Robins, E. G. (2020).
Molecular Imaging and Biology.

Modulation of lymphocyte potassium channel K V 1.3 by membrane-penetrating, joint-targeting immunomodulatory plant defensin.

Ong, S. T., Bajaj, S., Tanner, M. R., Chang, S. C., Krishnarjuna, B., Ng, X. R., … Chandy, G. (2020).
ACS Pharmacology & Translational Science.

Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine.

Lu, H., Shagirova, A., Goggi, J. L., Yeo, H. L., & Roy, S. (2020).
Biology Open.

Longitudinal [18F]FB-IL-2 PET Imaging to Assess the Immunopathogenicity of O’nyong-nyong Virus Infection.

Chan, Y. H., Teo, T. H., Torres-Ruesta, A., Hartimath, S. V., Chee, R. S. L., Khanapur, S., … Ng, L. F. P. (2020).
Frontiers in Immunology.

Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis.

Grandjean, J., Canella, C., Anckaerts, C., Ayrancı, G., Bougacha, S., Bienert, T., … Gozzi, A. (2020).
NeuroImage, 205, 116278.

Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies.

Goh, Y., Balasundaram, G., Moothanchery, M., Attia, A., Li, X., Lim, H. Q., … Olivo, M. (2020).
Translational Oncology, 13(2), 254–261.

Handheld confocal Raman spectroscopy (CRS) for objective assessment of skin barrier function and stratification of severity in atopic dermatitis (AD) patients.

Ho, C. J. H., Yew, Y. W., Dinish, U. S., Kuan, A. H. Y., Wong, M. K. W., Bi, R., … Olivo, M. (2020).
Journal of Dermatological Science.

Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation.

Sun, L., Yan, J., Goh, H. J., Govindharajulu, P., Verma, S., Michael, N., … Leow, M. K. S. (2020).
Journal of Clinical Endocrinology and Metabolism, 105(3).

Brown Fat Activity Determined by Infrared Thermography and Thermogenesis Measurement Using Whole Body Calorimetry (BRIGHT Study).

Tay, S. H., Goh, H. J., Govindharajulu, P., Cheng, J., Camps, S. G. J. A., Haldar, S., … others. (2020).
Physiological Research, 69(1), 85–97.

Examining Immunotherapy Response Using Multiple Radiotracers.

Goggi, J. L., Hartimath, S. V., Hwang, Y., Tan, Y. X., Khanapur, S., Ramasamy, B., … Robins, E. G. (2020).
Molecular Imaging and Biology.

A mouse model of gestation-specific transient hyperglycemia for translational studies.

Li, H. Y., Liu, Y. X., Harvey, L., Shafaeizadeh, S., van der Beek, E. M., & Han, W. (2020).
The Journal of Endocrinology, 244(3), 501–510.

Optoacoustic characterization of breast conserving surgery specimens – A pilot study.

Balasundaram, G., Goh, Y., Moothanchery, M., Attia, A., Lim, H. Q., Burton, N. C., … Olivo, M. (2020).
Photoacoustics, 19, 100164.

Fast pulsatile blood flow measurement in deep tissue through a multimode detection fiber.

Bi, R., Du, Y., Singh, G., Ho, C. J.-H., Zhang, S., Attia, A. B. E., … Olivo, M. (2020).
Journal of Biomedical Optics, 25(05), 1.

Dual-triggered nanoaggregates of cucurbit[7]uril and gold nanoparticles for multi-spectroscopic quantification of creatinine in urinalysis.

Chio, W.-I. K., Moorthy, S., Perumal, J., U. S., D., Parkin, I. P., Olivo, M., & Lee, T.-C. (2020).
Journal of Materials Chemistry C.

Development of highly reliable SERS‐active photonic crystal fiber probe and its application in the detection of ovarian cancer biomarker in cyst fluid.

Beffara, F., Perumal, J., Puteri Mahyuddin, A., Choolani, M., Khan, S. A., Auguste, J., … Olivo, M. (2020)
Journal of Biophotonics, 13(3).