Barnaby Young

Barnaby YOUNG

Organisation: National Centre for Infectious Diseases
Designation: Senior Consultant
Email: barnaby_young@ncid.sg

Biography

Dr Barnaby Young graduated in Medicine with a B.A. in Genetics from the University of Cambridge. He has a Masters in Infectious Diseases from the London School of Hygiene and Tropical Medicine and a doctorate for his work on Influenza Vaccination in the Tropics from the Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Dr Young is Head of the Singapore Clinical Infectious Diseases Research Network (SCRN) and works as a Senior Consultant at the National Centre for Infectious Diseases and Tan Tock Seng Hospital. Dr Young’s current research involves the study of the epidemiology, clinical characteristics, and vaccinology of COVID-19. He is the principal investigator of several observational COVID-19 studies and a clinical trial of homologous/heterologous COVID-19 vaccine boosters and is a member of the Singapore COVID-19 Research and Treatment Work Groups. 

Research Focus

  • Respiratory virus infections
  • Human challenge studies
  • Clinical trials

Publications

  • Antibody response of heterologous vs homologous mRNA vaccine boosters against the SARS-CoV-2 Omicron variant: interim results from the PRIBIVAC study, A Randomized Clinical Trial Poh XY, Tan CW, Lee IR, Chavatte JM, Fong SW, Prince T, Hartley C, Yeoh AY, Rao S, Chia PY, Ong SW, Lee TH, Sadarangani SP, Lin RJ, Lim C, Teo J, Lim DR, Chia W, Hiscox JA, Ng LFP, Ren EC, Lin RT, Renia L, Lye DC, Wang LF, Young BE. Clin Infect Dis. 2022 May 11:ciac345. doi: 10.1093/cid/ciac345. Online ahead of print. 20.999
  • Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study Chia PY, Ong SWX, Chiew CJ, Ang LW, Chavatte JM, Mak TM, Cui L, Kalimuddin S, Chia WN, Tan CW, Chai LYA, Tan SY, Zheng S, Lin RTP, Wang L, Leo YS, Lee VJ, Lye DC, Young BE. Clin Microbiol Infect. 2022 Apr;28(4):612.e1-612.e7. doi: 10.1016/j.cmi.2021.11.010. Epub 2021 Nov 23. 13.31
  • Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective cohort study comparing B.1.1.7 (Alpha), B.1.351 (Beta), and B.1.617.2 (Delta) Ong SWX, Chiew CJ, Ang LW, Mak TM, Cui L, Toh MPHS, Lim YD, Lee PH, Lee TH, Chia PY, Maurer-Stroh S, Lin RTP, Leo YS, Lee VJ, Lye DC, Young BE. Clin Infect Dis. 2021 Aug 23:ciab721. doi: 10.1093/cid/ciab721. Online ahead of print. 20.999
  • Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors Tan CW, Chia WN, Young BE, Zhu F, Lim BL, Sia WR, Thein TL, Chen MI, Leo YS, Lye DC, Wang LF. N Engl J Med. 2021 Oct 7;385(15):1401-1406. doi: 10.1056/NEJMoa2108453. Epub 2021 Aug 18. 176.08
  • Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity Young BE, Ong SWX, Ng LFP, Anderson DE, Chia WN, Chia PY, Ang LW, Mak TM, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Fong SW, Chan YH, Tan CW, Lee B, Rötzschke O, Ding Y, Tambyah P, Low JGH, Cui L, Barkham T, Lin RTP, Leo YS, Renia L, Wang LF, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. Clin Infect Dis. 2021 Nov 2;73(9):e2932-e2942. doi: 10.1093/cid/ciaa1280. 20.999
  • Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study Young BE, Fong SW, Chan YH, Mak TM, Ang LW, Anderson DE, Lee CY, Amrun SN, Lee B, Goh YS, Su YCF, Wei WE, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Chen YYC, Barkham T, Lin RTP, Maurer-Stroh S, Leo YS, Wang LF, Renia L, Lee VJ, Smith GJD, Lye DC, Ng LFP. Lancet. 2020 Aug 29;396(10251):603-611. doi: 10.1016/S0140-6736(20)31757-8. Epub 2020 Aug 18. 202.73
  • A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction Tan CW, Chia WN, Qin X, Liu P, Chen MI, Tiu C, Hu Z, Chen VC, Young BE, Sia WR, Tan YJ, Foo R, Yi Y, Lye DC, Anderson DE, Wang LF. Nat Biotechnol. 2020 Sep;38(9):1073-1078. doi: 10.1038/s41587-020-0631-z. Epub 2020 Jul 23. 68.164
  • Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients Chia PY, Coleman KK, Tan YK, Ong SWX, Gum M, Lau SK, Lim XF, Lim AS, Sutjipto S, Lee PH, Son TT, Young BE, Milton DK, Gray GC, Schuster S, Barkham T, De PP, Vasoo S, Chan M, Ang BSP, Tan BH, Leo YS, Ng OT, Wong MSY, Marimuthu K; Singapore 2019 Novel Coronavirus Outbreak Research Team. Nat Commun. 2020 May 29;11(1):2800. doi: 10.1038/s41467-020-16670-2. 17.69
  • SARS-CoV-2 Infection among Travelers Returning from Wuhan, China Ng OT, Marimuthu K, Chia PY, Koh V, Chiew CJ, De Wang L, Young BE, Chan M, Vasoo S, Ling LM, Lye DC, Kam KQ, Thoon KC, Kurupatham L, Said Z, Goh E, Low C, Lim SK, Raj P, Oh O, Koh VTJ, Poh C, Mak TM, Cui L, Cook AR, Lin RTP, Leo YS, Lee VJM. N Engl J Med. 2020 Apr 9;382(15):1476-1478. doi: 10.1056/NEJMc2003100. Epub 2020 Mar 12. 176.08
  • Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM, Lau SK, Anderson DE, Chan KS, Tan TY, Ng TY, Cui L, Said Z, Kurupatham L, Chen MI, Chan M, Vasoo S, Wang LF, Tan BH, Lin RTP, Lee VJM, Leo YS, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. JAMA. 2020 Apr 21;323(15):1488-1494. doi: 10.1001/jama.2020.3204. 157.3

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