Kumar D, Puan KJ, Andiappan AK, Lee B, Westerlaken GH, Haase D, Melchiotti R, Li Z, Yusof N, Lum J, Koh G, Foo S, Yeong J, Alves AC, Pekkanen J, Sun LD, Irwanto A, Fairfax BP, Naranbhai V, Common JE, Tang M, Chuang CK, Jarvelin MR, Knight JC, Zhang X, Chew FT, Prabhakar S, Jianjun L, Wang Y, Zolezzi F, Poidinger M, Lane EB, Meyaard L, Rötzschke O. A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus. Genome Med. 2017 Feb 20;9(1):18. doi: 10.1186/s13073-017-0404-6
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Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP,
Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sudhaharan T, Ishiwata S,
Lane EB, Chang YT, Tseng YH, Suzuki M, Raghunath M. Optical visualisation of
thermogenesis in stimulated single-cell brown adipocytes. Sci Rep. 2017 May
3;7(1):1383. doi: 10.1038/s41598-017-00291-9
Link
Badowski C, Sim AYL, Verma C, Szeverényi I, Natesavelalar C,
Terron-Kwiatkowski A, Harper J, O'Toole EA, Lane EB. Modeling the Structure of
Keratin 1 and 10 Terminal Domains and their Misassembly in Keratoderma. J Invest
Dermatol. 2017 Sep;137(9):1914-1923. doi: 10.1016/j.jid.2017.03.038
Link
Zupancic T, Sersa G, Törmä H, Lane EB, Herrmann H, Komel R, Liovic M. Keratin
gene mutations influence the keratinocyte response to DNA damage and cytokine
induced apoptosis. Arch Dermatol Res. 2017 Jun 24. doi:
10.1007/s00403-017-1757-9
Link
Sundaram GM, Ismail HM, Bashir M, Muhuri M, Vaz C, Nama S, Ow GS, Vladimirovna
IA, Ramalingam R, Burke B, Tanavde V, Kuznetsov V, Lane EB, Sampath P. EGF
hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway
toward metastasis. J Exp Med. 2017 Oct 2;214(10):2889-2900. doi:
10.1084/jem.20170354
Link
Wong XFCC, Denil SLIJ, Foo JN, Chen H, Tay ASL, Haines RL, Tang MBY, McLean WHI, Sandilands A, Smith FJD, Lane EB, Liu J, Common JEA. Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants. J Allergy Clin Immunol. 2017 Oct 19. pii: S0091-6749(17)31588-9. doi: 10.1016/j.jaci.2017.10.001.
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Itoh H, Arai S, Sudhaharan T, Lee SC, Chang YT, Ishiwata S, Suzuki M and Lane EB. Direct organelle thermometry with fluorescence lifetime imaging microscopy in single myotubes. Chem. Commun. (2016) DOI: 10.1039/C5CC09943A
Link
Tan TS, Ng YZ, Badowski C, Dang T, Common JE, Lacina L, Szeverényi I, Lane EB. Assays to Study Consequences of Cytoplasmic Intermediate Filament Mutations: The Case of Epidermal Keratins. Methods Enzymol. 2016;568:219-53. doi: 10.1016/bs.mie.2015.09.030
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Kern Rei Chng, Angeline Su Ling Tay, Chenhao Li, Amanda Hui Qi Ng, Jingjing Wang, Bani Kaur Suri, Sri Anusha Matta, Naomi McGovern, Baptiste Janela, Xuan Fei Colin C. Wong, Yang Yie Sio, Bijin Veonice Au, Andreas Wilm, Paola Florez De Sessions, Thiam Chye Lim, Mark Boon Yang Tang, Florent Ginhoux, John E. Connolly, E. Birgitte Lane, Fook Tim Chew, John E. A. Common & Niranjan Nagarajan. Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare. Nature Microbiology 2016;1:16106. doi:10.1038/nmicrobiol.2016.106
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Benny P1, Badowski C, Lane B, Raghunath M. “Making more matrix: Enhancing the deposition of dermal-epidermal junction components in vitro and accelerating organotypic skin culture development, using macromolecular crowding.” Tissue Eng Part A. 2015 Jan;21(1-2):183-92. doi: 10.1089/ten.TEA.2013.0784.
Ma D, Chua AW, Yang E, Teo P, Ting Y, Song C, Lane EB, Lee ST. “Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis.” Stem Cell Res Ther. 2015 Mar 24;6:43. doi: 10.1186/s13287-015-0032-2
Oyama K, Arai T, Isaka A, Sekiguchi T, Itoh H, Seto Y, Miyazaki M, Itabashi T, Ohki T, Suzuki M, Ishiwata S. “Directional bleb formation in spherical cells under temperature gradient.” Biophys J. 2015 Jul 21;109(2):355-64. doi: 10.1016/j.bpj.2015.06.016.
Zupancic T, Stojan J, Lane EB, Komel R, Bedina-Zavec A, Liovic M. (2014) “Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease.” PLoS One 9(6): e99398. doi: 10.1371/journal.pone.0099398.
Tan KKB, Salgado G, Connolly J, Chan JKY, Lane EB. “Characterization of fetal keratinocytes, showing enhanced stem cell-like properties: A potential source of cells for skin reconstruction.” Stem Cell Reports 3(2):324-38. doi: 10.1016/j.stemcr.2014.06.005.
Hideki Itoh, Kotaro Oyama, Madoka Suzuki, Shin’ichi Ishiwata. “Microscopic heat pulse-induced calcium dynamics in single WI-38 fibroblasts.” Biophysics Vol. 10, pp. 109–119 (2014) doi: 10.2142/biophysics.10.109
Andiappan AK, Foo JN, Choy MW, Chen H, Common JE, Tang MB, van Bever HP, Giam YC, Suri BK, Ramani A, Nilkanth PP, Lane EB, Wang DY, Chew FT, Liu J. (2012) Validation of GWAS Loci for Atopic Dermatitis in a Singapore Chinese Population. J Invest Dermatol. doi: 10.1038/jid.2011.471. [Epub ahead of print] PMID: 22318392
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Cai SC, Chen H, Koh WP, Common JE, van Bever HP, McLean WH, Lane EB, Giam YC, Tang MB. (2011) Filaggrin Mutations are Associated with Recurrent Skin Infection in Singaporean Chinese Patients with Atopic Dermatitis. Br J Dermatol. doi: 10.1111/j.1365-2133.2011.10541.x. [Epub ahead of print] PMID: 21790526
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Canning CA, Chan JS, Common JE, Lane EB, Jones CM. (2011) Developmental expression of the fermitin/kindlin gene family in Xenopus laevis embryos. Dev Dyn. 240(8):1958-63. doi: 10.1002/dvdy.22683.
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Chen H, Common JE, Haines RL, Balakrishnan A, Brown SJ, Goh CS, Cordell HJ, Sandilands A, Campbell LE, Kroboth K, Irvine AD, Goh DL, Tang MB, van Bever HP, Giam YC, McLean WH, Lane EB. (2011) Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations. Br J Dermatol. 165(1):106-114. doi: 10.1111/j.1365-2133.2011.10331.x. PMID: 21428977
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Atkinson SD, McGilligan VE, Liao H, Szeverenyi I, Smith FJ, Moore CB, McLean WH. (2011) Development of Allele-Specific Therapeutic siRNA for Keratin 5 Mutations in Epidermolysis Bullosa Simplex. J Invest Dermatol. Jun 30. [Epub ahead of print] PMID: 21716320
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Goudie DR, D’Alessandro M, Merriman B, Lee H, Szeverenyi I, Avery S, O’Connor BD, Nelson SF, Coats SE., Stewart A, Christie L, Pichert G, Friedel J, Hayes I, Burrows N, Whittaker S, Geredes AM, Broesby-Oslen S, Ferguson-Smith MA, Verma C, Lunny DP, Reversade B, Lane EB (2011) Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genetics 43(4):365-9. PMID: 21358634
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D’Alessandro M, Coats SE, Jonkman MF, Leigh IM, Lane EB. (2011) Keratin 14-Null Cells a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells. J Invest Dermatol. 131(7):1412-9. PMID: 21326298
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Common JE, Brown SJ, Haines RL, Goh CS, Chen H, Balakrishnan A, Munro CS, Tan AW, Tan HH, Tang MB, Lane EB. (2011) Filaggrin Null Mutations Are Not a Protective Factor for Acne Vulgaris. J Invest Dermatol. 2011 Jun;131(6):1378-80. Epub 2011 Feb 17. PMID: 21326297
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O'Regan GM, Kemperman PM, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, Puppels GJ, McLean WH, Caspers PJ, Irvine AD. (2010). Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes. J Allergy Clin Immunol. 126:574-80.e1. PMID: 20621340
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Chong KL, Common JE, Lane EB, Goh BK. (2010). A novel mutation in the kinase domain of KIT in an Indian family with a mild piebaldism phenotype. J Dermatol Sci. 59(3):206-9. Epub 2010 Jul 8. PMID: 20688482
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Russell D, Ross H, Lane EB. (2010). ERK involvement in resistance to apoptosis in keratinocytes with mutant keratin. J Invest Dermatol. 130:671-81. Epub 2009 Oct 22. PMID: 19847192
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Wilson NJ, Messenger AG, Leachman SA, O'Toole EA, Lane EB, McLean WH, Smith FJ. (2010). Keratin K6c Mutations Cause Focal Palmoplantar Keratoderma. J Invest Dermatol. 130: 425-9. PMID: 19609311
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Neoh CY, Chen H, Ng SK, Lane EB, Common JE. (2009). A rare connexin 26 mutation in a patient with a forme fruste of keratitis-ichthyosis-deafness (KID) syndrome. Int J Dermatol. 48:1078-81. PMID: 19785089
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Liovic M, D'Alessandro M, Tomic-Canic M, Bolshakov VN, Coats SE, Lane EB. (2009). Severe keratin 5 and 14 mutations induce down-regulation of junction proteins in keratinocytes. Exp Cell Res. 315: 2995-3003. PMID: 19616543
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Chen H, Toh TK, Szeverenyi I, Ong RT, Theng CT, McLean WH, Seielstad M, Lane EB (2008). Association of Skin Barrier Genes within the PSORS4 Locus Is Enriched in Singaporean Chinese with Early-Onset Psoriasis. J Invest Dermatol. 129: 606-14. PMID: 18787534
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Fudge D, Russell D, Beriault D, Moore W, Lane EB and Vogl AW (2008). The intermediate filament network in cultured human keratinocytes is remarkably extensible and resilient. PLoS One 3: e2327. PMID 18523546
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Szeverenyi I, Cassidy AJ, Chung CW, Lee BT, Common JE, Ogg SC, Chen H, Sim SY, Goh WL, Ng KW, Simpson JA, Chee LL, Eng GH, Li B, Lunny DP, Chuon D, Venkatesh A, Khoo KH, McLean WH, Lim YP, Lane EB (2007). The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases. Hum Mutat 29: 351-360. PMID: 18033728
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D'Alessandro M, Coats SE, Morley SM, Mackintosh L, Tessari G, Turco A, Gerdes A-M, Pichert G, Whittaker S, Brandrup F, Broesby-Olsen S, Gomez-Lira M, Girolomoni G, Maize JC, Feldman RJ, Kato N, Koga Y, Ferguson-Smith MA, Goudie DR, Lane EB (2007). Multiple self-healing squamous epithelioma in different ethnic groups: more than a founder mutation disorder? J Invest Dermatol 127: 2336-2344. PMID: 17554363
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Rugg EL, Horn HM, Smith FJ, Wilson NJ, Hill AJM, Magee GJ, Shemanko CS, Baty DU, Tidman JM and Lane EB (2007). Epidermolysis simplex in Scotland caused by a spectrum of keratin mutations. J Invest Dermatol 127: 574-80. PMID: 17039244
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Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L,Omary MB, Parry DA, Rogers MA and Wright MW (2006). New consensus nomenclature for mammalian keratins. J Cell Biol 174: 169-174. PMID: 16831889
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Russell D, Andrews PD, James J and Lane EB (2004). Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes. J Cell Sci 117: 5233 PMID: 15454576
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Owens DW, Wilson NJ, Hill AJM, Rugg EL, Porter RM, Hutcheson AM, Quinlan RA, van Heel D, Parkes M, Jewell DP, Campbell SS, Ghosh S, Satsangi J and Lane EB (2004). Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients. J Cell Sci 117: 1989-1999. PMID: 15090596
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D'Alessandro M, Morley SM, Ogden P, Liovic M, Porter R and Lane EB (2004). Functional improvement of mutant keratin cells on addition of desmin: an alternative approach to gene therapy for dominant diseases. Gene Therapy 11: 1290-1295. PMID: 15215887
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Liovic M, Mogensen MM, Prescott AR and Lane EB (2003). Observation of keratin particles showing fast bidirectional movement colocalised with microtubules. J Cell Sci 116: 1417-1427. PMID: 12640027
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Owens DW and Lane EB (2003). The quest for the function of simple epithelial keratins. Bioessays 25: 748-758. PMID: 12879445
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