Aneuploidy & Genome Instability

Please note members of Giulia Rancati's lab transferred to the Skin Research Institute of Singapore

We are fascinated by evolvability, which is the remarkable capacity of cells to adapt to a variety of hostile conditions. In out lab we combine cell and systems biology approaches to understand cellular evolvability in mechanistic terms using yeast, mammalian and mouse model systems.  We are currently focusing our efforts in dissecting mechanisms of adaptation in response to harsh environmental or genetic perturbations and the role of cellular stresses in promoting genome instability. This research programme has important implications for our understanding of the design principles of cellular systems as well as for both medical and synthetic biology applications.