Glycotherapeutics & the Treatment of Stroke

I am interested in how to apply treatments based on the chemistry of heparan sugars for a variety of disorders, particularly Stroke (cerebrovascular accident). Even though Stroke is the second biggest killer of Asians, more than cancer, and rehabilitation costs are increasing, the medicines to treat it have barely changed since the mid-1990s. Most Strokes occur when there is a blockage in one of the major arteries feeding our brains. Even after the blockage, usually a clot, is physically removed, there remains an urgent need to get new blood vessels into the affected areas. The major protein growth factors which drive the development of new blood vessels are all dependent on heparan sugars for their effectiveness. We are thus trying to deliver suitable heparan sugar variants into affected brain areas to speed up angiogenesis, and thus the process of tissue repair. Such approaches have applications not only for damaged brains, but for tissue repair after heart attack and for the peripheral vascular disease which accompanies diabetes.

For more information, please contact Victor Nurcombe