Research Fellows

Postdoc Position

Date posted: 04 Mar 2019

Date available: immediately


We are seeking TWO self-motivated postdoctoral researchers to join the laboratory of Dr. Feng Xu at the Institute of Molecular and Cell Biology (IMCB), A-STAR, Singapore (https://www.a-star.edu.sg/imcb/Science/Investigators/Pls/Pls-Profile/ResearchListID/104 ).The research in our laboratory focuses on the epigenetic regulation of energy balance. This topic includes the study of microRNAs, post-translational modifications on histones and non-histone metabolic regulators in the maintenance of metabolic homeostasis. Our lab utilizes both advanced genomic tools as well as classic biochemistry and molecular biology techniques to tackle the scientific questions of interest. In addition, we are also interested in developing novel therapeutic approaches to treat metabolic disorders such as obesity and diabetes. The model systems used in our study include white, brown and beige fat cells. We also use various mouse models to investigate the in vivo metabolic phenotypes.

A-STAR institutes offer highly competitive salaries.

Qualifications:
* PhD degree in the broad field of biology, a successful graduate study demonstrated by first-author papers in peer reviewed international journals.
* Self-motivated, creative, and devoted to project and career goals.
* Independently carry out research work including performing experiments, analyzing data and writing papers.
* Prior experience in animal studies or bioinformatics is strongly desired, but not required.

To apply, please email a cover letter, CV, and the names and contact information (including phone numbers) of three references to fxu@imcb.a-star.edu.sg .

We regret that only shortlisted applicants will be notified.

Research Fellow Position in Structural Biology

Date posted: 23 Jan 2019

Date available: immediately

We are seeking an enthusiastic and self-motivated postdoctoral research fellow to study proteins involved in maintaining genome stability and the Hippo signaling pathway. We take a combinatorial approach of molecular biology, biochemical and biophysical methods, and structural biology (crystallography and cryo-EM). ­Significant aspests of our projects have translatinal potential. Candidates with an interest in the development of small molecules/peptides for cancer therapeutics are also welcome.


Singapore is an excellent environment to do research with many research groups close by in Biopolis [
https://www.a-star.edu.sg/imcb]

Requirements:
· PhD in biochemistry, biophysics, molecular and cell biology or  a related field
· Solid practical experience in Cryo-EM and/or X-ray crystallography
· Practical skills in molecular biology, protein expression
  (prefererally insect and/or mammalian cells) and  purification, and various biochemical techniques
· Good publication record
· Competent in scientific writing

Interested applicants should send a CV, publication list, a brief description of research interests and experience,
and three confidential letters of reference to
: Prof. Haiwei Song, Email: haiwei@imcb.a-star.edu.sg.

We regret that only shortlisted applicants will be notified.