Research Fellows

Research Fellow: Humanized Mouse Unit (HMU)

Date posted: 01 Nov 2019

Date available: Immediately

Two Research Fellow (postdoctoral) positions are available in the Humanized Mouse Unit (HMU) of the Institute of Molecular and Cell Biology, A*STAR, Singapore.

The understanding of many biological processes in humans relies on experimental studies in animal models, particularly rodents. However, many aspects of the human biological system are species specific, such as human specific cell types and immune genes. Our mission is to develop humanized mouse models which closely recapitulate in vivo human biology for the study of human diseases and drug development. This is critical to the understanding and development of therapeutics to many human specific diseases. For a research overview please refer to   https://www.a-star.edu.sg/imcb/Science/Investigators/Senior-Pls/Senior-Pls-Profile/ResearchListID/21

Specific requirements:

  • The candidate should be self-driven to pursue a scientific career, motivated, independent and passionate about immunology research
  • Hold a PhD in a relevant field of immunology or biomedicine.
  • Good knowledge and concept of immunology and demonstrated research experience and achievement
  • Good technical writing skills
  • Prior experience in working with mice, flow cytometry, immunofluorescence etc.

Responsibilities:

  • Undertake independent research under the direction of the PI and with other lab members
  • Assist the PI in quality control for experiments, data analysis, manuscript preparation, grant applications and lab management
  • Assist the PI in guiding and training students and junior research staff.
  • Present research achievements at internal and external seminars and conferences

Please email a detailed CV containing a list of publications to
Dr. Qingfeng Chen,
qchen@imcb.a-star.edu.sg.

We regret that only shortlisted applicants will be notified.

 

 

Research Fellow Position

Date posted: 14 Oct 2019

Date available: immediately

We are seeking an enthusiastic and self-motivated postdoctoral research fellow to study proteins involved in maintaining genome stability and the Hippo signaling pathway. We take a combinatorial approach of molecular biology, biochemical and biophysical methods, and structural biology (crystallography and cryo-EM). ­Significant aspects of our projects have translational potential. The candidate is expected to be involved in the development of small molecules/peptides for cancer therapeutics.

 

Singapore is an excellent environment to do research with many research groups close by in Biopolis [https://www.a-star.edu.sg/imcb].
A*STAR offers highly competitive salaries with benefits.

 

Requirements:

  • PhD in biochemistry, biophysics, molecular & cell biology or in  medicinal chemistry

  • Practical experience in structural biology (Cryo-EM and/or X-ray crystallography) or in medicinal chemistry

  • Good publication record

  • Competent in scientific writing 

Interested applicants should send a CV and three confidential letters of reference to:
Prof. Haiwei Song (Email: haiwei@imcb.a-star.edu.sg),
Institute of Molecular and Cell Biology, A*STAR, Singapore.  

Research Fellow in the Laboratory of Molecular and Vascular Medicine

Date posted: 29 May 2019

Date available: immediately

We are looking for talented individuals to join our Laboratory of Molecular and Vascular Biology. Our team aims to understand blood vessel pathophysiology in development and diseases. We develop human vascular cell-based models to perform functional genomics, phenotypic and molecular assays. We provide vibrant atmospheres and state-of-arts core facilities. Being funded by the prestigious Human Frontier Science Program grant, the best candidates will have exciting opportunities in working with international collaborators, as well as outstanding scientists, clinicians and engineers across Singapore. Highly motivated individuals with a passion to advance personalised and preventive medicine are encouraged to apply.

For more information, please visit: www.cheung-lab.com

Responsibilities:

· Project planning, data analysis, manuscript preparation and grant applications.

· Perform experiments involving cell culture, molecular biology, sequencing,
  phenotypic assays, imaging and bioinformatics, etc. 

· Present research findings at lab meetings and seminars

· Contribute to collaborative projects.

· Guide and train students and junior lab members.

· Assist in lab management with other lab members.

·  Uphold research integrity and ensure safety compliance.


Experience and Competency:

·  Applicants should possess a PhD in life sciences, biomedical sciences, biochemistry,
   bioengineering or equivalent from a well-recognized university.

·  Experience with stem cells, molecular and cell biology, gene editing and/or bioinformatics will be considered favorably.

· Good publication records in peer-reviewed journals.
· Able to undertake independent research and be an effective team player.
· Strong analytical, technical and problem solving skills.
· Committed, able to work flexible hours and within the deadline.
· Excellent written and oral communication skills.

Application Procedure:

If you are interested to pursue a career with us, please write to Dr Christine Cheung (ccheung@imcb.a-star.edu.sg)
with your CV and contact details of 2 referees.
Only shortlisted candidates will be notified.

 

 

Postdoc Position

Date posted: 04 Mar 2019

Date available: immediately


We are seeking TWO self-motivated postdoctoral researchers to join the laboratory of Dr. Feng Xu at the Institute of Molecular and Cell Biology (IMCB), A-STAR, Singapore (https://www.a-star.edu.sg/imcb/Science/Investigators/Pls/Pls-Profile/ResearchListID/104 ).The research in our laboratory focuses on the epigenetic regulation of energy balance. This topic includes the study of microRNAs, post-translational modifications on histones and non-histone metabolic regulators in the maintenance of metabolic homeostasis. Our lab utilizes both advanced genomic tools as well as classic biochemistry and molecular biology techniques to tackle the scientific questions of interest. In addition, we are also interested in developing novel therapeutic approaches to treat metabolic disorders such as obesity and diabetes. The model systems used in our study include white, brown and beige fat cells. We also use various mouse models to investigate the in vivo metabolic phenotypes.

A-STAR institutes offer highly competitive salaries.

Qualifications:
* PhD degree in the broad field of biology, a successful graduate study demonstrated by first-author papers in peer reviewed international journals.
* Self-motivated, creative, and devoted to project and career goals.
* Independently carry out research work including performing experiments, analyzing data and writing papers.
* Prior experience in animal studies or bioinformatics is strongly desired, but not required.

To apply, please email a cover letter, CV, and the names and contact information (including phone numbers) of three references to fxu@imcb.a-star.edu.sg .

We regret that only shortlisted applicants will be notified.

Research Fellow Position in Structural Biology

Date posted: 23 Jan 2019

Date available: immediately

We are seeking an enthusiastic and self-motivated postdoctoral research fellow to study proteins involved in maintaining genome stability and the Hippo signaling pathway. We take a combinatorial approach of molecular biology, biochemical and biophysical methods, and structural biology (crystallography and cryo-EM). ­Significant aspests of our projects have translatinal potential. Candidates with an interest in the development of small molecules/peptides for cancer therapeutics are also welcome.


Singapore is an excellent environment to do research with many research groups close by in Biopolis [
https://www.a-star.edu.sg/imcb]

Requirements:
· PhD in biochemistry, biophysics, molecular and cell biology or  a related field
· Solid practical experience in Cryo-EM and/or X-ray crystallography
· Practical skills in molecular biology, protein expression
  (prefererally insect and/or mammalian cells) and  purification, and various biochemical techniques
· Good publication record
· Competent in scientific writing

Interested applicants should send a CV, publication list, a brief description of research interests and experience,
and three confidential letters of reference to
: Prof. Haiwei Song, Email: haiwei@imcb.a-star.edu.sg.

We regret that only shortlisted applicants will be notified.