Camilo LIBEDINSKY

NeuroTechnology

Profile

Camilo LIBEDINSKY

Camilo Libedinsky obtained his B.Sc. in Biology at Universidad de Chile and got his Ph.D. in Neurosciences at Harvard University. He was a postdoctoral fellow at Duke-NUS and SICS, A*STAR, before becoming an Assistant Professor at NUS, Department of Psychology, a PI at the Singapore Institute for Neurotechnology, and a joint PI at IMCB, A*START in 2015.

Research

Laboratory of Neurotechnology

The Laboratory of Neurotechnology carries out work in two broad areas: (1) Cognitive Single-Cell Neurophysiology and (2) Development of Neuroprosthesis and Brain-Machine Interface. 

1) Cognitive Single-Cell Neurophysiology:

Selective activation of individual neurons is a cornerstone of our modern understanding of how brain activity relates to cognitive processes, such as perception, attention, memory and decision making. However, understanding neuronal activity in the context of other brain cells (i.e. networks of neurons) is essential to achieve a deeper understanding of brain function. In our lab we record the activity of dozens of neurons simultaneously while animals perform complex behavioral tasks. The goal is to understand information processing in networks of neurons distributed in multiple brain regions.

 

Figure: Electrode array locations in prefrontal cortex

 

2) Development of Neuroprosthesis and Brain-Machine Interface:

 

Damage to the central or peripheral nervous system can have devastating consequences. Due to the limited capacity of neurons to regenerate, alternative solutions are required. Neurodevices that use nervous information (by measuring activity) and/or induce activations (by stimulation) have been applied to multiple conditions, such as deep brain stimulation for the treatment of epilepsy or cochlear implants for the treatment of hearing impairments. This is an area of rapid progress, and there are many more applications and new technologies in the horizon waiting to reach the clinic. In our lab we employ neurophysiological techniques to test and apply novel neurotechnologies in collaboration with engineers. The goal is to develop novel treatments to aid patients with neurological disorders or lesions. 

Figure: First and second principal components of population activity during a motor task with four movement categories. 

Job Openings

Career Opportunities: Postdocs and Graduate students

 

We are looking for graduate (Ph.D.) students interested cellular neurophysiology in awake-behaving animals to study cognition and/or develop neurotechnologies. AGS NGS and returning A*STAR scholars are welcome to apply to the lab. 

Ph.D. fellowships for Singaporeans and international students are administered through:
- Agency for Science, Technology and Research (A*STAR): https://www.singa.a-star.edu.sg/
- National University of Singapore (NUS): http://www.nus.edu.sg/ngs/AGS.html

Post-doctoral candidates can apply directly to Camilo (camilo@nus.edu.sg)


Publications

Recent Publications

Parthasarathy, A., Herikstad, R., Bong, J. H., Medina, F. S., Libedinsky, C.*, & Yen, S. C.* (2017). 
Mixed selectivity morphs population codes in prefrontal cortex. 
Nature Neuroscience, 1-10. 
*Equal Contribution

Camilo Libedinsky*, Rosa So* , Zhiming Xu, Toe K. Kyar, Duncun Ho, Clement Lim, Louiza Chan, Yuanwei Chua, Lei Yao, Jia Hao Cheong, Jung Hyup Lee, Kulkarni Vinayak Vishal, Yongxin Guo, Zhi Ning Chen, Lay K. Lim, Peng Li, Lei Liu, Xiaodan Zou, Kai K. Ang, Yuan Gao, Wai Hoe Ng, Boon Siew Han, Keefe Chng, Cuntai Guan, Minkyu Je, Shih-Cheng Yen (2016)
Independent Mobility Achieved through a Wireless Brain-Machine Interface.
PLOS One 11(11): e0165773.

Sheshadri, S., Kortelainen, J., Nag, S., Ng, K. A., Bazley, F. A., Michoud, F., et al. (2014).
Correlation between muscular and nerve signals responsible for hand grasping in non-human primates.
Conference Proceedings IEEE Engineering in Medicine and Biology Society, 2014, 2314–2317.

Libedinsky C, Massar SAA, Ling A, Chee WY, Huettel SA, Chee MWL (2013).
Sleep-Deprivation alters effort discounting but not delay discounting of monetary rewards.
Sleep. Jun 1;36(6):899-904. 

Libedinsky C, Smith D.V., Teng C.S., Namburi P., Chen V.W., Huettel S.A., Chee M.W. (2011)
 Sleep deprivation alters valuation signals in the ventromedial prefrontal cortex.
Front Behav Neurosci.,5:70.

Libedinsky C., Livingstone M.S. (2011)
Role of prefrontal cortex in conscious visual perception.
Journal of Neuroscience, Jan 5;31(1):64-9.

Libedinsky C., Savage T, Livingstone M.S. (2009)
Perceptual and Physiological evidence for a role for Early Visual Areas in Motion-Induced Blindness.
Journal of Vision, 9(1):14, 1-10