Frederic BARD

Lab Location: #5-12   Email:  Tel: 65869585   

Frederic Bard did his graduate work at Yale University, USA and at the Ecole Normale Superieure of Lyon, France where he obtained his PhD. He worked on the dynamics of the sealing zone, a unique actin cytoskeleton structure in osteoclasts required for bone resorption. During his postdoctoral work at the University of California San Diego (2001-2006), he identified a collection of new genes essential for general protein secretion, the TANGO genes. After starting his group IMCB in 2006, he has established a genome-wide RNAi screening platform. The group has focused on membrane trafficking regulation, Golgi organisation and how signalling at the Golgi can control protein glycosylation.

Regulation of Membrane Traffic

The human cell is organized into multiple intracellular compartments. Compartmentalization controls many aspects of cellular physiology and has increased in complexity throughout evolution. Most cellular compartments are bound, like the whole cell itself, by lipid-based membranes and exchange material through the trafficking of membrane-bound structures. We wish to understand how this membrane traffic is regulated to mediate various cellular functions. One of the technologies we use to address these questions is RNA interference screening at the genomic scale, which allows us to identify novel key players in these processes.
We focus on two questions:

1) How trafficking regulation at the Golgi complex affects glycosylation in health and disease
2) How intracellular trafficking is exploited by pathogens and toxins

The Golgi apparatus

Legend: Human Hela cells stained for the nucleus (blue), the microtubules network (red) and the Golgi apparatus (green).