Biosensors: Hormonal Attractions

IME researchers have developed a highly sensitive silicon nanowire-based biosensor used for studying the interactions between human estrogen receptor (ER) proteins and estrogen response elements. The ER-functionalized silicon nanowire biosensor can determine estrogen-response elements at low concentration of 10 fM - 10000 times more sensitive than conventional Gel Mobility Assay Method. The highly sensitive biosensor can pick up subtle differences in ER-DNA binding affinities, making it possible to glean new insights to ER-mediated gene expression for breast cancer. IME's new biosensor is expected to be a valuable tool for elucidating the complex metabolic pathways leading to estrogen-dependent breast cancer, paving the way for new cancer treatments.