Events

Events

Hybrid nanoparticles for theranostics in complex media

Event Date: 06 Mar 2018 (Tuesday) - 06 Mar 2018 (Tuesday)

Kinesis Building, Seminar Room 1, Level 5

Time :04:00 - 05:00

Dr. Tung Chun Lee

Institute for Materials Discovery and Department of Chemistry, University College London

Host: Dr. Bai Shiqiang, Soft Materials Department (SOF), IMRE

 

ABSTRACT
Novel materials properties can be achieved by engineering the size, shape and composition of an object at the nanoscale. Control over these parameters at will, however, remains as a critical challenge because minimisation of the surface energy and crystallisation forces generally result in symmetric and homogeneous nanostructures.

In this presentation, the speaker will highlight how designer nanoparticles (NPs) can be made in a programmable manner using a physical vapour deposition technique, known as nano-GLAD [1]. Through engineering the geometry and materials combination of plasmonic NPs, the speaker and his team achieved record refractive index sensitivity of 1,091 nm RIU-1 at λ = 921 nm.[2], which is significantly higher than that of classical gold NPs (~50 nm RIU-1 at λ = 520 nm). The designed chirality of these NPs allows background-free detection of optical signal with a high figure of merit (FOMs > 2,800 RIU-1).

The team also extended the system to functioning as active nanorheology probes by combining a plasmonic material and a magnetic material within the same nanostructure. The resultant magnetoplasmonic NPs can extract rheological parameters in full blood samples (up to 50% haematocrit). These nanoscale probes can directly reveal viscosity of blood plasma without interference of red blood cells, which contribute majorly to the shear-thinning properties of
blood.[3]

Additionally, he will also discuss the ongoing efforts of developing functional and biocompatible coatings for inorganic NPs. In particular, his team have recently demonstrated that compartmentalised coating of block copolymers can gate the release of hydrophobic drug (e.g. DOX) upon a pH trigger.[4] Meanwhile the polymer-coated NPs exhibit high biocompatibility plus excellentcolloidal stability and antifouling capability in bio-media (50% PBS/FBS), showing promising potential applications in theranostics.

 

ABOUT THE SPEAKER
Dr. Tung Chun Lee received his BSc in Chemistry from University of Hong Kong in 2005 and his PhD in Chemistry from University of Cambridge in 2012. He was a Post-doctoral Fellow at the Max Planck Institute for Intelligent Systems in Stuttgart from 2011 to 2014. In 2014, he joined University College London as a Lecturer and started his independent academic career. Currently, he is leading a research group of PDRAs, PhDs and MScs, to work on cutting-edge research in nanomaterials and nanochemistry. His research interests include exotic nanoparticles, nanofabrication, nanochemistry, active matter and supramolecular chemistry, all of which show potential applications in sensing, drug delivery, photovoltaic and catalysis.


References

1. A. G. Mark, J. G. Gibbs, T.-C. Lee, P. Fischer, “Hybrid nanocolloids with programmed three-dimensional shape and
material composition”, Nat. Mater., 2013, 12, 802–807.

2. H.-H. Jeong, A. G. Mark, M. Alarcón-Correa, I. Kim, P. Oswald, T.-C. Lee, P. Fischer, “Dispersion and shape engineered plasmonic nanosensors”, Nat. Commun., 2016, 7:11331.

3. H.-H. Jeong, A. G. Mark, T.-C. Lee, M. Alarcón-Correa, S. Eslami, T. Qiu, J. G. Gibbs, P. Fischer, “Active nanorheology with plasmonics”, Nano Lett., 2016, 16, 4887–4894.

4.E. Ellis, K. Zhang, Q. Lin, E. Ye, A. Poma, G. Battaglia, X. J. Loh, T.-C. Lee, “Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy”, J. Mater. Chem. B, 2017, 5, 4421–4425. (Emerging Investigators 2017 Issue)

 

Admission is free
Dress Code: Office attire
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Last update : 8/21/2018 2:59:21 PM