Personal Details

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Dr. SONG Hong Yan

Scientist I


Nanofabrication (NFB) Department


2 Fusionopolis Way. Innovis, #08-03, Singapore 138634

Research Details

- Bioassay design and analysis

- Surface functionalization

- Bio-sensor and bio-imaging

- Biosensor based bioassay design and analysis using Surface Plasmon Resonance (SPR), Dual Polarization Interferometry (DPI), QCM-D etc.

- Surface modification and characterization using AFM, SEM, biological SEM

- Materials and small molecules analysis and characterization using NMR, MS, HPLC, etc.


- Synthetic Heparan Sulfates for Bone Trauma 

- Portable micro total analysis system for rapid on-site determination of environmental TCLP metals in waste materials

- 2009 - Current  Scientist I, IMRE 

- 2005 - 2008  Postdoc, NUS

- 2003 - 2005  Medicinal Scientist, S*BIO

- Ph.D. 2000 – 2005, Chemistry Department, NUS, Singapore

- M.Sc. 1997 – 2000, Pharmaceutical Chemistry, Shenyang Pharmaceutical Univ., China

Xiaodi SU, Hong Yan Song, “Surface Plasmon Resonance Study of Cooperative Interactions of Estrogen Receptor α and Specificity Protein 1 with Composite DNA Elements”, Methods in Molecular Biology, 2015, Chapter 20.  

Hong Yan Song, Ten It Wong, Shifeng GUO, Jie Deng, Christina TAN, Sergey Gorelik, Xiaodong Zhou, “Nanoimprinted thrombin aptasensor with picomolar sensitivity based on plasmon excited quantum dots”, Sensors and Actuators B: Chemical, 2015, 221, 207-216

Hong Yan Song, Ten It Wong, Anton Sadovoy, Lin Wu, Ping Bai, Jie Deng, Shifeng Guo, Yi Wang, Wolfgang Knoll, Xiaodong Zhou, “Imprinted Gold 2D Nanoarray for Highly Sensitive and Convenient PSA Detection via Plasmon Excited Quantum Dots”, Lab on a chip, 2015, 15(1), 253-263.

Hong Yan Song, Jonathan HOBLEY, Xiaodi SU, Xiaodong ZHOU, “End-on Covalent Antibody Immobilization on Dual Polarization Interferometry Sensor Chip for Enhanced Immuno-sensing”, Plasmonics, 2014, 9(4), 851-858.

Xiaodong Zhou, Ten It Wong, Hong Yan Song, Lin Wu, Yi Wang, Ping Bai Development of Localized Surface Plasmon Resonance-Based Point-of-Care System”, Plasmonics, 2014, 9(4), 835-844.

Hong Yan Song, Xiaodi SU, “Spacer Effect of Cooperative Binding of Estrogen Receptor a and Specificity Protein 1 to Composite DNA: A Surface Plasmon Resonance Study”, Sensors and Actuators B: Chemical, 2014, 195, 635-642.

Siebenhofer B, Gorelik S, Lear MJ, Song HY, Nowak C, Hobley J. Transient absorption spectroscopy on spiropyran monolayers using nanosecond pump-probe Brewster angle reflectometry, Photochem Photobiol Sci. 2013, May;12(5):848-53.

Hongyan SONG, Sergey GORELIK, Jonathan HOBLEY, Jiexun Li, Martin LEAR, “Pyrene Emission from Monolayers ‘clicked’ onto quartz”, Journal of Molecular and Engineering Materials, (J. Mol. Eng. Mater.) 2013, 1, 1250007.

Hong Yan Song, Wenjie SUN, Shyam Prabhakar, Khin Moh Moh AUNG, Xiaodi SU, “Study Sequence Rules of ERα - DNA Interactions Using Dual Polarisation Interferometry and Computational Modeling”, Analytical Biochemistry, 2013, 433, 121-128. (doi:pii: S0003-2697(12)00532-5.

Bernhard Siebenhofer, Sergey Gorelik, Anton V. Sadovoy, Martin J. Lear, Hong Yan Song, Christoph Nowak, and Jonathan HobleyPhotoconversion of spiropyran to merocyanine in a monolayer observed using nanosecond pump-probe Brewster-angle reflectometry”, Australian Journal of Chemistry, 2012, 65, 283–289.

Hong Yan Song, Xiaodong ZHOU, Jonathan HOBLEY, Xiaodi SU, “Comparative Study of Random and Oriented Antibody Immobilization as Measured by Dual Polarization Interferometry and Surface Plasmon Resonance Spectroscopy”, Langmuir, 2012, 28(1), 997–1004.

X. H. Liu, H. Y. Song, J. X. Zhang, B. C. Han, X. N. Wei, X. H. Ma, W. K. Cui, Y. Z. Chen, “Identifying Novel Type ZBGs and Nonhydroxamate HDAC Inhibitors Through a SVM Based Virtual Screening Approach”, Molecular Informatics 2010, 29, 407-420.

X. H. Liu, H. Y. Song, X. Ma, M. J. Lear, Y. Z. Chen, “Virtual Screening Prediction of New Potential Organocatalysts for Direct Aldol Reactions”, Journal of Molecular Catalysis A: Chemical, 2010, 319, 114-118.

S. Gorelik, H. Song, M. J. Lear and J Hobley, "Transient Brewster Angle Reflectometry of Spiropyran Monolayers", Photochemistry and Photobiology Science, 2010, 9, 141-151.

H. Y. Song, M. H. Ngai, Z. Y. Song, P. A. MacAry, J. Hobley and M. J. Lear, “Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides”, Org. Biomol. Chem., 2009, 7, 3400-3406. Hot paper & front cover. Sep. 2009.

S. Gorelik, J. Hobley, M. J. Lear, H. Y. Song, S. Y. S. Yong, J. Cheng, “Quantification of transient absorption in photo-reactive monolayers using reflectometry in the vicinity of Brewster angle”, International Journal of Nanoscience, 2009, 8, 213-218.

Wang H, Yu N, Song H., etc.N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity”, Bioorg Med Chem Lett. 2009, 19(5):1403-8.

Hong Yan SONG (35% of contribution), Ten It WONG, Anton Valentinovich SADOVOY, Xiaodong ZHOU, Ping BAI, Lin WU, “Method of using gold nanostructures to enhance the quantum dot emission with large emission-excitation wavelength gap”, Singapore patent No. 2014008098, 2014.

Last updated on : 04 Sep 2017 06:43 PM