Personal Details

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Dr. ZHANG Zhongxing

Scientist II


Soft Materials (SOF) Department


2 Fusionopolis Way, #08-03, Innovis, Singapore 138634

Research Details

  • Thermogelling polymers as biomaterials for sustained release of antibodies and drugs etc.
  • Self-healing hydrogels for soft robotics and wound dressing etc.
  • Polymers synthesis by using living/controlled radical polymerization and free radical polymerization etc.
  • Soft material development (e.g. gels, capsules, films etc.)


Material analysis techniques like NMR, GPC, TGA, DSC, TEM, XRD, DLS and FTIR etc.
Polymer synthesis, Supramolecular self-assembly, Organic synthesis, Coordination chemistry

OrBID (OculaR Blomaterials and Device): A Biomaterials (polymer) platform providing clinical solutions for retinal disease (member, on-going)

Conducting polymer based hybrid composites as high performance thermoelectric materials (member, on-going)

Apr 2014 - Current

Scientist II, IMRE

May 2009 - Mar 2014

Scientist I (Research Engineer), IMRE

Jun 2006 - Feb 2009

Research Fellow, Department of Bioengineering, Faculty of Engineering, National University of Singapore

Jan 2005 − Jun 2006

Research Assistant, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences

Ph.D. in Polymer Chemistry and Physics, Institute of Chemistry, Chinese Academy of Sciences, China, 2005
M.E. in Material Science, Beijing University of Chemical Technology, China, 2001
B.E. in Polymer Engineering, North China University of Science and Technology, China, 1998

[1] Hyflux-SNIC Award in Environmental Chemistry 2014.
[2] Best Poster Award (Springer Prize) for poster presentation at Singapore's 15th Asian Chemical Congress (15ACC) 2013.

2013 - Current, SNIC member.

[1]  Zhang, Z. X.; Young, D. J.; Li, Z. B.; Loh, X. J., Going Beyond Traditional Applications? The Potential of Hydrogels. Small Methods 2019, 3 (1), 5.

[2]  Song, X.; Zhu, J.-l.; Wen, Y.; Zhao, F.; Zhang, Z.-X.; Li, J., Thermoresponsive supramolecular micellar drug delivery system based on star-linear pseudo-block polymer consisting of β-cyclodextrin-poly(N-isopropylacrylamide) and adamantyl-poly(ethylene glycol). Journal of Colloid and Interface Science 2017, 490, 372-379.

[3]  Song, X.; Wen, Y. T.; Zhu, J. L.; Zhao, F.; Zhang, Z. X.; Li, J., Thermoresponsive Delivery of Paclitaxel by beta-Cyclodextrin-Based Poly(N-isopropylacrylamide) Star Polymer via Inclusion Complexation. Biomacromolecules 2016, 17 (12), 3957-3963.

[4]  Qi, M.; Chew, B. K. J.; Yee, K. G.; Zhang, Z.-X.*; Young, D. J.; Hor, T. S. A., A catch-release catalysis system based on supramolecular host-guest interactions. Rsc Advances 2016, 6 (28), 23686-23692.

[5]  Qi, M.; Tan, P. Z.; Xue, F.; Malhi, H. S.; Zhang, Z.-X.*; Young, D. J.*; Hor, T. S. A.*, A supramolecular recyclable catalyst for aqueous Suzuki-Miyaura coupling. Rsc Advances 2015, 5 (5), 3590-3596.

[6]  Liu, X.; Yin, H.; Zhang, Z.*; Diao, B.; Li, J.*, Functionalization of lignin through ATRP grafting of poly(2-dimethylaminoethyl methacrylate) for gene delivery. Colloids and Surfaces B-Biointerfaces 2015, 125, 230-237.

[7]  Zhang, Z.-X.; Ni, X.; Li, J., Cationic brush-like terpolymer with pH responsive thickening behavior in a surfactant system. Polymer International 2014, 63 (9), 1584-1592.

[8]  Wen, Y.; Zhang, Z.; Li, J., Highly Efficient Multifunctional Supramolecular Gene Carrier System Self-Assembled from Redox-Sensitive and Zwitterionic Polymer Blocks. Advanced Functional Materials 2014, 24 (25), 3874-3884.

[9]  Diao, B.; Zhang, Z.; Zhu, J.; Li, J., Biomass-based thermogelling copolymers consisting of lignin and grafted poly(N-isopropylacrylamide), poly(ethylene glycol), and poly(propylene glycol). Rsc Advances 2014, 4 (81), 42996-43003.

[10] Zhang, Z.-X.; Liu, K. L.; Li, J., A Thermoresponsive Hydrogel Formed from a Star-Star Supramolecular Architecture. Angewandte Chemie-International Edition 2013, 52 (24), 6180-6184.

[11] Liu, C.; Zhang, Z.; Liu, X.; Ni, X.; Li, J., Gelatin-based hydrogels with beta-cyclodextrin as a dual functional component for enhanced drug loading and controlled release. Rsc Advances 2013, 3 (47), 25041-25049.

[12] Zhao, F.; Yin, H.; Zhang, Z.; Li, J., Folic Acid Modified Cationic gamma-Cyclodextrin-oligoethylenimine Star Polymer with Bioreducible Disulfide Linker for Efficient Targeted Gene Delivery. Biomacromolecules 2013, 14 (2), 476-484.

[13] Liu, C.; Zhang, Z.; Liu, K. L.; Ni, X.; Li, J., Biodegradable thermogelling poly(ester urethane)s consisting of poly(1,4-butylene adipate), poly(ethylene glycol), and poly(propylene glycol). Soft Matter 2013, 9 (3), 787-794.

[14] Li, Z.; Zhang, Z.; Liu, K. L.; Ni, X.; Li, J., Biodegradable Hyperbranched Amphiphilic Polyurethane Multiblock Copolymers Consisting of Poly(propylene glycol), Poly(ethylene glycol), and Polycaprolactone as in Situ Thermogels. Biomacromolecules 2012, 13 (12), 3977-3989.

[15] Chen, B.; Liu, K. L.; Zhang, Z.; Ni, X.; Goh, S. H.; Li, J., Supramolecular hydrogels formed by pyrene-terminated poly(ethylene glycol) star polymers through inclusion complexation of pyrene dimers with gamma-cyclodextrin. Chemical Communications 2012, 48 (45), 5638-5640.

[16] Tan, H.; Zhang, Y.; Wang, M.; Zhang, Z.; Zhang, X.; Yong, A. M.; Wong, S. Y.; Chang, A. Y.-c.; Chen, Z.-K.; Li, X.; Choolani, M.; Wang, J., Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging. Biomaterials 2012, 33 (1), 237-246.

[17] Zhang, Z.-X.; Liu, K. L.; Li, J., Self-Assembly and Micellization of a Dual Thermoresponsive Supramolecular Pseudo-Block Copolymer. Macromolecules 2011, 44 (5), 1182-1193.  (Top 10 Most Read Articles for Q1 2011)

[18] Liu, K. L.; Zhang, Z.; Li, J., Supramolecular hydrogels based on cyclodextrin-polymer polypseudorotaxanes: materials design and hydrogel properties. Soft Matter 2011, 7 (24), 11290-11297. (Top Ten most-read Soft Matter articles in October)

[19] Ping, Y.; Liu, C.; Zhang, Z.; Liu, K. L.; Chen, J.; Li, J., Chitosan-graft-(PEI-beta-cyclodextrin) copolymers and their supramolecular PEGylation for DNA and siRNA delivery. Biomaterials 2011, 32 (32), 8328-8341.

[20] Zhu, J.-L.; Liu, K. L.; Zhang, Z.; Zhang, X.-Z.; Li, J., Amphiphilic star-block copolymers and supramolecular transformation of nanogel-like micelles to nanovesicles. Chemical Communications 2011, 47 (48), 12849-12851.

[21] Loh, X. J.; Zhang, Z.-X.; Mya, K. Y.; Wu, Y.-l.; He, C. B.; Li, J., Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes. Journal of Materials Chemistry 2010, 20 (47), 10634-10642.

[22] Xu, F. J.; Zhang, Z. X.; Ping, Y.; Li, J.; Kang, E. T.; Neoh, K. G., Star-Shaped Cationic Polymers by Atom Transfer Radical Polymerization from beta-Cyclodextrin Cores for Nonviral Gene Delivery. Biomacromolecules 2009, 10 (2), 285-293.

[23] Loh, X. J.; Zhang, Z.-X.; Wu, Y.-L.; Lee, T. S.; Li, J., Synthesis of Novel Biodegradable Thermoresponsive Triblock Copolymers Based on Poly[(R)-3-hydroxybutyrate] and Poly(N-isopropylacrylamide) and Their Formation of Thermoresponsive Micelles. Macromolecules 2009, 42 (1), 194-202.

[24] Zhang, Z.-X.; Liu, X.; Xu, F. J.; Loh, X. J.; Kang, E.-T.; Neoh, K.-G.; Li, J., Pseudo-Block Copolymer Based on Star-Shaped Poly(N-isopropylacrylamide) with a β-Cyclodextrin Core and Guest-Bearing PEG: Controlling Thermoresponsivity through Supramolecular Self-Assembly. Macromolecules 2008, 41 (16), 5967-5970.

[25] Zhang, Z. X.; Hao, J. K.; Xie, P.; Zhang, X. J.; Han, C. C.; Zhang, R. B., A well-defined ladder polyphenylsilsesquioxane (Ph-LPSQ) synthesized via a new three-step approach: Monomer self-organization-lyophilization-surface-confined polycondensation. Chem. Mat. 2008, 20 (4), 1322-1330.

[26] Yu, S. Y.; Zhang, Z. X.; Cheng, E. C. C.; Li, Y. Z.; Yam, V. W. W.; Huang, H. P.; Zhang, R. B., A chiral luminescent AU(16) ring self-assembled from achiral components. J. Am. Chem. Soc. 2005, 127 (51), 17994-17995. (Highlighted as an Editor's Choice of Science. "Chiral Golden Rings" Science, 2005, 310, 1745.)



[1]   Li J, Zhang ZX, Liu C, Gelatin-based Microgels for Cell Encapsulation, (Filing Date: 14 Dec 2012), ETPL ref: IMR/P/07559/00/SG, IMRE ref: 201234. Singapore Patent Application No. 201209244-1

[2] Li J, Zhang ZX, Loh XJ, Ni XP, Method for Synthesis of Cationic Brush-like Poly(PEG/PPG/DMAEMA) Copolymers and Their Use for Hair/Skin Care Formulations, (Filing Date: 17 Oct 2011), ETPL ref: IMR/P/06831/00/US, IMRE ref: 201126. Singapore Patent Application No. 201207735-0; United States Patent Application No. 13/654,251

[3]  Wang Suxi, Li Xu, Hor Tzi Sum Andy, Zhang Zhongxing, Benny Chew Kia Jia, Free-standing MOF-derived hybrid porous carbon nanofiber mats; IMRE ref: 2015023; ETPL ref: IMR/P/09267/02/SG; Priority Date: 14/1/2016; SG Patent Application No. 11201805804S; US Patent Application No. 16/069,707


Last updated on : 08 Apr 2019 09:15 AM