Personal Details

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Dr. ZHOU Xiaodong, Donna

Senior Scientist I


Nanofabrication (NFB) Department

(+65) 6501 1907

2 Fusionopolis Way. Innovis, #08-03, Singapore 138634

Research Details

MEMS fabrication on glass and polymer substrate

Optical sensor detection and simulation

Localized surface plasmon resonance (LSPR) point-of-care (POC) system

Heavy metal and other ion detection in water, solid waste or soil

Optical design and simulation

MEMS and nanostructure design and fabrication

Optical based devices and sensor development

On-site and on-line sensing devices and systems


Localized surface plasmon resonance (LSPR) MEMS device with nano-structured noble metal (Jun’06 to May’08)

Development of highly sensitive localized surface plasmon resonance technology platform for point-of-care clinical screening and medical diagnostics (May’10 to 31 Oct’13)

Portable micro total analysis system for rapid on-site determination of environmental TCLP metals in waste materials (Aug’14 to Feb’18)

Nanohole array biochip based point-of-care system for procalcitonin measurement (Apr’14 to Mar’16)

Development for commercialization of a portable micro total analysis system for rapid on-site determination of heavy metals and phenolic compounds (Jan’19 to Jul’20)

2013 - Current     Senior Scientist I, IMRE

2005 - 2013         Scientist III, IMRE

2003 - 2005         Research Fellow, NTU

1999 - 2002         Senior Researcher, JDS Uniphase, Canada

1998 - 1999         Postdoctoral Fellow, Photonics Research Ontario, Canada

1997 - 1998         Associate Professor, Zhejiang University, China

1995 - 1997         Lecturer, Zhejiang University, China 

Ph.D in electrophotonics, Zhejiang University, China

M.Eng in electrophotonics, Zhejiang University, China

B.Eng in physical electronics, Zhejiang University, China

Institution of Engineers Singapore (IES) Prestigious Engineering Achievement Awards 2016

JDSUphase “CEO Award” in the year 2001-2002

Academic Excellence Scholarship of Zhejiang University for Bachelor students in each year of Bachelor study

Academic Excellence Scholarship (in addition to general Master scholarship for each Master student) of Zhejiang University for Master students in each year of Master study

Academic Excellence Scholarship (in addition to general PhD scholarship for each PhD student) for PhD candidates in Zhejiang University in each year of PhD study

Xu, Y.*; Bai, P.; Zhou, X.; Akimov, Y.; Png, C. E.; Ang, L.-K.*; Knoll, W.*; Wu, L.*, “Optical refractive index sensors with plasmonic and photonic structures: promising and inconvenient truth”, Adv. Opt. Mater. 2019,

Tan, M. J.; Pan, H.-C.; Tan, H. R.; Chai, J. W.; Lim, Q. F.; Wong, T. I.; Zhou, X.; Hong, Z.-Y.;  Liao, L.-D.; Kong, K. V.*, “Flexible modulation of CO-release via hybridization of medium and high nuclearity of metal carbonyl clusters on graphene oxide for stroke remediation”, Adv. Healthc. Mater. 2018, 7, 1701113.

Patra, A.; Ding, T.; Hong, M.; Richards, A. M.; Wong, T. I.; Zhou, X.; Drum, C.*, “Using extraordinary optical transmission to quantify cardiac biomarkers in human serum”, J. Vis. Exp. 2017, 130, e55597.

Zhang, Q; Wu, L.; Wong, T. I.; Zhang, J.; Liu, X.; Zhou, X.; Bai, P.; Liedberg, B.; Wang, Y.*, “Surface plasmon-enhanced fluorescence on Au nanohole array for prostate specific antigen detection”, Int. J. Nanomedicine 2017, 12, 2307–2314.

Deng, J.; Wong, T. I.; Sun, L. L.; Quan, C.; Zhou, X.*, “Acceleration of e-beam lithography by minimized resist exposure for large scale nanofabrication”, Microelectron. Eng. 2016, 166, 31–38.

Lin, S.; Zhou, X.; Ge, L.*; Ng, S. H.; Zhou, X.; Chang, W.-C., “Development of an accelerated leaching method for incineration bottom ash correlated to toxicity characteristic leaching protocol”, Electrophoresis 2016, doi: 10.1002/elps.201600129. 

Wong, T. I.; Limantoro, J.; Fong, K. P.; Ling, C. T. Y.;  Quan, C.; Sun, L. L.; Zhou, X.*, “Easy fabrication of high quality nickel mold for deep polymer microfluidic channels”, J. Micromech. Microeng. 2016, 26, 065016. 

Wang, Y.*; Wu, L.; Wong, T. I.; Bauch, M.; Zhang, Q.; Zhang, J.; Liu, X.; Zhou, X.; Bai, P.; Dostalek, J.; Liedberg, B.*, “ Directional fluorescence emission co-enhanced by localized and propagating surface plasmons for biosensing”, Nanoscale 2016, 8, 8008–8016.

Wong, T. I.; Wang, H.; Wang, F.; Sin, S. L.; Quan, C.; Wang, S. J.*; Zhou, X.*, “ Empirical formulae in correlating droplet shape and contact angle”, Aust. J. Chem. 2016, 69,  431–439, featured. 

Sharma, N.; Keshmiri, H.; Zhou, X.; Wong, T. I.; Petri, C.; Jonas, U.; Liedberg, B.; Dostalek, J.*, “ Tunable plasmonic nanohole arrays actuated by a thermoresponsive hydrogel cushion”, J. Phys. Chem. C 2016, 120, 561–568.

Zhang, J.; Wang Y.; Wong, T. I.; Liu, X.; Zhou, X.; Liedberg, B.*, “Electrofocusing-enhanced localized surface plasmon resonance biosensors”, Nanoscale 2015, 7, 17244–17248. 
Niu, L.; Zhang, N.; Liu, H.; Zhou, X.; Knoll, W.*, “Integrating plasmonic diagnostics and microfluidics”, Biomicrofluidics 2015, 9, 052611.   

Song, H. Y.; Wong, T. I.; Guo, S.; Deng, J.; Tan, C.; Gorelik, S.; Zhou, X.*, “Nanoimprinted thrombin aptasensor with picomolar sensitivity based on plasmon excited quantum dots”, Sensor. Actuat. B-Chem. 2015, 221, 207–216.

Ding, T.; Hong, M.; Richards, A. M.; Wong T. I.; Zhou, X.; Drum, C.*, “Quantification of a cardiac biomarker in human serum using localized surface plasmon resonance”, PLoS One 2015, 10, e0120974.

Song, H. Y.; Wong, T. I.; Sadovoy, A.; Wu, L.; Bai, P.; Deng, J.;  Guo, S.; Wang, Y.; Knoll, W.; Zhou, X.*, “Imprinted gold 2D nanoarray for highly sensitive and convenient PSA detection via plasmon excited quantum dots”, Lab Chip 2015, 15, 253‒263. 

Zhou, X.*; Wong, T. I.; Song, H. Y.; Wu, L.; Wang, Y.; Bai, P.; Kim, D.-H.; Ng, S. H.; Tse, M. S.; Knoll, W., “Development of localized surface plasmon resonance based point-of-care system”, Plasmonics 2014, 9, 835‒844.

Song, H. Y.; Hobley, J.; Su, X. D.*; Zhou, X.*, “End-on covalent antibody immobilization on dual polarization interferometry sensor chip for enhanced immuno-sensing”, Plasmonics 2014, 9, 851‒858.
Wu, L.; Zhou, X.; Bai, P.*, “Plasmonic metals for nanohole-array surface plasmon field-enhanced fluorescence spectroscopy biosensing”, Plasmonics 2014, 9, 825‒833.

Wang, Y.*;  Wu, L.; Zhou, X.*; Wong, T. I.; Zhang, J.;  Bai, P.; Li, E. P.; Liedberg, B., “Incident-angle dependence of fluorescence enhancement and biomarker immunoassay on gold nanohole array”, Sensor. Actuat. B-Chem. 2013, 186, 205‒211.

Ferhan, A. R.; Guo, L.; Zhou, X.; Chen, P.; Hong, S.; Kim, D.-H.*, “Solid-phase colorimetric sensor based on gold nanoparticle-loaded polymer brushes: Lead detection as a case study”, Anal. Chem. 2013, 85, 4094‒4099.

Zhang, N.; Su, X. D.; Free, P. F.; Zhou, X.*; Neoh, K. G.*; Teng, J.*; Knoll, W., “Plasmonic metal nanostructure array by glancing angle deposition for biosensing application”, Sensor. Actuat. B-Chem. 2013, 183, 310-318..

Wong, T. I.; Han, S.; Wang, Y.; Deng, J.; Tan, C. Y. L.; Wu, L,; Bai, P.; Loke, Y. C.; Yang, X. D.; Tse, M. S.; Ng, S. H.; Zhou, X.*, “High throughput and high yield nanofabrication of precisely designed gold nanohole array for fluorescence enhanced detection on biomarkers”, Lab Chip 2013, 13, 2405‒2413.

Wong, T. I.; Ong, H. Y.; Lu, H.; Tse, M. S.*; Quan, C.; Ng, S. H.; Zhou, X.*, “Wafer level silicon mould fabrication and imprinting of high density microstructures”, Microelectron. Eng. 2013, 104, 64‒68.

Wu, L.*; Bai, P.; Zhou, X.; Li, E. P., “Reflection and transmission modes in nanohole array based plasmonic sensors”, IEEE Photonics J. 2012, 4, 26‒33.

Song, H. Y.; Zhou, X.; Hobley, J.; Su, X. D.*, “Comparative study of random and oriented antibody immobilization as measured by dual polarization interferometry and surface plasmon resonance spectroscopy”, Langmuir 2012, 28, 997‒1004. 

Zhou, X.*; Liu, K. Y.; Zhang, N.; Kim, D.-H.; Tan, C., “Nanosphere dispersion on a large glass substrate by low dose ion implantation for localized surface plasmon resonance”, J. Nanopart. Res. 2011, 13, 2919‒2927. 

Guo, L.; Zhou, X.; Kim D.-H.*, “Facile fabrication of distance-tunable Au-nanorod chips for single-nanoparticle plasmonic biosensors”, Biosen. Bioelectron. 2011, 26, 2246‒2251. 

Zhou, X.*; Liu, K. Y.; Zhang, N.; Tan, C., “Simultaneous characterization of the shape and refractive index of transparent living cells by an optical aperture”, Appl. Opt. 2010, 49, 6416‒6424, featured. 

Zhou, X.*; Liu, K. Y.; Knoll, W.; Quan, C.; Zhang, N., “3D profile simulation of metal nanostructures obtained by closely-packed nanosphere lithography”, Plasmonics 2010, 5, 141‒148.

Xiang, G.; Zhang, N.; Zhou, X*, “Localized surface plasmon resonance biosensing with large area of gold nanoholes fabricated by nanosphere lithography”, Nanoscale Res. Lett. 2010, 5, 818‒822. 

Zhou, X.*; Zhang, N.; Tan, C., “Profile prediction and fabrication of wet etched gold nanostructures for localized surface plasmon resonance”, Nanoscale Res. Lett. 2010, 5, 344‒352.

Zhou, X.*; Zhang, N.; Liu, K. Y.; Tan, C.; Knoll, W., “Dispersion of nanospheres on large glass substrate by amorphous or polycrystalline silicon deposition for localized surface plasmon resonance”, J. Nanopart. Res. 2009, 11, 2061‒2069. 

Zhou*, X.; Knoll, W.; Zhang, N.; Liu, H., “Profile calculation of gold nanostructures by dispersed-nanosphere lithography through oblique etching for LSPR applications”, J. Nanopart. Res. 2009, 11, 1065‒1074.

Zhou, X*; Virasawmy, S.; Quan, C., “Wafer-level BCB bonding using a thermal press for microfluidics”, Microsyst. Technol. 2009, 15, 573‒580. 

Zhou, X.*; Poenar, D. P.; Liu, K. Y.; Tse, M. S.; Heng, C.-K.; Tan, S. N., “Design of MEMS devices with optical apertures for the detection of transparent biological cells”, Biomed. Microdevices 2008, 10, 639‒652.

Zhou, X.*; Virasawmy, S.; Knoll, W.; Liu, K. Y.; Tse, M. S.; Yen, L. W., “Fabrication of gold nanocrescents by angle deposition with nanosphere lithography for LSPR applications”, J. Nanosci. Nanotechnol. 2008, 8, 3369‒3378.

Zhou, X.*; Poenar, D. P.; Liu, K. Y.; Tse, M. S.; Heng, C.-K.; Tan, S. N.; Zhang, N., “Algorithm and simulation for analysis of bio-images obtained by aperture diffraction based optical MEMS”, Opt. Express 2008, 16, 11937‒11953.

Zhou, X.*; Knoll, W.; Liu, K. Y.; Tse, M. S.; Oh, S. R.; Zhang, N., “Design and fabrication of gold nanostructures with dispersed nanospheres for localized surface plasmon resonance applications”, J. Nanophotonics 2008, 2, 023502. 

Zhou, X.*; Virasawmy, S.; Knoll, W.; Liu, K. Y.; Tse, M. S.; Yen, L. W., “Profile simulation and fabrication of gold nanostructures by separated nanospheres with oblique deposition and perpendicular etching”, Plasmonics 2007, 2, 217‒230.

Zhou, X.*; Poenar, D. P.; Liu, K. Y.; Li, W.; Tse, M. S.; Chen, H.; Heng, C.-K.; Tan, S. N., “Glass-based bioMEMS devices for optically excited cell impedance measurement”, Sensor. Actuat. A-Phys. 2007, 33, 301‒310. 

Bercu, M.; Zhou, X.; Lee, A.; Poenar D. P.*; Heng, C.-K.; Tan, S. N., “Spectral characterization of yeast cells with an epitaxy-based UV-Vis optical sensor”, Biomed. Microdevices 2006, 8, 177‒185. 

Chen, H.; Heng, C.-K.; Poenar, D. P.; Zhou, X.; Tan, S. N*, “Detection of Saccharomyces cerevisiae immobilized on self-assembled monolayer (SAM) of alkanethiolate using electrochemical impedance spectroscopy”, Anal. Chim. Acta 2005, 554, 52‒59.  

Wong, T. I.; Zhou, X.; Zheng, X.; Tan, Y. N., “A simple, high-throughput ultrasonic device for contactless cell lysis applications”. Singaporean Patent 10201811713W, 2018

Sun, L. L., Ng, W., Zhou, X., Leo, Y. S., Wong, T. I., “Plasmonic biosensing based microfluidics point-of-care system for procalcitonin detection”, Singapore patent 10201606001Q, 2016 

Song, H. Y.; Wong, T. I.; Sadovoy, A. V.; Zhou, X.; Bai, P.; Wu, L., “Method of using gold nanostructures to enhance the quantum dot emission with large emission-excitation wavelength gap”, Singapore Patent 2014008098, 2014, US 14/613,649, 2015

Bai, P.; Zhou, X.; Wu, L., “Sensor and method of detecting a target analyte”, US 13/665,033, 2012 

Bai, P.; Zhou, X.; Wu, L.; Tse, M. S.; Kim, D.-H., “A plasmonic sensor for detecting small molecules”, Singapore Patent 201108104-9, 2011 

Zhou, X.; Liu, K. Y.; Zhang, N.; Oh, S. R.; Pan, J. S., “Method of modifying a substrate for deposition of charged particles thereon”, US PCT/SG2009/000270, 2009 

Liu, H.; Zhou, X., “Sensor chip for biological and chemical sensing”, US PCT/SG2009/000156, 2009

Last updated on : 09 Apr 2019 10:02 AM