Personal Details

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Dr. ZHENG Xinting

Scientist II

Staff

Soft Materials (SOF) Department

(+65) 63194888

zhengxt@imre.a-star.edu.sg

2 Fusionopolis Way. Innovis, #08-03, Singapore 138634


Research Details


- Nanoscale biosensors for diagnostics, food safety analysis & drug screening

- Antimicrobial materials

- Fluorescent nanomaterials for bioimaging, drug/gene delivery and theranostics

- Single cell analysis

- Phase change materials for thermal management


- Nanomaterial synthesis (metallic nanoparticles, carbon dots, graphene quantum dots, bio-dots, metal oxides, etc)

- Electrochemistry

- Biofunctionalization and conjugation techniques

- Biosensor design and bioassay development

- Cell culture and microbiology techniques

- Fluorescence imaging (CLSM, TIRF) and flow cytometry

- Nanomaterial characterizations (TEM, SEM, AFM, FTIR, XPS, BET, Raman, UV-vis, PL, DLS, DSC, TGA, thermal conductivity


- Molecular sensor for body fluid analysis

- Functional Nanoparticles for Bacteria Separation and Detection

- Bioinspired synthesis of bio-dots: towards the understanding of materials by design from biomolecular building blocks

- New Generation Metal Nanoparticles Assays for Detecting Mutant p53 Reactivation


2014 - Current     Research Scientist I, IMRE

2012 - 2013          Research Fellow, NTU

Ph.D.(Bioengineering), Nanyang Technological University, Singapore, 2012

B.Eng (Bioengineering), Nanyang Technological University, Singapore, 2008

- Poster award for “Bioinspired Carbon Dots for Ultrasensitive Bacteria Sensing and Broad Spectrum Antimicrobial Applications in Food Safety” @ Food Safety Analysis 2018

- Best presentation award for “Development of nanoparticle-enhanced sensing probe for cancer drug screening in cellular context” @ 8th International Conference on Key Engineering Materials 2018

- X.T. Zheng, W. Goh, F. Ghadessy, D. Lane, Y. N. Tan, Ultrasensitive Dynamic Light Scattering based Nanobiosensor for Rapid Anticancer Drug Screening, Sensors & Actuators: B. Chemical, 279, 79–86, 2019

- H. V. Xu#, X. T. Zheng#, Y, Zhao, Y. N. Tan, Uncovering the Design Principle of Amino acid-Derived Photoluminescent Bio-dots with Tailored-made Structure-Properties and Application for Cellular Bioimaging, ACS Appl. Mater. Interfaces, 10 (23), 19881–19888, 2018 (Equal contribution)

- H. V. Xu, X. T. Zheng, C. Wang, Y. L. Zhao, Y. N. Tan, Bioinspired Antimicrobial Nanodots with Amphiphilic and Zwitterionic-like Characteristics for Combating Multi-Drug Resistant Bacteria and Biofilm Removal, ACS Appl. Nano Mater., 1 (5), 2062–2068, 2018

- E. Assah, W. Goh, X. T. Zheng, J. Li, Y. N. Tan, Rapid Colorimetric Detection of p53 Protein Function using DNA-Gold Nanoconjugates with Applications for Drug Discovery and Cancer Diagnostics, Colloids and Surfaces B: Biointerfaces, 169, 214-221, 2018

- X. T. Zheng, H. V. Xu, Y. N. Tan, Bioinspired Design and Engineering of Functional Nanostructured Materials for Biomedical Applications. In Advances in Bioinspired and Biomedical Materials Volume 2, Chapter 7, pp 123-152, American Chemical Society, 2017

- W. Goh, E. Assah, X.T. Zheng, D. Lane, F. Ghadessy, Y.N. Tan, Transcription factors as detection and diagnostic biomarkers in cancer, Next generation point-of-care biomedical sensors technologies for cancer diagnosis, pp 31-58, Springer Nature, Germany, 2017

- Y. Yong, X.T. Zheng, B.W. Yee, Y. N. Tan, Biomimicking Synthesis of Photoluminescent Molecular Lantern Catalyzed by In-Situ Formation of Nanogold Catalysts, Materials Science and Engineering: C, 77,1111–1116, 2017

- J. Tian, H. Zhu, J. Chen, X.T. Zheng, H. Duan, K. Pu, P. Chen, Cobalt Phosphide Double-Shelled Nanocages: Broadband Light-Harvesting Nanostructures for Efficient Photothermal Therapy and Self-Powered Photoelectrochemical Biosensing, Small, 13 (22), 1700798, 2017

- Hesheng Victor Xu #, X. T. Zheng #, Beverly Yin Leng Mok, Salwa Ali Ibrahim, Yong Yu, Yen Nee Tan, Molecular Design of Bioinspired Nanostructures for Biomedical Applications: Synthesis, Self-Assembly and Functional Properties, J. Mol. Eng. Mater. 04, 1640003, 2016

- Y. N. Tan, X. T. Zheng, Y. Yong, Metallic nanobiosensor for biological analysis and medical diagnostics, Nanobiosensors for Personalized and Onsite Biomedical Diagnostics, The Institution of Engineering and Technology (IET), 2016

- X.T. Zheng, A. Ananthanarayanan, K.Q. Luo, P. Chen, Glowing graphene quantum dots and carbon dots: properties, syntheses, and biological applications, Small, 11, 1620-1636, 2015

- X.T. Zheng, A. Than, A. Ananthanaraya, D-H. Kim, P. Chen, Graphene Quantum Dots as Universal Fluorophores and Their Use in Revealing Regulated Trafficking of Insulin Receptors in Adipocytes. ACS Nano, 7, 6278-6286, 2013

- X. T. Zheng and C. M. Li, Single Cell Analysis at Nanoscales. Chem Soc Rev, 41, 2061-2071, 2012

- X. T. Zheng and C. M. Li, Anticancer Efficacy and Subcellular Site of Action Investigated by Real-time Monitoring of Cellular Responses to Localized Drug Delivery in Single Cells. Small, 8(17):2670-2674, 2012

- X. T. Zheng, W. H. Hu, H. Wang, H. Yang, W. Zhou and C. M. Li, Bifunctional Electro-optical Nanoprobe to Real-time Detect Local Biochemical Processes in Single Cells. Biosens Bioelectron, 26, 4484-4490, 2011

- C. X. Guo#, X. T. Zheng#, S. R. Ng, Y. Lai, Y. Lei and C. M. Li, In-situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm. Chem Commun, 47, 2652-2654, 2011 (# Equal contribution)

- X. T. Zheng, H. B. Yang, C. M. Li, Optical Detection of Single Cell Lactate Release for Cancer Metabolic Analysis. Anal Chem, 82 (12), 5082–5087, 2010

- X. T. Zheng, C. M. Li, Single Living Cell Detection of Telomerase Over-expression for Cancer Detection by an Optical Fiber Nanobiosensor. Biosens Bioelectron, 25, 1548–1552, 2010

- C.X. Guo, X. T. Zheng, Z. S. Lu, X. W. Lou, C. M. Li, Biointerface by Cell Growth on Layered Graphene-Biomimetic Enzyme-Protein Nanostructure for in Situ Quantitative Molecular Detection. Adv Mater, 22, 5164-5167, 2010

 

- P. Chen, X. T. Zheng, Biomolecule-graphene quantum dot conjugates and use thereof, US 10,114,024 Granted on 30 Oct 2018

- Y. N. Tan, X.T. Zheng, D. Lane, F. Ghadessy, W. Goh, L. Y. Yung, A Dynamic Light Scattering Nanoplatform For High-Throughput Drug Screening, US 15/382570; SG10201610586Q, 16/12/2016; PCT/SG2017/050625

- Y. N. Tan, X.T. Zheng, D. Lane, F. Ghadessy, W. Goh, A label-free, instrument-free visually enabled colorimetric method assay to detect tetramerization of transcription factors for disease and drug screening, SG10201703919T, 12/05/2017

- X.T. Zheng, Y. N. Tan, V. H. Xu, Hybrid Nanodots For Bacteria Staining And Antimicrobial Applications, SG10201809275W, US16/166,017, 19/10/2017

- X.T. Zheng, Y. N. Tan, A nanoparticle-based fluorescent reagent for lysis-free blood analysis and white blood cell differential counting, SG10201811828X, 31/12/2018

- T.I. Wong, D.X. Zhou, X.T. Zheng, Y. N. Tan, A simple, high-throughput ultrasonic device for contactless cell lysis applications SG 10201811713W, 27/12/2018

 


Last updated on : 08 Apr 2019 09:36 AM