Expanding the Boundaries of
Advanced Biomanufacturing Biology

Developing and applying synthetic biology and metabolic engineering to address challenges in advanced biomanufacturing, with a focus on sustainable manufacturing, nutrition and healthcare. Read More

  List of Publications

17. M. M. Zhang, Y. Qiao, E. Ang, and H. Zhao. “Using Natural Products for Drug Discovery: the Impact of the Genomics Era.” Expert Opinion in Drug Discovery, 12, 475-487 (2017).
16. J. Liang, Z. Liu, E. Ang, and H. Zhao. “Twin-primer Non-enzymatic DNA Assembly: an Efficient and Accurate Multi-part DNA Assembly Method.” Nucleic Acids Research, 45: e94 (2017).
15. W. L. Yeo,  X. Chew, D. J. Smith, K. P. Chan, H. Sun, H. Zhao, Y. H. Lim, and E. L. Ang. “Probing the Molecular Determinants of Fluorinase Specificity.” Chemical Communications, 53, 2559-2562 (2017).
14. M. M. Zhang, F. Wong, Y. Wang, S. Luo, Y. H. Lim, E. Heng, W. L. Yeo, R. E Cobb, B. Enghiad, E. Ang, and H. Zhao. “An Efficient CRISPR-Cas9 Mediated Knock-in Strategy for Activation of Silent Streptomyces Biosynthetic Gene Clusters for Natural Product Discovery.” Nature Chemical Biology, 13, 607-609 (2017).
13. Y. Liang, Z. Liu, E. Ang, and H. Zhao. “A New Era of Genome Integration – Simply Cut and Paste!” ACS Synthetic Biology, 6, 601−609 (2017).
12. H. Sun, W. L. Yeo, Y. H. Lim, X. Chew, D. J. Smith, B. Xue, K. P. Chan, R. C. Robinson, E. G. Robins, H. Zhao, and E. L. Ang. “Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate.” Angewandte Chemie International Edition, 46, 14275-14278 (2016).
11. Y. Liang, E. Ang, and H. Zhao. “A Step through the Looking Glass.” Science China Life Sciences, 59, 1-2 (2016).
10. S. Shi, T. Si, E. L. Ang, and H. Zhao. “Metabolic engineering of an endogenous pathway for n-butanol production in Saccharomyces cerevisiae.” Scientific Reports, 6, 25675 (2016).
9. M. M. Zhang, Y. Wang, E. L. Ang, and H. Zhao, “Engineering microbial hosts for production of bacterial natural products.” Natural Product Reports, 33, 963-987 (2016).
8. H. Zhang, X. Li, X. Su, E. Ang, Y. Zhang, and H. Zhao. “Production of Adipic Acid from Sugar Beet Residue by Combined Biological and Chemical Catalysis.” ChemCatChem, 8, 1500-1506 (2016).
7. Y. Liang, E. L. Ang, and H. Zhao. “Engineered Minicellulosomes for Consolidated Bioprocessing.” Handbook of Carbohydrate-Modifying Biocatalysts, (P. Grunwald, Ed.), Pan Stanford Publishing, Singapore, 963-990 (2016).
6. Y. Liang, M.M. Zhang, E. L. Ang, and H. Zhao. “Biocatalysis for Drug Discovery and Development.” In Biocatalysis-Green Technology, (R. Patel, Ed.), John Wiley & Sons, Hoboken, New Jersey, 421-455 (2016).
5. S. Shi, Y. Liang, M.M. Zhang, E. L. Ang, and H. Zhao. “A Highly Efficient Single-step, Markerless, and Multi-copy Strategy for Chromosomal Integration of Full Biochemical Pathways in Saccharomyces cerevisiae.” Metabolic Engineering, 33, 19-27 (2016).
4. Sun H., Liu Z., Zhao H., Ang E. L. “Recent Advances in Combinatorial Biosynthesis for Drug Discovery.” Drug Design, Development and Therapy, 9, 823-833 (2015).
3. Liang Y., Si T., Ang E. L. and Zhao H. “Pentafunctional Minicellulosome for Simultaneous Saccharification and Ethanol Fermentation in Saccharomyces cerevisiae” Applied and Environmental Microbiology, 80(21), 6677-6684 (2014).
2. Liang Y., Ang E. L. and Zhao H. “Directed Evolution of Enzymes for Industrial Biocatalysis.” Industrial Biocatalysis, (P. Grunwald, Ed.), Pan Stanford Publishing, Singapore, 73-110 (2014).
1. Zhang M. M., Su X., Ang E. L. and Zhao H. “Recent Advances in Biocatalyst Development in the Pharmaceutical Industry.” Pharmaceutical Bioprocessing, 1(2) 179-196 (2013).