Co-ordinator: Dr Lee Kuan Jin

The role of the MR Methods Development group is to develop and implement advanced sequences and protocols to support the MR imaging needs of collaborators, on both preclinical and clinical research projects. To illustrate the range of methods, some of the current projects include: 

pCASL perfusion imaging: The nuclear spin in blood is inverted and can be used as an endogenous contrast agent to quantify perfusion non-invasively. This is being used in conjunction with simultaneous blood oxygen measurement with NIRS to characterize cerebral metabolism, as part of the MRI-NIRS hybrid imaging system developed in collaboration with the Laboratory of Bio-optical Imaging (Prof Malini Olivo). 

Quantitative imaging of brown and white adipose tissue: The MR Methods Development group is part of the Body Composition Domain of the GUSTO Translational Clinical Research program, studying the effect of genetics, diet and environment during early childhood on health outcomes. Imaging is performed at KK hospital, where Dixon multi-echo sequences are used to measure fat-fraction maps of brown and white adipose tissue, which are then segmented and quantified. 

Atherosclerotic plaque imaging: Together with the Translational Cardiovascular Imaging group (Dr Joyce Chan), the group is developing methods for the quantification and characterization of atherosclerotic plaques. Methods being investigated include: targeted contrast agents, vessel wall imaging, and 4D flow. 

Non-human primate imaging: Our 3T Siemens Skyra is situated within the Biological Resource Centre, an AAALAC-accredited animal facility located in Biopolis. In a collaboration with the Singapore Immunology Network (Dr Lisa Ng), we have been developing methods for imaging and quantifying brain changes in a marmoset virus-infection model.


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